Nuclear Medicine Communications最新文献

{"title":"Interpretation of basal nuclei in brain dopamine transporter scans using a deep convolutional neural network.","authors":"Hsin-Yung Chen, Ya-Ju Tsai, Syu-Jyun Peng","doi":"10.1097/MNM.0000000000001963","DOIUrl":"10.1097/MNM.0000000000001963","url":null,"abstract":"<p><strong>Objective: </strong>Functional imaging using the dopamine transporter (DAT) as a biomarker has proven effective in assessing dopaminergic neuron degeneration in the striatum. In assessing the neuron degeneration, visual and semiquantitative methods are used to interpret DAT single-photon emission tomography (SPECT) scans based on striatal to background activity, striatal shape, and symmetry. Visual analysis, however, is subjective and reviewer dependent, whereas semiquantitative methods are operator dependent. Our goal in the current study was to derive results via deep learning to facilitate the clinical diagnosis of Parkinson's disease (PD).</p><p><strong>Methods: </strong>This retrospective study collected data from 416 patients with clinically uncertain Parkinsonian syndrome who underwent DAT SPECT via 99m Tc-TRODAT-1 ([2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato (3-)- N2,N2',S2,S2' ]oxo-[1 R -( exo - exo )]). Transfer learning was used to estimate the degree of dopaminergic neuron degeneration in the caudate and putamen for use in classifying images according to stage. Three pretrained models - Xception, InceptionV3, and ResNet101 - were retrained and tested after undergoing transfer learning for the classification of striatum dopaminergic neuron degeneration.</p><p><strong>Results: </strong>Overall, the performance of Xception exceeded that of InceptionV3 and ResNet101. The accuracy, macro F1 score, and kappa value of the proposed caudate classification model were 81.93%, 0.70, and 0.64, respectively. The accuracy, macro F1 score, and kappa value of the proposed putamen classification model were 88.75%, 0.64, and 0.61, respectively.</p><p><strong>Conclusion: </strong>The proposed deep convolutional neural network provided a good model by which to interpret DAT SPECT of basal nuclei. We believe that the model could be used as an auxiliary tool to facilitate image interpretation and enhance accuracy in the diagnosis of PD.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"418-426"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gated myocardial perfusion SPECT for evaluating left ventricular dyssynchrony in cardiac resynchronization therapy candidates: a systematic review.","authors":"Agnieszka Stępień-Wroniecka, Ewa Dziewięcka, Katarzyna Graczyk, Katarzyna Holcman, Mateusz Winiarczyk, Natalia Przytuła, Magdalena Kostkiewicz, Piotr Podolec, Paweł Rubiś","doi":"10.1097/MNM.0000000000001955","DOIUrl":"10.1097/MNM.0000000000001955","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiac resynchronization therapy (CRT) is an intervention for heart failure patients with reduced ejection fraction who exhibit specific electrocardiographic indicators of electrical dyssynchrony. However, electrical dyssynchrony does not universally correspond to left ventricular mechanical dyssynchrony (LVMD). Gated single-photon emission computed tomography (SPECT) myocardial perfusion allows for the assessment of LVMD, yet its role in the CRT selection process remains debated.</p><p><strong>Methods: </strong>We conducted a systematic literature review to critically evaluate the evidence for the prediction and prognostic utility of SPECT for LVMD in assessing LVMD among CRT candidates. The review adhered to PRISMA 2020 Statement criteria and included articles from PubMed, Embase, and Cochrane databases. The quality of evidence was appraised using the Grading of Recommendations, Assessment, Development, and Evaluation framework.</p><p><strong>Results: </strong>From an initial pool of 1055 records, 33 met the inclusion criteria and provided original data on the predictive value of myocardial perfusion SPECT for LVMD. Most of them measured LVMD according to established recommendations, focusing on phase histogram bandwidth (HBW) and phase histogram standard deviation (PSD). Out of 2066 patients from 27 studies, 62% ( n  = 1214) were qualified as CRT responders. Five studies reported SPECT-based cutoffs for predicting CRT response (HBW ranging 55°-152° and for PSD 20°-54°). Only five studies assessed the prognostic implications of baseline SPECT-measured LVMD, indicating that elevated baseline HBW and PSD values are associated with poorer outcomes.