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Role of precision nutrition in improving military performance. 精确营养在提高军事性能中的作用。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-16 DOI: 10.2217/pme-2021-0120
Coimbatore Subburaj Thiruvenkataswamy, M. Appukutty, K. S. Vimaleswaran
{"title":"Role of precision nutrition in improving military performance.","authors":"Coimbatore Subburaj Thiruvenkataswamy, M. Appukutty, K. S. Vimaleswaran","doi":"10.2217/pme-2021-0120","DOIUrl":"https://doi.org/10.2217/pme-2021-0120","url":null,"abstract":"Graphical abstract [Formula: see text] Role of precision nutrition in improving military performance.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49388425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
State-of-the-art knowledge on the regulation of advanced therapy medicinal products. 先进治疗药品监管方面的最新知识。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-16 DOI: 10.2217/pme-2021-0111
Patcharaphun Kidpun, Warit Ruanglertboon, R. Chalongsuk
{"title":"State-of-the-art knowledge on the regulation of advanced therapy medicinal products.","authors":"Patcharaphun Kidpun, Warit Ruanglertboon, R. Chalongsuk","doi":"10.2217/pme-2021-0111","DOIUrl":"https://doi.org/10.2217/pme-2021-0111","url":null,"abstract":"Advanced therapy medicinal products (ATMPs) constitute therapeutic agents based on obtained cells, tissues or genes representing a novel treatment opportunity in medicine. In addition, ATMPs are administered into the cells or tissues of humans from the patient's own cells, donors, or genetically modified cells. Recently, the field of developing ATMPs has become a point of attention due to the clinical efficacy expected in defeating incurable diseases such as cancers and neurodegenerative disorders. Currently, there are two modes regarding the distribution of ATMPs. First, ATMPs that might be legally authorized for marketing. Second, the patients are able to access unapproved ATMPs through the hospital exemption (HE) or clinical practice program or through the compassionate use and expanded access program. The aim of this review is to discuss state-of-the-art knowledge on the regulation of ATMPs and provide regulatory recommendations.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45924052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
How can we address the uncertainties regarding the potential clinical utility of polygenic score-based tests? 我们如何解决基于多基因评分的测试潜在临床效用的不确定性？
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-15 DOI: 10.2217/pme-2021-0148
S. Moorthie, A. Hall, Chantal Babb de Villiers, Joanna Janus, Tanya Brigden, Laura Blackburn, M. Kroese
{"title":"How can we address the uncertainties regarding the potential clinical utility of polygenic score-based tests?","authors":"S. Moorthie, A. Hall, Chantal Babb de Villiers, Joanna Janus, Tanya Brigden, Laura Blackburn, M. Kroese","doi":"10.2217/pme-2021-0148","DOIUrl":"https://doi.org/10.2217/pme-2021-0148","url":null,"abstract":"As common low penetrance variants associated with diseases are uncovered, attempts continue to be made to harness this knowledge for improving healthcare. Polygenic scores have been developed as the mechanism by which knowledge of common variants can be used to investigate genetic contributions to disease risk. They serve as a biomarker to provide an estimate of the genetic liability for a particular disease. Discussion continues as to whether polygenic scores are a useful biomarker and their readiness for incorporation into clinical and public health practice. In this paper, we investigate the key challenges that need to be addressed, in the description and assessment of the clinical utility of polygenic score-based tests for use in clinical and public health practice.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47165117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Exploring the usefulness of plasma level determination and pharmacogenetics for patients treated with clozapine. 探讨血浆水平测定和药物遗传学对氯氮平治疗患者的有用性。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-09 DOI: 10.2217/pme-2021-0029
Estela Sangüesa, Christine Cirujeda, Julia Concha, P. Padilla, C. García, M. Ribate
