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Therapeutic drug monitoring guided fluconazole therapy in a patient with cholangitis sepsis. 治疗药物监测指导氟康唑治疗胆管炎脓毒症1例。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-11-08 DOI: 10.2217/pme-2021-0010
Jana Duricova, Pavla Jadrnickova, Hana Brozmanova, Ivana Kacirova
{"title":"Therapeutic drug monitoring guided fluconazole therapy in a patient with cholangitis sepsis.","authors":"Jana Duricova,&nbsp;Pavla Jadrnickova,&nbsp;Hana Brozmanova,&nbsp;Ivana Kacirova","doi":"10.2217/pme-2021-0010","DOIUrl":"https://doi.org/10.2217/pme-2021-0010","url":null,"abstract":"<p><p><i>Candida</i> and other fungal species play an increasing role in nosocomial infections, including cholangitis and cholangiosepsis. Early diagnosis and prompt treatment are essential in successful patient outcomes. Fluconazole is an antifungal of choice in fluconazole-sensitive <i>Candida</i> infections. Little information is known about the fluconazole biliary excretion. Decreased tissue penetration may be one of the possible causes of treatment failure. Due to favorable pharmacokinetics, therapeutic drug monitoring of this antifungal has not been recommended routinely. In the presented case we report the successful therapeutic drug monitoring-guided fluconazole treatment in a patient with cholangitis and cholangiosepsis caused by fluconazole-sensitive <i>Candida</i> spp.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"9-14"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39688304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The United States 2020 Census data: implications for precision medicine and the research landscape. 美国2020年人口普查数据:对精准医学和研究前景的影响。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-11-08 DOI: 10.2217/pme-2021-0129
Youssef Roman
{"title":"The United States 2020 Census data: implications for precision medicine and the research landscape.","authors":"Youssef Roman","doi":"10.2217/pme-2021-0129","DOIUrl":"https://doi.org/10.2217/pme-2021-0129","url":null,"abstract":"","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"5-8"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39688307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Somatic mitochondrial DNA mutations in different grades of glioma. 不同级别胶质瘤的体细胞线粒体DNA突变。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-12-07 DOI: 10.2217/pme-2021-0033
Bee Hong Soon, Nadiah Abu, Nor Azian Abdul Murad, Sue-Mian Then, Azizi Abu Bakar, Farizal Fadzil, Jegan Thanabalan, Mohd Saffari Mohd Haspani, Charng Jeng Toh, Ramesh Kumar, Ainul Syahrilfazli Jaafar, Anis Nabillah Mohd Azli, Mohd Syakir Mohd Azahar, Sanmugarajah Paramasvaran, Kamalanathan Palaniandy, Azmi Mohd Tamil, Rahman Jamal
{"title":"Somatic mitochondrial DNA mutations in different grades of glioma.","authors":"Bee Hong Soon,&nbsp;Nadiah Abu,&nbsp;Nor Azian Abdul Murad,&nbsp;Sue-Mian Then,&nbsp;Azizi Abu Bakar,&nbsp;Farizal Fadzil,&nbsp;Jegan Thanabalan,&nbsp;Mohd Saffari Mohd Haspani,&nbsp;Charng Jeng Toh,&nbsp;Ramesh Kumar,&nbsp;Ainul Syahrilfazli Jaafar,&nbsp;Anis Nabillah Mohd Azli,&nbsp;Mohd Syakir Mohd Azahar,&nbsp;Sanmugarajah Paramasvaran,&nbsp;Kamalanathan Palaniandy,&nbsp;Azmi Mohd Tamil,&nbsp;Rahman Jamal","doi":"10.2217/pme-2021-0033","DOIUrl":"https://doi.org/10.2217/pme-2021-0033","url":null,"abstract":"<p><p><b>Aim:</b> Mitochondrial DNA (mtDNA) alterations play an important role in the multistep processes of cancer development. Gliomas are among the most diagnosed brain cancer. The relationship between mtDNA alterations and different grades of gliomas are still elusive. This study aimed to elucidate the profile of somatic mtDNA mutations in different grades of gliomas and correlate it with clinical phenotype. <b>Materials & methods:</b> Forty histopathologically confirmed glioma tissue samples and their matched blood were collected and subjected for mtDNA sequencing. <b>Results & conclusion:</b> About 75% of the gliomas harbored at least one somatic mutation in the mtDNA gene, and 45% of these mutations were pathogenic. Mutations were scattered across the mtDNA genome, and the commonest nonsynonymous mutations were located at complex I and IV of the mitochondrial respiratory chain. These findings may have implication for future research to determine the mitochondrial energetics and its downstream metabolomics on gliomas.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"25-39"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39698808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HER2 in gastric adenocarcinoma: where do we stand today? 胃腺癌中HER2的研究进展如何?