</p><p><strong>Conclusion: </strong>The objective and reproducible measurement of LVMD provided by SPECT underscores its potential as a valuable tool. Such assessment seems to be emerging as a promising adjunctive technique with potential to enhance CRT outcomes.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"285-303"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal oncocytoma: a rare presentation of a benign 18 F-fluorodeoxyglucose PET avid virilising adrenal tumour.","authors":"Danielle Lee, Jonathan Green, James Crane, David R Taylor, Saira Reynolds, Wen Ng, Koshy Jacob, Benjamin Whitelaw, Simon Aylwin, Gabriele Galata, Dylan Lewis, Matthew Seager","doi":"10.1097/MNM.0000000000001932","DOIUrl":"10.1097/MNM.0000000000001932","url":null,"abstract":"<p><p>A woman in her 70s presented with features of hyperandrogenism including clitoral enlargement and deepening of her voice. Biochemical investigations revealed raised plasma androgens and urinary androgen metabolites and imaging findings showed a highly F-18 fluorodeoxyglucose (FDG)-PET avid left adrenal tumour initially suspected to be a malignant adrenocortical carcinoma (ACC). She subsequently underwent an uncomplicated laparoscopic adrenalectomy where complete resection of her tumour was achieved. Histopathological analysis demonstrated a benign adrenal oncocytoma with no evidence of malignancy. This case illustrates a rare presentation of a functioning virilising adrenal oncocytoma as a benign mimic of ACC.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"367-372"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of selenium on the dysfunction of rat salivary glands induced by 131I and expression of insulin-like growth factors and aquaporins.","authors":"Ju Fang, Nan Huang, Xiaoqian Li, Rongli Yue, Zhuoqi Qin, Qiyao Cheng, Yunzhi Wang, Huiling Li, Xinzhong Hao, Yan Cheng","doi":"10.1097/MNM.0000000000001950","DOIUrl":"10.1097/MNM.0000000000001950","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of selenium on functional and histopathological changes and mRNA expression levels of insulin-like growth factors 1 and 2 (IGF-1 and -2) and aquaporins 4 and 5 (AQP-4 and -5) in 131 I-induced damaged rat parotid glands.</p><p><strong>Methods: </strong>Rats were divided into three groups: iodotherapy-with-selenium, iodotherapy-only, and control. Rats in the iodotherapy-with-selenium group were intragastrically administered 131 I on the first day and selenomethionine through drinking water. Rats in the iodotherapy-only group were only administered 131 I. Changes in parotid gland function were evaluated using the functional parameters of salivary gland dynamics imaging pre-experiment and on days 7, 30, and 90 post-treatment. Immunofluorescence and quantitative real-time PCR analyses detected IGF-1, IGF-2, AQP-4, and AQP-5 expression levels in tissues.</p><p><strong>Results: </strong>The gland-to background ratio at a maximum count (G/BG max ), T max /T min , and S max values were significantly impacted over time in the iodotherapy-with-selenium group; on day 30, the G/BG max value was significantly higher than that in the iodotherapy-only group. Histopathological analysis revealed that on days 30 and 90, the iodotherapy-with-selenium group displayed greater parotid gland repair than the iodotherapy-only group. In the iodotherapy-with-selenium group, fluorescence intensity and mRNA levels of AQP-5 increased with the selenium supplementation period, reaching significantly higher levels on days 30 and 90 than in the iodotherapy-only group. Whereas the fluorescence intensity and mRNA levels of IGF-1 in the iodotherapy-with-selenium group were significantly higher on day 7 than on day 30 in the iodotherapy-only group.</p><p><strong>Conclusion: </strong>Selenium may repair 131 I-induced tissue and functional damage in rat salivary glands by upregulating AQP-5 and IGF-1 expression.