Nuclear Medicine Communications最新文献

{"title":"Retrospective analysis of neuroblastoma and pheochromocytoma therapy with I-131 metaiodobenzylguanidine at a reference oncology hospital in Brazil.","authors":"Matheus N Dos Santos, Filipe Dos S Soares, Renata C M Felix, Priscilla B Pujatti","doi":"10.1097/MNM.0000000000001993","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001993","url":null,"abstract":"<p><strong>Background: </strong>Metaiodobenzylguanidine (MIBG) is a norepinephrine analogue with high affinity and specificity for the norepinephrine transporter. I-131-labeled MIBG (I-131 MIBG) is a therapeutic radiopharmaceutical used in selected cases of refractory or metastatic neuroblastoma and pheochromocytoma, tumors that overexpress the norepinephrine transporter. While the use of I-131 MIBG in neuroblastoma and pheochromocytoma therapy is well-established, the literature shows significant variability in treatment response, regarding the dose of the radiopharmaceutical, previous therapies administered, and the clinical condition of the patients involved in the studies. To contribute to the current literature, this study analyzed the use of I-131 MIBG at a cancer treatment institution in Brazil.</p><p><strong>Methods: </strong>Retrospective, observational, single-center study was conducted, with a descriptive and exploratory character, involving patients diagnosed with neuroblastoma and pheochromocytoma treated with I-131 MIBG from 2010 to 2025. Demographic, clinical, and laboratory parameters were collected before and after I-131 MIBG therapy. The outcome was determined through survival analysis.</p><p><strong>Results: </strong>Thirty-two patients were treated with I-131 MIBG, including 24 patients with neuroblastoma and six patients with pheochromocytoma. Leukocytes and platelets showed a reduction, and aspartate aminotransferase (AST) levels exhibited a significant increase posttherapy in patients with neuroblastoma. Survival rate was 84% in patients with pheochromocytoma and 55% in patients with neuroblastoma in the first year following I-131 MIBG therapy; however, both groups showed a gradual reduction in the cumulative survival rates, reaching 20% after 5 years.</p><p><strong>Conclusion: </strong>I-131 MIBG was primarily used for the treatment of neuroblastoma in pediatric patients, and pheochromocytomas in adults. Anemia, leukopenia, thrombocytopenia, and increased serum AST were the main adverse events, and cumulative survival rates were 20% after 5 years.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semiquantitative analysis of 18F-aluminum fluoride fibroblast activation protein inhibitor 42 PET/computed tomography in primary liver cancer and factors influencing imaging positivity rates.","authors":"Qi-Chang Wang, Mu-Hua Cheng, Liang-Jun Xie","doi":"10.1097/MNM.0000000000001994","DOIUrl":"10.1097/MNM.0000000000001994","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated 18F-aluminum fluoride fibroblast activation protein inhibitor 42 (18F-AlF-FAPI-42) PET/computed tomography (CT) imaging characteristics in primary liver cancer (PLC) and analyzed detection rate determinants.</p><p><strong>Methods: </strong>Fifty-three untreated patients (76 lesions) with suspected PLC [hepatocellular carcinoma (HCC) or non-HCC subtypes] underwent 18F-AlF-FAPI-42 PET/CT. Maximum standardized uptake value (SUV max ) of lesions and mean SUV of adjacent normal liver tissue were measured to calculate target-to-background ratio (TBR). Patients were stratified by pathology, cirrhosis status, lesion size [small (3 cm), nodular (3-5 cm), massive (>5 cm)], lesion number, and alpha-fetoprotein (AFP).</p><p><strong>Results: </strong>Overall positivity rate was 86.8% (66/76 lesions). Non-HCC lesions showed significantly higher SUV max (15.6 vs. 10.3; P < 0.001) and TBR (12.6 vs. 3.9; P < 0.001) than HCC. Lesion size correlated with SUV max ( r = 0.54) and TBR ( r = 0.37) (both P < 0.001). HCC demonstrated lower detection than non-HCC (80.6 vs. 100%; P = 0.018), while cirrhotic patients showed reduced detection vs. noncirrhotic (80 vs. 96.8%; P = 0.034). Detection rates increased with lesion size: 72.0% (small), 80.0% (nodular), and 100% (massive) ( P = 0.004). Lesion number and AFP levels showed no significant impact. Subgroup analysis confirmed lesion size and pathological type as independent predictors ( P < 0.05), while cirrhosis showed no independent effect ( P > 0.05).