Paediatric and perinatal epidemiology最新文献

{"title":"Changes in social relationships from 26 to 34 years of age in adults born very preterm.","authors":"Elif Gonen, E Sabrina Twilhaar, Nicole Baumann, Barbara Busch, Peter Bartmann, Dieter Wolke","doi":"10.1111/ppe.13133","DOIUrl":"10.1111/ppe.13133","url":null,"abstract":"<p><strong>Background: </strong>Very preterm and/or very low birthweight (VP/VLBW; <32 weeks' gestation and/or <1500 g birthweight) individuals rated their partner and peer relationships lower than term-born individuals in emerging adulthood, but their quality of relationships with parents has been rarely investigated. Moreover, it is unclear whether previously reported differences in social relationship characteristics persist or lessen from emerging to established adulthood.</p><p><strong>Objectives: </strong>To investigate changes in social relationship characteristics in VP/VLBW adults compared to term-born adults from 26 to 34 years and whether the association between VP/VLBW and social relationship characteristics varies according to sex.</p><p><strong>Methods: </strong>In this prospective whole-population birth cohort study in South Bavaria, Germany, social relationship characteristics with parents, partners and peers, and overall social relationships across these domains were evaluated with a Life Course Interview at 26 and 34 years. Interview items related to these domains were extracted and scored as 0 (optimal) and 1 (non-optimal). Each score was summed into domain-specific composite scores and standardised according to the total sample.</p><p><strong>Results: </strong>Participants included 262 VP/VLBW (52.7% males) and 230 term-born individuals (47.0% males). VP/VLBW adults had lower overall social relationship scores than term-born adults (β = -.61, 95% CI -0.85, -0.37). Specifically, partner (β = -.50, 95% CI-0.74, -0.27) and peer relationship scores (β = -.55, 95% CI-0.78, -0.32) were lower than those of term-born adults, but scores did not differ for parent relationships. On average, partner (β = .25, 95% CI 0.14, 0.35) and peer relationship scores increased (β = .16, 95% CI 0.03, 0.29), while parent relationship scores decreased (β = -.64, 95% CI-0.79, -0.49) from 26 to 34 years. These changes were similar for VP/VLBW and term-born individuals.</p><p><strong>Conclusions: </strong>Patterns of change for the improved partner and peer but worsening parental social relationship scores were common across VP/VLBW and term-born adults, but differences between the two groups persisted from 26 to 34 years.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"15-26"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Exposure Misclassification in Case-Control Studies of Self-Reported Medication Use.","authors":"Nedghie Adrien, Richard F MacLehose, Martha M Werler, Mahsa M Yazdy, Matthew P Fox, Samantha E Parker","doi":"10.1111/ppe.13161","DOIUrl":"10.1111/ppe.13161","url":null,"abstract":"<p><strong>Background: </strong>Empirically evaluating the potential impact of recall bias on observed associations of prenatal medication exposure is crucial.</p><p><strong>Objective: </strong>We sought to assess the effects of exposure misclassification on previous studies of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy and increased risk of amniotic band syndrome (ABS).</p><p><strong>Methods: </strong>Using data from the National Birth Defects Prevention Study (NBDPS) on births from 1997 to 2011, we included 189 mothers of infants with ABS and 11,829 mothers of infants without congenital anomalies. We identified external studies of medication use during pregnancy to obtain validity parameters for a probabilistic bias analysis to adjust for exposure misclassification. Due to uncertainty about the transportability of these parameters, we conducted multidimensional bias analyses to explore combinations of values on the results.</p><p><strong>Results: </strong>When we assumed higher specificity in cases or higher sensitivity in controls, misclassification-adjusted estimates suggested confounding-adjusted estimates were attenuated. However, in a few instances, when we assumed greater sensitivity in the cases than the controls (and Sp ≥ 0.9), the misclassification-adjusted estimates suggested upward bias in the confounding-adjusted estimates.