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"304-316"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of I-131 therapy in pediatric and adolescent differentiated thyroid cancer: a long-term follow-up of a single-center Indian cohort.","authors":"Ajit Nimmagadda, Zakir Ali Abubacker, Prathyusha Bikkina, Virpakshappa C B, Lakshmi Pratyusha Paladugula","doi":"10.1097/MNM.0000000000001981","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001981","url":null,"abstract":"<p><strong>Background: </strong>Pediatric differentiated thyroid cancer (DTC), particularly papillary thyroid carcinoma, is the most common endocrine malignancy in children and adolescents. Despite its aggressive presentation, including lymph nodes and distant metastases, pediatric DTC generally has an excellent prognosis. The 2015 American Thyroid Association (ATA) guidelines emphasize a risk-stratified approach, but dynamic risk stratification (DRS) has been less studied in this population. This study aimed to evaluate DRS in predicting persistent and recurrent disease in pediatric DTC over a mean follow-up of nearly 10 years.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 88 pediatric patients with DTC who underwent surgery and radioactive iodine therapy (RAIT) between March 2009 and September 2017. Inclusion criteria were patients aged less than or equal to 18 years with postsurgical RAIT and at least 5 years of follow-up. DRS was applied based on clinical, biochemical, and imaging findings.</p><p><strong>Results: </strong>The cohort had a mean age of 15 years, predominantly female (72.7%). At diagnosis, 70.5% had lymph node metastases, and 15.9% had distant metastases. DRS categorized patients into excellent response, biochemical incomplete response, and structural incomplete response. At the final follow-up, 86.4% of patients had complete or stable disease. High-risk patients required additional treatments, including repeat RAIT.</p><p><strong>Conclusion: </strong>DRS is a valuable tool for predicting persistent and recurrent disease in pediatric DTC, refining risk categories beyond ATA stratification. It provides a more personalized approach, potentially improving outcomes by identifying high-risk individuals for tailored treatment and follow-up. Further prospective studies are needed to standardize DRS in pediatric DTC.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 18 F-FDG PET/CT in detecting recurrence and metastasis in posttreatment nasopharyngeal carcinoma patients with elevated Epstein-Barr virus DNA.","authors":"Shuting Su, Ge Wang, Xiuhuan Ye, Hao Wang, Yuxuan Chen, Shaoli Song, Zhongyi Yang","doi":"10.1097/MNM.0000000000001954","DOIUrl":"10.1097/MNM.0000000000001954","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to evaluate and compare the clinical utility of 18 F-fluoro-2-deoxy-d-glucose PET and computed tomography ( 18 F-FDG PET/CT) in detecting recurrence and metastasis in patients with nasopharyngeal carcinoma (NPC) who exhibit elevated levels of Epstein-Barr virus (EBV) DNA following treatment.</p><p><strong>Methods: </strong>A total of 103 patients with NPC were studied retrospectively. All patients were in remission following initial treatment. Elevated EBV DNA was found for the first time at review and 18 F-FDG PET/CT imaging was completed. The number of tracer lesions and the maximum standardized uptake value in the body region were recorded to evaluate the diagnostic ability of 18 F-FDG PET/CT. The final diagnosis was confirmed either through pathology or clinical follow-up lasting 6 months or longer.</p><p><strong>Results: </strong>Out of the 103 patients, 97 patients had a total of 434 lesions that were ultimately diagnosed as recurrent or metastatic. In patient-based analyses, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 18 F-FDG PET/CT imaging were 100%, 50%, 97%, and 100%, respectively. In lesion-based analyses, the sensitivity, specificity, PPV, and NPV of 18 F-FDG PET/CT imaging were 99.3%, 30.3%, 94.9%, and 83.3%, respectively.</p><p><strong>Conclusion: </strong>18 F-FDG PET/CT demonstrates potential value in detecting recurrence and metastasis of NPC.