Pathologie-biologie最新文献_第8页

Exercise and sleep in aging: Emphasis on serotonin 运动和睡眠对衰老的影响:强调血清素

Pathologie-biologie Pub Date : 2014-10-01 DOI: 10.1016/j.patbio.2014.07.004

M.O. Melancon , D. Lorrain , I.J. Dionne

{"title":"Exercise and sleep in aging: Emphasis on serotonin","authors":"M.O. Melancon , D. Lorrain , I.J. Dionne","doi":"10.1016/j.patbio.2014.07.004","DOIUrl":"10.1016/j.patbio.2014.07.004","url":null,"abstract":"<div><p>Reductions in central serotonin activity with aging might be involved in sleep-related disorders in later life. Although the beneficial effects of aerobic exercise on sleep are not new, sleep represents a complex recurring state of unconsciousness involving many lines of transmitters which remains only partly clear despite intense ongoing research. It is known that serotonin released into diencephalon and cerebrum might play a key inhibitory role to help promote sleep, likely through an active inhibition of supraspinal neural networks. Several lines of evidence support the stimulatory effects of exercise on higher serotonergic pathways. Hence, exercise has proved to elicit acute elevations in forebrain serotonin concentrations, an effect that waned upon cessation of exercise. While adequate exercise training might lead to adaptations in higher serotonergic networks (desensitization of forebrain receptors), excessive training has been linked to serious brain serotonergic maladaptations accompanied by insomnia. Dietary supplementation of tryptophan (the only serotonin precursor) is known to stimulate serotonergic activity and promote sleep, whereas acute tryptophan depletion causes deleterious effects on sleep. Regarding sleep-wake regulation, exercise has proved to accelerate resynchronization of the biological clock to new light-dark cycles following imposition of phase shifts in laboratory animals. Noteworthy, the effect of increased serotonergic transmission on wake state appears to be biphasic, i.e. promote wake and thereafter drowsiness. Therefore, it might be possible that acute aerobic exercise would act on sleep by increasing activity of ascending brain serotonergic projections, though additional work is warranted to better understand the implication of serotonin in the exercise-sleep axis.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32569209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62

Prevalence and correlates of disturbed dreaming in children 儿童梦境紊乱的患病率及相关因素

Pathologie-biologie Pub Date : 2014-10-01 DOI: 10.1016/j.patbio.2014.05.016

A. Gauchat , J.R. Séguin , A. Zadra

{"title":"Prevalence and correlates of disturbed dreaming in children","authors":"A. Gauchat , J.R. Séguin , A. Zadra","doi":"10.1016/j.patbio.2014.05.016","DOIUrl":"10.1016/j.patbio.2014.05.016","url":null,"abstract":"<div><p>Relatively little is known about nightmares and other forms of disturbed dreaming in children. This article reviews the literature on the prevalence and correlates of nightmares in children and highlights key methodological issues in the field. Results show that regardless of how they are defined and measured, nightmares affect a significant proportion of children of all ages and there is some evidence to suggest that nightmare frequency may peak around the age of 10. Gender differences in nightmare frequency, with girls reporting more nightmares than do boys, tend to appear between the ages of 10 and 15. Although nightmares are associated with a range of psychosocial difficulties (e.g., stress, behavioural problems), elevated anxiety and concomitant sleep-related disorders (e.g., sleepwalking) are among the most robust correlates of nightmares. Very few studies have examined nightmare treatment in children, but promising results have been obtained with imagery rehearsal therapy. Overall, research in the field has been hampered by inconsistent definitions for nightmares, by extensive variability in questionnaire items used to measure nightmare frequency, and by a lack of awareness of how using parents versus children as respondents may impact results. Longitudinal studies are needed to better understand how nightmares and their correlates evolve during childhood and adolescence, to delineate their clinical significance, and to develop effective and age-appropriate treatment strategies.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.05.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32572725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Neuroimaging findings in primary insomnia 原发性失眠症的神经影像学表现