</p><p><strong>Conclusions: </strong>Results from our bias analysis highlighted that the magnitude of bias depended on the mechanism and the extent of misclassification. However, the parameters available from the validation studies were not directly applicable to our study. In the absence of reliable validation studies, considering mechanisms of bias and simulation studies to outline combinations of plausible scenarios to better inform conclusions on the effects of these medications on pregnancy outcomes remains important.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer incidence and stage at diagnosis in children and adolescents in the Community of Madrid, 2015-2018.","authors":"Raquel López-González, David Parra-Blázquez, Daniel Moñino, Candela Pino-Rosón, Marina Pollán, Nuria Aragonés","doi":"10.1111/ppe.13144","DOIUrl":"https://doi.org/10.1111/ppe.13144","url":null,"abstract":"<p><strong>Background: </strong>Cancer is the leading cause of death in children aged 1-14 and the second in 15-19-year-old adolescents in Spain. The Paediatric Population-Based Cancer Registry of the Community of Madrid was created to monitor its incidence and survival.</p><p><strong>Objectives: </strong>This study presents the incidence of childhood and adolescent cancer (0-19 years) in Madrid at a population level by sex, age group, type of tumour and stage at diagnosis.</p><p><strong>Methods: </strong>This study was a retrospective analysis of the total number of cases registered in the Paediatric Population-Based Cancer Registry of the Community of Madrid. The registry employs passive and active case finding: by cross-referencing hospital discharge data, primary healthcare data, mortality data and administrative information; and by validation of all potential incident cases through a review of electronic medical charts. All new diagnoses of malignant neoplasms, non-malignant neoplasms of the Central Nervous System, and uncertain and in situ neoplasms of the bladder, identified in 2015-2018 in individuals under age 20 residing in Madrid, were included. Patient information was collected along with tumour characteristics, including stage at diagnosis according to the Toronto Childhood Cancer Stage Guidelines. Age-specific and age-standardised incidence rates were computed with 95% confidence intervals (CI).</p><p><strong>Results: </strong>A total of 1002 tumours were registered in 5,269,524 person-years, yielding an age-standardised rate of 192.7 (95% CI 184.3, 201.4) cases per million person-years. Male/female rate ratio was 1.1. The most common cancers across all ages comprised CNS tumours, leukaemias and lymphomas (primarily Hodgkin): 45.5 (95% CI 39.9, 51.7), 41.1 (95% CI 35.7, 47.1) and 35.8 (95% CI 30.9, 41.3) cases per million person-years, respectively. The proportion of metastatic tumours at diagnosis was similar for ages 0-14 (18.6%) and 15-19 (18.7%).</p><p><strong>Conclusions: </strong>This study provides a comprehensive understanding of childhood and adolescent cancer incidence in Madrid. The registry provides high-quality data and consolidates epidemiological surveillance of cancer in the region.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance Use and Cardiovascular Health in Pre-Conception Care: Surprising Findings!","authors":"Amy R Mahar, Jorge E Chavarro","doi":"10.1111/ppe.13145","DOIUrl":"https://doi.org/10.1111/ppe.13145","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":"38 8","pages":"677-678"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the use of fertility indicators and fecundability in a Danish preconception cohort.","authors":"Emma Skovgaard Pedersen, Ellen M Mikkelsen, Henrik Toft Sørensen, Elizabeth E Hatch, Lauren A Wise, Kenneth J Rothman, Joseph B Stanford, Anne Sofie Dam Laursen","doi":"10.1111/ppe.13108","DOIUrl":"10.1111/ppe.13108","url":null,"abstract":"<p><strong>Background: </strong>The use of fertility indicators to predict ovulation has largely been studied for contraceptive purposes, while less so as fertility-promoting tools.