NPJ Parkinson's Disease最新文献_第4页

CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants 伴有或不伴有 GBA1 变异的帕金森病和路易体痴呆的 CSF d18:1 鞘脂种类

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-24 DOI: 10.1038/s41531-024-00820-0

Stefanie Lerche, Isabel Wurster, Enza Maria Valente, Micol Avenali, Daniela Samaniego, Marta Martínez-Vicente, Jorge Hernández-Vara, Ariadna Laguna, Andrea Sturchio, Per Svenningsson, Nicholas P. France, Carrolee Barlow, Sethu Sankaranarayanan, Kathrin Brockmann

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Vagus nerve stimulation in Parkinson’s disease: a scoping review of animal studies and human subjects research 迷走神经刺激治疗帕金森病：动物研究和人体研究范围综述

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-24 DOI: 10.1038/s41531-024-00803-1

Alexandra Evancho, Melissa Do, Damiana Fortenberry, Rebecca Billings, Alibek Sartayev, William J. Tyler

{"title":"Vagus nerve stimulation in Parkinson’s disease: a scoping review of animal studies and human subjects research","authors":"Alexandra Evancho, Melissa Do, Damiana Fortenberry, Rebecca Billings, Alibek Sartayev, William J. Tyler","doi":"10.1038/s41531-024-00803-1","DOIUrl":"https://doi.org/10.1038/s41531-024-00803-1","url":null,"abstract":"Parkinson’s Disease (PD) is a prevalent, progressive neurodegenerative disease with motor and non-motor symptoms. Vagus Nerve Stimulation (VNS) has emerged as a potential therapeutic approach for PD, but published research on this topic varies widely. This scoping review maps existing literature on VNS for PD, highlighting stimulation methods, operational parameters, safety profiles, neurophysiological mechanisms, and clinical outcomes in human and animal models. Online databases were used to identify 788 papers published between 2013 and 2023, from which 17 publications on invasive and non-invasive VNS in PD were selected. Studies showed high variability in VNS parameters and study design. Evidence in animal models and human subjects suggests potential neurophysiological effects on PD-related pathology and motor function improvements. However, significant gaps in the literature remain. Future research should include rigorous reporting of study design, standardization of stimulation parameters, and larger sample sizes to ultimately facilitate translation of VNS into clinical practice.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"4 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Significance of neurodegeneration and neuroplasticity serum biomarkers in Parkinson’s disease patients treated with subthalamic stimulation 接受丘脑下刺激治疗的帕金森病患者的神经变性和神经可塑性血清生物标志物的意义

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-24 DOI: 10.1038/s41531-024-00808-w

Florencia Sanmartino, Fátima Cano-Cano, Raúl Rashid-López, Álvaro Javier Cruz-Gómez, Elena Lozano-Soto, Paloma Macías-García, Francisco L. Sánchez-Fernández, Fernando López-Sosa, Laura Gómez-Jaramillo, Jesús Riqué-Dormido, Francisco Escamilla-Sevilla, Raúl Espinosa-Rosso, Javier J. González-Rosa

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The effect of air pollution on hospitalizations with Parkinson’s disease among medicare beneficiaries nationwide 空气污染对全国医疗保险受益人帕金森病住院治疗的影响

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-24 DOI: 10.1038/s41531-024-00815-x

Veronica A. Wang, Scott Delaney, Lauren E. Flynn, Brad A. Racette, Gary W. Miller, Danielle Braun, Antonella Zanobetti, Daniel Mork

{"title":"The effect of air pollution on hospitalizations with Parkinson’s disease among medicare beneficiaries nationwide","authors":"Veronica A. Wang, Scott Delaney, Lauren E. Flynn, Brad A. Racette, Gary W. Miller, Danielle Braun, Antonella Zanobetti, Daniel Mork","doi":"10.1038/s41531-024-00815-x","DOIUrl":"https://doi.org/10.1038/s41531-024-00815-x","url":null,"abstract":"We examined the effect of annual exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3), on the rate of first hospitalization with a PD-related diagnosis (hospitalization with PD) among Medicare Fee-for-Service beneficiaries (2001-2016). Machine learning-derived annual air pollution concentrations were linked to residential ZIP codes. For each exposure, we fitted four models: 1) traditional outcome stratification, 2) marginal structural, 3) doubly robust, and 4) generalized propensity score matching Poisson regression models, adjusted for sociodemographic and meteorological confounders and long-term trends. Among 49,121,026 beneficiaries, incidence rate ratios of 1.08 (95% CI: 1.07, 1.10), 1.07 (95% CI: 1.05, 1.08), and 1.03 (95% CI: 1.02, 1.05) for an interquartile range increase in PM2.5 (3.72 µg/m3), NO2 (13.84 ppb), and O3 (10.09 ppb), respectively, were estimated from doubly robust models. Results were similar across modeling approaches. In this nationwide study, higher air pollution exposure increased the rate of hospitalizations with PD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"21 2 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease 时间干扰、纳米粒子、超声波、基因疗法和帕金森病设计受体综述