</p><p><strong>Conclusion: </strong>18F-AlF-FAPI-42 PET/CT demonstrates high sensitivity for PLC, particularly for non-HCC subtypes and larger lesions. While smaller HCCs show reduced detection, cirrhosis doesn't significantly impair diagnostic performance, supporting its clinical utility in cirrhotic populations.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of quantitative growth plate uptake parameters on bone scintigraphy with growth velocity in children.","authors":"Ki Jin Jung, Sun-Pyo Hong, Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee","doi":"10.1097/MNM.0000000000001992","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001992","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to examine the association between quantitative growth plate uptake parameters in bone scintigraphy and growth velocity among children.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 30 pediatric patients (21 male and nine female; age range, 3-15 years) who underwent planar bone scintigraphy. Ratios of maximum growth plate uptake to mean diaphyseal uptake (GPmax/D) and mean growth plate uptake to mean diaphyseal uptake (GPmean/D) were calculated for both femurs on anterior and posterior bone scintigraphy images. A total of eight GPmax/D parameters and eight GPmean/D parameters were measured. The relationships of growth plate uptake parameters with age and growth velocity (cm/year) were assessed.</p><p><strong>Results: </strong>Correlation analysis with growth velocity revealed that the anterior GPmax/D (numerical mean of GPmax/D between the right and left femurs on an anterior image) exhibited the highest correlation coefficient (0.409) among the bone scintigraphy parameters (P = 0.034). The anterior GPmax/D also demonstrated a significant negative correlation with age (P = 0.042, correlation coefficient: -0.373). In a multiple regression analysis to predict growth velocity with adjusting for age and sex, the model that included left GPmean/D (geometric mean of GPmean/D between anterior and posterior images of the left femur) yielded the highest adjusted R2 value (0.786), followed by anterior GPmax/D (0.734).</p><p><strong>Conclusion: </strong>Quantitative growth plate uptake parameters on the distal femur in bone scintigraphy are significantly associated with growth velocity. These findings suggest that growth plate uptake in bone scintigraphy could potentially serve as a predictive marker of growth in children.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumoricidal dosing approach with parenchymal sparing using voxel-based dosimetry in 90Y glass microspheres treatment of hepatocellular carcinoma.","authors":"Burcu E Akkaş, Cihan Şin, Elife Akgün, Tevfik Guzelbey, Cagri Erdim, Özge Vural Topuz, Emrah Birol, Özgür Kilickesmez, Meryem Kaya","doi":"10.1097/MNM.0000000000001991","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001991","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the effect of tumor absorbed doses (TAD) on treatment response in patients with hepatocellular cancer (HCC) treated with 90Y glass microspheres. We aimed to define a cutoff value for complete response (CR).</p><p><strong>Methods: </strong>The voxel-based dosimetry for the treatment of 66 HCC lesions in 56 patients was analyzed retrospectively. Nineteen patients had BCLC A, 23 patients had BCLC B, and 14 patients had BCLC C disease. Treatments were grouped as selective (radiation segmentectomy and super-selective segmentectomy, n:49) and nonselective (palliative treatments for tumors occupying >2 segments, n:17). Treatment response was evaluated by mRECIST criteria, defined as CR, partial response (PR), stable lesion (SL), and progressive lesion (PL). TAD associated with CR was analyzed.</p><p><strong>Results: </strong>TAD was 525 ± 222 Gy in our cohort. Fifteen lesions had CR, 28 had PR, eight remained stable, and 15 lesions progressed. CR, PR, SL, and PL rates for selective vs. nonselective treatments were 31, 42, 12, and 14% vs. 0, 41, 11, and 47% for nonselective treatments, respectively (P:0.01). TAD was significantly associated with treatment response. Receiver operating characteristic analysis showed TAD > 475 Gy predicted CR with 100% sensitivity and 68% specificity (area under the curve = 0.83, P < 0.001). Overall survival declined as treatment response deteriorated. None of the patients had radiation-induced liver dysfunction on follow-up (6-21 months).