Nuclear Medicine Communications最新文献

{"title":"Quantitative whole-body measurement of inflammothrombotic immunologic response disease using Fleming method for tissue and vascular differentiation and metabolism: Retraction.","authors":"","doi":"10.1097/MNM.0000000000002227","DOIUrl":"10.1097/MNM.0000000000002227","url":null,"abstract":"","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":"47 10","pages":"1220"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative AV-45 PET imaging for assessing treatment response to lecanemab and deep cervical lymphatic-venous anastomosis in Alzheimer's disease.","authors":"Luqiang Jin, Xinyu Wang, Fahuan Song, Jie Hou, Yueqian Bi, Xuehua Wen, Xu Wang, Fangyuan Lai, Aiping Cheng","doi":"10.1097/MNM.0000000000002184","DOIUrl":"10.1097/MNM.0000000000002184","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to validate the clinical utility of visual and software-based quantitative AV-45 PET analyses and compare treatment effects between lecanemab and deep cervical lymphatic-venous anastomosis (dcLVA).</p><p><strong>Methods: </strong>This retrospective cohort study included Alzheimer's disease patients who received 6-month lecanemab therapy or dcLVA surgery between July 2024 and 2025. AV-45 PET was performed 1 week before and 6 months after treatment. Standardized uptake value ratios (SUVRs) and centiloids (CLs) were obtained using visual and quantitative analyses. Agreement was assessed using Cohen's κ and intraclass correlation coefficients (ICC). Receiver operating characteristic (ROC) analysis evaluated diagnostic performance. Logistic regression used Informant Questionnaire on Cognitive Decline in the Elderly score greater than or equal to 3.3 as the outcome.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups (all P > 0.05). Visual assessment showed good agreement with centiloid quantification ( κ = 0.72, ICC = 0.663). ROC analysis identified ΔCL as the optimal marker (area under the curve = 0.764, P = 0.026), with a cutoff of -11.5%. ΔCL ≥ -11.5% independently predicted cognitive decline in the lecanemab group (odds ratio = 10.281, 95% confidence interval = 1.289-82.005; P = 0.028). Cognitive decline was less frequent in the lecanemab group (23.5 vs. 81.8%; P < 0.001). ΔCL differed significantly between groups ( P = 0.006), whereas ΔSUVR did not.</p><p><strong>Conclusion: </strong>Visual and centiloid-based AV-45 PET analyses show good concordance for monitoring Alzheimer's disease treatment response. ΔCL is a robust marker of lecanemab efficacy, which is superior to dcLVA in reducing amyloid-β burden and delaying cognitive decline.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1188-1195"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral metabolism mediates cognitive impairment in stroke-free atrial fibrillation patients: a mediation analysis using 18F-fluorodeoxyglucose PET/computed tomography.","authors":"Yue Yue, Wenji Yu, Dan Jiang, Yu Tian, ChunBo Wang, Fan Sun, Shan Shao, Peng Wan, Yuetao Wang","doi":"10.1097/MNM.0000000000002185","DOIUrl":"10.1097/MNM.0000000000002185","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Atrial fibrillation, one of the most common types of arrhythmia, is a major risk factor for stroke. Previous studies have demonstrated cognitive decline in atrial fibrillation patients regardless of stroke comorbidity. This study aimed to investigate the relationship between cerebral metabolic alterations and cognitive impairment in stroke-free atrial fibrillation patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In the retrospective cohort study, we enrolled 68 stroke-free atrial fibrillation patients and 68 age-matched sinus rhythm controls who underwent 18F-fluorodeoxyglucose PET-computed tomography imaging between 1 January 2018 and 31 December 2022 in the third Affiliated Hospital of Soochow University. Regional cerebral metabolism was assessed using DPABI software, with the standardized uptake value ratio (SUVR) of regions of interest calculated as the average standardized uptake value (SUV mean ) of specific brain regions divided by the average SUV of the cerebellum. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE). The MMSE has a total score of 30 points, with scores &lt;24 indicating cognitive impairment. Clinical data, electrocardiograms, echocardiograms, and other relevant information were systematically collected. Correlation analyses were performed to investigate the association between metabolic changes and cognitive impairment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Cognitive assessment using the MMSE revealed significantly lower scores in atrial fibrillation patients compared to control [25.00 (24.00-26.00) vs. 27.00 (25.00-28.00), P  &lt; 0.001] and the prevalence of cognitive impairment was significantly higher in the atrial fibrillation group than in the control group (17.64% vs. 4.41%, P  = 0.012). Regional cerebral metabolic analysis demonstrated widespread SUVR reductions in atrial fibrillation patients across multiple cognition-related regions, including the frontal, temporal, parietal, and occipital lobes, cingulate gyrus, thalamus, basal ganglia, and cerebellum. Multivariable logistic regression identified significant inverse associations between elevated SUVR values and cognitive impairment in the right calcarine fissure and surrounding cortex (Calcarine_R: adjusted OR = 0.004, P  = 0.033), bilateral lingual gyrus (Lingual_L/R: adjusted OR = 0.002, P  &lt; 0.04), and Lobule VI-VIII of vermis (Vermis_6/7: adjusted OR = 0.000, P  &lt; 0.035). Mediation analysis confirmed these regions as significant pathways linking atrial fibrillation to cognitive dysfunction, with Calcarine_R showing the strongest mediation effect (proportion: 40.80% crude, 36.30% adjusted; all P  &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;These findings suggest that stroke-free atrial fibrillation patients exhibit abnormal cerebral metabolic patterns in specific brain regions, and some of the abnormal cerebral metabolic activities are closely linked to cognitive decline. These metabolic alterations may serve as pot","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1176-1187"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workforce fragility in hospital-based radiopharmaceutical production: implications for nuclear medicine practice.","authors":"Hiroshi Yamaguchi","doi":"10.1097/MNM.0000000000002189","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002189","url":null,"abstract":"","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":"47 10","pages":"1218-1219"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorine-18 fluorodeoxyglucose PET/computed tomography-based radiomics for predicting risk groups, tumor stage, and capsular and fat tissue invasion in thymomas.","authors":"Ebru Tatci, Büşra Bozca, Kayacan Dizdar, Tuba İnal Cengiz, Nesrin Gürcay, Leyla Nesrin Acar, Ülkü Yilmaz, Özlem Özmen, Pinar Tari, Nur Aydinbelge Dizdar","doi":"10.1097/MNM.0000000000002179","DOIUrl":"10.1097/MNM.0000000000002179","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the predictive value of fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) based radiomics in patients with thymoma for risk stratification and tumor staging, including capsular and fat tissue invasion.</p><p><strong>Methods: </strong>A total of 67 (50 for training and 17 for validation) patients with thymoma were analyzed. Thymomas were categorized as low risk (types A, AB, and B1) or high risk (types B2 and B3) and as early stage (I-II) or advanced stage (III-IV). PET- and CT-derived radiomic features extracted. Three models were constructed: a PET model, a CT model, and a PET/CT (combined) model. Feature selection was conducted using the Mann-Whitney U test and least absolute shrinkage and selection operator regression.</p><p><strong>Results: </strong>For risk group discrimination, the combined model demonstrated the highest performance [area under the curve (AUC) = 0.80], outperforming the PET (AUC = 0.78) and CT (AUC = 0.72) models. In stage discrimination, the PET model and the combined model achieved superior performance (AUC = 0.82 for both), compared with the CT-based model (AUC = 0.75). For capsular invasion detection, predictive performance was achieved only with CT-based radiomics (AUC = 0.70). For fat tissue invasion detection, the combined model achieved the highest performance (AUC = 0.79), followed by CT (AUC = 0.76) and PET (AUC = 0.70). Maximum standardized uptake value of thymomas showed no significant discriminative value across any clinical categories ( P > 0.05).