发布求助
文献互助 智能选刊 最新文献

NPJ Parkinson's Disease最新文献

筛选
英文 中文
New PET ligand 3H-M503-1619 captures α-synuclein in human postmortem LBDs but not in MSA tissue 新的PET配体3H-M503-1619在人死后lbd中捕获α-突触核蛋白，而在MSA组织中不捕获α-突触核蛋白
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-15 DOI: 10.1038/s41531-026-01564-9
Dinahlee Saturnino Guarino, John-Grey Crosby, Zoe L. Sessions, Dhruva D. Dhavale, John L. Robinson, Theresa Schuck, Edward B. Lee, Paul T. Kotzbauer, Kelvin C. Luk, Virginia M.-Y. Lee, Robert H. Mach
{"title":"New PET ligand 3H-M503-1619 captures α-synuclein in human postmortem LBDs but not in MSA tissue","authors":"Dinahlee Saturnino Guarino, John-Grey Crosby, Zoe L. Sessions, Dhruva D. Dhavale, John L. Robinson, Theresa Schuck, Edward B. Lee, Paul T. Kotzbauer, Kelvin C. Luk, Virginia M.-Y. Lee, Robert H. Mach","doi":"10.1038/s41531-026-01564-9","DOIUrl":"https://doi.org/10.1038/s41531-026-01564-9","url":null,"abstract":"Alpha synuclein (a-syn) is an intracellular protein that is normally present as an alpha helix. Misfolding to form a beta pleated sheet leads to intracellular aggregates having strain diversity, which has presented a challenge to those trying to design a PET imaging agent for this purpose. Here, we describe the in vitro binding properties of a new compound, M503-1619, characterized through radioligand binding studies in amplified Lewy body disease fibrils and in vitro autoradiography using human post-mortem samples from neurodegenerative diseases and mouse models of seeded α-synucleinopathy in conjunction with immunohistochemistry. Potential off-target binding towards monoamine oxidase-B (MAO-B) was also evaluated. Results suggest high affinity and target engagement with a-synuclein inclusions in LBDs but not in MSA brains. Off-target binding to MAO-B was minimal. Overall, these results indicate that the novel radioligand [3H]M503-1619 has a suitable in vitro profile for detecting α-synuclein pathology in LBDs but not in MSA patients.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"92 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘Managing the mental state’ to tackle anxiety-related freezing of gait in people with Parkinson’s disease: a randomized controlled trial “管理精神状态”以解决帕金森病患者与焦虑相关的步态冻结：一项随机对照试验
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-15 DOI: 10.1038/s41531-026-01571-w
Gijs Vissers, Anouk Tosserams, Annelien A. Duits, Rick C. Helmich, Bastiaan R. Bloem, William R. Young, Jorik Nonnekes
{"title":"‘Managing the mental state’ to tackle anxiety-related freezing of gait in people with Parkinson’s disease: a randomized controlled trial","authors":"Gijs Vissers, Anouk Tosserams, Annelien A. Duits, Rick C. Helmich, Bastiaan R. Bloem, William R. Young, Jorik Nonnekes","doi":"10.1038/s41531-026-01571-w","DOIUrl":"https://doi.org/10.1038/s41531-026-01571-w","url":null,"abstract":"Freezing of gait (FOG) is a debilitating symptom in Parkinson’s disease (PD), characterized by paroxysmal episodes wherein there is an inability to step effectively, despite attempting to do so. Anxiety is known to exacerbate FOG. Although anxiety-relieving compensation strategies are anecdotally reported to reduce FOG, their effectiveness awaits systematic evaluation. In this randomized controlled trial, we evaluated a personalized, non-pharmacological intervention aimed at reducing anxiety-related FOG. Forty-one participants with PD and anxiety-related FOG were randomly assigned (1:1) to either an intervention group or a waitlist control group. The intervention consisted of four weekly sessions combining psychoeducation with tailored behavioral strategies targeting anxiety in relation to FOG. The primary outcome was the percentage of time spent frozen during a home-based walking task designed to provoke FOG. The intervention did not reduce the time spent frozen during the walking course compared with the waitlist group. Likewise, no differences were found for most secondary outcomes. In preplanned exploratory longitudinal analyses combining both groups, reductions in time spent frozen and improvements in several secondary outcomes were observed over time. This randomized controlled trial shows that a brief, four‑session tailored behavioral intervention did not reduce objectively measured anxiety‑related FOG compared with a waitlist control. Trial registration: ClinicalTrials.gov NCT06302309. Registered on March 4, 2024.