Nuclear Medicine Communications最新文献

{"title":"Bifunctional chelator-plerixafor complex for targeting CXCR4 receptors: radiolabeling, in-vitro, and preclinical study.","authors":"Tamanna Lakhanpal, Jaya Shukla, Rajender Kumar, Yogesh Rathore, Pankaj Malhotra, Alka Khadwal, Amanjit Bal, Bhagwant Rai Mittal","doi":"10.1097/MNM.0000000000001998","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001998","url":null,"abstract":"<p><strong>Objective: </strong>Overexpression of chemokine receptor subtype 4 (CXCR4) receptors is the root cause of the metastatic spread of various cancers. The use of CXCR4 antagonists as specific ligands to inhibit the CXCR4 interaction with its only natural ligand stromal cell derived factor-1α would benefit. Plerixafor is one such Food and Drug Administration approved CXCR4 antagonist used for hematopoietic stem cell mobilization in patients. Taking the specific advantage of low molecular weight, plerixafor conjugation with different bifunctional chelating agents, was optimized.</p><p><strong>Methods and results: </strong>Radiolabeling of the complex with 68Ga radionuclide was standardized at pH (3-8), incubation time (5-30 min), temperature (25-100 °C), and volume (0.5-4.5 ml) followed by quality control checks: radionuclide, radiochemical purity, sterility, and pyrogenicity. In-vivo biodistribution studies were performed using gallium-68-diethylenetriamine pentacectic acid (68Ga-DTPA)-plerixafor in normal rats. The molecular weights of DTPA- and 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated plerixafor were 1087 and 1014 Da, respectively. Radiolabeling yield of DTPA conjugated plerixafor was greater than or equal to 99% at pH 5.5; 10-15 min incubation at room temperature; and 2.5-4.5 ml maximum volume. Radionuclide and radiochemical purities were greater than or equal to 99%. Radiopharmaceuticals were sterile and pyrogen-free. Physiological uptake of 68Ga-DTPA-plerixafor was noted in the spleen (~20% ID/g), liver (4-5% ID/g), blood pool (6-13% ID/g), and faster clearance via kidneys (18-19% ID) up to 180 min.</p><p><strong>Conclusion: </strong>Radiolabelled 68Ga-DTPA-plerixafor has the potential as a diagnostic carrier molecule for imaging in-vivo CXCR4 expression.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging wastewater data to enhance understanding of medical radionuclide usage in the UK.","authors":"Alexandra Adrych-Brunning, James W Scuffham, Lakshmi Sasi, Nadia A S Smith, Rebecca Nutbrown","doi":"10.1097/MNM.0000000000002001","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002001","url":null,"abstract":"<p><strong>Objective: </strong>The secure supply of medical radionuclides, such as Tc-99m and I-131, is at risk because of aging production facilities worldwide. To advocate for investment in radionuclide production infrastructure in the UK, it is essential to understand current radionuclide usage. Accessing hospital data to determine the types and numbers of procedures performed with radionuclides is challenging, and reporting is inconsistent across the devolved nations. By utilising open-source records of radioactive waste discharge held by environmental agencies and creating an interactive map that visualizes the amount and types of radionuclides used in healthcare centers across the UK, we can gain insights into the UK's radionuclide usage and provide valuable information to inform future policies and address geographic disparities.</p><p><strong>Methods: </strong>Waste discharge records from different environmental agencies were interrogated to calculate the amount of administered radionuclide radioactivity at healthcare sites across the UK, which was cross-checked against hospital workload data of procedures performed with Tc-99m, I-131, and Lu-177.</p><p><strong>Results: </strong>The findings indicate that the wastewater data provides a reliable overview of radionuclide use, particularly for Lu-177 and I-131, with agreement between reported and calculated excreted activity within 10%. For Tc-99m, the agreement was within 40%, likely because of variations in clinical practices.</p><p><strong>Conclusion: </strong>The wastewater-reported data offers an independent and valuable source for understanding radionuclide usage across the UK. Enhancing coordination between environmental agencies and improving data collection practices would help improve the interrogation of radionuclide usage in the UK and hence support national strategy and planning for medical radionuclide supply.