Nuclear Medicine Communications最新文献

{"title":"Advances in the application of 18 F-sodium fluoride PET in the assessment of atherosclerosis.","authors":"Yan Wang, Mingyuan Hou, Taiyang Zuo","doi":"10.1097/MNM.0000000000001988","DOIUrl":"10.1097/MNM.0000000000001988","url":null,"abstract":"<p><p>Atherosclerosis serves as the primary cause of cardiovascular diseases (CVDs), with its pathological processes encompassing lipid deposition, inflammatory responses, and calcification. Traditional imaging techniques, such as computed tomography angiography and MRI, are primarily utilized for detecting arterial stenosis and calcified plaques, yet they face challenges in accurately assessing plaque activity and instability. 18 F-sodium fluoride PET ( 18 F-NaF PET) offers a novel approach for plaque activity and stability assessment by labeling and quantifying arterial wall calcification. This article reviews the advances in the application of 18 F-NaF PET in the assessment of atherosclerosis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"662-672"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and clinical impact of ultra-low-dose FDG-PET imaging in pregnancy-associated breast cancer: the experience of a major tertiary oncology referral centre in the UK and suggested imaging protocol.","authors":"Karen Desouza, Petros Fessas, Emma Spurrell, Elisavet Papadimitraki, Fharat Raja, Rebecca Roylance, Diego Ottaviani, Joanna Franks, Dibendu Betal, Mahwash Babar, Irene Athanasiou, Massimilano Cariati, Neill Patani, Sirwan Hadad, Yusuf Kayani, Darren Walls, Catherine Scott, Marilena Rega, Mubarik Arshad, Jamshed Bomanji, Stefan Vöö","doi":"10.1097/MNM.0000000000001997","DOIUrl":"10.1097/MNM.0000000000001997","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy-associated breast cancer (PABC) is a complex condition affecting 1 in 3000 pregnancies worldwide. While clinical management has improved, the optimal staging approach for PABC remains uncertain. 18 F-fluorodeoxyglucose PET (FDG-PET) imaging is a standard diagnostic tool for many cancers. However, its use in PABC staging is controversial due to potential radiation risks to the foetus.</p><p><strong>Methods: </strong>This retrospective case series analysed clinical data from six patients with high-risk PABC who underwent FDG-PET imaging for staging between 2022 and 2023. FDG-PET was based on locally implemented ultra-low-dose imaging protocols. The radiation doses to the foetus were dosimetrically estimated based on dose-per-unit activity values and correlated with postpartum neonatal outcomes.</p><p><strong>Results: </strong>The median foetal radiation dose was 0.975 mGy (range 0.6-1.5 mGy) and was below the threshold for deterministic toxicities. PET imaging upstaged nodal involvement in 33% of patients and influenced treatment decisions. FDG-PET imaging provided valuable staging information in all cases. No adverse foetal effects were observed.</p><p><strong>Conclusion: </strong>Ultra-low-dose FDG-PET imaging is a valuable tool providing accurate staging information to guide treatment decisions. The low radiation dose associated with this technique makes it a clinically acceptable modality for cancer staging in pregnant women. A larger case series is needed to precisely quantify foetal radiation doses and assess long-term safety.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"772-779"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of quantitative growth plate uptake parameters on bone scintigraphy with growth velocity in children.","authors":"Ki Jin Jung, Sun-Pyo Hong, Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee","doi":"10.1097/MNM.0000000000001992","DOIUrl":"10.1097/MNM.0000000000001992","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to examine the association between quantitative growth plate uptake parameters in bone scintigraphy and growth velocity among children.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 30 pediatric patients (21 male and nine female; age range, 3-15 years) who underwent planar bone scintigraphy. Ratios of maximum growth plate uptake to mean diaphyseal uptake (GP max /D) and mean growth plate uptake to mean diaphyseal uptake (GP mean /D) were calculated for both femurs on anterior and posterior bone scintigraphy images. A total of eight GP max /D parameters and eight GP mean /D parameters were measured. The relationships of growth plate uptake parameters with age and growth velocity (cm/year) were assessed.