Oral health & preventive dentistry最新文献

{"title":"Assessing the Impact of 2D:4D Ratio on Oral Hygiene Performance and Gingival Health in Turkish Adults.","authors":"Ekin Beşiroğlu-Turgut, Gökçe Aykol-Şahin, Yiğit Cem Öğretmen","doi":"10.3290/j.ohpd.c_2767","DOIUrl":"10.3290/j.ohpd.c_2767","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between the second-to-fourth digit ratio (2D:4D), a marker of prenatal hormone exposure, and oral hygiene performance and gingival health.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted with 126 adults aged 18-55 years (71 males, 55 females) at Istanbul Okan University's Periodontology Clinic. Participants were classified by sex, hand dominance, and 2D:4D ratio (cut-off: 1). Oral hygiene was assessed using the Turesky Modification of the Quigley-Hein Plaque Index (QHPI) and Gingival Index (GI) at baseline and one week after standardised oral hygiene education. Finger lengths were measured to calculate 2D:4D. Statistical analyses included t-tests, repeated-measures ANOVA, Pearson's correlation, and Bonferroni post-hoc tests (α=0.05).</p><p><strong>Results: </strong>No statistically significant difference in 2D:4D ratio was found between sexes (p=0.395) or hand dominance (p=0.730). QHPI and GI scores statistically significantly improved across all groups after education (p0.001). No statistically significant association was found between 2D:4D ratios and changes in QHPI or GI. However, left-handed individuals showed statistically significantly lower QHPI scores at both time points (p 0.05), and males with 2D:4D 1 reported more frequent brushing habits, though this was not reflected in clinical indices. The highest GI values were observed in males with 2D:4D ≥1, while the lowest were in females with 2D:4D<1.</p><p><strong>Conclusions: </strong>The 2D:4D ratio was not a reliable predictor of oral hygiene status or gingival health. However, handedness may influence oral hygiene performance. Standardized oral hygiene education led to comparable improvements regardless of biological variability.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"571-576"},"PeriodicalIF":1.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13410761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation Analysis.","authors":"Jiakui Wang, Pengxian Xie, Zhengqiang Kang","doi":"10.3290/j.ohpd.c_2765","DOIUrl":"10.3290/j.ohpd.c_2765","url":null,"abstract":"<p><strong>Purpose: </strong>Periodontitis has been linked to systemic inflammation and nutrition. The albumin-to-globulin ratio (AGR) is a readily available inflammatory and nutritional index, but its relationship with periodontitis remains to be fully clarified. This study examined the association between AGR and periodontitis using the National Health and Nutrition Examination Survey (NHANES) data and Mendelian randomisation (MR).</p><p><strong>Methods and materials: </strong>The cross-sectional analysis included 10,094 participants from NHANES 2009-2014. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses, and threshold effect analysis were performed. Furthermore, MR analysis was conducted using genetic data for AGR (98,626 individuals) and periodontitis (9,560 cases and 169,166 controls) to further evaluate the relationship.</p><p><strong>Results: </strong>After fully adjusting for confounders, logistic regression shows elevated AGR was associated with lower odds of periodontitis (OR = 0.52, 95% CI: 0.40-0.67). The top quartile group had 44% fewer cases of periodontitis than the lowest quartile group (OR = 0.56, 95% CI: 0.46-0.68). The RCS revealed an L-shaped nonlinear association between AGR and periodontitis. Threshold effect analysis showed that when AGR 1.79, higher AGR was significantly associated with lower odds of periodontitis (OR = 0.37, 95% CI: 0.28-0.50). Stratified analyses suggested a stronger association among participants aged 60 years. MR did not substantiate a genetic correlation between AGR and periodontitis (p = 0.304).</p><p><strong>Conclusion: </strong>Higher AGR was associated with a lower prevalence of periodontitis, particularly among adults aged 60 years. However, MR analysis did not provide genetic evidence supporting this link. Prospective studies are needed to clarify this relationship.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"559-570"},"PeriodicalIF":1.