Nuclear Medicine Communications最新文献

{"title":"Serum cytokine profiles in papillary thyroid carcinoma patients with lung metastases: characteristics and the relationship with prognosis.","authors":"Jiayu Chen, Hanji Jiang, Yuan Zhu, Xiancun Hou, Zhiyong Li","doi":"10.1097/MNM.0000000000002192","DOIUrl":"10.1097/MNM.0000000000002192","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the serum cytokine profiles of papillary thyroid carcinoma (PTC) patients with lung metastases prior to initial 131 I therapy and to evaluate the predictive value of such profiles for therapeutic response.</p><p><strong>Methods: </strong>A retrospective study was conducted on PTC patients who received thyroidectomy at the Affiliated Hospital of Xuzhou Medical University from June 2021 to December 2024. Propensity score matching was utilized to a group with lung metastasis and select a control group without distant metastasis. Serum levels of 12 cytokines were compared between groups. Correlations between clinicopathological features and cytokines within the metastasis group were analyzed, and receiver operating characteristic curves were utilized to assess the predictive efficacy of cytokines for 131 I treatment failure.</p><p><strong>Results: </strong>From 2397 eligible patients, 51 patients with confirmed lung metastases were matched with 102 control patients (1 : 2 ratio) to form a final cohort of 153 patients. Levels of IL-6, IL-10, IL-12p70, IFN-γ, and TNF-α were significantly higher in the lung metastasis group ( P  < 0.05). Subgroup analysis showed that IL-10 levels were elevated in older patients (>55 years) and IL-6 levels correlated strongly with the size of pulmonary lesions (>2 cm). Baseline IL-6 and TNF-α demonstrated robust predictive value for the outcome of adjuvant 131 I therapy (progressive disease vs. nonprogression). IL-6 yielded an area under the receiver operating characteristic curve of 0.772 (95% confidence interval: 0.633-0.912, P  < 0.05), optimal cutoff value: 7.85 pg/ml (specificity: 78.2%, sensitivity: 80.6%) and TNF-α yielded an area under the receiver operating characteristic curve of 0.746 (95% confidence interval: 0.592-0.899, P  < 0.05), optimal cutoff value: 15.32 pg/ml (specificity: 72.5%, sensitivity: 71.8%).</p><p><strong>Conclusion: </strong>Preradiotherapy serum IL-6 and TNF-α levels serve as indicators of metastatic burden and potential predictors of 131 I resistance. They offer a complementary objective basis for personalized prognostic assessment in PTC patients with pulmonary involvement.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1258-1264"},"PeriodicalIF":1.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in personalized internal dosimetry for radiopharmaceutical therapy: a narrative mini-review.","authors":"Mohammed A Jowhari","doi":"10.1097/MNM.0000000000002253","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002253","url":null,"abstract":"<p><p>Personalized internal radiation dosimetry supports individualized radiopharmaceutical therapy but remains difficult to implement because workflows require repeated quantitative imaging, segmentation, registration, kinetic modeling, and absorbed-dose calculation. This mini-review summarizes current evidence on artificial intelligence across the personalized dosimetry workflow and considers clinical readiness. A narrative PubMed search was completed in early 2026 and covered peer-reviewed studies published from 2015 to early 2026. Studies addressing artificial intelligence, machine learning, or deep learning in quantitative image reconstruction, segmentation, registration, time-activity curve estimation, absorbed-dose calculation, or clinical decision support were considered. Studies reporting quantitative performance or validation results were prioritized. Deep learning reduced yttrium-90 single-photon emission computed tomography reconstruction error from 149.5% ± 31.2% to 9.2% ± 1.7%; lesion dose-rate error was 8.6% ± 5.7% in virtual-patient testing. Learning-based registration reduced computation time from about 50 s to under 6 s. Single-time-point approaches can simplify imaging, and recent machine learning work has explored prediction of organ effective half-life. Automated segmentation methods show improving reproducibility, whereas evidence for artificial intelligence-based clinical decision support remains mainly retrospective and single-center. Artificial intelligence applications in reconstruction and segmentation appear closer to clinical readiness, while decision-support applications still require prospective, multicenter validation.