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-12-09 DOI: 10.2217/pme-2021-0004
Khalil El Gharib, Makram Khoury, Hampig Raphael Kourie
{"title":"HER2 in gastric adenocarcinoma: where do we stand today?","authors":"Khalil El Gharib,&nbsp;Makram Khoury,&nbsp;Hampig Raphael Kourie","doi":"10.2217/pme-2021-0004","DOIUrl":"https://doi.org/10.2217/pme-2021-0004","url":null,"abstract":"<p><p><b>Aim:</b><i>HER2</i> is a proto-oncogene expressed in 10-30% of gastric adenocarcinomas and is an ideal target for inhibition in malignancy with high recurrence and dismal survival rates. <b>Materials & methods:</b> A systematic search was conducted via PubMed, Google Scholar and the clinicaltrials.gov database to report the results of ongoing and past studies investigating HER2 inhibitors in gastric cancer. <b>Results:</b> Twenty-five studies were included; ToGA trial is the pivotal trial approving the use of trastuzumab in metastatic gastric cancer, followed by more studies investigating other HER2 inhibitors in this setting, as well as in local and locoregional malignancy. <b>Conclusion:</b> Anti-HER2 molecules are proving efficacy and safety in gastric cancer; the evidence is growing and association with other cancer agents is under investigation.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"67-78"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39794455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prioritizing pharmacogenomics implementation initiates: a survey of healthcare professionals. 优先考虑药物基因组学实施启动:对医疗保健专业人员的调查。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-12-09 DOI: 10.2217/pme-2021-0061
Teresa T Ho, Maja Gift, Earnest Alexander
{"title":"Prioritizing pharmacogenomics implementation initiates: a survey of healthcare professionals.","authors":"Teresa T Ho,&nbsp;Maja Gift,&nbsp;Earnest Alexander","doi":"10.2217/pme-2021-0061","DOIUrl":"https://doi.org/10.2217/pme-2021-0061","url":null,"abstract":"<p><p><b>Aim:</b> Characterize current perceptions, practices, preferences and barriers to integrating pharmacogenomics into patient care at an institution with an established pharmacogenomics clinic. <b>Materials & methods:</b> A 16-item anonymous survey was sent to healthcare professionals practicing at Tampa General Hospital and the University of South Florida Health. <b>Results:</b> Survey participants consisted of nine advanced practice providers, 41 pharmacists and 64 physicians. Majority of survey participants did not feel confident in their ability to interpret and apply pharmacogenomic results. In the past 12 months, 27% of physicians reported ordering a pharmacogenomic test. The greatest reported barrier to integrating pharmacogenomics was the absence of established guidelines or protocols. <b>Conclusion:</b> Most clinicians believed pharmacogenomics would be useful in their clinical practice but do not feel prepared to interpret pharmacogenomic results.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"15-23"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39794456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Biomarker-driven immunotherapy for precision medicine in prostate cancer. 生物标志物驱动免疫疗法在前列腺癌精准医学中的应用。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-12-07 DOI: 10.2217/pme-2021-0079
Arianna Ottini, Pierangela Sepe, Teresa Beninato, Mélanie Claps, Valentina Guadalupi, Elena Verzoni, Patrizia Giannatempo, Giulia Baciarello, Filippo de Braud, Giuseppe Procopio
{"title":"Biomarker-driven immunotherapy for precision medicine in prostate cancer.","authors":"Arianna Ottini,&nbsp;Pierangela Sepe,&nbsp;Teresa Beninato,&nbsp;Mélanie Claps,&nbsp;Valentina Guadalupi,&nbsp;Elena Verzoni,&nbsp;Patrizia Giannatempo,&nbsp;Giulia Baciarello,&nbsp;Filippo de Braud,&nbsp;Giuseppe Procopio","doi":"10.2217/pme-2021-0079","DOIUrl":"https://doi.org/10.2217/pme-2021-0079","url":null,"abstract":"<p><p>Although immunotherapy has recently revolutionized standard of care in different cancer types, prostate cancer has generally failed to show dramatic responses to immune checkpoint inhibitors. As in other tumors, the goal in prostate cancer is now to target treatments more precisely on patient's individual characteristics through precision medicine. Defects in mismatch repair, mutations in the exonuclease domain of the DNA polymerase epsilon (<i>POLE</i>), high tumor mutational burden and the presence of biallelic loss of <i>CDK12</i> among others, are predictive biomarkers of response to immunotherapy. In the present review, we summarize the evolving landscape of immunotherapy in prostate cancer, including precision approaches and strategies to define classes of responsive patients and scale up resistance to immune checkpoint inhibitors.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"51-66"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39812110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Welcome to the 19th volume of Personalized Medicine. 欢迎来到《个性化医疗》第19卷。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-01-01 DOI: 10.2217/pme-2021-0138
Ryan Gilroy
{"title":"Welcome to the 19th volume of <i>Personalized Medicine</i>.","authors":"Ryan Gilroy","doi":"10.2217/pme-2021-0138","DOIUrl":"https://doi.org/10.2217/pme-2021-0138","url":null,"abstract":"","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 1","pages":"1-4"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39834964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment. GABRD基因多态性与美沙酮维持治疗疗效和剂量的相关性研究。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2021-09-01 Epub Date: 2021-06-23 DOI: 10.2217/pme-2021-0063