Pathologie-biologie Pub Date : 2014-10-01 DOI: 10.1016/j.patbio.2014.05.013

J.N. O’Byrne , M. Berman Rosa , J.-P. Gouin , T.T. Dang-Vu

{"title":"Neuroimaging findings in primary insomnia","authors":"J.N. O’Byrne , M. Berman Rosa , J.-P. Gouin , T.T. Dang-Vu","doi":"10.1016/j.patbio.2014.05.013","DOIUrl":"10.1016/j.patbio.2014.05.013","url":null,"abstract":"<div><p>State-of-the-art neuroimaging techniques have accelerated progress in the study and understanding of sleep in humans. Neuroimaging studies in primary insomnia remain relatively few, considering the important prevalence of this disorder in the general population. This review examines the contribution of functional and structural neuroimaging to our current understanding of primary insomnia. Functional studies during sleep provided support for the hyperarousal theory of insomnia. Functional neuroimaging also revealed abnormalities in cognitive and emotional processing in primary insomnia. Results from structural studies suggest neuroanatomical alterations in primary insomnia, mostly in the hippocampus, anterior cingulate cortex and orbitofrontal cortex. However, these results are not well replicated across studies. A few magnetic resonance spectroscopy studies revealed abnormalities in neurotransmitter concentrations and bioenergetics in primary insomnia. The inconsistencies among neuroimaging findings on insomnia are likely due to clinical heterogeneity, differences in imaging and overall diversity of techniques and designs employed. Larger samples, replication, as well as innovative methodologies are necessary for the progression of this perplexing, yet promising area of research.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.05.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32591018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

Sleep and wake disturbances following traumatic brain injury 创伤性脑损伤后的睡眠和觉醒障碍

Pathologie-biologie Pub Date : 2014-10-01 DOI: 10.1016/j.patbio.2014.05.014

C. Duclos , M. Dumont , C. Wiseman-Hakes , C. Arbour , V. Mongrain , P.-O. Gaudreault , S. Khoury , G. Lavigne , A. Desautels , N. Gosselin

{"title":"Sleep and wake disturbances following traumatic brain injury","authors":"C. Duclos , M. Dumont , C. Wiseman-Hakes , C. Arbour , V. Mongrain , P.-O. Gaudreault , S. Khoury , G. Lavigne , A. Desautels , N. Gosselin","doi":"10.1016/j.patbio.2014.05.014","DOIUrl":"10.1016/j.patbio.2014.05.014","url":null,"abstract":"<div><p>Traumatic brain injury (TBI) is a major health concern in industrialised countries. Sleep and wake disturbances are among the most persistent and disabling sequelae after TBI. Yet, despite the widespread complaints of post-TBI sleep and wake disturbances, studies on their etiology, pathophysiology, and treatments remain inconclusive. This narrative review aims to summarise the current state of knowledge regarding the nature of sleep and wake disturbances following TBI, both subjective and objective, spanning all levels of severity and phases post-injury. A second goal is to outline the various causes of post-TBI sleep-wake disturbances. Globally, although sleep-wake complaints are reported in all studies and across all levels of severity, consensus regarding the objective nature of these disturbances is not unanimous and varies widely across studies. In order to optimise recovery in TBI survivors, further studies are required to shed light on the complexity and heterogeneity of post-TBI sleep and wake disturbances, and to fully grasp the best timing and approach for intervention.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.05.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32574685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Transfert de compétence : la mise en place d’un statut infirmier(ère) de greffe pour le suivi post-greffe : un rapport par la SFGM-TC 能力转移:为移植后随访建立移植护士状态:SFGM-TC的一份报告

Pathologie-biologie Pub Date : 2014-08-01 DOI: 10.1016/j.patbio.2014.05.003

J. Cornillon , R. Peffault de Latour , S. Apaza , M.-A. Bourg , C. Courbon , S. Evard , M. Guiraud , L. Le Bars , S. Petit , L. Magro , S. Schmitt , L. Tardieu , O. Samsonova , R. Tipton , I. Yakoub-Agha

{"title":"Transfert de compétence : la mise en place d’un statut infirmier(ère) de greffe pour le suivi post-greffe : un rapport par la SFGM-TC","authors":"J. Cornillon , R. Peffault de Latour , S. Apaza , M.-A. Bourg , C. Courbon , S. Evard , M. Guiraud , L. Le Bars , S. Petit , L. Magro , S. Schmitt , L. Tardieu , O. Samsonova , R. Tipton , I. Yakoub-Agha","doi":"10.1016/j.patbio.2014.05.003","DOIUrl":"10.1016/j.patbio.2014.05.003","url":null,"abstract":"<div><p>The number of Hematopoietic Stem Cell Transplantations has globally taken off in the past decade. However, this increase in transplantation activity has put in the spotlight the need to create a special transplantation-skilled population of nurses. This type of specialisation allocated solely to this activity has not existed within the French nursing community until now. In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC) sets up its forth annual series of workshops which brought together practitioners from all member centers and took place in September 2013 in Lille. Here we report our results and recommendations regarding the implementation of a transplant nurse status for post-transplant follow-up care.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32460769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prise en charge des séquelles après greffe de cellules souches hématopoïétiques chez l’enfant : recommandations de la SFGM-TC 儿童造血干细胞移植后遗症的管理:SFGM-TC的建议

