NPJ Parkinson's Disease最新文献_第5页

Metabolic dysregulation and resistance to high-fat diet-induced weight gain in mice overexpressing human wild-type α-synuclein 过度表达人野生型α-突触核蛋白的小鼠代谢失调和对高脂肪饮食诱导的体重增加的抵抗

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-24 DOI: 10.1038/s41531-025-00961-w

K. C. Biju, Enrique Torres Hernandez, Alison Michelle Stallings, Ada C. Felix-Ortiz, Skanda K. Hebbale, Luke Norton, Michael J. Mader, Robert A. Clark

{"title":"Metabolic dysregulation and resistance to high-fat diet-induced weight gain in mice overexpressing human wild-type α-synuclein","authors":"K. C. Biju, Enrique Torres Hernandez, Alison Michelle Stallings, Ada C. Felix-Ortiz, Skanda K. Hebbale, Luke Norton, Michael J. Mader, Robert A. Clark","doi":"10.1038/s41531-025-00961-w","DOIUrl":"https://doi.org/10.1038/s41531-025-00961-w","url":null,"abstract":"Unintentional weight loss is common among patients with Parkinson’s disease (PD) and is associated with poor quality of life and accelerated disease progression. To explore how early α-synuclein pathology contributes to metabolic dysregulation leading to weight loss in PD, transgenic mice overexpressing human wild-type α-synuclein (α-Syn) and controls were fed a high-fat diet (HFD) chow for 4 months. Compared with controls on HFD, α-Syn mice on HFD exhibited a dramatically leaner phenotype, improved glucose tolerance, a major decrease in fat mass, an increase in energy expenditure, a decrease in insulin signaling in the olfactory bulb, aggravated olfactory and motor dysfunctions, and an increase in mortality. Our results show that high-fat diet in α-Syn mice provides a sensitive tool for assessing the underlying mechanism of metabolic dysfunction and its impact on weight loss and disease progression in PD. Moreover, a role is proposed for olfactory dysfunction in PD-related unintentional weight loss.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"34 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of apathy in early Parkinson’s disease 早期帕金森病冷漠的改善

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-24 DOI: 10.1038/s41531-025-00937-w

A. Castrioto, E. Schmitt, M. Anheim, S. Meoni, H. Klinger, D. Sourd, P. Pelissier, E. Lhommée, A. Bichon, C. Tranchant, E. Moro, V. Fraix, S. Thobois, P. Krack

{"title":"Improvement of apathy in early Parkinson’s disease","authors":"A. Castrioto, E. Schmitt, M. Anheim, S. Meoni, H. Klinger, D. Sourd, P. Pelissier, E. Lhommée, A. Bichon, C. Tranchant, E. Moro, V. Fraix, S. Thobois, P. Krack","doi":"10.1038/s41531-025-00937-w","DOIUrl":"https://doi.org/10.1038/s41531-025-00937-w","url":null,"abstract":"Apathy is a disabling symptom in Parkinson’s disease (PD). The effect of dopaminergic treatment on apathy is inconsistent, depending on the stage of the disease, the type of apathy and strongly influenced by placebo effect. Our study assessed the evolution of a cohort of 86 de novo, drug naive PD patients for 4 years, after dopaminergic treatment introduction. The main objective of the study was the change of apathy from baseline to follow-up and secondary outcomes were the change of other neuropsychiatric symptoms. At 4 years there was an improvement of apathy (p = 0.002), mainly driven by improvement of baseline apathy (p = 0.001). This was associated with an improvement of anxiety (p = 0.001), an increase in hyperdopaminergic behavior including nocturnal hyperactivity with consecutive diurnal sleepiness (p = 0.001 and p < 0.001), independently of the presence of apathy at baseline. These findings confirm, in a large real-life cohort, that dopaminergic treatment improves motivational apathy in early PD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"15 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Midbrain and pallidal iron changes identify patients with REM sleep behaviour disorder and Parkinson’s disease 中脑和苍白质铁的变化可识别快速眼动睡眠行为障碍和帕金森病患者

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-23 DOI: 10.1038/s41531-025-00916-1

Erind Alushaj, Alan Kuurstra, Ravi S. Menon, Hooman Ganjavi, Anisa Morava, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R. Khan, Penny A. MacDonald