</p><p><strong>Objective: </strong>To investigate the association between fertility indicators and fecundability in Danish women trying to conceive.</p><p><strong>Methods: </strong>Web-based preconception cohort study. We analysed data from 11,328 females aged 18-49 years trying to conceive without fertility treatment for ≤6 menstrual cycles, from the Danish SnartGravid.dk and SnartForældre.dk cohorts (2007-2023). Participants reported the use of fertility indicators (counting days since the last menstrual period, cervical fluid monitoring, urinary ovulation testing, feeling ovulation, using a smartphone fertility app and measuring basal body temperature [BBT]). Time to pregnancy was measured in menstrual cycles ascertained by self-reported pregnancy status. We estimated fecundability ratios (FR) and 95% confidence intervals (CI) using proportional probabilities regression models adjusted for age, socio-economic position, health indicators, reproductive history and gynaecological factors.</p><p><strong>Results: </strong>Fertility indicators were used by 63.3% of participants at study entry. Counting days was the most common (46.9%), while measuring BBT was the least (3.0%). Other indicators ranged from 17.0% to 23.6%, with 69.7% using more than one indicator. Compared with non-use, use of any fertility indicator was associated with greater fecundability (adjusted FR 1.14, 95% CI 1.08, 1.19). Cervical fluid monitoring showed the strongest association (aFR 1.46, 95% CI 1.03, 2.07), followed by urinary ovulation testing (aFR 1.35, 95% CI 1.16, 1.58) and counting days (aFR 1.18, 95% CI 1.09, 1.29). Feeling ovulation and fertility apps were modestly associated with fecundability, while measuring BBT was not associated. Sensitivity analysis restricting to ≤2 cycles of attempt time and two cycles of follow-up showed an aFR for any indicator use of 1.21 (95% CI 1.13, 1.31).</p><p><strong>Conclusion: </strong>In this Danish preconception cohort, use of fertility indicators was associated with a higher fecundability, varying by type of indicator.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"641-650"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life menstrual characteristics and gestational diabetes in a large US cohort.","authors":"Zifan Wang, Donna D Baird, Michelle A Williams, Anne Marie Z Jukic, Allen J Wilcox, Christine L Curry, Tyler Fischer-Colbrie, Jukka-Pekka Onnela, Russ Hauser, Brent A Coull, Shruthi Mahalingaiah","doi":"10.1111/ppe.13129","DOIUrl":"10.1111/ppe.13129","url":null,"abstract":"<p><strong>Background: </strong>Associations between early-life menstrual cycle characteristics (MCC) and gestational diabetes (GDM) remain unclear.</p><p><strong>Objectives: </strong>To evaluate associations between early-life MCCs and GDM in first pregnancy, across pregnancies and its recurrence.</p><p><strong>Methods: </strong>This analysis included participants from a US-based digital cohort enrolled between 11/2019 and 9/2023 who provided consent, completed relevant surveys, were without diabetes and aged ≥18 at first pregnancy (n = 30,473). Age at menarche [<11 (early), 11-15 (referent), ≥16 (late) years] and time from menarche to cycle regularity [<1 (referent), 1-2, 3-4, ≥5 years, not yet regular, regular after hormones] were self-recalled at enrolment. Additionally, the last three categories were considered prolonged time-to-regularity (PTTR). GDM history was recalled at enrolment for each pregnancy. We restricted to pregnancies of ≥24 weeks with a live birth. We evaluated associations of early-life MCCs with GDM at first pregnancy using modified Poisson regression, across pregnancies using cluster-weighted Poisson generalised estimating equation and GDM recurrence using multinomial logistic regression, adjusted for sociodemographic, early-life factors and age at pregnancy. Missing variables were imputed with multiple imputation by chained equations.</p><p><strong>Results: </strong>Among 30,473 participants, 20,591 had eligible first pregnancies, of which 5.9% reported GDM. In 17,512 participants with ≥2 pregnancies, 8.3% had GDM once and 3.7% had recurrent GDM. Early menarche (<11 years, vs. 11-15 years) was associated with GDM in first pregnancy (RR 1.34, 95% CI 1.15, 1.57), across pregnancies (RR 1.24, 95% CI 1.10, 1.39) and recurrence (OR 1.51, 95% CI 1.21, 1.89). PTTR was associated with GDM in the first pregnancy (RR 1.22, 95% CI 1.08, 1.38), across pregnancies (RR 1.16, 95% CI 1.05, 1.27) and recurrence (OR 1.19, 95% CI 0.99, 1.43).