NPJ Parkinson's Disease最新文献_第4页

Multiparametric quantitative MRI uncovers putamen microstructural changes in Parkinson’s disease 多参数定量MRI揭示帕金森病壳核微结构变化

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-03 DOI: 10.1038/s41531-025-01020-0

Elior Drori, Lee Cohen, David Arkadir, Gilad Yahalom, Aviv A. Mezer

{"title":"Multiparametric quantitative MRI uncovers putamen microstructural changes in Parkinson’s disease","authors":"Elior Drori, Lee Cohen, David Arkadir, Gilad Yahalom, Aviv A. Mezer","doi":"10.1038/s41531-025-01020-0","DOIUrl":"https://doi.org/10.1038/s41531-025-01020-0","url":null,"abstract":"Parkinson’s disease (PD) is a progressive neurodegenerative disorder dominated by motor and non-motor dysfunction. Despite extensive research, in vivo characterization of PD-related brain microstructure remains a challenge, limiting diagnostic and therapeutic advances. The putamen, a subcortical region crucial for movement regulation, is prominently affected in early PD. Here, we collected multiparametric quantitative MRI (qMRI) data from PD patients and healthy controls, to investigate biophysical alterations in the putamen. Gradient analysis revealed significant spatial variation and interhemispheric asymmetries in biophysical properties – including relaxation rates (R1, R2, R2*), water fraction (WF), susceptibility, MTsat, and diffusion metrics (MD, FA) – along its anterior-posterior axis. PD patients showed altered gradients, particularly increased WF in the posterior putamen, suggesting tissue atrophy or neuroinflammation, and correlating with motor symptom laterality. Our findings highlight the posterior putamen as a PD pathology hotspot and demonstrate the potential of qMRI gradient analysis for detecting clinically relevant brain changes.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"20 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson’s disease and related alpha-synucleinopathies 帕金森病及相关α -突触核蛋白病家庭筛查中快速眼动睡眠行为障碍检测的新技术

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-03 DOI: 10.1038/s41531-025-01032-w

Kaat Colman, An-Marie Schyvens, Ilse De Volder, Johan Verbraecken, Angelique Pijpers, Mineke Viaene, Wolfgang Oertel, Femke Dijkstra, David Crosiers

{"title":"Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson’s disease and related alpha-synucleinopathies","authors":"Kaat Colman, An-Marie Schyvens, Ilse De Volder, Johan Verbraecken, Angelique Pijpers, Mineke Viaene, Wolfgang Oertel, Femke Dijkstra, David Crosiers","doi":"10.1038/s41531-025-01032-w","DOIUrl":"https://doi.org/10.1038/s41531-025-01032-w","url":null,"abstract":"Isolated REM sleep behavior disorder (iRBD) is a prodromal marker of Parkinson’s disease (PD) and related alpha-synucleinopathies. Identification of RBD is crucial for timely intervention and disease-modifying treatments. While video-polysomnography (vPSG) remains the diagnostic gold standard, its costly and resource-intensive nature limits its utility. This systematic review evaluates emerging non-PSG tools and modalities for home-based RBD detection. A systematic search of PubMed, Web of Science, and Cochrane Library identified 17 studies, categorized into actigraphy devices (n = 9), novel tools (n = 5), and emerging modalities (n = 3). Advances in actigraphy, through machine learning integration, have significantly improved RBD detection. Novel tools, including portable biopotential systems and temporary tattoo electrodes, show promise for home-based REM sleep without atonia monitoring, while contactless cameras demonstrate high sensitivity for dream-enacting behavior detection. Future studies for validation are needed, ensuring reliability and clinical applicability for large-scale screening efforts aimed at identifying individuals at risk for PD and related alpha-synucleinopathies.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"69 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient, target, device, and program selection for DBS in Parkinson's disease: advancing toward precision care. 帕金森病DBS的患者、靶标、设备和方案选择：向精准护理迈进。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01015-x

Aparna Wagle Shukla,Manuel Bange,Muthuraman Muthuraman

{"title":"Patient, target, device, and program selection for DBS in Parkinson's disease: advancing toward precision care.","authors":"Aparna Wagle Shukla,Manuel Bange,Muthuraman Muthuraman","doi":"10.1038/s41531-025-01015-x","DOIUrl":"https://doi.org/10.1038/s41531-025-01015-x","url":null,"abstract":"In Parkinson's disease (PD), several key factors influence patient selection for deep brain stimulation (DBS) as they directly affect long-term outcomes. A comprehensive interdisciplinary assessment is the first step to evaluating risks, benefits, and establishing appropriate goals. Patient-defined symptom priorities play a critical role in selecting the brain target for DBS. The entry of multiple manufacturers of hardware has spurred a rapid acceleration of technological progress. While innovations in programming such as sensing-based physiology-guided programming have introduced the concept of delivering an optimal or \"Goldilocks dose\", a precise, personalized therapy to address specific PD symptoms, image-guided programming acts like a \"GPS,\" enabling faster determination of dose parameters. Emerging tools such as adaptive and automated programming offer clinicians the potential to provide optimal, energy-efficient stimulation. This review, integrating both old and well-established knowledge and new insights, provides a comprehensive summary of the multidimensional aspects of patient selection, target-specific benefits, advancements in hardware technology, and innovative strategies that are either currently available or on the horizon for DBS programming.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"11 1","pages":"195"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG alpha peak frequency: cognitive impairment severity marker in isolated REM sleep behavior disorder 脑电图α峰频率：孤立性快速眼动睡眠行为障碍的认知障碍严重程度标志