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of [18F]fluoro-L-dopa PET/computed tomography imaging to evaluate the extent of liver fibrosis.","authors":"Kai Zhang, Manman Qi, Jingai Jian, Zhi Li, Haiyan Wang, Yue Liu, Jian Zhang","doi":"10.1097/MNM.0000000000002012","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002012","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the feasibility of using 6-[18F]fluoro-L-dopa ([18F]FDOPA) PET/computed tomography (PET/CT) imaging, targeting dopamine receptor D1 (DRD1), for the noninvasive assessment of liver fibrosis severity.</p><p><strong>Methods: </strong>A rat model of liver fibrosis with different degrees of fibrosis was established. [18F]FDOPA PET/CT imaging was performed to measure the radioactivity uptake in the liver. The stage of liver fibrosis was determined through pathological testing, and the correlation between imaging findings and the fibrosis stage was assessed. In addition, the expression levels of DRD1 and dopa decarboxylase (DDC) were detected to evaluate the relationship between liver uptake and DRD1 expression.</p><p><strong>Results: </strong>The 29 surviving rats were categorized into stages F0-F4 according to the Metavir grading system based on the hematoxylin and eosin and Masson staining pathology findings. Liver radioactivity uptake was significantly and positively correlated with the stage of liver fibrosis (r = 0.8006, P < 0.001). After adjusting for errors using the ratio method, the area under the curve (AUC) for PET/CT imaging to discriminate significant liver fibrosis from no fibrosis and severe liver fibrosis from mild-to-moderate liver fibrosis were 0.9342 and 0.9639, respectively, at the optimal cut-off value. DRD1 expression was significantly correlated with both liver fibrosis stage (r = 0.9412, P < 0.001) and relative uptake value (r = 0.8182, P < 0.001).</p><p><strong>Conclusion: </strong>[18F]FDOPA PET/CT imaging is a valuable tool for assessing liver fibrosis severity. The level of radioactivity uptake in the liver is significantly correlated with the degree of liver fibrosis and DRD1 expression level.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between brown adipose tissue activity, serum lipid profiles, and cardiovascular events: insights from 18F-fluorodeoxyglucose PET/computed tomography analysis.","authors":"Kewei Yang, Ruiqiu Zhang, Xiaohui Zhang, Qiaoling Gao, Xiuyu Guo, Lianyu Gu, Han Zhang, Jingfeng Zhang, Jianjun Zheng, Maoqing Jiang","doi":"10.1097/MNM.0000000000002007","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002007","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the associations between brown adipose tissue (BAT) metabolic parameters, serum lipid profiles, and cardiovascular disease (CVD) events.</p><p><strong>Methods: </strong>A retrospective cohort study involving 13 530 patients who underwent 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography between November 2019 and March 2024 was conducted to evaluate semiquantitative BAT indices, including the maximum standardized uptake value (B-SUVmax), total metabolic volume (TBMV), and total BAT glycolytic activity (TBG), as well as their associations to lipid profiles [total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and TC/HDL-C and LDL-C/HDL-C ratios) and CVD outcomes. Propensity score matching was applied, resulting in a comparison group of 74 BAT-positive patients and 148 BAT-negative controls.</p><p><strong>Results: </strong>BAT-positive individuals exhibited significantly higher HDL-C levels (P = 0.005) and lower TC/HDL-C (P = 0.006) and LDL-C/HDL-C (P = 0.014) ratios compared with controls, while no significant differences were observed in triglyceride, TC, or LDL-C levels. TBG showed the strongest correlations with HDL-C (r = 0.256, P < 0.001), TC/HDL-C (r = -0.223, P < 0.001), and LDL-C/HDL-C (r = -0.195, P = 0.004), outperforming B-SUVmax and TBMV. Patients exhibiting BAT had a lower incidence of CVD events compared to those without detectable BAT (P = 0.018). Multivariate logistic regression analysis showed that the presence of BAT is an independent predictor of CVD events.