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between extent of jeopardized myocardium derived from myocardial viability study to post-myocardial infarction outcome.","authors":"Geet Garg, Ashwini Kalshetty, Sandip Basu","doi":"10.1097/MNM.0000000000002246","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002246","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the relationship between the extent of jeopardized myocardium, quantified using cardiac viability imaging, and clinical outcomes in patients after myocardial infarction. By utilizing rest myocardial perfusion imaging (MPI) and cardiac 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) analyzed with Emory Cardiac Toolbox software (ECTb), the study aimed to determine how quantitative viability parameters correlate with left ventricular functional recovery and post-myocardial infarction outcomes, and to assess their utility in guiding clinical decision-making.</p><p><strong>Methods: </strong>This prospective study included 85 patients who underwent 2-day rest MPI followed by cardiac FDG-PET/CT imaging. Quantitative parameters, including the percentage of jeopardized myocardium, comprising viable, scarred, and total jeopardized myocardial segments, along with left ventricular ejection fraction (LVEF) were obtained using the ECTb platform (version 4.2). The relationship between these quantitative PET parameters and functional myocardial recovery, defined as improvement in ≥5% LVEF as assessed by two-dimensional echocardiography, was evaluated using receiver operating characteristic curve analysis. Follow-up was conducted over a period of 3 months, 6 months, and 1 year to assess the association between baseline quantitative imaging parameters and the occurrence of adverse cardiac events.</p><p><strong>Results: </strong>The analysis demonstrated that the extent of viable myocardium was a strong predictor of functional recovery (area under the curve, 0.762; P < 0.001), with a cutoff of approximately 17% yielding 76.7% sensitivity, 68.8% specificity, and 71.8% accuracy. Major adverse cardiac events (MACE) occurred in 16% of patients. There was no significant association with imaging parameters, except a nonsignificant trend for scar burden in medically managed patients. Patients undergoing surgical intervention had a significantly greater extent of jeopardized myocardium, underscoring the role of viability imaging in therapeutic decision-making.</p><p><strong>Conclusion: </strong>The extent of viable myocardium identified through imaging was strongly correlated with functional recovery, as reflected by improvements in cardiac function on follow-up echocardiography. Although no significant relationship with MACE was seen in the overall cohort, the higher burden of jeopardized myocardium in surgically treated patients underscores the value of viability imaging in guiding revascularization decisions, supporting FDG-PET/CT as a useful tool for post-myocardial infarction risk stratification and management.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical demand-based model for determining cyclotron irradiation time in routine 18F-FDG production.","authors":"Hiroshi Yamaguchi","doi":"10.1097/MNM.0000000000002250","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002250","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to develop and evaluate a practical model for determining cyclotron irradiation time based on planned fluorodeoxyglucose (FDG) supply in a hospital-based production setting.</p><p><strong>Methods: </strong>Irradiation time was calculated using a composite coefficient of 2.8 min per GBq of planned clinical demand. The coefficient integrated a facility-specific conversion between required end-of-bombardment activity and irradiation time, a conservative synthesis yield of 55%, quality control activity consumption of 11.1%, radioactive decay during an approximately 30-min processing interval, and an operational safety factor of 1.2.</p><p><strong>Results: </strong>During a fixed 24-month evaluation period, the model was applied on 516 consecutive scheduled FDG production days. Sufficient FDG activity was supplied for all scheduled examinations on all 516 days (100%), with no activity shortage attributable to underestimation of the required irradiation time.</p><p><strong>Conclusion: </strong>A demand-based irradiation model incorporating conservative yield assumptions, quality control consumption, and handling margins enables reliable FDG supply while maintaining an appropriate activity margin. This approach provides a practical framework for hospital-based radiopharmaceutical production.