</p><p><strong>Conclusion: </strong>F luorine-18 fluorodeoxyglucose PET/CT-based radiomics may provide complementary, noninvasive biomarkers for the management of patients with thymoma.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1166-1175"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of 18F-fluorodeoxyglucose PET/computed tomography in relapsing polychondritis: a systematic review and meta-analysis.","authors":"Pareena Malik, Dhananjaya Saraswat, Piyush Aggarwal, Harmandeep Singh, Ananya Sharma, Rajender Kumar, Aman Sharma, Bhagwant Rai Mittal","doi":"10.1097/MNM.0000000000002188","DOIUrl":"10.1097/MNM.0000000000002188","url":null,"abstract":"<p><p>Relapsing polychondritis is a rare chronic autoimmune inflammation of the cartilage associated with life-threatening respiratory complications. Currently, no clear role of imaging modalities such as 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) is defined in the literature. This systematic review and meta-analysis provide current evidence on the PET-positivity rate and utility in relapsing polychondritis. Prospective or retrospective studies with more than five patients of suspected relapsing polychondritis who underwent 18F-FDG PET/CT during their management and reported a PET-positivity rate were included. Low-sample-size studies describing chondritis due to other aetiologies or utilizing PET-based radiopharmaceuticals other than FDG were excluded. A systematic search using relevant keywords was conducted across four databases (PubMed, Embase, Scopus and Web of Science) to include studies up to 25 April 2025. The Joanna Briggs Institute critical appraisal tools were used for risk-of-bias analysis. Data were analysed using the R software package (v4.3.1; 2023). Out of 962 articles, three with a total of 97 patients were included. With a pooled PET-positivity rate of 94% [95% confidence interval (CI): 73-99%, I2 = 0%, P = 0.76] and a pooled baseline SUVmax of 4.0 (95% CI: 3.5-4.6, I2 = 32%, P = 0.23), 18F-FDG PET identified asymptomatic cartilage involvement in more than 25% patients and PET parameters correlated well with inflammatory markers. It had a higher positivity rate for inaccessible sites, such as peripheral airways, and was crucial in treatment monitoring. The pooled PET-positivity rate of 18F-FDG PET in relapsing polychondritis is high but requires prospective large-sample-size studies to explore the diagnostic accuracy and prognostic implications of 18F-FDG PET in relapsing polychondritis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":"47 10","pages":"1117-1125"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grading and detecting gastroenteropancreatic neuroendocrine neoplasms with dual-tracer ( 18 F-AlF-NOTA-octreotide/ 18 F-FDG) PET/CT: a metabolic parameter-based study.","authors":"Qing Dong, Qiuchen Zhou, Yang Liu, Qian Wang, Zhao Yang, Qian Su","doi":"10.1097/MNM.0000000000002187","DOIUrl":"10.1097/MNM.0000000000002187","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate quantitative metabolic indices from dual-tracer 18 F-AlF-NOTA-octreotide ( 18 F-AlF-OC) and 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) for grading gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), focusing on total lesion glycolysis ratio (TLGR).</p><p><strong>Methods: </strong>This retrospective study included 34 patients with GEP-NENs (198 target lesions) who underwent both 18 F-AlF-OC and 18 F-FDG PET/CT. Parameters included maximum standardized uptake value (SUV max ), total lesion glycolysis (TLG), SUV ratio (SUVR), and TLGR (ratio of 18 F-AlF-OC volumetric somatostatin receptor uptake to 18 F-FDG TLG by conventional TLG framework). Diagnostic performance for differentiating G1/G2 from G3/neuroendocrine carcinoma (NEC) and neuroendocrine tumor (NET) from NEC was assessed using receiver operating characteristic (ROC) analysis. Incremental value was evaluated using Δarea under the curve (AUC) and continuous net reclassification improvement with patient-level cluster bootstrap resampling. Generalized estimating equation (GEE) models accounted for multiple lesions per patient. Internal validation used leave-one-patient-out cross-validation.