</p><p><strong>Conclusion: </strong>Higher TAD is crucial for CR. Segmentectomy with TAD > 475 Gy is associated with favorable response and better survival in HCC patients. Even for palliative treatments, as high as reasonably tolerated doses must be applied to achieve a favorable response.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the application of 18F-sodium fluoride PET in the assessment of atherosclerosis.","authors":"Yan Wang, Mingyuan Hou, Taiyang Zuo","doi":"10.1097/MNM.0000000000001988","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001988","url":null,"abstract":"<p><p>Atherosclerosis serves as the primary cause of cardiovascular diseases (CVDs), with its pathological processes encompassing lipid deposition, inflammatory responses, and calcification. Traditional imaging techniques, such as computed tomography angiography and MRI, are primarily utilized for detecting arterial stenosis and calcified plaques, yet they face challenges in accurately assessing plaque activity and instability. 18F-sodium fluoride PET (18F-NaF PET) offers a novel approach for plaque activity and stability assessment by labeling and quantifying arterial wall calcification. This article reviews the advances in the application of 18F-NaF PET in the assessment of atherosclerosis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic pitfalls in [68Ga]Ga-DOTATATE PET/CT imaging: a systematic review.","authors":"Ahmed Saad Abdlkadir, Dhuha Al-Adhami, Mohammed Al Rammahi, Mohannad Badarneh, Salem Al Yasjeen, Khalid Al Busaidi, Aysar Khalaf, Haider Al-Alawi, Hasan Al-Alawi, Akram Al-Ibraheem","doi":"10.1097/MNM.0000000000001987","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001987","url":null,"abstract":"<p><p>[68Ga]Ga-DOTA-Tyr3-octreotate ([68Ga]Ga-DOTATATE) is an established somatostatin receptor imaging agent that has demonstrated superior efficacy in visualizing neuroendocrine tumors (NETs) and meningiomas compared with traditional [111In]In-octreotide imaging. Despite its enhanced affinity and sensitivity, [68Ga]Ga-DOTATATE imaging is not without challenges. To date, numerous diagnostic pitfalls and false-positive findings have been reported. This systematic review investigates the currently recognized diagnostic pitfalls in [68Ga]Ga-DOTATATE positron imaging. A systematic literature search was conducted using PubMed, Scopus, and Web of Science databases, with the most recent update on 8 March 2024. Two authors screened the titles and abstracts of retrieved articles and selected studies based on predefined inclusion and exclusion criteria. Qualitative analysis of 70 included research articles, encompassing 199 patients, identified 234 diagnostic pitfalls. Malignant neoplastic etiologies predominated, constituting 56% of pitfalls, followed by nononcologic pitfalls (32.1%), and benign oncologic tumors (11.9%). Anatomically, the head and neck region was the most frequent site for pitfalls (35.5%), followed by the musculoskeletal system (27.4%), abdomen (17.5%), and chest (16.6%). Pelvic-related pitfalls were least common, accounting for only 3% of cases. This study details potential diagnostic pitfalls, predominantly occurring in the head-neck regions - primary sites for meningiomas and paragangliomas. Understanding these diagnostic pitfalls is crucial for accurate diagnosis. Moreover, recognizing these diagnostic pitfalls may lead to novel applications of [68Ga]Ga-DOTATATE beyond its conventional use in NETs and meningiomas, potentially expanding its diagnostic utility.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET image nonuniformity texture features for metastasis risk prediction in osteosarcoma.","authors":"Muath Almaslamani, Byung-Hyun Byun, Kanghyon Song, Chang-Bae Kong, Sang-Keun Woo","doi":"10.1097/MNM.0000000000001989","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001989","url":null,"abstract":"<p><strong>Objective: </strong>PET image analysis provides tumor heterogeneity data related to neoadjuvant chemotherapy response (NACR) and metastatic risk in osteosarcoma. Ki-67 expression is used to predict metastasis. The accuracy of prediction models with image quantitative features can be improved by including genetic information. Here, we aimed to evaluate the accuracy of a combination of heterogeneous 18F-fluorodeoxyglucose PET image texture features and Ki-67 expression as predictive indicators of metastasis.