Xiaohu Xie, Jun Gu, Dingding Zhuang, Xiaoyu Chen, Yun Zhou, Wenwen Shen, Longhui Li, Yue Liu, Wenjin Xu, Qingxiao Hong, Weisheng Chen, Wenhua Zhou, Huifen Liu
{"title":"Association study of genetic polymorphisms in <i>GABRD</i> with treatment response and dose in methadone maintenance treatment.","authors":"Xiaohu Xie,&nbsp;Jun Gu,&nbsp;Dingding Zhuang,&nbsp;Xiaoyu Chen,&nbsp;Yun Zhou,&nbsp;Wenwen Shen,&nbsp;Longhui Li,&nbsp;Yue Liu,&nbsp;Wenjin Xu,&nbsp;Qingxiao Hong,&nbsp;Weisheng Chen,&nbsp;Wenhua Zhou,&nbsp;Huifen Liu","doi":"10.2217/pme-2021-0063","DOIUrl":"https://doi.org/10.2217/pme-2021-0063","url":null,"abstract":"<p><p><b>Aim:</b> This study determined if gene variants in the GABA receptor delta subunit (<i>GABRD</i>) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. <b>Materials & methods:</b> A total of 286 MMT patients were recruited and divided into response and nonresponse groups based on retention time in therapy. A total of 177 responders were classified into low dose and high dose subgroups according to the stabilized methadone dose. Four (single nucleotide polymorphisms) SNPs (rs13303344, rs4481796, rs2376805 and rs2229110) in <i>GABRD</i> were genotyped using the TaqMan SNP assay. Logistic regression was used to assess the genetic effects of the SNPs in MMT. <b>Results:</b> No significant associations were observed between the SNPs and treatment response or dose, except the frequency of haplotype ACGC at the four SNPs significantly differed between responders and nonresponders. <b>Conclusion:</b> The results indicated that <i>GABRD</i> variants may play a small role in modulating methadone treatment response.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"18 5","pages":"423-430"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39099313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Creating accessible Spanish language materials for Clinical Sequencing Evidence-Generating Research consortium genomic projects: challenges and lessons learned. 为临床测序证据生成研究联盟基因组学项目创建无障碍西班牙语材料：挑战与经验教训。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2021-09-01 Epub Date: 2021-08-27 DOI: 10.2217/pme-2020-0075
Nangel M Lindberg, Amanda M Gutierrez, Kathleen F Mittendorf, Michelle A Ramos, Beatriz Anguiano, Frank Angelo, Galen Joseph
{"title":"Creating accessible Spanish language materials for Clinical Sequencing Evidence-Generating Research consortium genomic projects: challenges and lessons learned.","authors":"Nangel M Lindberg, Amanda M Gutierrez, Kathleen F Mittendorf, Michelle A Ramos, Beatriz Anguiano, Frank Angelo, Galen Joseph","doi":"10.2217/pme-2020-0075","DOIUrl":"10.2217/pme-2020-0075","url":null,"abstract":"<p><p><b>Aim:</b> To increase Spanish speakers' representation in genomics research, accessible study materials on genetic topics must be made available in Spanish. <b>Materials & methods:</b> The Clinical Sequencing Evidence-Generating Research consortium is evaluating genome sequencing for underserved populations. All sites needed Spanish translation of recruitment materials, surveys and return of results. <b>Results:</b> We describe our process for translating site-specific materials, as well as shared measures across sites, to inform future efforts to engage Spanish speakers in research. <b>Conclusion:</b> In translating and adapting study materials for roughly 1000 Spanish speakers across the USA, and harmonizing translated measures across diverse sites, we overcame numerous challenges. Translation should be performed by professionals. Studies must allocate sufficient time, effort and budget to translate and adapt participant materials.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"18 5","pages":"441-454"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438935/pdf/pme-18-441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39357000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intelligent health system for the investigation of consenting COVID-19 patients and precision medicine. 新型冠状病毒肺炎患者自愿调查与精准医疗智能健康系统。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2021-09-01 Epub Date: 2021-10-08 DOI: 10.2217/pme-2021-0068
Zeeshan Ahmed
{"title":"Intelligent health system for the investigation of consenting COVID-19 patients and precision medicine.","authors":"Zeeshan Ahmed","doi":"10.2217/pme-2021-0068","DOIUrl":"https://doi.org/10.2217/pme-2021-0068","url":null,"abstract":"<p><p>Advancing frontiers of clinical research, we discuss the need for intelligent health systems to support a deeper investigation of COVID-19. We hypothesize that the convergence of the healthcare data and staggering developments in artificial intelligence have the potential to elevate the recovery process with diagnostic and predictive analysis to identify major causes of mortality, modifiable risk factors and actionable information that supports the early detection and prevention of COVID-19. However, current constraints include the recruitment of COVID-19 patients for research; translational integration of electronic health records and diversified public datasets; and the development of artificial intelligence systems for data-intensive computational modeling to assist clinical decision making. We propose a novel nexus of machine learning algorithms to examine COVID-19 data granularity from population studies to subgroups stratification and ensure best modeling strategies within the data continuum.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"18 6","pages":"573-582"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39495766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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