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact and value of [18F]-FDG PET-CT on management of patients with cervical cancer with service evaluation audited against national evidence-based PET-CT guidelines.","authors":"Maged Elsewafy, Naomi Knox, Chamani Punchihewa, Sarah Amro, Kate Lankester, Sonali Kaushik, Nitasha Singh, Sabina Dizdarevic","doi":"10.1097/MNM.0000000000002248","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002248","url":null,"abstract":"<p><strong>Purpose: </strong>First, to assess the diagnostic value of fluorine-18-fluorodeoxyglucose PET-computed tomography ([18F]-FDG PET-CT) compared with conventional MRI and/or CT. Second, to audit the clinical indications for referring patients with cervical cancer for [18F]-FDG PET-CT against the 2022 guidelines published by the Royal College of Radiologists and the Royal College of Physicians. Finally, to evaluate the impact of [18F]-FDG PET-CT on management plans.</p><p><strong>Methods: </strong>A retrospective cohort study of 49 patients with histologically proven cervical cancer across the Sussex Cancer Network underwent 59 [18F]-FDG PET-CT between 1 November 2020 and 31 October 2022. Scans were compared with the most recent CT and MRI scan conducted within 4 months of the [18F]-FDG PET-CT. Scan indications were categorized as either 'in accordance' or 'outside' the guidelines. Those in accordance fell into one of four groups: staging, response assessment, suspected recurrence, or staging when considering exenterative surgery. A questionnaire investigating the impact of the [18F]-FDG PET-CT on the management plan of each patient was answered by one clinical oncology consultant.</p><p><strong>Results: </strong>[18F]-FDG PET-CT identified new metastatic sites in 16/59 (27.1%) scans. The remaining scans were concordant with the CT and MRI. The majority, 57/59 (96.6%), of the scans were performed in accordance with the guidelines. The management plan was changed by 5/59 scans (8.4%), confirmed by 48/59 (81.4%) and was not impacted with 6/59 (10.2%) scans.</p><p><strong>Conclusion: </strong>[18F]-FDG PET-CT is superior to conventional imaging and enhances the management plan. Future cohort studies with larger patient numbers involving multicentric studies are needed to fully assess its impact on cervical cancer management and prognosis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic 99mTc-MIBI uptake and washout as functional biomarkers of glycyrrhizic acid-induced mitochondrial dysfunction and P-glycoprotein activity in HepG2 cells.","authors":"Fatma J Al-Saeedi, Farah Y Sohrabi, Dana A Aryan, Fatema F Marafi, Yousef A Al-Fadhli, Abdelaziz A Saber, Faisal A Esbita","doi":"10.1097/MNM.0000000000002249","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002249","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of glycyrrhizic acid on HepG2 cell viability and the cellular uptake, retention, and washout kinetics of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI), with particular emphasis on the potential involvement of mitochondrial function and P-glycoprotein (P-gp)-mediated efflux.</p><p><strong>Methods: </strong>HepG2 cells were treated with glycyrrhizic acid at concentrations ranging from 0 to 100 μM, and cell viability was assessed using the MTT assay. Cellular 99mTc-MIBI uptake was evaluated over 5-120 min to characterize time-dependent tracer accumulation. Pulse-chase experiments were performed to assess intracellular tracer retention and washout over 30-180 min following tracer loading. The contribution of P-gp-mediated efflux was further investigated by assessing the effect of the P-gp inhibitor verapamil on intracellular 99mTc-MIBI accumulation in glycyrrhizic acid-treated cells.</p><p><strong>Results: </strong>Glycyrrhizic acid reduced HepG2 cell viability in a concentration- and time-dependent manner, with an IC50 of approximately 60 μM after 48 h. In untreated cells, 99mTc-MIBI accumulation progressively increased and approached a plateau between 60 and 120 min. Glycyrrhizic acid treatment reduced intracellular tracer uptake in a concentration-dependent manner. Pulse-chase experiments demonstrated decreased intracellular tracer retention and increased washout following glycyrrhizic acid treatment. Pretreatment with verapamil partially increased intracellular 99mTc-MIBI accumulation compared with glycyrrhizic acid treatment alone, indicating that P-gp-mediated efflux may contribute to the reduced tracer retention observed after glycyrrhizic acid exposure.</p><p><strong>Conclusion: </strong>Glycyrrhizic acid alters 99mTc-MIBI uptake, intracellular retention, and washout kinetics in HepG2 cells. The observed changes are consistent with altered mitochondrial tracer sequestration and increased transporter-mediated efflux, although the present findings do not establish these mechanisms directly. Dynamic 99mTc-MIBI kinetics may therefore provide a functional approach for assessing cellular responses to glycyrrhizic acid, warranting further mechanistic and in-vivo validation.