</p><p><strong>Methods: </strong>PET images and clinical data of 82 patients with osteosarcoma before and after treatment were collected. Quantitative features were extracted from the PET images obtained before treatment, and the area under the receiver operating characteristic curve (AUC) for NACR and metastatic event was calculated. Relative risk and odds analyses of the quantitative features of the entire image were performed. Kaplan-Meier survival analysis was performed to determine the relationship between image quantitative features and clinical information. The machine learning prediction model was evaluated using valid image quantitative features and various algorithms of the univariate analysis.</p><p><strong>Results: </strong>Forty-seven image textures were obtained. The AUC values were 0.504-0.62 for NACR and 0.510-0.598 for metastatic events. The NACR and metastatic risk were related to the gray-level run length matrix (GLRLM) run length nonuniformity (RLNU) (relative risk: 1.3846, P = 0.0138 for NACR; relative risk: 2.1284, P = 0.049 for metastatic event) in the univariate analysis. The accuracy of the prediction model using the random forest algorithm with GLRLM RLNU, Ki-67 expression, and NACR was 0.91 for metastatic risk. NACR and metastatic risk were predicted with high accuracy using the nonuniformity in PET image texture.</p><p><strong>Conclusion: </strong>Combining PET image texture nonuniformity with Ki-67 expression and clinical data can enhance the accuracy of metastasis prediction in osteosarcoma. This multimodal approach may support metastasis risk prediction in osteosarcoma and aid in personalized treatment planning.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of 18F-fluorodeoxyglucose PET/computed tomography in the initial staging of malignant peritoneal mesothelioma.","authors":"Hui Zhang, Lifang Pang, Jun Hou, Beilei Li, Yiqiu Zhang","doi":"10.1097/MNM.0000000000001990","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001990","url":null,"abstract":"<p><strong>Objective: </strong>This study was aimed at evaluating the significance of 18F-fluorodeoxyglucose PET/computed tomography (FDG PET/CT) in the staging and differentiation of malignant peritoneal mesothelioma (MPeM).</p><p><strong>Materials and methods: </strong>We retrospectively analyzed clinical and imaging data of 21 women and 21 men with MPeM who underwent 18F-FDG PET/CT, and reviewed and analyzed 18F-FDG PET/CT characteristics of the patients. Standardized uptake values (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG = MTV × SUVmean) were determined for peritoneal lesions at the highest glycolysis point. Two experienced readers assessed tumor-node-metastasis (TNM) staging and peritoneal cancer index according to Peritoneal Surface Oncology Group International diagnostic requirements.</p><p><strong>Results: </strong>The SUVmax and MTV values were significantly lower for the epithelial cases than for the nonepithelioid cases, with the difference being significant (P < 0.05). The mean TLG value was significantly lower for the epithelial cases than for the nonepithelioid cases; however, the difference was NS (P > 0.05). Exploratory laparotomy was performed in 18 patients, the 18F-FDG PET/CT diagnostic accuracy for the T stage was 72.2%, and the TNM stage diagnostic accuracy was 94.4%. However, lymph node metastasis was more common in the biphasic type group, and metastasis was more often seen in the sarcomatoid type group.</p><p><strong>Conclusion: </strong>Using a previously suggested novel approach for TNM staging in 18F-FDG PET/CT assessment of MPeM may improve the accuracy of staging; however, SUVmax values showed slight variations depending on the pathology type. 18F-FDG PET/CT can improve the accuracy of TNM staging, and SUVmax values vary slightly depending on the pathology type. Furthermore, 18F-FDG PET/CT can afford simultaneous visualization of lesions throughout the body, which can help develop a treatment strategy.