</p><p><strong>Conclusion: </strong>TBG is a moderate biomarker reflecting HDL-C levels and the ratios of TC/HDL-C and LDL-C/HDL-C, while detectable BAT activity independently correlates with reduced CVD risk, highlighting its potential for cardiovascular risk stratification.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 18F-FDG PET on management in patients with recurrent head and neck cancer: a meta-analysis.","authors":"Hai-Jeon Yoon, Kyoungjune Pak","doi":"10.1097/MNM.0000000000002005","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002005","url":null,"abstract":"<p><strong>Objective: </strong>Head and neck cancers (HNC) comprise malignancies occurring in the oral cavity, pharynx, larynx, and salivary glands. This meta-analysis assessed the effect of 18F-fluorodeoxyglucose (FDG) PET on the management of recurrent HNC.</p><p><strong>Methods: </strong>We conducted systematic reviews focused on the role of FDG PET in managing recurrent HNC. We defined management change as the percentage of patients whose treatment was altered following FDG PET results relative to those assessed with this imaging technique.</p><p><strong>Results: </strong>We included seven studies encompassing 444 patients. The studies evaluated the role of FDG PET in detecting recurrence or metastasis in HNC patients by examining the rates of management change, with a pooled effect of 26.6%.</p><p><strong>Conclusion: </strong>The findings from our meta-analysis indicate that FDG PET substantially affects the management of patients with recurrent HNC. These outcomes align with current guidelines recommending the use of FDG PET under these circumstances.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of simulations to study the effect of acquisition schemes and quantification methods using positron emission tomography: an 18F-Fallypride study.","authors":"Mohlapoli S Mohlapholi, Alex Doruyter, Michael Mix, Chris Trauernicht, Annare Ellmann, James Warwick, Patrick Dupont","doi":"10.1097/MNM.0000000000001995","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001995","url":null,"abstract":"<p><strong>Introduction: </strong>This computational study evaluates the accuracy of kinetic models and acquisition schemes in dynamic PET imaging using simulations of 18F-fallypride PET in the human brain on the real-world data.</p><p><strong>Methods: </strong>We employed a 2-tissue 4-k model to generate ideal tissue curves for three regions (putamen, thalamus, and temporal cortex) and a reference region (cerebellum), incorporating a simulated metabolite-corrected input function. Realistic measurements were simulated over a 240-min PET scan by defining acquisition protocols (frame timings and durations), modeling tracer decay, and adding noise. Distribution volume ratios (DVRs) were calculated using the Logan reference analysis and the simplified reference tissue model (SRTM), the relative error in DVR was also assessed across various acquisition protocols. Rate constants from the 2-tissue model were varied, and Bland-Altman analysis was quantified to determine bias relative to ground-truth DVR.</p><p><strong>Results: </strong>Results indicate that, under low noise conditions, the Logan reference method performed optimally with a protocol involving a 60-min dynamic scan, a 60-min break, a 30-min scan, another 60-min break, and a final 30-min scan. In noisier conditions, the SRTM yielded the best results with a 150-min effective scan time incorporating three breaks.</p><p><strong>Conclusion: </strong>These findings highlight the impact of noise and acquisition strategy on model performance, informing optimal PET imaging protocols.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-FAPI PET/CT in chronic liver disease: myocardial fibroblast activation and its correlates.","authors":"Yangyang Wang, Guangjie Yang, Wenlong Yan, Wenji Yu, Ben Li, Lei Yan, Ju Zhang, Xin Wang, Yuan Zhuang, Zhenguang Wang, Yuetao Wang","doi":"10.1097/MNM.0000000000002002","DOIUrl":"10.1097/MNM.0000000000002002","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the relationship between cardiac fibroblast activation and clinical parameters, electrophysiological findings, serum fibrosis markers, and hepatic fibroblast activation in patients with chronic liver disease.