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary Oxidative Stress Biomarkers as Predictors of Oral Health Risk Among Coffee-Drinking Smokers and Non-Smokers: Implications for Preventive Dentistry.","authors":"Poppy Andriany, Cut Fera Novita, Herwanda Herwanda, Munifah Abdat, Subhaini Jakfar, Basri A Gani","doi":"10.3290/j.ohpd.c_2710","DOIUrl":"10.3290/j.ohpd.c_2710","url":null,"abstract":"<p><strong>Purpose: </strong>The goal of this study was to look at the link between smoking, drinking coffee, and salivary oxidative stress biomarkers malondialdehyde (MDA) and superoxide dismutase (SOD) as signs of oral health risk among university students in Aceh, Indonesia, and to see if they could be used as non-invasive screening tools in a clinical setting.</p><p><strong>Methods and materials: </strong>There were three groups of students: active smokers, passive smokers, and non-smokers. We used validated questionnaires (Cronbach's alpha = 0.872) to gather behavioural data. We collected unstimulated saliva in a controlled manner and then used enzyme-linked immunosorbent assay (ELISA) to analyse it. We also looked at the physicochemical properties of saliva. We used ANOVA, the Kruskal-Wallis test, and receiver operating characteristic (ROC) curve analysis to analyse the data.</p><p><strong>Results: </strong>Smokers had much higher MDA levels (4.1 ± 0.05 nmol/ml) and much lower SOD levels (0.72 ± 0.010 U/ml) than non-smokers (2.5 ± 0.01 nmol/ml; 1.20 ± 0.012 U/ml; P 0.001). Drinking coffee by itself didn't have a direct effect on oxidative stress, but when combined with smoking, it made the oxidative imbalance much worse. ROC analysis showed that the tests were very good at diagnosing (AUC = 0.88 for MDA; 0.84 for SOD).</p><p><strong>Conclusion: </strong>Salivary MDA and SOD are reliable, non-invasive markers that can detect early oxidative stress-related risk. It is a good idea to add saliva-based screening and culturally appropriate prevention strategies to campus health services. These results show that salivary biomarkers are useful in clinical settings for preventive dentistry.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"549-557"},"PeriodicalIF":1.7,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effect of Simulated Gastric Acid on the Surface Properties of Different Fluoride-Releasing Dental Restorative Materials.","authors":"Lizeth Romero-Cabrera, Bernardo Teutle-Coyotecatl, Abigailt Flores-Ledesma, Rosario Jiménez-Flores, María Guadalupe Sol-Gamboa, Rosalía Contreras-Bulnes, Laura Emma Rodríguez-Vilchis, Eunice de Anda-Reyes, María de Los Angeles Moyaho-Bernal","doi":"10.3290/j.ohpd.c_2761","DOIUrl":"10.3290/j.ohpd.c_2761","url":null,"abstract":"<p><strong>Purpose: </strong>Eating disorders such as bulimia and anorexia negatively impact on oral health due to repeated exposure to gastric acid, leading to dental erosion and deterioration of restorative materials. Resin-Modified Glass-Ionomer Cement (RMGIC), Giomers and glass hybrid may offer greater resistance in these adverse environments. This study aimed to compare the effect of simulated gastric acid on the surface properties of different fluoride-releasing composite materials.</p><p><strong>Materials and methods: </strong>An in-vitro experimental study was conducted using disks of RMGIC (Gold Label Light-Cured Universal Restorative; G1_GLLC), Giomer (Beautifil II; G2_BFII), and glass hybrid (EQUIA Forte Fil; G3_EF), prepared according to manufacturers' instructions. Surface roughness, fluoride release and solubility were evaluated before and after 18 h of immersion in simulated gastric acid. Additionally, surface morphology was analyzed by scanning electron microscopy (SEM). Data were analyzed with one-way ANOVA and Student's t-test (p 0.05).</p><p><strong>Results: </strong>G1_GLLC exhibited the highest increase in surface roughness after immersion (0.38 ± 0.25 µm), while G2_BFII demonstrated lower changes in surface roughness (0.17 ± 0.16 µm) and the lowest fluoride release (0.001 ppm) and solubility (0.93%). G3_EF showed the highest solubility (5.50%), indicating greater susceptibility to acidic environments.</p><p><strong>Conclusion: </strong>The surface roughness, fluoride release, and solubility of all tested materials were affected by simulated gastric acid. Giomer (G2_BFII) proved to be a suitable alternative in a highly acidic oral environment, as it remains stable and releases fluoride under acidic conditions compared to RMGIC (G1_GLLC) and glass hybrid (G3_EF).