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-23 DOI: 10.1038/s41531-024-00804-0

A. D. Currie, J. K. Wong, M. S. Okun

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Depletion of ATP13A2 in adult brain induces a Parkinsonian phenotype in mice and non-human primates. 在小鼠和非人灵长类动物中，成人大脑中 ATP13A2 的耗竭会诱发帕金森表型。

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-23 DOI: 10.1038/s41531-024-00814-y

Veerle Baekelandt

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CRBN modulates synuclein fibrillation via degradation of DNAJB1 in mouse model of Parkinson disease 在帕金森病小鼠模型中，CRBN通过降解DNAJB1调节突触核蛋白纤维化

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-23 DOI: 10.1038/s41531-024-00801-3

Uroos Akber, Jun-Hyung Jung, Heewoong Yoon, Jiwon Seo, Chul-Seung Park

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Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2 转录因子 USF2 和 ONECUT2 对 β-葡糖脑苷脂的直接和间接调控

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-22 DOI: 10.1038/s41531-024-00819-7

Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi

{"title":"Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2","authors":"Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi","doi":"10.1038/s41531-024-00819-7","DOIUrl":"https://doi.org/10.1038/s41531-024-00819-7","url":null,"abstract":"Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson’s disease (PD), with 10–30% of carriers developing the disease. To identify genetic modifiers contributing to the incomplete penetrance, we examined the effect of 1634 human transcription factors (TFs) on GCase activity in lysates of an engineered human glioblastoma line homozygous for the pathogenic GBA1 L444P variant. Using an arrayed CRISPR activation library, we uncovered 11 TFs as regulators of GCase activity. Among these, activation of MITF and TFEC increased lysosomal GCase activity in live cells, while activation of ONECUT2 and USF2 decreased it. While MITF, TFEC, and USF2 affected GBA1 transcription, ONECUT2 might control GCase trafficking. The effects of MITF, TFEC, and USF2 on lysosomal GCase activity were reproducible in iPSC-derived neurons from PD patients. Our study provides a systematic approach to identifying modulators of GCase activity and deepens our understanding of the mechanisms regulating GCase.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"21 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Grip strength, genetic predisposition, and Incident Parkinson’s disease: a prospective cohort study in the UK Biobank 握力、遗传倾向和帕金森病：英国生物库的前瞻性队列研究

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-21 DOI: 10.1038/s41531-024-00810-2

Wei Hu, Chun-Hua Zhao, Yue-Qing Huang, Bao-Peng Liu, Cun-Xian Jia

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α-synuclein seed amplification assay sensitivity may be associated with cardiac MIBG abnormality among patients with Lewy body disease 路易体病患者的α-突触核蛋白种子扩增测定敏感性可能与心脏 MIBG 异常有关

IF 8.7 1区医学

NPJ Parkinson's Disease Pub Date : 2024-10-21 DOI: 10.1038/s41531-024-00806-y

Masanori Kurihara, Katsuya Satoh, Ryosuke Shimasaki, Keiko Hatano, Kensuke Ohse, Kenichiro Taira, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Masashi Kameyama, Atsushi Iwata

{"title":"α-synuclein seed amplification assay sensitivity may be associated with cardiac MIBG abnormality among patients with Lewy body disease","authors":"Masanori Kurihara, Katsuya Satoh, Ryosuke Shimasaki, Keiko Hatano, Kensuke Ohse, Kenichiro Taira, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Masashi Kameyama, Atsushi Iwata","doi":"10.1038/s41531-024-00806-y","DOIUrl":"https://doi.org/10.1038/s41531-024-00806-y","url":null,"abstract":"Although α-synuclein seed amplification assays (α-syn SAA) are promising, its sensitivity may be affected by heterogeneity among patients with Lewy body disease (LBD). We evaluated whether α-syn SAA sensitivity is affected by patient heterogeneity, using 123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in early drug-naïve patients. Thirty-four patients with clinically established or probable Parkinson’s disease (PD) and seven with dementia with Lewy bodies (DLB) or prodromal DLB were included. While 85.2% of patients with abnormal cardiac MIBG were α-syn SAA positive, only 14.3% were positive among those with normal scans. Logistic regression analysis showed that MIBG positivity was the only significant variable associated with α-syn SAA positivity (odds ratio 74.2 [95% confidence interval 6.1–909]). Although α-syn SAA is sensitive for LBD in patients with abnormal MIBG, the sensitivity may be lower in those with normal MIBG. Further studies are necessary to evaluate the association between patient heterogeneity and α-syn SAA sensitivity.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"36 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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