</p><p><strong>Methods: </strong>In this prospective study conducted from December 2021 to April 2022, 46 patients with chronic liver disease underwent fluorine-18 ( 18 F)-labeled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) imaging and 12-lead electrocardiogram (ECG). Abnormal cardiac 18 F-FAPI uptake was defined as uptake greater than that of the blood pool.</p><p><strong>Results: </strong>Among 46 patients with chronic liver disease analyzed, 14 showed positive myocardial FAPI uptake and 32 were negative. Significant differences were observed between positive and negative myocardial 18 F-FAPI PET/CT imaging groups in terms of age ( P = 0.006), epicardial fat volume (EFV) ( P = 0.004), Cornell voltage QRS amplitude ( P = 0.022), and QRS duration ( P = 0.032). The multivariable logistic regression analysis demonstrated a significant association between EFV [odds ratio (OR) = 1.019; P = 0.024] and age (OR = 1.162; P = 0.019) and positive myocardial FAPI uptake. Myocardial maximum target-to-background ratio (TBR max ) was positively correlated with hepatic TBR max ( r = 0.405; P = 0.005) and hepatic TBR mean ( r = 0.412, P = 0.004). Moreover, myocardial maximum standardized uptake value was positively correlated with serum laminin levels ( r = 0.367; P = 0.042).</p><p><strong>Conclusions: </strong>In patients with chronic liver disease, FAPI PET/CT imaging observed cardiac fibroblast activation, which was associated with electrophysiological parameters, hepatic FAPI uptake, and serum liver fibrosis markers. These findings suggest that 18 F-FAPI PET/CT imaging may offer a noninvasive approach for identifying early myocardial changes in chronic liver disease.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET for predicting chemoradiotherapy survival in cervical cancer: the search continues.","authors":"Matheus Henrique Leite E Silva, Matheus Aleixo Barbosa da Silva, Daniel Simões Reis Dos Santos, Theara Cendi Fagundes, Angélica Nogueira-Rodrigues, Andreia Cristina de Melo, Andrea Lima Bastos, Marcelo Mamede","doi":"10.1097/MNM.0000000000001999","DOIUrl":"10.1097/MNM.0000000000001999","url":null,"abstract":"<p><strong>Objective: </strong>Cervical c ancer is still a global health concern. The push for personalized care has been the mainstay and the use of noninvasive approaches to stratify patients is a corollary of this management strategy. 18 F-fluorodeoxyglucose PET/computed tomography is frequently used for cervical c ancer staging. Identifying predictive factors PET-based imaging scores could mean increased benefit for these patients, at no increased cost.</p><p><strong>Methods: </strong>An observational study was conducted with stage IIB-IIIB cervical cancer patients receiving erlotinib concomitantly to standard therapy. Survival analyses employed Kaplan-Meier and Cox proportional hazards models, waterfall, and heatmap plots to investigate survival associations. Maximum and average PET measures were obtained before and 3 months after treatment.</p><p><strong>Results: </strong>Thirty patients were enrolled in this phase I/II study. IIB Staging was significantly associated with longer survival when compared with IIIB. Simultaneous lower 2SD algorithm mean standard uptake value (SUV 2SD ) (<4.1) and greater BMI reduction (< -0.17 kg/m 2 ), or lower PERCIST SUV (SUV per ) (<7.6) and greater BMI reduction, predicted worse overall and progression-free survival ( P < 0.05). Unifying pretreatment maximum SUV (SUV max ), SUV per , and SUV 2SD demonstrated a trend toward significant overall survival stratification ( P = 0.057). In the heatmap analysis, there was a lack of high percentile pretreatment tumor-to-liver ratio, SUV max , SUV per , and SUV 2SD features in patients with worse endpoints. The waterfall plots suggested pretreatment lesion volume may predict volume reduction.</p><p><strong>Conclusion: </strong>SUV 2SD and SUV per , paired with BMI variation, were associated with survival prediction. PET might play an important role in individualizing patients before treatment decisions for optimal management of locally advanced disease.