</p><p><strong>Results: </strong>Correlation analysis with growth velocity revealed that the anterior GP max /D (numerical mean of GP max /D between the right and left femurs on an anterior image) exhibited the highest correlation coefficient (0.409) among the bone scintigraphy parameters ( P  = 0.034). The anterior GP max /D also demonstrated a significant negative correlation with age ( P  = 0.042, correlation coefficient: -0.373). In a multiple regression analysis to predict growth velocity with adjusting for age and sex, the model that included left GP mean /D (geometric mean of GP mean /D between anterior and posterior images of the left femur) yielded the highest adjusted R2 value (0.786), followed by anterior GP max /D (0.734).</p><p><strong>Conclusion: </strong>Quantitative growth plate uptake parameters on the distal femur in bone scintigraphy are significantly associated with growth velocity. These findings suggest that growth plate uptake in bone scintigraphy could potentially serve as a predictive marker of growth in children.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"720-725"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging wastewater data to enhance understanding of medical radionuclide usage in the UK.","authors":"Alexandra Adrych-Brunning, James W Scuffham, Lakshmi Sasi, Nadia A S Smith, Rebecca Nutbrown","doi":"10.1097/MNM.0000000000002001","DOIUrl":"10.1097/MNM.0000000000002001","url":null,"abstract":"<p><strong>Objective: </strong>The secure supply of medical radionuclides, such as Tc-99m and I-131, is at risk because of aging production facilities worldwide. To advocate for investment in radionuclide production infrastructure in the UK, it is essential to understand current radionuclide usage. Accessing hospital data to determine the types and numbers of procedures performed with radionuclides is challenging, and reporting is inconsistent across the devolved nations. By utilising open-source records of radioactive waste discharge held by environmental agencies and creating an interactive map that visualizes the amount and types of radionuclides used in healthcare centers across the UK, we can gain insights into the UK's radionuclide usage and provide valuable information to inform future policies and address geographic disparities.</p><p><strong>Methods: </strong>Waste discharge records from different environmental agencies were interrogated to calculate the amount of administered radionuclide radioactivity at healthcare sites across the UK, which was cross-checked against hospital workload data of procedures performed with Tc-99m, I-131, and Lu-177.</p><p><strong>Results: </strong>The findings indicate that the wastewater data provides a reliable overview of radionuclide use, particularly for Lu-177 and I-131, with agreement between reported and calculated excreted activity within 10%. For Tc-99m, the agreement was within 40%, likely because of variations in clinical practices.</p><p><strong>Conclusion: </strong>The wastewater-reported data offers an independent and valuable source for understanding radionuclide usage across the UK. Enhancing coordination between environmental agencies and improving data collection practices would help improve the interrogation of radionuclide usage in the UK and hence support national strategy and planning for medical radionuclide supply.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"673-681"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of 18 F-fluorodeoxyglucose PET/computed tomography in the initial staging of malignant peritoneal mesothelioma.","authors":"Hui Zhang, Lifang Pang, Jun Hou, Beilei Li, Yiqiu Zhang","doi":"10.1097/MNM.0000000000001990","DOIUrl":"10.1097/MNM.0000000000001990","url":null,"abstract":"<p><strong>Objective: </strong>This study was aimed at evaluating the significance of 18 F-fluorodeoxyglucose PET/computed tomography (FDG PET/CT) in the staging and differentiation of malignant peritoneal mesothelioma (MPeM).