{"title":"Midbrain and pallidal iron changes identify patients with REM sleep behaviour disorder and Parkinson’s disease","authors":"Erind Alushaj, Alan Kuurstra, Ravi S. Menon, Hooman Ganjavi, Anisa Morava, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R. Khan, Penny A. MacDonald","doi":"10.1038/s41531-025-00916-1","DOIUrl":"https://doi.org/10.1038/s41531-025-00916-1","url":null,"abstract":"Idiopathic REM sleep behaviour disorder (iRBD) is considered a prodromal form of Parkinson’s Disease (PD), potentially exhibiting similar patterns of neurodegeneration, such as brain iron changes. We investigated midbrain and pallidal iron using quantitative susceptibility mapping (QSM) in 16 iRBD patients, 30 PD patients, and 38 age-matched healthy controls (HCs) with 3T MRI. QSM revealed elevated substantia nigra pars compacta (SNc) mean susceptibility in both iRBD and PD patient groups compared to HCs, though iRBD and PD QSM measures did not differ. There were no SN pars reticulata group differences. Mean susceptibility was reduced for PD relative to iRBD and HCs in the globus pallidus externa (GPe). Furthermore, mean susceptibility was reduced for PD relative to iRBD in the GP interna (GPi). GPe/GPi mean susceptibility decreased with PD subgroup motor severity. Consistent with this, QSM in left GPi and MDS-UPDRS-III scores correlated negatively in PD patients, as well as in iRBD and PD patients combined. PD patients also evidenced higher mean susceptibility in the right ventral tegmental area (VTA) compared to iRBD and HCs, consistent with later VTA degeneration. RBD symptomatology did not correlate with QSM values. Combining SNc, GPe, GPi, and VTA QSM values, we distinguished iRBD-HCs, PD-HCs, and iRBD-PD patients at single-subject levels (0.84, 0.86, and 0.81 accuracies), using ROC curve analyses with repeated k-folds cross-validation. Using 3T MRI, QSM values in SNc, GPe, GPi, and VTA demonstrate promise as investigational measures and diagnostic/progression biomarkers of prodromal and early PD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"33 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection 环境暴露和家族背景改变了SARS-CoV-2感染后神经病理和炎症的诱导

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-23 DOI: 10.1038/s41531-025-00925-0

Debotri Chatterjee, Drishya Kurup, Richard Jay Smeyne

引用次数: 0

Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein 配体磁性纳米颗粒用于α-突触核蛋白的磁共振成像

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-23 DOI: 10.1038/s41531-025-00918-z

Hope Pan, Melinda Balbirnie, Ke Hou, Naomi S. Sta Maria, Shruti Sahay, Paul Denver, Stefano Lepore, Mychica Jones, Xiaohong Zuo, Chunni Zhu, Hilda Mirbaha, Hedieh Shahpasand-Kroner, Marisa Mekkittikul, Jiahui Lu, Carolyn J. Hu, Xinyi Cheng, Romany Abskharon, Michael R. Sawaya, Christopher K. Williams, Harry V. Vinters, Russell E. Jacobs, Neil G. Harris, Gregory M. Cole, Sally A. Frautschy, David S. Eisenberg

{"title":"Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein","authors":"Hope Pan, Melinda Balbirnie, Ke Hou, Naomi S. Sta Maria, Shruti Sahay, Paul Denver, Stefano Lepore, Mychica Jones, Xiaohong Zuo, Chunni Zhu, Hilda Mirbaha, Hedieh Shahpasand-Kroner, Marisa Mekkittikul, Jiahui Lu, Carolyn J. Hu, Xinyi Cheng, Romany Abskharon, Michael R. Sawaya, Christopher K. Williams, Harry V. Vinters, Russell E. Jacobs, Neil G. Harris, Gregory M. Cole, Sally A. Frautschy, David S. Eisenberg","doi":"10.1038/s41531-025-00918-z","DOIUrl":"https://doi.org/10.1038/s41531-025-00918-z","url":null,"abstract":"Aggregation of the protein α-synuclein (α-syn) is the histopathological hallmark of neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), which are collectively known as synucleinopathies. Currently, patients with synucleinopathies are diagnosed by physical examination and medical history, often at advanced stages of disease. Because synucleinopathies are associated with α-syn aggregates, and α-syn aggregation often precedes onset of symptoms, detecting α-syn aggregates would be a valuable early diagnostic for patients with synucleinopathies. Here, we design a liganded magnetic nanoparticle (LMNP) functionalized with an α-syn-targeting peptide to be used as a magnetic resonance imaging (MRI)-based biomarker for α-syn. Our LMNPs bind to aggregates of α-syn in vitro, cross the blood-brain barrier in mice with mannitol adjuvant, and can be used as an MRI contrast agent to distinguish mice with α-synucleinopathy from age-matched, wild-type control mice in vivo. These results provide evidence for the potential of magnetic nanoparticles that target α-syn for diagnosis of synucleinopathies.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"26 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory 利用多队列、机器学习和项目反应理论开发一种简化的嗅觉测试，以识别帕金森病