</p><p><strong>Conclusions: </strong>Earlier menarche and prolonged time-to-regularity are associated with higher risk of GDM and recurrence, suggesting menstrual characteristics during childhood/adolescence as potential early-life markers for GDM.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":"38 8","pages":"654-665"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering fertility: Integrating indicators into personalised reproductive care.","authors":"Michaela S Olabisi, Sunni L Mumford","doi":"10.1111/ppe.13125","DOIUrl":"10.1111/ppe.13125","url":null,"abstract":"","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"651-653"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal mortality among term births: Informing decisions about singleton early term births in Western Australia.","authors":"Ye'elah E Berman, John P Newnham, Elizabeth A Nathan, Dorota A Doherty, Kiarna Brown, Sarah V Ward","doi":"10.1111/ppe.13124","DOIUrl":"10.1111/ppe.13124","url":null,"abstract":"<p><strong>Background: </strong>To minimise the risk of perinatal mortality, clinicians and expectant mothers must understand the risks and benefits associated with continuing the pregnancy.</p><p><strong>Objectives: </strong>Report the gestation-specific risk of perinatal mortality at term.</p><p><strong>Methods: </strong>Population-based cohort study using linked health data to identify all singleton births at gestations 37-41 weeks, in Western Australia (WA) from 2009 to 2019. Lifetable analysis was used to combine the risk of each type of perinatal mortality and calculate the cumulative risk of perinatal mortality, termed the perinatal risk index (PRI). Rates of antepartum and intrapartum stillbirth and neonatal death, as well as the PRI, were examined for each gestational week at term by non-Aboriginal and Aboriginal ethnicity. For non-Aboriginal women, rates were also examined by time-period (pre- vs. post-WA Preterm Birth Prevention Initiative (the Initiative) rollout), primiparity, and obstetric risk.</p><p><strong>Results: </strong>There were 332,084 singleton term births, including 60 perinatal deaths to Aboriginal mothers (3.2 deaths per 1000 births to Aboriginal mothers) and 399 perinatal deaths to non-Aboriginal mothers (1.3 deaths per 1000 births to non-Aboriginal mothers). For non-Aboriginal women, the PRI was at its lowest (PRI 0.80, 95% CI 0.61, 1.00) at 39 weeks gestation. For Aboriginal women, it was at its lowest at 38 weeks (PRI 2.43, 95% CI 0.48, 4.39) with similar risk at 39 weeks (PRI 2.68, 95% CI 1.22, 4.14). The PRI increased steadily after 39 weeks gestation. The risk of perinatal mortality was higher among Aboriginal women. The gestation-specific perinatal mortality rates were similar by the time-period, primiparity and obstetric risk.</p><p><strong>Conclusions: </strong>The gestational ages at term associated with the lowest risk of perinatal mortality reinforce that the recommendation not to deliver before 39 weeks without medical indication is applicable to both Aboriginal and non-Aboriginal women giving birth in WA. There was no increase in the perinatal mortality rate associated with the introduction of the Initiative.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"717-729"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early childhood body mass index growth and school readiness: A longitudinal cohort study.","authors":"Xuedi Li, Alyssa Kahane, Charles D G Keown-Stoneman, Jessica A Omand, Cornelia M Borkhoff, Gerald Lebovic, Jonathon L Maguire, Muhammad Mamdani, Patricia C Parkin, Janis Randall Simpson, Mark S Tremblay, Leigh M Vanderloo, Eric Duku, Caroline Reid-Westoby, Magdalena Janus, Catherine S Birken","doi":"10.1111/ppe.13114","DOIUrl":"https://doi.org/10.1111/ppe.13114","url":null,"abstract":"<p><strong>Background: </strong>Child growth influences future health and learning. School readiness refers to a child's ability to meet developmental expectations at school entry. The association of early growth rate and patterns with school readiness remains unknown.