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between prostatic fluorodeoxyglucose uptake, prostatic calcifications, and urologic symptom questionnaires.","authors":"Jai Hyuen Lee, Jonghyuk Choi, Seokgun Park, Gilho Lee","doi":"10.1097/MNM.0000000000002181","DOIUrl":"10.1097/MNM.0000000000002181","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the potential clinical value of fluorodeoxyglucose (FDG) PET/computed tomography (CT) for assessing urological symptom questionnaires including National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Score (IPSS), and quality of life (QoL) measures. Relationships among incidental prostate FDG uptake, prostatic calcifications (PCs), urological symptom questionnaires in men undergoing health screening were explored.</p><p><strong>Methods: </strong>Men who underwent health checkups including FDG PET/CT and completed urological symptom questionnaires were enrolled. Multiple clinical parameters such as prostate-specific antigen were used as adjustment variables. Univariate analyses compared groups based on the presence/absence of FDG uptake and calcification. Multiple logistic regression and Spearman correlation evaluated associations with symptom scores.</p><p><strong>Results: </strong>Of 368 participants, 104 presented FDG uptake or calcification, where 31 exhibited positive FDG uptake, 84 had PCs, and 11 patients presented both. Spearman's correlation revealed strong associations between IPSS scores or QoL and total CPSI (r = 0.60 and 0.58, P < 0.001 for both). In univariate analysis, participants with FDG uptake, prostatic calcification, or at least one of the two findings had significantly higher NIH-CPSI, IPSS, and QoL scores than their respective counterparts without each finding (all P < 0.01). In multivariate logistic regression, prostatic FDG uptake and calcification were associated with higher IPSS and QoL scores (P < 0.001, for both).</p><p><strong>Conclusion: </strong>Prostate FDG uptake and calcification observed on FDG PET/CT were strongly associated with higher urological symptom questionnaires. FDG PET/CT may provide adjunctive information about latent urinary tract symptoms and supplement the evaluation of chronic prostatitis/chronic pelvic pain syndrome.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1148-1154"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of single photon emission computed tomography/computed tomography bone scintigraphy on the clinical management of patients with recurrent pain post spinal fusion.","authors":"Daisy Ozdoeva, Joris Bleyen, André Harth, Bieke Van Den Bossche, Jeroen Mertens, Dieter Berwouts, Matthieu Baert, Nadine Vermeire, Geert Michielsen, Ronald Coessens, Tom Matton, Amaury Baetslé, Arne Vermeulen, Jan Vandereycken, Jan Hendrickx, Nick Baelde, Philippe Lagae, Jeroen Cortier, Valerie Verstraeten, Bieke Lambert","doi":"10.1097/MNM.0000000000002177","DOIUrl":"10.1097/MNM.0000000000002177","url":null,"abstract":"<p><strong>Objective: </strong>Persistent or recurrent pain following spinal fusion surgery presents a significant diagnostic and therapeutic challenge. This study aims to assess the clinical utility of single photon emission computed tomography/computed tomography (SPECT/CT) bone scintigraphy in identifying pain generators and guiding management decisions in patients with pain occurring or persisting following spinal fusion surgery.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of patients who underwent a SPECT/CT 6-24 months after cervical or lumbar spinal fusion. The impact of SPECT/CT findings on clinical decision-making was evaluated based on postoperative records. We also examined a subset of nonunion cases receiving multiple SPECT/CTs over time to assess changes in bone remodeling patterns at the fusion site.</p><p><strong>Results: </strong>A total of 114 SPECT/CT scans (94 lumbar and 20 cervical) were reviewed in 106 patients and revealed pseudarthrosis with or without screw loosening (51%), adjacent level degeneration of facet joint or endplates (19%), screw irritation (12%), and extraspinal pain sources (5%). Positive SPECT/CT reports had an impact on the subsequent clinical management in 69% of cases. In 36 patients with nonunion and serial SPECT/CT scans over time, 94% showed unchanged bone remodeling patterns over time.</p><p><strong>Conclusion: </strong>SPECT/CT bone scintigraphy significantly contributed to clinical decision-making in the majority of patients with pain following spinal fusion. It effectively identified pain generators thereby guiding appropriate treatments. Furthermore, the imaging modality demonstrated a high degree of consistency in bone remodeling patterns over time. Our findings underscore the valuable role of SPECT/CT as a diagnostic adjunct in complex cases of failed back surgery syndrome.