{"title":"Exploring the usefulness of plasma level determination and pharmacogenetics for patients treated with clozapine.","authors":"Estela Sangüesa, Christine Cirujeda, Julia Concha, P. Padilla, C. García, M. Ribate","doi":"10.2217/pme-2021-0029","DOIUrl":"https://doi.org/10.2217/pme-2021-0029","url":null,"abstract":"Aims: The aims of the present study were to assess the variance of plasma clozapine (CLZ) levels and to identify the influence of sociodemographic and pharmacogenetic factors on it and to introduce these tools in a clinical setting. Patients & methods: CLZ concentration was measured and genetic variants of CLZ pharmacokinetic and pharmacodynamic factors were assessed in 23 patients with psychotic disorders. Results: A significant association between mean concentration/dose ratio (C/D) and smoking status, age and weight were found. There was a significant difference in mean plasma CLZ levels and gender. The rs762551 AA genotype in smokers had a significantly lower C/D. Conclusion: In addition to classical factors, monitoring of plasma concentrations together with pharmacogenetics led to greater individualization of treatment.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41651554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Interindividual variability in diabetic patients' response to opium poppy: an overview of impressive factors. 糖尿病患者对罂粟反应的个体差异:令人印象深刻的因素概述。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-01 DOI: 10.2217/pme-2021-0107
Fatemeh Hendijani, Fatemeh Sadat Hosseini
{"title":"Interindividual variability in diabetic patients' response to opium poppy: an overview of impressive factors.","authors":"Fatemeh Hendijani,&nbsp;Fatemeh Sadat Hosseini","doi":"10.2217/pme-2021-0107","DOIUrl":"https://doi.org/10.2217/pme-2021-0107","url":null,"abstract":"<p><p>Diabetic patients always seek alternative treatments to lower their blood glucose level efficiently, because antidiabetic drugs produce adverse effects and many patients experience reduced response after a treatment period. Opium poppy (<i>Papaver somniferum</i>) is frequently consumed by diabetic patients for reduction of blood glucose level. Scientific studies found controversial results in the investigation of the blood glucose-lowering effects of opium poppy. In this regard, we explored the antidiabetic effect of opium poppy more closely. The antidiabetic or antihyperglycemic effect of <i>P. somniferum</i> alkaloids were reviewed. Next, opioid receptors and their role in diabetes were explored. In the final part origins of interindividual variabilities in opioid receptors and metabolizing enzymes' functions including genetic and epigenetic factors were reviewed.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 2","pages":"155-163"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BRAF: a biomarker not to be missed in glioblastoma. BRAF:胶质母细胞瘤不可错过的生物标志物。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-01 Epub Date: 2022-01-21 DOI: 10.2217/pme-2021-0118
Georges Ayoub, Elie Chalhoub, Hampig Raphael Kourie
{"title":"BRAF: a biomarker not to be missed in glioblastoma.","authors":"Georges Ayoub,&nbsp;Elie Chalhoub,&nbsp;Hampig Raphael Kourie","doi":"10.2217/pme-2021-0118","DOIUrl":"https://doi.org/10.2217/pme-2021-0118","url":null,"abstract":"","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"79-82"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum. 有待纠正。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-01 Epub Date: 2022-02-24 DOI: 10.2217/pme-2021-0061c1
{"title":"Corrigendum.","authors":"","doi":"10.2217/pme-2021-0061c1","DOIUrl":"https://doi.org/10.2217/pme-2021-0061c1","url":null,"abstract":"","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"165"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39949548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalized approach in arrhythmology by genetic-based data: a case report. 基于遗传学数据的心律失常个性化方法:1例报告。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-01 Epub Date: 2022-01-21 DOI: 10.2217/pme-2021-0090
Anastasia Victorovna Blokhina, Alexandra Igorevna Ershova, Elena Vitalievna Zyatenkova, Alexey Nikolaevich Meshkov, Anna Vitalievna Kiseleva, Marina Vyacheslavovna Klimushina, Evgeniia Andreevna Sotnikova, Olga Petrovna Skirko, Anastasia Alexandrovna Zharikova, Yurii Valerievich Doludin, Maria Sergeevna Kharlap, Oxana Mikhailovna Drapkina