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01059-z

Sophia Schopp, Jan de Zeeuw, Sophia Stotz, Martin Haberecht, Katy Sahra Weihrich, Michail Plotkin, Frederik Bes, Dieter Kunz

{"title":"EEG alpha peak frequency: cognitive impairment severity marker in isolated REM sleep behavior disorder","authors":"Sophia Schopp, Jan de Zeeuw, Sophia Stotz, Martin Haberecht, Katy Sahra Weihrich, Michail Plotkin, Frederik Bes, Dieter Kunz","doi":"10.1038/s41531-025-01059-z","DOIUrl":"https://doi.org/10.1038/s41531-025-01059-z","url":null,"abstract":"Isolated REM sleep behavior disorder (iRBD) is a prodrome of α-synucleinopathies like Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The best marker for prediction of lead time to phenoconversion is reduced striatal dopamine transporter (DaT)-binding, unavailable for most patients. This study investigated EEG alpha peak frequency (APF) slowing – an established marker of cognitive deterioration – as a severity marker in iRBD patients. In 320 patients clinically suspected of RBD 3-night-polysomnography was performed. After exclusion of 131 patients, mainly due to psychotropic medication, three groups were studied: Non-Syn – motor behavior unrelated to RBD (n = 34); iRBD (n = 122); RBD converted to overt α-synucleinopathies (PD = 19; DLB = 14). Data show in patients with iRBD significant correlations between APF, DaT-binding ratios and cognition. The strong correlation of APF < 8 Hz with caudate DaT-binding (r = 0.50–0.65) suggests, APF could be an easy-to-use severity marker for counseling patients on lead time until possible conversion to overt α-synucleinopathy especially in DLB.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"16 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning for Parkinson’s disease: a comprehensive review of datasets, algorithms, and challenges 帕金森病的机器学习：对数据集、算法和挑战的全面回顾

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01025-9

Sahar Shokrpour, AmirMehdi MoghadamFarid, Sepideh Bazzaz Abkenar, Mostafa Haghi Kashani, Mohammad Akbari, Mostafa Sarvizadeh

{"title":"Machine learning for Parkinson’s disease: a comprehensive review of datasets, algorithms, and challenges","authors":"Sahar Shokrpour, AmirMehdi MoghadamFarid, Sepideh Bazzaz Abkenar, Mostafa Haghi Kashani, Mohammad Akbari, Mostafa Sarvizadeh","doi":"10.1038/s41531-025-01025-9","DOIUrl":"https://doi.org/10.1038/s41531-025-01025-9","url":null,"abstract":"Parkinson’s disease (PD) is a devastating neurological ailment affecting both mobility and cognitive function, posing considerable problems to the health of the elderly across the world. The absence of a conclusive treatment underscores the requirement to investigate cutting-edge diagnostic techniques to improve patient outcomes. Machine learning (ML) has the potential to revolutionize PD detection by applying large repositories of structured data to enhance diagnostic accuracy. 133 papers published between 2021 and April 2024 were reviewed using a systematic literature review (SLR) methodology, and subsequently classified into five categories: acoustic data, biomarkers, medical imaging, movement data, and multimodal datasets. This comprehensive analysis offers valuable insights into the applications of ML in PD diagnosis. Our SLR identifies the datasets and ML algorithms used for PD diagnosis, as well as their merits, limitations, and evaluation factors. We also discuss challenges, future directions, and outstanding issues.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"19 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of two types of repetitive transcranial magnetic stimulation on brain network in Parkinson’s disease 两种重复经颅磁刺激对帕金森病脑网络的影响