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"17 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to 'The method matters: free water imaging in Parkinson's disease is not a binary verdict'. 回复“方法很重要：帕金森病的免费水显像不是一个二元结论”。
IF 8.5 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-12 DOI: 10.1038/s41531-026-01490-w
Yun Hwa Roh, Jinyoung Youn, Sang-Young Kim, Hwan Heo, Soohwa Song, Beomseok Sohn
{"title":"Reply to 'The method matters: free water imaging in Parkinson's disease is not a binary verdict'.","authors":"Yun Hwa Roh, Jinyoung Youn, Sang-Young Kim, Hwan Heo, Soohwa Song, Beomseok Sohn","doi":"10.1038/s41531-026-01490-w","DOIUrl":"10.1038/s41531-026-01490-w","url":null,"abstract":"<p><p>We reply to the Matters Arising on our study comparing neuromelanin and free water imaging for early Parkinson's disease diagnosis. The authors raised considerations regarding image registration, age imbalance, repetition time, and conceptual framing. We clarify that our registration pipeline is validated for subcortical structures, that age does not account for neuromelanin's superior performance, and that our acquisition parameters meet recommended standards. Our findings reflect comparative performance, not a verdict.</p>","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"12 1","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The method matters: free water imaging in Parkinson's disease is not a binary verdict. 方法很重要：帕金森病的自由水显像不是一个二元结论。
IF 8.5 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-12 DOI: 10.1038/s41531-026-01492-8
A Enrique Martinez-Nunez, Angelos Barmpoutis, Michael S Okun, David Vaillancourt
{"title":"The method matters: free water imaging in Parkinson's disease is not a binary verdict.","authors":"A Enrique Martinez-Nunez, Angelos Barmpoutis, Michael S Okun, David Vaillancourt","doi":"10.1038/s41531-026-01492-8","DOIUrl":"10.1038/s41531-026-01492-8","url":null,"abstract":"<p><p>A recent comparison of neuromelanin and free water (FW) imaging in Parkinson's disease concluded that FW imaging underperforms. We argue this reflects methodological constraints, not biological truth. Three issues compromise FW sensitivity: use of a registration template that degrades substantia nigra localization, an age imbalance between groups that favors neuromelanin detection, and repetition times insufficient to capture the FW compartment. With unmet acquisition requirements, the technique was never correctly applied.</p>","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"12 1","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ganoderma lucidum polysaccharides ameliorate cognitive decline and neuroinflammation in aging via the Blautia coccoides-butyrate-NLRP3 axis 灵芝多糖通过蓝球藻-丁酸酯- nlrp3轴改善衰老过程中的认知能力下降和神经炎症
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-11 DOI: 10.1038/s41531-026-01535-0
Shengyao Zhang,Han Wei,Qiongfang Wang,Meng Zhang,Guoran Wan,Jian Wang,Jiajie Leng,Jing Li,Dilong Chen,Boyue Huang,Jianhua Ran
{"title":"Ganoderma lucidum polysaccharides ameliorate cognitive decline and neuroinflammation in aging via the Blautia coccoides-butyrate-NLRP3 axis","authors":"Shengyao Zhang,Han Wei,Qiongfang Wang,Meng Zhang,Guoran Wan,Jian Wang,Jiajie Leng,Jing Li,Dilong Chen,Boyue Huang,Jianhua Ran","doi":"10.1038/s41531-026-01535-0","DOIUrl":"https://doi.org/10.1038/s41531-026-01535-0","url":null,"abstract":"","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"4 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the metabolic landscape of Parkinson’s disease: dansylated urinary amines and phenols submetabolomes for signature profiling and biomarker discovery 解读帕金森病的代谢景观：用于特征分析和生物标志物发现的尿胺和酚亚代谢组