{"title":"Personalized approach in arrhythmology by genetic-based data: a case report.","authors":"Anastasia Victorovna Blokhina,&nbsp;Alexandra Igorevna Ershova,&nbsp;Elena Vitalievna Zyatenkova,&nbsp;Alexey Nikolaevich Meshkov,&nbsp;Anna Vitalievna Kiseleva,&nbsp;Marina Vyacheslavovna Klimushina,&nbsp;Evgeniia Andreevna Sotnikova,&nbsp;Olga Petrovna Skirko,&nbsp;Anastasia Alexandrovna Zharikova,&nbsp;Yurii Valerievich Doludin,&nbsp;Maria Sergeevna Kharlap,&nbsp;Oxana Mikhailovna Drapkina","doi":"10.2217/pme-2021-0090","DOIUrl":"https://doi.org/10.2217/pme-2021-0090","url":null,"abstract":"<p><p>The results of molecular genetic testing may affect recommended treatment or therapeutic decisions and risk assessment, may help with identification of family members at risk. Here, we report a case of a young patient with a paradoxical combination of two inherited arrhythmic syndromes and demonstrate the role of genetic testing as one of the basis of personalized approach in diagnosis, treatment and prevention complications of inherited channelopathies complications. Integration of genetic testing results into clinical practice is a successful example of the concept of personalized medicine.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"83-91"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39846040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient views on genetics and functional imaging for precision medicine: a willingness-to-pay analysis. 患者对精准医学遗传学和功能成像的看法:付费意愿分析。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-01 Epub Date: 2022-01-05 DOI: 10.2217/pme-2021-0067
Kerstin Clasen, Cihan Gani, Christopher Schroeder, Olaf Riess, Daniel Zips, Oliver Schöffski, Stephan Clasen
{"title":"Patient views on genetics and functional imaging for precision medicine: a willingness-to-pay analysis.","authors":"Kerstin Clasen,&nbsp;Cihan Gani,&nbsp;Christopher Schroeder,&nbsp;Olaf Riess,&nbsp;Daniel Zips,&nbsp;Oliver Schöffski,&nbsp;Stephan Clasen","doi":"10.2217/pme-2021-0067","DOIUrl":"https://doi.org/10.2217/pme-2021-0067","url":null,"abstract":"<p><p><b>Purpose:</b> Willingness-to-pay (WTP) analyses can support allocation processes considering the patients preferences in personalized medicine. However, genetic testing especially might imply ethical concerns that have to be considered. <b>Methods:</b> A WTP questionnaire was designed to compare preferences for imaging and genetic testing in cancer patients and to evaluate potential ethical concerns. <b>Results:</b> Comparing the options of imaging and genetics showed comparable WTP values. Ethical concerns about genetic testing seemed to be minor. Treatment success was the top priority irrespective of the diagnostic modality. In general, the majority of patients considered personalized medicine to be beneficial. <b>Conclusion:</b> Most patients valued personalized approaches and rated the benefits of precision medicine of overriding importance irrespective of modality or ethical concerns.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"103-112"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The interplay between pharmacogenetics, concomitant drugs and blood levels of amitriptyline and its main metabolites. 药物遗传学、伴随药物与阿米替林及其主要代谢物血药水平之间的相互作用。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-03-01 Epub Date: 2022-02-04 DOI: 10.2217/pme-2021-0022
Luana Mifsud Buhagiar, Marilyn Casha, Anton Grech, Anthony Serracino Inglott, Godfrey LaFerla
{"title":"The interplay between pharmacogenetics, concomitant drugs and blood levels of amitriptyline and its main metabolites.","authors":"Luana Mifsud Buhagiar,&nbsp;Marilyn Casha,&nbsp;Anton Grech,&nbsp;Anthony Serracino Inglott,&nbsp;Godfrey LaFerla","doi":"10.2217/pme-2021-0022","DOIUrl":"https://doi.org/10.2217/pme-2021-0022","url":null,"abstract":"<p><p><b>Background:</b> The research considers the impact of genotype-inferred variability on blood levels of amitriptyline and its main metabolites, as may be moderated by phenocopying. <b>Patients & methods:</b><i>CYP2D6</i> and <i>CYP2C19</i> genotypes, and serum concentrations of amitriptyline, nortriptyline and hydroxymetabolites, were determined in 33 outpatients. Co-medications were reviewed to identify CYP inhibition risk. <b>Results:</b> CYP2C19 metabolizer status explained interpatient variation in nortriptyline to amitriptyline concentration ratios. The hydroxymetabolite to parent ratios increased with higher CYP2D6 activity scores and lower CYP2D6 inhibition risk. In patients at high CYP2D6 inhibition risk, the amitriptyline + nortriptyline concentration was, on average, 52% above the higher end of expected ranges. <b>Conclusion:</b> Practical construal of pharmacogenetics and drug interactions tantamount to aberrant metabolism can facilitate patient-tailored use of the established drug.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"113-123"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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