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01054-4

Shuo Liu, Shuo Yang, Chen Wang, Jiarui Li, Lei Wang

{"title":"Effects of two types of repetitive transcranial magnetic stimulation on brain network in Parkinson’s disease","authors":"Shuo Liu, Shuo Yang, Chen Wang, Jiarui Li, Lei Wang","doi":"10.1038/s41531-025-01054-4","DOIUrl":"https://doi.org/10.1038/s41531-025-01054-4","url":null,"abstract":"Intermittent theta burst stimulation (iTBS) may have higher efficiency and stronger excitatory effects compared to conventional high-frequency repetitive transcranial magnetic stimulation (HF-rTMS). To evaluate the therapeutic effects of the two modalities, we compared the differences in spatiotemporal variability of electroencephalography (EEG) microstate-based brain networks between 51 PD patients and 21 healthy controls. The 51 PD patients were randomly assigned to either iTBS or 10Hz-rTMS groups to compare pre- and post-treatment clinical assessment results and spatiotemporal variability changes. Baseline measurements showed significant differences in spatiotemporal variability between PD patients and healthy controls, with certain brain regions demonstrating significant correlations between spatiotemporal variability and clinical assessment results. Both treatment groups exhibited significant improvements in all clinical outcomes compared to baseline. The iTBS group showed post-treatment changes involving more brain regions in spatiotemporal variability. This study demonstrates that compared to 10Hz-rTMS, iTBS can reduce treatment time while providing superior improvement in functional brain connectivity for PD patients.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"47 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration 直接通路毒蕈碱m4受体信号的突触后适应遵循多巴胺能变性的时间和区域模式

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01047-3

Beatriz E. Nielsen, Christopher P. Ford

引用次数: 0

Enrichment of gut-derived metabolites in a Parkinson’s disease subtype with REM sleep behavior disorder 帕金森病亚型伴快速眼动睡眠行为障碍的肠道代谢物富集

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01040-w

Sunjae Lee, Jihyun Kim, Jae Woo Baek, Ki-Young Jung, Yunjong Lee, Ara Koh, Han-Joon Kim

引用次数: 0

Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD 顺磁易感性图谱更好地量化帕金森病伴RBD患者脑铁含量

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01043-7

Lining Dong, Wenyu Zhou, Ran An, Zheng Wang, Wei Wei, Hongjiang Wei, Zhenchang Wang, Xuan Wei

{"title":"Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD","authors":"Lining Dong, Wenyu Zhou, Ran An, Zheng Wang, Wei Wei, Hongjiang Wei, Zhenchang Wang, Xuan Wei","doi":"10.1038/s41531-025-01043-7","DOIUrl":"https://doi.org/10.1038/s41531-025-01043-7","url":null,"abstract":"The specific mechanism underlying the effect of changes in brain iron content on the development of RBD secondary to PD remains unclear. 27 PD patients with secondary RBD (PD-RBD+), 24 PD patients without RBD (PD-RBD-), and 32 healthy controls (HCs) were included. Paramagnetic susceptibility was isolated using APART-QSM. The QSM and paramagnetic susceptibility (χpara) values of the whole brain and subcortical nuclei were compared among groups. The diagnostic performance was evaluated using receiver operating characteristic curve analysis. Compared with PD-RBD-, PD-RBD+ patients presented a lower χpara value in the left middle temporal gyrus. The QSM and χpara values of bilateral substantia nigra pars compacta (SNpc) were increased in both groups. The diagnostic performance of the combined index of χpara values was superior to that of the QSM value or the single index. In conclusion, paramagnetic susceptibility isolated from QSM is helpful for iron quantification and exploring the mechanism of PD-RBD+.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"8 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials 时间事件分析减轻了对症治疗对帕金森病试验治疗效益的影响

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2025-07-01 DOI: 10.1038/s41531-025-01041-9

Gennaro Pagano, Dylan Trundell, Tanya Simuni, Nicola Pavese, Kenneth Marek, Ronald B. Postuma, Nima Shariati, Annabelle Monnet, Emma Moore, Evan W. Davies, Hanno Svoboda, Nathalie Pross, Azad Bonni, Tania Nikolcheva

{"title":"Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials","authors":"Gennaro Pagano, Dylan Trundell, Tanya Simuni, Nicola Pavese, Kenneth Marek, Ronald B. Postuma, Nima Shariati, Annabelle Monnet, Emma Moore, Evan W. Davies, Hanno Svoboda, Nathalie Pross, Azad Bonni, Tania Nikolcheva","doi":"10.1038/s41531-025-01041-9","DOIUrl":"https://doi.org/10.1038/s41531-025-01041-9","url":null,"abstract":"The use of symptomatic medications represents a challenge for clinical trials of novel medicines designed to slow Parkinson’s disease progression. A time-to-event (TTE) approach using a defined motor progression milestone may mitigate the confounding effect of symptomatic therapy on the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). This analysis uses prasinezumab- and placebo-treated groups from the PASADENA study to evaluate the impact of symptomatic medications on treatment effects by comparing a TTE approach to a change-from-baseline approach with and without censoring the population upon starting symptomatic therapy. While the TTE approach yielded consistent hazard ratios between censored and non-censored analyses, the estimated difference between treatment arms using the change-from-baseline approach was lower without censoring than with censoring, suggesting a potential masking of prasinezumab treatment effects by symptomatic therapy. Thus, the TTE approach may mitigate the potential confounding effect of symptomatic therapy on MDS-UPDRS Part III.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"36 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0