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-23 DOI: 10.1038/s41531-025-00904-5

Juan Li, Kelsey Grimes, Joseph Saade, Julianna J. Tomlinson, Tiago A. Mestre, Sebastian Schade, Sandrina Weber, Mohammed Dakna, Tamara Wicke, Elisabeth Lang, Claudia Trenkwalder, Natalina Salmaso, Andrew Frank, Tim Ramsay, Douglas Manuel, Brit Mollenhauer, Michael G. Schlossmacher

{"title":"Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory","authors":"Juan Li, Kelsey Grimes, Joseph Saade, Julianna J. Tomlinson, Tiago A. Mestre, Sebastian Schade, Sandrina Weber, Mohammed Dakna, Tamara Wicke, Elisabeth Lang, Claudia Trenkwalder, Natalina Salmaso, Andrew Frank, Tim Ramsay, Douglas Manuel, Brit Mollenhauer, Michael G. Schlossmacher","doi":"10.1038/s41531-025-00904-5","DOIUrl":"https://doi.org/10.1038/s41531-025-00904-5","url":null,"abstract":"To develop a simplified smell test for identifying patients with Parkinson’s disease (PD), we reevaluated the Sniffin’-Sticks-Identification-Test (SST-ID) and University-of-Pennsylvania-Smell-Identification-Test (UPSIT), using three case-control studies. These included 301 patients with PD or dementia with Lewy bodies (DLB), 68 subjects with multiple-system atrophy (MSA) or progressive supranuclear palsy (PSP), and 281 healthy controls (HC). Scents were ranked by area-under-the-curve values for group classification and results leveraged by 8 published studies with 5853 individuals. PD/DLB patients showed markedly worse olfaction than controls, whereas scores for MSA/PSP subjects were intermediate. We identified and validated a subset of 7 shared odorants that performed similarly to the traditional 16-scent SST-ID and 40-scent UPSIT tests in distinguishing PD/DLB from HC. There, the identification of 4 or fewer scents out of 7 served as an effective cut-off between the two groups. We also identified a critical role for distractors (from correct answers) and age on olfaction performance.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"5 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD 在iRBD中，DTI-ALPS降低的临床和脑容量相关性提示局部淋巴功能障碍

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-23 DOI: 10.1038/s41531-025-00942-z

Ignacio Roura, Jèssica Pardo, Cristina Martín-Barceló, Carles Falcon, Javier Oltra, Anna Campabadal, Nuria Bargalló, Mònica Serradell, Gerard Mayà, Angelica Montini, Claustre Pont-Sunyer, Carles Gaig, Mariateresa Buongiorno, Carme Junqué, Alex Iranzo, Bàrbara Segura

{"title":"Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD","authors":"Ignacio Roura, Jèssica Pardo, Cristina Martín-Barceló, Carles Falcon, Javier Oltra, Anna Campabadal, Nuria Bargalló, Mònica Serradell, Gerard Mayà, Angelica Montini, Claustre Pont-Sunyer, Carles Gaig, Mariateresa Buongiorno, Carme Junqué, Alex Iranzo, Bàrbara Segura","doi":"10.1038/s41531-025-00942-z","DOIUrl":"https://doi.org/10.1038/s41531-025-00942-z","url":null,"abstract":"Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal synucleinopathy stage. Furthermore, its associations with clinical symptoms and brain structural abnormalities remain unexplored. We assessed the DTI-ALPS in sixty-two patients with iRBD and twenty-three healthy controls (HC), exploring its associations with clinical symptoms, cortical thickness and brain volumetric data. iRBD patients exhibited a lower DTI-ALPS and poorer odor identification, semantic fluency and processing speed relative to HC. The DTI-ALPS positively correlated with cognitive performance, olfactory function and amygdalar, hippocampal, brainstem and diencephalic volumes, and negatively with age in iRBD. Perivascular glymphatic activity is compromised in iRBD and is associated with brain atrophy and clinical risk factors of progression to alpha-synucleinopathies, supporting the potential of the DTI-ALPS index as an early imaging neurodegeneration marker.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"23 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD PD患者小脑皮质高代谢对运动和认知功能的影响

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-22 DOI: 10.1038/s41531-025-00931-2

