多粘菌素b非调整剂量与基于肾功能调整剂量的急性肾损伤风险比较。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-07-01 Epub Date: 2022-06-28 DOI:10.2217/pme-2021-0003

Guanhao Zheng, Jiaqi Cai, Shenghui Zhou, Ning Du, Hao Bai, Juan He, Xiaolan Bian

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引用次数: 0

摘要

目的:观察多粘菌素B (PMB)引起的急性肾损伤(AKI)发生风险根据患者肾功能调整剂量与不调整剂量的差异。材料与方法:对2018年11月至2019年10月接受PMB治疗的115例患者进行回顾性队列分析。结果:两组AKI发生率及次要结局无显著差异(47.5% vs 37.14%;p = 0.304)。结论:基于肾功能的剂量调整并不能显著降低pmb诱发AKI的风险。对于表现出不同程度肾功能损害的患者，建议采用非调整的PMB给药策略。

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Risk of polymyxin B-induced acute kidney injury with a non adjusted dose versus adjusted dose based on renal function.

Aim: To observe the difference in the risk of polymyxin B (PMB)-induced acute kidney injury (AKI) with or without dose adjustment based on the patients renal function. Materials & methods: This retrospective cohort analysis was carried out in 115 patients treated with PMB from November 2018 to October 2019. Results: No significant difference in the incidence of AKI as well as secondary outcomes was observed between these two groups (47.5 vs 37.14%; p = 0.304). Conclusion: Dosing adjustment based on renal function does not significantly lower the risk of PMB-induced AKI. A non adjusted dosing strategy for PMB is recommended in patients exhibiting various levels of renal impairment.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.