</p><p><strong>Objective: </strong>To determine the association of child body mass index (BMI) growth with school readiness in a cohort of young children.</p><p><strong>Methods: </strong>A prospective cohort study (2015-2022) was conducted in children 0-6 years enrolled in the TARGet Kids! research network in Toronto, Canada. Two analytical approaches were used to measure growth using child weight and height/length data between 0 and 4 years: (i) age- and sex-standardised BMI (zBMI) growth rate per year using a piecewise linear model; and (ii) distinct zBMI trajectories using latent class mixed models. School readiness (4-6 years) was measured using teacher-completed Early Development Instrument (EDI). Robust Poisson models and marginal linear models using generalised estimating equations were used adjusting for confounders identified a priori.</p><p><strong>Results: </strong>In this study of 1077 children (mean age at EDI completion: 4.8 years; 52.6% male) with 6415 zBMI measurements, mean growth rate was 0.65 zBMI units/year (0-2 years) and -0.11 zBMI units/year (2-4 years). Two distinct zBMI trajectories were identified: the stable trajectory and the catch-up trajectory. There was insufficient evidence that zBMI growth rates (risk ratio 1.10, 95% confidence interval 0.78, 1.55 for 0-2 years; risk ratio 0.71, 95% confidence interval 0.32, 1.57 for 2-4 years) or trajectories (risk ratio 1.05, 95% confidence interval 0.82, 1.35, catch-up trajectory vs. stable trajectory) were associated with school readiness.</p><p><strong>Conclusions: </strong>No association was found between BMI growth and school readiness. School readiness may be more impacted by factors directly related to obesity or adiposity at the time of EDI measurement rather than growth.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":"38 8","pages":"733-744"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in adverse effects of medical treatment in Paediatric populations in the United States: A global burden of disease study, 2000-2019.","authors":"Shintaro Fujiwara, Emily Leibovitch, Ko Harada, Yoshito Nishimura, Russell Woo, Fumio Otsuka, Akshaya Srikanth Bhagavathula","doi":"10.1111/ppe.13116","DOIUrl":"10.1111/ppe.13116","url":null,"abstract":"<p><strong>Background: </strong>Adverse effects of medical treatment (AEMT) pose significant risks to paediatric patients. However, the mortality trends associated with AEMT in this population have been unclear.</p><p><strong>Objective: </strong>We aimed to clarify the trends in the incidence, disability-adjusted life years (DALYs) and mortality rates of AEMT for children in the US from 2000 to 2019.</p><p><strong>Methods: </strong>Data were retrieved from the Global Burden of Disease study 2019. We estimated age-standardized incidence, DALYs and mortality rates of paediatric AEMT per 100,000 children in the US using a Bayesian meta-regression model. We also analysed incidence, DALYs and mortality in different age groups, and employed Joinpoint regression models to assess the age- and sex-specific trends.</p><p><strong>Results: </strong>The number of deaths due to AEMT in children, the number of cases, and DALYs were 105.1, 551,076 and 145,555 in 2019, decreased by 37.5%, 6% and 28% from those in 2000, respectively. Age-standardized mortality rates decreased across all age groups, while the incidence increased across all age groups with an average annual percentage change (AAPC) of 2.2% in those children <1 year and 4.5% in 5-9 years of age. The increases in DALYs over time was higher in children aged 1-4 years (AAPC: 0.51, 95% CI: 0.47, 0.62) and 5-9 years (AAPC: 0.33, 95% CI: 0.15, 0.50), with the 1-4 year age group being the highest.</p><p><strong>Conclusion: </strong>The study reveals declining AEMT mortality but rising incidence and DALYs, emphasizing a disproportionate burden in <1, 1-4 and 5-9 years. To develop effective mitigation strategies, future research is warranted to identify the causes of increased AEMT in children, especially young males.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":"692-699"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}