Wen-Hua Ren, Bin Chen, Jiu-Qin He, Yu-Meng Qi, Ya-Yun Yan, Shu-Xian Jin, Ying Chang

{"title":"Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD","authors":"Wen-Hua Ren, Bin Chen, Jiu-Qin He, Yu-Meng Qi, Ya-Yun Yan, Shu-Xian Jin, Ying Chang","doi":"10.1038/s41531-025-00931-2","DOIUrl":"https://doi.org/10.1038/s41531-025-00931-2","url":null,"abstract":"Previous studies suggest the cerebellum may play a role in both motor and non-motor symptoms of Parkinson’s disease (PD), though molecular evidence remains insufficient. We enrolled 104 PD patients to analyze the correlation between cerebellar glucose metabolism and motor and cognitive functions. Metabolic differences across motor subtypes and cognitive stages were examined, along with their relationship to supratentorial structures. Results showed that glucose metabolism in left cerebellar lobules IV and V was negatively correlated with motor function, with no significant differences between tremor-dominant (TD) and postural instability gait difficulty (PIGD) groups. Metabolism in lobules VI, VIII, and the dentate nucleus negatively correlated with cognitive function, with significant differences across cognitive stages. Cerebellar metabolism was closely linked to the cerebral cortex, and a correlation with the thalamus was observed in the TD group. These findings suggest cerebellar glucose metabolism may reflect compensatory mechanisms, highlighting the cerebellum as a potential therapeutic target.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"47 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinson’s disease with possible REM sleep behavior disorder correlated with more severe glymphatic system dysfunction 帕金森病伴有可能的快速眼动睡眠行为障碍与更严重的淋巴系统功能障碍相关

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-21 DOI: 10.1038/s41531-025-00962-9

Xinxin Ma, Yueying Liu, Miaoxian Xie, Chunmei Li, Xinyang Li, Dandan Shang, Min Chen, Haibo Chen, Wen Su

引用次数: 0

Microstructure is associated with motor outcomes following Deep Brain Stimulation in Parkinson’s disease 帕金森病患者脑深部电刺激后的微结构与运动结果相关

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-04-21 DOI: 10.1038/s41531-025-00930-3

Philipp Alexander Loehrer, Julia Freigang, Miriam H. A. Bopp, Alexander Calvano, Haidar S. Dafsari, Julius Wichmann, Amelie Seidel, Carolin Aberle, Susanne Knake, Christopher Nimsky, Lars Timmermann, Marcus Belke, David J. Pedrosa

{"title":"Microstructure is associated with motor outcomes following Deep Brain Stimulation in Parkinson’s disease","authors":"Philipp Alexander Loehrer, Julia Freigang, Miriam H. A. Bopp, Alexander Calvano, Haidar S. Dafsari, Julius Wichmann, Amelie Seidel, Carolin Aberle, Susanne Knake, Christopher Nimsky, Lars Timmermann, Marcus Belke, David J. Pedrosa","doi":"10.1038/s41531-025-00930-3","DOIUrl":"https://doi.org/10.1038/s41531-025-00930-3","url":null,"abstract":"Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established intervention for alleviating both motor and non-motor symptoms in advanced Parkinson’s disease (PD). However, patient outcomes may vary widely, underscoring the need for predictive biomarkers. Neuroimaging techniques, such as neurite orientation dispersion and density imaging (NODDI), a biophysical model-based MRI technique, offer promise in forecasting clinical outcomes and supporting preoperative counseling. This prospective, open-label study aimed to identify microstructural markers that correlate with short-term motor outcomes following STN-DBS in PD patients. Thirty-five patients underwent diffusion MRI and comprehensive clinical evaluations preoperatively and six months postoperatively. Evaluations were performed in the ON-medication as well as ON-medication/ON-stimulation state. A whole-brain voxel-wise analysis was conducted to explore associations between microstructural metrics and motor outcomes. Permutation-based statistical methods were applied to adjust for multiple comparisons. Intact microstructure in the bilateral putamen, bilateral insula, and left pallidum was significantly associated with a greater postoperative motor symptom improvement. Additionally, preserved microstructure in the pre- and postcentral gyrus and right precuneus was associated with increased duration with good mobility and without troublesome dyskinesia, and reduced time with poor mobility. These findings suggest that diffusion MRI may serve as valuable tool for identifying patients likely to exhibit favorable motor outcomes following STN-DBS. Incorporating microstructural data into preoperative counseling could enhance patient selection and optimize therapeutic strategies.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"108 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0