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo simulation of radiation dose to infant patients from urine-contaminated diapers during diuretic renal scintigraphy.","authors":"Yonggang Lu, Sachin Kumbhar, Yu Liu, Nghia Jack Vo, Marjorie Bessette Baker, Jing Qi","doi":"10.1097/MNM.0000000000002000","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002000","url":null,"abstract":"<p><strong>Objectives: </strong>To quantify the radiation doses received by infants from urine-contaminated diapers during diuretic renal scintigraphy examinations, a Monte Carlo dose simulation method integrated with advanced image processing techniques was proposed and evaluated.</p><p><strong>Methods: </strong>Organ-specific dose coefficients with radiation sourcing from diapers were calculated by a Monte Carlo dose simulation package (GAMOS 6.1.0) with the International Commission on Radiological Protection reference infant phantoms modified to include diapers as computational phantoms. Doses absorbed by organs of patients in the exams were estimated by multiplying the computed organ-specific dose coefficients by the cumulative activities of contaminated diapers estimated from time-series renal scintigraphy images. Data from 10 infant patients (five male and five female) who underwent renal scintigraphy exams were evaluated.</p><p><strong>Results: </strong>The dose coefficients of representative organs (mGy/Bq.s) were calculated to be 2.82E-13 (total body), 4.84E-13 (penis), 6.48E-14 (testes), 4.35E-14 (scrotum), and 6.75E-15 (prostate) for male infants; 4.37E-14 (total body), 6.71E-13 (uterus), 5.11E-14 (bladder), 3.19E-15 (ovaries), and 2.77E-15 (sigmoid) for female infants. Absorbed doses (mGy) in male patients from the evaluated patient data were quantified to be 1.94 (total body), 4.45E-01 (testes), 3.32E-01 (penis), 2.98 E-01 (scrotum), and 4.63 E-02 (prostate), and in female patients were 1.18 (total body), 1.81E-01 (uterus), 1.38 E-01 (bladder), 8.62E-02 (ovaries), and 7.49 E-02 (sigmoid).</p><p><strong>Conclusion: </strong>The study proposed and evaluated a method to quantify radiation dose from urine-contaminated diapers during renal scintigraphy exams in infants. The results indicated that the radiation dose from the contaminated diaper cannot be ignored, especially for radiation-sensitive organs such as testes and ovaries.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting clinical outcomes using 18F-FDG PET/CT-based radiomic features and machine learning algorithms in patients with esophageal cancer.","authors":"Gozde Mutevelizade, Nazim Aydin, Ozge Duran Can, Orkun Teke, Ahmet Furkan Suner, Merve Erdugan, Elvan Sayit","doi":"10.1097/MNM.0000000000002003","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002003","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the relationship between 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) radiomic features and clinical parameters, including tumor localization, histopathological subtype, lymph node metastasis, mortality, and treatment response, in esophageal cancer (EC) patients undergoing chemoradiotherapy and the predictive performance of various machine learning (ML) models.</p><p><strong>Methods: </strong>In this retrospective study, 39 patients with EC who underwent pretreatment 18F-FDG PET/CT and received concurrent chemoradiotherapy were analyzed. Texture features were extracted using LIFEx software. Logistic regression, Naive Bayes, random forest, extreme gradient boosting (XGB), and support vector machine classifiers were applied to predict clinical outcomes. Cox regression and Kaplan-Meier analyses were used to evaluate overall survival (OS), and the accuracy of ML algorithms was quantified using the area under the receiver operating characteristic curve.</p><p><strong>Results: </strong>Radiomic features showed significant associations with several clinical parameters. Lymph node metastasis, tumor localization, and treatment response emerged as predictors of OS. Among the ML models, XGB demonstrated the most consistent and highest predictive performance across clinical outcomes.</p><p><strong>Conclusion: </strong>Radiomic features extracted from 18F-FDG PET/CT, when combined with ML approaches, may aid in predicting treatment response and clinical outcomes in EC. Radiomic features demonstrated value in assessing tumor heterogeneity; however, clinical parameters retained a stronger prognostic value for OS.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}