</p><p><strong>Results: </strong>18 F-AlF-OC detected more lesions in G1/G2 NETs, while detection was similar in NEC. In ROC analysis, TLGR, SUVR, and TLGR + SUVR yielded AUCs of 0.760, 0.760, and 0.767 for G1/G2 versus G3/NEC, and 0.811, 0.829, and 0.827 for NET versus NEC, respectively. Adding TLGR to SUVR or FDG SUV max provided only modest improvement. TLGR was significant alone in GEE models but attenuated after SUVR adjustment, and cross-validation showed reduced out-of-sample performance.</p><p><strong>Conclusion: </strong>Dual-tracer PET/CT provides complementary information for GEP-NEN grading. TLGR is an exploratory volumetric dual-tracer parameter, but its incremental value beyond SUVR and FDG SUV max is limited. Further validation is required.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1207-1217"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of quantitative dual lumbar vertebral radioactive counts ratio using 99m-technetium-labeled methylene diphosphonate single-photon emission computed tomography/computed tomography in the assessment of osteoporosis.","authors":"Yili Wang, Runqing Duan","doi":"10.1097/MNM.0000000000002182","DOIUrl":"10.1097/MNM.0000000000002182","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the utility of 99m-technetium-labeled methylene diphosphonate single-photon emission computed tomography/computed tomography (SPECT/CT) in the quantitative analysis of the dual lumbar spine to assess osteoporosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 60 patients who underwent SPECT/CT bone imaging between January 2018 and April 2025. Based on dual-energy X-ray absorptiometry measurements of lumbar spine and femoral T-scores, participants were divided into osteoporotic ( n  = 31) and non-osteoporotic ( n  = 29) groups. The mean radioactive counts ratio (T/NTmean) of the two normal lumbar vertebrae to the erector spinae at the L3 level were measured. Correlations of lower T-score, age, height, weight, BMI, and lower bone mineral density (BMD) with the T/NTmean were explored using Pearson correlation analyses. Diagnostic value of the T/NTmean for osteoporosis was assessed by receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Weight, BMI, lower T-score, and lower BMD were positively correlated with T/NTmean for different bilumbar spine combinations ( r : 0.417-0.701, all P  < 0.01). Age was negatively correlated ( r : 0.595 to -0.409, all P  < 0.05); height showed no correlation (all P  > 0.05). ROC curve analysis revealed that the T/NTmean had diagnostic efficacy for osteoporosis, with an area under the curve of 0.845, a sensitivity of 85.2%, and a specificity of 72.8%.</p><p><strong>Conclusion: </strong>Quantitative evaluation of the dual lumbar spine using SPECT/CT effectively reflects the BMD of patients, which can provide a viable basis for screening for opportunistic osteoporosis in some patients with lumbar spine lesions.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1133-1139"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental value of whole-body 18 F-fluorodeoxyglucose PET/computed tomography in cavernous sinus syndrome: guiding biopsy and improving diagnostic outcome.","authors":"Raza Abbas Mahdi, Aastha Takkar, Rajender Kumar, Harmandeep Singh, Chirag Kamal Ahuja, Sandeep Bansal, Debajyoti Chatterjee, Apinderpreet Singh, Harpreet Singh, Bhagwant Rai Mittal, Vivek Lal","doi":"10.1097/MNM.0000000000002180","DOIUrl":"10.1097/MNM.0000000000002180","url":null,"abstract":"<p><strong>Objective: </strong>Cavernous sinus syndrome (CSS) has diverse causes and correctly identifying the underlying pathology is difficult. The study aimed to determine the incremental value of whole-body 18 F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in detecting extra-cranial involvement in CSS, to guide biopsy sites; and characterizing cavernous sinus pathologies based on metabolic activity.