</p><p><strong>Materials and methods: </strong>We retrospectively analyzed clinical and imaging data of 21 women and 21 men with MPeM who underwent 18 F-FDG PET/CT, and reviewed and analyzed 18 F-FDG PET/CT characteristics of the patients. Standardized uptake values (SUV max ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG = MTV × SUV mean ) were determined for peritoneal lesions at the highest glycolysis point. Two experienced readers assessed tumor-node-metastasis (TNM) staging and peritoneal cancer index according to Peritoneal Surface Oncology Group International diagnostic requirements.</p><p><strong>Results: </strong>The SUV max and MTV values were significantly lower for the epithelial cases than for the nonepithelioid cases, with the difference being significant ( P  < 0.05). The mean TLG value was significantly lower for the epithelial cases than for the nonepithelioid cases; however, the difference was NS ( P  > 0.05). Exploratory laparotomy was performed in 18 patients, the 18 F-FDG PET/CT diagnostic accuracy for the T stage was 72.2%, and the TNM stage diagnostic accuracy was 94.4%. However, lymph node metastasis was more common in the biphasic type group, and metastasis was more often seen in the sarcomatoid type group.</p><p><strong>Conclusion: </strong>Using a previously suggested novel approach for TNM staging in 18 F-FDG PET/CT assessment of MPeM may improve the accuracy of staging; however, SUV max values showed slight variations depending on the pathology type. 18 F-FDG PET/CT can improve the accuracy of TNM staging, and SUV max values vary slightly depending on the pathology type. Furthermore, 18 F-FDG PET/CT can afford simultaneous visualization of lesions throughout the body, which can help develop a treatment strategy.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"746-752"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic quantitative kinetic analysis in salivary gland scintigraphy.","authors":"Rogério Anton Faria, Graziella Chagas Jaguar, Eduardo Nóbrega Pereira Lima","doi":"10.1097/MNM.0000000000002037","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002037","url":null,"abstract":"<p><p>Salivary gland scintigraphy (SGS) is a valuable imaging modality for assessing major salivary gland function, particularly in patients with Sjögren syndrome, and postradiotherapy conditions. Despite the existence of multiple quantitative analysis methods, clinical practice remains dominated by qualitative interpretation due to the lack of standardization, time-consuming procedures, and absence of user-friendly tools. In this study, we present a fully automated method for quantitative SGS analysis based on kinetic modeling of time-activity curves, implemented without altering standard imaging protocols, using a software we developed in-house on a Xeleris (GE HealthCare) workstation. The curves were segmented into uptake, excretion, and postexcretion phases, each fitted to specific kinetic models. From the fitted parameters, we derived functional variables, including vascular flow, active uptake, uptake velocity, total accumulation, absolute excretion, excretion fraction, and excretion rate. This approach enables rapid and reproducible extraction of functional data, with processing time under 5 s per study. We demonstrate its clinical utility through two case studies, highlighting how kinetic parameters reflect salivary gland function and its longitudinal changes. Our method bridges the gap between complex quantitative analysis and practical clinical application, offering a robust tool for monitoring disease progression and treatment response, potentially improving diagnostic reliability and research scalability.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignancy classification of thyroid incidentalomas using 18F-fluorodeoxy-d-glucose PET/computed tomography-derived radiomics.","authors":"Melda Yeghaian, Marceline W Piek, Annemarieke Bartels-Rutten, Mohamed A Abdelatty, Marina Herrero-Huertas, Wouter V Vogel, Jan Paul de Boer, Koen J Hartemink, Zuhir Bodalal, Regina G H Beets-Tan, Stefano Trebeschi, Iris M C van der Ploeg","doi":"10.1097/MNM.0000000000002031","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002031","url":null,"abstract":"<p><strong>Background: </strong>Thyroid incidentalomas (TIs) are incidental thyroid lesions detected on fluorodeoxy-d-glucose (18F-FDG) PET/computed tomography (PET/CT) scans. This study aims to investigate the role of noninvasive PET/CT-derived radiomic features in characterizing 18F-FDG PET/CT TIs and distinguishing benign from malignant thyroid lesions in oncological patients.