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of imaging conditions for technetium-99m dimercaptosuccinic acid single photon emission computed tomography examinations in neonates.","authors":"Haruto Kimoto, Yoshiki Owaki, Kazuya Minamishima, Kazumasa Inoue","doi":"10.1097/MNM.0000000000001962","DOIUrl":"10.1097/MNM.0000000000001962","url":null,"abstract":"<p><strong>Objective: </strong>This study validated the optimal acquisition and reconstruction conditions for technetium-99m dimercaptosuccinic acid single-photon emission computed tomography examinations in neonates.</p><p><strong>Methods: </strong>We developed renal phantoms representing neonatal and adult kidneys, derived from clinical data to achieve this. The radioactivity concentration to be encapsulated in the renal part was adjusted according to the Japanese consensus guidelines for the appropriate implementation of pediatric nuclear medicine examinations. The evaluation of optimal acquisition conditions considered factors such as acquisition time and magnification ratio, while the determination of optimal reconstruction conditions focused on the cutoff frequency of the Butterworth filter and the appropriate correction methods. The physical evaluation assessed defect contrast and background coefficient of variation, while the visual evaluation assessed the ability of the images to depict the defect.</p><p><strong>Results: </strong>The defect contrast was almost constant after acquisition times of 10 min for neonates and 12 min for adults. For the magnification ratio, the effect was greater for neonates than for adults. In addition, in contrast to adults, the use of resolution recovery significantly decreased scores in visual evaluation in neonates.</p><p><strong>Conclusion: </strong>Our study suggests better images can be obtained in neonates with shorter acquisition times than adults. In addition, the optimal reconstruction conditions are shown to differ between neonates and adults.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"427-436"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a threshold for maximum standardized uptake value on 18 F-fluorodeoxyglucose PET/CT to predict high-grade lung adenocarcinoma and its prognostic significance.","authors":"Miao Huang, Yaqi Wang, Xin Yang, Nan Li, Bing Liu, Xiang Li, Shanyuan Zhang, Fangliang Lu, Shaolei Li, Shi Yan, Dongmei Lin, Nan Wu","doi":"10.1097/MNM.0000000000001959","DOIUrl":"10.1097/MNM.0000000000001959","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to determine an optimal threshold for the maximum standardized uptake value (SUVmax) of 18 F-fluorodeoxyglucose PET/CT to predict the newly proposed high-grade tumor classification and assess its prognostic significance in invasive lung adenocarcinoma (LUAD).</p><p><strong>Methods: </strong>Surgical specimens from 185 patients with pathological stage I invasive LUAD in the training group, along with 90 patients in the validation group, were analyzed using the novel IASLC grading system. The receiver operating characteristic curve was used to determine the optimal SUVmax threshold and assess its predictive accuracy. Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier survival curves and Cox regression analysis.</p><p><strong>Results: </strong>Linear correlation analysis demonstrated a significant positive association between SUVmax and the proportion of high-grade histological patterns ( R ² = 0.346, P  < 0.001). The optimal SUVmax cutoff for predicting grade 3 tumors was 3.8, with an area under the curve of 0.866 in the training dataset and 0.899 in the validation dataset. Multivariate logistic regression analysis identified an SUVmax >3.8 as an independent predictor of grade 3 tumors ( P  < 0.001). In Cox regression analysis, SUVmax >3.8 was independently associated with reduced DFS (HR = 4.009, 95% CI: 1.568-10.250, P  = 0.004) and OS (HR = 5.536, 95% CI: 1.175-26.075, P  = 0.030).</p><p><strong>Conclusion: </strong>As a noninvasive preoperative parameter, SUVmax >3.8 is a significant indicator of high-grade tumors as classified by the IASLC grading system and is strongly associated with worse DFS and OS.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"444-452"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}