Pathologie-biologie Pub Date : 2014-08-01 DOI: 10.1016/j.patbio.2014.05.009

E. de Berranger , G. Michel , M. Fahd , V. Gandemer , C. Jubert , A. Marie-Cardine , C. Pochon , P.S. Rohrlich , A. Sirvent , M. Cartigny , A. Deschildre , I. Yakoub-Agha

引用次数: 4

Indications d’allogreffe dans les neutropénies constitutionnelles : recommandation de la SFGM-TC 同源性中性粒细胞减少症的适应症:SFGM-TC的建议

Pathologie-biologie Pub Date : 2014-08-01 DOI: 10.1016/j.patbio.2014.05.008

J.-H. Dalle , J. Donadieu , C. Paillard , F. Rialland , P. Schneider , F. Sicre De Fontbrune , Y. Hichri , B. Neven , I. Yakoub-Agha

引用次数: 4

Greffes de cellules souches hématopoïétiques à partir d’un donneur haploidentique : recommandations de la SFGM-TC (deuxième partie) 单倍相同供体造血干细胞移植:SFGM-TC的建议(第二部分)

Pathologie-biologie Pub Date : 2014-08-01 DOI: 10.1016/j.patbio.2014.05.002

S. Nguyen , D. Blaise , J.-O. Bay , P. Chevallier , N. Contentin , N. Dhédin , R. Duléry , J.-F. Eliaou , M.-T. Rubio , F. Suarez , C.-E. Bulabois , J. Cornillon , A. Huynh , L. Magro , M. Michallet , C. Paillard , P. Turlure , I. Yakoub-Agha

引用次数: 11

Recommandations de la SFGM-TC concernant l’injection prophylactique, préemptive et curative des lymphocytes du donneur (DLI) après allogreffe de cellules souches hématopoïétiques SFGM-TC对同种异体造血干细胞移植后供体淋巴细胞(DLI)的预防、预防和治疗注射的建议

Pathologie-biologie Pub Date : 2014-08-01 DOI: 10.1016/j.patbio.2014.05.011

T. Guillaume , S. Porcheron , F. Audat , N. Bancillon , A. Berceanu , A. Charbonnier , R. Dulery , N. Edy , J. El Cheikh , E. Hermet , N. Maurer , F. Paul , J. Konopacki-Potet , P. Turlure , A. Wallart , F. Boulanger , N. Dhédin , F. Suarez , I. Yakoub-Agha

引用次数: 14

Modalités de conservation et de destruction des produits cellulaires cryopréservés : recommandations de la SFGM-TC 冷冻保存细胞产品的保存和销毁方法:SFGM-TC的建议

Pathologie-biologie Pub Date : 2014-08-01 DOI: 10.1016/j.patbio.2014.05.006

B. Calmels , F. Boulanger , E. Baudoux , V. Decot , A. Fawaz , C. Giraud , B. Hivert , L. Garderet , N. Milpied , I. Yakoub-Agha

{"title":"Modalités de conservation et de destruction des produits cellulaires cryopréservés : recommandations de la SFGM-TC","authors":"B. Calmels , F. Boulanger , E. Baudoux , V. Decot , A. Fawaz , C. Giraud , B. Hivert , L. Garderet , N. Milpied , I. Yakoub-Agha","doi":"10.1016/j.patbio.2014.05.006","DOIUrl":"10.1016/j.patbio.2014.05.006","url":null,"abstract":"<div><p>Thousands of autologous and at less extent allogeneic hematopoietic stem cells (HSC) bags are cryopreserved in France. The majority of autologous HSC grafts are used within a year after collection. However, many bags are still unused and cryopreserved for many years. In France and on a European scale, the ever-growing number of cryopreserved bags represents a real economic health concern. Indeed, the cost of storage is about 100€ per bag and per year. In addition, quality and therapeutic value of these long-term cryopreserved grafts needs to be evaluated. In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC) set up its fourth annual series of workshops which brought together practitioners from its member centers across France. These workshops took place in September 2013 in Lille. In this article, we addressed the issue of the destruction of long-term cryopreserved grafts be them autologous or allogeneic and provide recommendations regarding their destruction.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.05.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32481402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3