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"356-361"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined single-photon emission computed tomography-myocardial perfusion imaging with coronary calcium score for assessing coronary disease.","authors":"Enrico Calandri, Monica Verdoia, Roberta Sirovich, Maria Teresa Giraudo, Mirco Pultrone, Viviana Frantellizzi, Orazio Viola, Francesca Crivelli, Sonya Gallina, Monica Serralunga, Andrea Rognoni, Giuseppe De Vincentis","doi":"10.1097/MNM.0000000000001947","DOIUrl":"10.1097/MNM.0000000000001947","url":null,"abstract":"<p><strong>Purpose: </strong>Coronary artery disease (CAD) underestimation represents a major pitfall of single-photon emission computed tomography-myocardial perfusion imaging (SPECT-MPI). Coronary artery calcium score (CACS) has emerged as a sensitive tool for the assessment of suspect CAD; however, the integration of SPECT-MPI with CACS has been seldom evaluated, so far, and was therefore the aim of the present study.</p><p><strong>Methods: </strong>Patients undergoing SPECT-MPI with CACS and subsequent coronary angiography were included. ROC curves were used to identify the CACS values best predictive for CAD. In SPECT-MPI negative patients, the formula: defined the optimal CACS cut-points. The Systematic Coronary Risk Evaluation 2 was applied for 10-year cardiovascular risk estimation. Significant CAD was defined for an epicardial coronary stenosis >70 or 50% for the left main.</p><p><strong>Results: </strong>Among 124 patients, 61 (49.19%) displayed positive SPECT-MPI, whereas 69 (56%) had significant CAD at angiography. Sensitivity, specificity, and positive predictive value (PPV) for SPECT-MPI were, respectively, 74, 82, and 84%. Considering 63 SPECT-MPI negative cases, the index values for CACS at the optimal cutoff value of 1949 were: sensitivity 28%, specificity 89%, and PPV 50%, allowing to further detect five (8%) of the patients with significant CAD. The increased discriminative power of the combined SPECT-MPI with CACS was not conditioned by the pretest cardiovascular risk.</p><p><strong>Conclusion: </strong>Among patients with suspect CAD undergoing SPECT-MPI, the addition of CACS in negative cases allows to detect a consistent further 8% of patients with significant CAD, thus limiting the risk of disease underestimation and offering potential prognostic benefits.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"317-325"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leg-muscle perfusion reserve on 99mTc-MIBI stress-rest scintigraphy: the novel use of radionuclide imaging in assessing lower extremity functional capacity.","authors":"Tejasvini Singhal, Parneet Singh, Girish Kumar Parida, Kanhaiyalal Agrawal","doi":"10.1097/MNM.0000000000001978","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001978","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the utility of lower extremity 99mTc-MIBI imaging as a noninvasive correlate to lower extremity functional capacity.</p><p><strong>Materials and methods: </strong>Patients referred for stress myocardial perfusion imaging with no known history of peripheral artery disease (PAD) were included in the study. 99mTc-MIBI perfusion scintigraphy was performed for calf muscles at stress and rest. Perfusion reserve (PR) for bilateral calves was calculated as: (average stress counts-average rest counts)/average rest counts × 100. Correlation of PR was assessed for functional/exercise capacity [metabolic equivalents (METs) and exercise duration].</p><p><strong>Results: </strong>Eighty-six patients (70 male and 16 female) with a median age of 53.5 (range 28-77) years were included in the study. The mean PR for calf muscles was 62.9 ± 37.9%. There was a significant correlation between the functional capacity of the patients (METs achieved and exercise duration) and PR of bilateral calf muscles.</p><p><strong>Conclusion: </strong>Radionuclide imaging with 99 m-Tc MIBI allows noninvasive assessment of changes in both macrovascular and microvascular perfusion under dynamic exercise. Thus, it may serve as an ideal noninvasive imaging to provide insight into physiological adaptations as well as to detect the macrovascular and microvascular perfusion disturbances in PAD and skeletal muscle adaptation in response to exercise therapy commonly prescribed for PAD or other novel therapies.