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-11 DOI: 10.1038/s41531-026-01572-9
Zhihong Li,Peijing Cui,Lei Zhang,Xiaojun Huang,Yifan Zhou,Siqi Xu,Yanfei Mao,Yanping Wang,Li Liu,Yu Zhang
{"title":"Decoding the metabolic landscape of Parkinson’s disease: dansylated urinary amines and phenols submetabolomes for signature profiling and biomarker discovery","authors":"Zhihong Li,Peijing Cui,Lei Zhang,Xiaojun Huang,Yifan Zhou,Siqi Xu,Yanfei Mao,Yanping Wang,Li Liu,Yu Zhang","doi":"10.1038/s41531-026-01572-9","DOIUrl":"https://doi.org/10.1038/s41531-026-01572-9","url":null,"abstract":"","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"8 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty acid nitroalkene inhibition of LRRK2 hyperactivation and induction of neuroprotection in a model of Parkinson’s disease 脂肪酸硝基烯抑制LRRK2过度激活和诱导帕金森病模型的神经保护
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-11 DOI: 10.1038/s41531-026-01551-0
Marco Fazzari,Ahssan Sekandari,Macy Stoddard,Christine Odoux,Ese S. Ekhator,Isabella Sanders,Sandra Castro,Stacey J. Sukoff Rizzo,Francisco J. Schopfer,Timothy Greenamyre,Bruce A. Freeman,Roberto Di Maio
{"title":"Fatty acid nitroalkene inhibition of LRRK2 hyperactivation and induction of neuroprotection in a model of Parkinson’s disease","authors":"Marco Fazzari,Ahssan Sekandari,Macy Stoddard,Christine Odoux,Ese S. Ekhator,Isabella Sanders,Sandra Castro,Stacey J. Sukoff Rizzo,Francisco J. Schopfer,Timothy Greenamyre,Bruce A. Freeman,Roberto Di Maio","doi":"10.1038/s41531-026-01551-0","DOIUrl":"https://doi.org/10.1038/s41531-026-01551-0","url":null,"abstract":"","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"71 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential thyroid–immune coupling across central and peripheral axes in Parkinson’s disease 帕金森病中轴和外周轴的差异甲状腺免疫偶联
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-09 DOI: 10.1038/s41531-026-01570-x
Cailing Feng,Zixuan Zhang,Jinghui Xu,Xiangqin Cui,Xiao Zhou,Yunqi Xu
{"title":"Differential thyroid–immune coupling across central and peripheral axes in Parkinson’s disease","authors":"Cailing Feng,Zixuan Zhang,Jinghui Xu,Xiangqin Cui,Xiao Zhou,Yunqi Xu","doi":"10.1038/s41531-026-01570-x","DOIUrl":"https://doi.org/10.1038/s41531-026-01570-x","url":null,"abstract":"","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"59 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin α-synuclein seed amplification assay for the identification of multiple system atrophy 皮肤α-突触核蛋白种子扩增法鉴定多系统萎缩
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-08 DOI: 10.1038/s41531-026-01565-8
Yihua Ma,Sandrina Weber,Carly M. Farris,Susana Schnell,Jens Ebentheuer,Yannic Saathoff,Jesusa Kalinkara-Gomez,Davan M. Murphy,Brit Mollenhauer,Luis Concha-Marambio
{"title":"Skin α-synuclein seed amplification assay for the identification of multiple system atrophy","authors":"Yihua Ma,Sandrina Weber,Carly M. Farris,Susana Schnell,Jens Ebentheuer,Yannic Saathoff,Jesusa Kalinkara-Gomez,Davan M. Murphy,Brit Mollenhauer,Luis Concha-Marambio","doi":"10.1038/s41531-026-01565-8","DOIUrl":"https://doi.org/10.1038/s41531-026-01565-8","url":null,"abstract":"","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"468 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian syndrome and incident Parkinson’s disease: a population-based cohort study 昼夜节律综合征和帕金森病：一项基于人群的队列研究
IF 8.7 1区 医学
NPJ Parkinson's Disease Pub Date : 2026-09-08 DOI: 10.1038/s41531-026-01545-y
Xiaomin Xu,Cunpeng Hou,Feiyang Zhao,Yanling Lv,Xiao Tan,Liangkai Chen
{"title":"Circadian syndrome and incident Parkinson’s disease: a population-based cohort study","authors":"Xiaomin Xu,Cunpeng Hou,Feiyang Zhao,Yanling Lv,Xiao Tan,Liangkai Chen","doi":"10.1038/s41531-026-01545-y","DOIUrl":"https://doi.org/10.1038/s41531-026-01545-y","url":null,"abstract":"","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"20 1","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书