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1140-1147"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of apolipoprotein E ε4 on amyloid deposition and relative cerebral perfusion in cognitively normal individuals: a dual-phase 18 F-florbetaben PET study.","authors":"Ji-Young Kim, Donghyeon Kim, Geon Ha Kim, Hai-Jeon Yoon","doi":"10.1097/MNM.0000000000002186","DOIUrl":"10.1097/MNM.0000000000002186","url":null,"abstract":"<p><strong>Objectives: </strong>Apolipoprotein E (APOE) genotypes, amyloid burden, and relative cerebral perfusion surrogate provide crucial insights into Alzheimer's disease pathophysiology. This study aimed to investigate the effects of APOE ε4 on relative perfusion and amyloid deposition in cognitively normal individuals using dual-phase 18 F-florbetaben PET.</p><p><strong>Methods: </strong>Cognitively normal subjects who underwent dual-phase 18 F-FBB PET and APOE genotyping were included. Participants carrying at least one ε4 allele were classified as carriers. Standardized uptake value ratios (SUVRs) were analyzed for relative perfusion and amyloid deposition using early phase 18 F-florbetaben (eFBB) and delayed-phase FBB (dFBB), respectively, in the composite region, including the frontal, parietal, temporal, and occipital cortices, as well as the precuneus, cingulate, and striatum. Target subregions comprised the frontal, parietal, temporal, and occipital cortices along with the precuneus. Correlations between eFBB and dFBB SUVRs were also examined.</p><p><strong>Results: </strong>APOE ε4 carriers exhibited significantly higher relative perfusion in the composite region ( P  = 0.0042), frontal cortex ( P  = 0.0054), and parietal cortex ( P  = 0.0056). Increased amyloid burden was observed in the composite region ( P  = 0.0065), frontal cortex ( P  = 0.0028) and precuneus ( P  = 0.0071). Moreover, eFBB and dFBB SUVRs were significantly positively correlated in the temporal cortex ( P  = 0.0007) and precuneus ( P  = 0.0080).</p><p><strong>Conclusion: </strong>APOE ε4 may be associated with distinct patterns of increased amyloid deposition and relative perfusion in specific brain regions in cognitively normal individuals. Dual-phase 18 F-FBB PET may provide complementary information on Alzheimer's disease-related changes in APOE ε4 carriers during the preclinical stage.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1196-1206"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum 25-hydroxyvitamin D levels and thyroid hormone profiles in Graves' disease: a retrospective cross-sectional stratified analysis.","authors":"Reyhan Toyran","doi":"10.1097/MNM.0000000000002175","DOIUrl":"10.1097/MNM.0000000000002175","url":null,"abstract":"<p><strong>Aim: </strong>Graves' disease is an autoimmune thyroid disorder mediated by thyroid-stimulating hormone receptor antibodies (TRAb). Vitamin D has been proposed as a modulator of autoimmunity; however, its relationship with thyroid hormone profiles in Graves' disease remains unclear.</p><p><strong>Methods: </strong>We retrospectively analyzed 182 patients with Graves' disease and 172 healthy controls. Serum 25-hydroxyvitamin D [25(OH)D] levels were stratified into four categories (<10, 10-20, 20-30, and ≥30 ng/ml). Thyroid parameters [thyroid-stimulating hormone (TSH), free T3 (fT3), free T4 (fT4)] were compared across groups using Kruskal-Wallis and Mann-Whitney U tests. Multivariate linear regression analyses were performed in the Graves' disease group to evaluate independent associations between 25(OH)D levels and thyroid hormone parameters, adjusting for age and sex.</p><p><strong>Results: </strong>Severe vitamin D deficiency (<10 ng/ml) was associated with lower TSH levels compared with the other vitamin D groups (all P  < 0.05). FT3 levels were highest in Group I and significantly lower in Groups II-IV (all P  < 0.001). Similarly, fT4 levels were higher in Group I compared with Groups II and III ( P  < 0.001) and Group IV ( P  = 0.002). No statistically significant differences were observed among higher vitamin D categories. In multivariate analysis, serum 25(OH)D levels were independently and inversely associated with both fT3 ( β = -0.260, P  < 0.001) and fT4 levels ( β = -0.253, P  = 0.001), whereas no independent association was observed with TSH ( β = 0.107, P  = 0.158).</p><p><strong>Conclusion: </strong>Serum 25(OH)D levels were inversely associated with peripheral thyroid hormone levels in patients with Graves' disease, while no independent association was observed with TSH. These findings suggest a potential relationship between vitamin D status and thyroid hormone dynamics; however, given the cross-sectional design, no causal inference can be made. Further prospective studies are required to clarify the clinical significance of this association.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1126-1132"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}