</p><p><strong>Methods: </strong>Participants with treatment-naive CSS after clinical assessment and MRI brain were recruited prospectively from July 2022 to December 2023. All the participants underwent whole-body 18 F-FDG-PET/CT, and images were analyzed for the presence, site, extent, and standardized uptake value (SUV max ) and feasibility of biopsy from cavernous sinus and extracranial lesions. Reference standards were histopathology, definite MRI findings, or established diagnostic criteria for immunoglobulin G 4 -related disease, neurosarcoidosis and Tolosa-Hunt syndrome.</p><p><strong>Results: </strong>Data of 54 patients (mean age: 44.8 years) was analyzed. Cavernous sinus lesion was detected in all 54 patients, and 26 (48.1%) patients had extra-cranial lesions. PET-directed biopsies were done from the local extension of FDG-avid cavernous sinus lesions in 20 (37%) and extra-cranial lesions in 12 (22.2%) patients. The final etiological diagnoses were infection in 18 (33.3%), inflammatory disorders in 18 (33.3%), benign neoplasms in 11 (20.5%), and malignancy in seven (12.9%) cases. PET/CT demonstrated significantly lower FDG-avidity in benign cavernous sinus neoplasms (median SUV max : 5.5, IQR: 4.5-8.0) as compared to the infective, inflammatory, and malignant conditions involving the cavernous sinus (median: 15.0, IQR: 10.7-22.4; P  < 0.001). Bony erosions and contiguous paranasal involvement were more frequently associated with infective CSS ( P  < 0.001).</p><p><strong>Conclusion: </strong>Whole-body 18 F-FDG-PET/CT effectively identifies extracranial disease in CSS, enables less invasive biopsy site selection, and enhances diagnostic yield while minimizing high-risk intracranial biopsies. 18 F-FDG-PET/CT should be considered in imaging of CSS, especially when definite diagnosis is not established with conventional workup.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1155-1165"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET-derived metabolic-immunonutritional SUVmax-lactate dehydrogenase-albumin-lymphocyte index for survival prediction in human epidermal growth factor receptor 2-positive metastatic breast cancer receiving pertuzumab-based therapy.","authors":"Emine Bihter Eniseler, Ferhat Ekinci, Mustafa Şahbazlar, Atike Pinar Erdoğan","doi":"10.1097/MNM.0000000000002237","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002237","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prognostic value of the PET-derived SUVmax-lactate dehydrogenase-albumin-lymphocyte (SUV-LAL) index in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer treated with pertuzumab.</p><p><strong>Methods: </strong>This retrospective single-center study included patients with HER2-positive metastatic breast cancer treated with pertuzumab-containing regimens between January 2018 and October 2025. Baseline clinical, pathological, laboratory, and 18F-fluorodeoxyglucose PET/computed tomography data were retrospectively collected. The SUV-LAL index was calculated as (primary tumor maximum standardized uptake value × lactate dehydrogenase)/(albumin × absolute lymphocyte count). Overall survival (OS) and progression-free survival (PFS) were evaluated using Cox proportional hazards regression analyses. Kaplan-Meier survival analysis, receiver operating characteristic (ROC) analysis, and time-dependent ROC analyses were performed to assess prognostic performance.</p><p><strong>Results: </strong>A total of 80 patients were included, of whom 36 (45.0%) died during follow-up. The SUV-LAL index remained an independent prognostic factor for OS in multivariate analysis [hazard ratio = 1.755, 95% confidence interval (CI) = 1.053-2.927; P = 0.031], together with the number of pertuzumab cycles (hazard ratio = 0.921, 95% CI = 0.872-0.972; P = 0.003). Patients with a high SUV-LAL index had significantly shorter OS and PFS than those with a low SUV-LAL index (log-rank P < 0.001 and P = 0.002, respectively). ROC analysis yielded an area under the curve (AUC) of 0.760. Compared with its individual components, the SUV-LAL index showed the strongest association with OS in univariate Cox regression analysis and achieved the highest 1-year time-dependent AUC (0.735), while maintaining acceptable prognostic performance at 3 years (AUC = 0.705).</p><p><strong>Conclusion: </strong>The PET-derived SUV-LAL index independently predicts OS in HER2-positive metastatic breast cancer treated with pertuzumab.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}