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients, parents and professional perspectives on molecular radiotherapy for neuroblastoma and paediatric neuroendocrine cancers.","authors":"Lisa Whittaker, Leona Knox, Zara Aitchison, Connie Peet, Aine O'Donovan, Juliet Gray, Simon Wan, Glenn D Flux, Mark N Gaze","doi":"10.1097/MNM.0000000000001956","DOIUrl":"10.1097/MNM.0000000000001956","url":null,"abstract":"<p><p>Treatment with radioactive drugs (molecular radiotherapy, MRT) is an option for selected children with neuroblastoma and neuroendocrine cancers. As few hospitals are appropriately equipped and staffed to provide paediatric MRT, many families have to travel long distances from home for prolonged periods. To improve professional understanding of the challenges faced by children receiving these treatments and their parents, and to help them appreciate the difficulties faced by professionals in delivering complex treatments, a meeting bringing together parents, patients and professionals was held. Ten people (five parents of children with neuroblastoma, two parents of children with neuroendocrine cancers, two adults who had received treatment for neuroendocrine cancers in childhood and one adult treated for neuroblastoma) gave personal perspectives of treatment with MRT. Three professionals from different disciplines involved with this treatment and research to improve its results gave their views on the administration of MRT, and how treatment outcomes might be improved. Fifteen people, including parents and professionals, contributed to the general discussion. Following the meeting, a questionnaire was circulated to those attending to capture their overall views, and any reflections they may have had after the meeting. Whilst many positive comments and compliments were received, this report focuses on the reported challenges and difficulties. The event is an example of meaningful Patient and Public Involvement and Engagement and has resulted in development of better information resources, strategies to mitigate inconveniences experienced and a standing group of advocates to advise on research design and acceptability.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"373-377"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of serum cholinesterase and 18 F-FDG PET/CT-derived metabolic parameters in non-small cell lung cancer patients: a retrospective cohort study.","authors":"Na Hu, Gang Yan, Maowen Tang, Shengmei Yuan, Xing Xia, Pinggui Lei","doi":"10.1097/MNM.0000000000001952","DOIUrl":"10.1097/MNM.0000000000001952","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective of this study was to explore the prognostic significance of serum cholinesterase (CHE) and metabolic parameters obtained from 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) scans in patients with non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>A retrospective observational cohort study was conducted with 202 NSCLC patients. Serum CHE was evaluated alongside metabolic tumor volume (MTV) and total lesion glycolysis (TLG) derived from PET/CT scans. The correlation between these parameters and overall survival (OS) was analyzed using log-rank tests, as well as univariate and multivariate Cox regression analyses. A nomogram prediction model was developed and assessed using time-dependent receiver operating characteristic curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>High MTV (≥16) and TLG (≥108) were found to be significantly correlated with worse OS outcomes (both P < 0.001), whereas lower CHE levels (<6818) were associated with worse OS ( P = 0.002). A multivariate analysis revealed that MTV, TLG, serum CHE, and the presence of distant metastasis were independent prognostic factors for OS. The nomogram prediction model, incorporating these variables, exhibited strong predictive performance, as indicated by area under the curve values of 0.826, 0.796, and 0.845 for 1-, 3-, and 5-year OS predictions, respectively. Calibration curves demonstrated good concordance between predicted and observed survival rates, and DCA confirmed clinical relevance.</p><p><strong>Conclusions: </strong>Serum CHE and 18 F-FDG PET/CT metabolic parameters may serve as important prognostic indicators for patients with NSCLC. The integration of these factors into a nomogram prediction model can assist in clinical decision-making and patient risk stratification.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"337-346"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}