</p><p><strong>Materials and methods: </strong>We included 46 patients with PET/CT TIs who underwent thyroid ultrasound and thyroid surgery at our oncological referral hospital. Radiomic features extracted from regions of interest (ROI) in both PET and CT images and analyzed for their association with thyroid cancer and their predictive ability. The TIs were graded using the ultrasound TIRADS classification, and histopathological results served as the reference standard. Univariate and multivariate analyses were performed using features from each modality individually and combined. The performance of radiomic features was compared to the TIRADS classification.</p><p><strong>Results: </strong>Among the 46 included patients, 36 patients (78%) had malignant thyroid lesions, while 10 patients (22%) had benign lesions. The combined run length nonuniformity radiomic feature from PET and CT cubical ROIs demonstrated the highest area under the curve (AUC) of 0.88 (P < 0.05), with a negative correlation with malignancy. This performance was comparable to the TIRADS classification (AUC: 0.84, P < 0.05), which showed a positive correlation with thyroid cancer. Multivariate analysis showed higher predictive performance using CT-derived radiomics (AUC: 0.86 ± 0.13) compared to TIRADS (AUC: 0.80 ± 0.08).</p><p><strong>Conclusion: </strong>This study highlights the potential of 18F-FDG PET/CT-derived radiomics to distinguish benign from malignant thyroid lesions. Further studies with larger cohorts and deep learning-based methods could obtain more robust results.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of 18F-2-fluoro-2-deoxyglucose PET/computed tomography radiomics in epidermal growth factor receptor mutation subtypes prediction and progression-free survival in advanced lung adenocarcinoma patients with first-line epidermal growth factor receptor tyrosine kinase inhibitors therapy.","authors":"Yi Liu, Yushi Peng, Fangansheng Chen, Rui Yao, Ling Wang, Kun Tang","doi":"10.1097/MNM.0000000000002032","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002032","url":null,"abstract":"<p><strong>Objective: </strong>Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) improve survival of EGFR-mutated lung adenocarcinoma (LUAD); however, outcomes vary with genetic subtypes and tumor heterogeneity in late-stage. We aimed to construct pretreatment 18F-2-fluoro-2-deoxyglucose PET/computed tomography (18F-FDG PET/CT) radiomics models for EGFR-subtype prediction and prognosis in first-line TKIs-treated patients.</p><p><strong>Methods: </strong>We retrospectively analyzed 131 EGFR-mutated advanced LUAD patients from 2017 to 2024: 72 exon 19 deletion (19Del) and 59 exon 21 L858R (21L858R) mutations. After feature selection, support vector machine models: PET, CT, PET-CT, and clinical PET-CT combined models were built. Performance was evaluated by areas under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA). Model-derived radscore was used to explore progression-free survival (PFS) in first-line EGFR-TKIs-treated patients. Multivariate Cox regression was conducted to identify independent factors.</p><p><strong>Results: </strong>The clinical PET/CT combined model achieved AUCs of 0.854 [95% confidence interval (CI): 0.776-0.932] and 0.785 (95% CI: 0.639-0.932) in training and test sets. The calibration curves showed good agreement, and the DCA confirmed clinical utility. Among 125 successfully followed patients, 21L858R mutation patients showed poorer median PFS (P = 0.008) compared to 19Del mutation. High radscore [hazard ratio (HR): 0.57, 95% CI: 0.34-0.94, P = 0.029], third-generation TKI therapy (HR: 0.45, 95% CI: 0.27-0.73, P = 0.001), and high maximum standardized uptake value (HR: 1.67, 95% CI: 1.03-2.69, P = 0.036) were independent factors of PFS.</p><p><strong>Conclusion: </strong>Integrating 18F-FDG PET/CT radiomics with clinical data precisely identifies EGFR mutation subtypes and guides initial TKI monotherapy in advanced LUAD.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined 82-rubidium PET and coronary computed tomography in coronary artery disease: insights into the association between calcium score, coronary artery disease-reporting and data system, ischemia, and blood flow.","authors":"Ujwal Bhure, Matthias Bossard, Hannes Grünig, Thiago Lima, Tatjana Leike, Nina Lampe, Florim Cuculi, Klaus Strobel","doi":"10.1097/MNM.0000000000002026","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002026","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate correlation between various parameters from integrated 82-rubidium PET/coronary computed tomography angiography (RbPET/CCTA), like coronary artery calcium (CAC) score, coronary artery disease-reporting and data system (CAD-RADS), myocardial ischemia scores, and myocardial blood flow parameters [stress myocardial blood flow (sMBF) and myocardial flow reserve (MFR)].</p><p><strong>Methods: </strong>In this retrospective study, 184 consecutive patients [107 women, 77 men, median age: 67 years [(interquartile range: 61-74 years)] with suspicion of CAD were imaged with RbPET/CCTA in the 'one-stop imaging' approach. The association between CAC score, CAD-RADS, relative perfusion, and myocardial blood flow was assessed.</p><p><strong>Results: </strong>There was a weak but statistically significant inverse correlation between the global CAD-RADS score and global sMBF (ρ = -0.239, P = 0.001) and global MFR (ρ = -0.248, P = 0.0001). There was a significant difference in CAD-RADS 3-5 vs. CAD-RADS 0-2 for global as well as per-vessel sMBF and MFR values (P < 0.05). There was a very weak inverse correlation between global CAC and global sMBF (ρ = -0.165, P = 0.026) and a nonsignificant, very weak inverse correlation between global CAC and global MFR (ρ = -0.120, P = 0.106).</p><p><strong>Conclusion: </strong>Combined CCTA and RbPET 'one-stop imaging' provides comprehensive anatomical and physiological information in patients with suspected CAD. The PET and computed totmography parameters seem to lack linear and robust correlation. In the given circumstances, CAD-RADS scores appear to have a relatively better, though weak, correlation with sMBF, MFR, and relative ischemia scores compared with CAC scores.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of 18F-prostate-specific membrane antigen-1007 PET/MRI versus 18F-prostate-specific membrane antigen-1007 PET/computed tomography for biochemical recurrence of prostate cancer after radical prostatectomy.","authors":"Yuping Zeng, Hengbin Liao, Guihua Jiang, Gongfa Wu, Junyuan Zhong","doi":"10.1097/MNM.0000000000002028","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002028","url":null,"abstract":"<p><strong>Objective: </strong>To assess the diagnostic value of fluorine 18 (18F)-labeled prostate-specific membrane antigen (PSMA)-1007 PET/MRI and compare with that of 18F-PSMA-1007 PET/computed tomography (CT) for biochemical recurrence (BCR) of prostate cancer (PCa) after radical prostatectomy.</p><p><strong>Materials and methods: </strong>We enrolled 40 patients who underwent 18F-PSMA-1007 PET/CT and 18F-PSMA-1007 PET/MRI for BCR after radical prostatectomy. Two readers independently assessed the images and determined their overall assessment of positive lesions on PET/MRI and PET/CT. The association between the patients' clinical characteristics and positive detection results on the PET/CT and PET/MRI was explored. The PET/CT and PET/MRI results were verified during a 24-month follow-up to calculate their diagnostic accuracy.</p><p><strong>Results: </strong>The detection rate of positive patients on 18F-PSMA-1007 PET/CT and PET/MRI were consistent, with a value of 77.50%. The positive detection results were moderately associated with the patients' prostate-specific antigen (PSA) levels at examination, and the detection rate increased significantly with values of 50.00%, 72.73%, 90.91%, and 100% for PSA levels <0.5, 0.5-<1.0, 1.0-<2.0, and ≥2.0 ng/ml, respectively. Conclusive follow-up for affirmation or refutation of PCa recurrence was available for 33 patients. Compared with the follow-up results, on the patient-based level, the diagnostic accuracies for PET/MRI and PET/CT were both 100%. On the lesion-based level, PET/MRI excluded a false positive of bone metastasis on PET/CT.</p><p><strong>Conclusion: </strong>18F-PSMA-1007 PET/MRI and 18F-PSMA-1007 PET/CT demonstrate almost equal diagnostic value in detecting BCR, but PET/MRI can provide more lesion information, facilitating diagnosis and treatment due to its superior soft tissue resolution.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}