</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"541-548"},"PeriodicalIF":1.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content Gaps and Informational Quality of TikTok and Bilibili Videos on Pit and Fissure Sealing in China: A Cross-Sectional Study.","authors":"Feng Cai, Wending Gao, Linhu Wang","doi":"10.3290/j.ohpd.c_2759","DOIUrl":"10.3290/j.ohpd.c_2759","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the disease-specific content coverage, overall quality, reliability, and transparency of Chinese-language short videos on pit and fissure sealing posted on TikTok and Bilibili.</p><p><strong>Methods and materials: </strong>In this cross-sectional study, videos were retrieved from TikTok and Bilibili on December 20, 2025, using the Chinese search term '' (pit and fissure sealing). The first 150 results from each platform were screened, and 204 eligible videos were included. Overall quality, reliability, and transparency were assessed using the Global Quality Score (GQS), modified DISCERN (mDISCERN), and Journal of the American Medical Association (JAMA) benchmark criteria, respectively. A predefined disease-specific coding framework was used to evaluate content coverage. Group comparisons, Spearman's rank correlation, and multivariable ordered logistic regression were performed.</p><p><strong>Results: </strong>Benefits and indications were the most frequently covered domains, appearing in 87.75% and 78.92% of videos, respectively, whereas contraindications and cost were addressed in only 21.57% and 28.92%. The median GQS, mDISCERN, and JAMA scores were all 3.00. No significant differences in validated assessment scores were observed between TikTok and Bilibili. Videos uploaded by healthcare professionals, especially specialised healthcare professionals, achieved higher scores than those uploaded by individual users. Video duration showed weak positive correlations with validated assessment scores, whereas engagement indicators were not meaningfully associated with informational quality.</p><p><strong>Conclusion: </strong>Short videos on pit and fissure sealing provide moderately useful information, but content coverage remains incomplete and uneven. Greater participation by healthcare professionals and better access to balanced, trustworthy preventive information are needed on short-video platforms.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"527-539"},"PeriodicalIF":1.7,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Oral Health-Related Quality of Life Following Restorative Dental Treatment of Untreated Dental Caries: A Prospective Study in the Saudi Population.","authors":"Azhar Iqbal, Farooq Ahmad Chaudhary, Saeed Alqahtani, Hmoud Ali Algarni, Meshal Aber Alonazi, Yasir Alyahya, Bilal Arjumand, Yasir Dilshad Siddiqui, Kumar Chandan Srivastava","doi":"10.3290/j.ohpd.c_2758","DOIUrl":"10.3290/j.ohpd.c_2758","url":null,"abstract":"<p><strong>Purpose: </strong>The effect of restorative dental treatment on oral health-related quality of life (OHRQoL) and general well-being in Saudi adults is not well-documented. This study therefore evaluated the sensitivity of the OHIP-14, OIDP, and WHOQOL-BREF instruments in capturing changes in OHRQoL and health-related quality of life (HRQoL) after restorative care for caries.</p><p><strong>Materials and methods: </strong>Between September 2024 and March 2025, a prospective longitudinal cohort of 269 adult patients with untreated caries was recruited from Jouf University Dental Clinics in Saudi Arabia. Standardized restorative protocols were followed for all treatments. The three validated Arabic version of OHIP-14, OIDP, and WHOQOL-BREF instruments were used to assess the quality of life at baseline and at a one-month follow-up. To examine discriminant validity, responsiveness of the instruments, and factors predicting therapeutic change, statistical analysis involved paired and independent t-tests, effect size calculation (Cohen's d), and multiple linear regression.</p><p><strong>Results: </strong>Statistically significant post-treatment improvements were observed across all subdomians of the three instruments. Mean OHIP-14 and OIDP scores decreased markedly (20.64 to 6.81 and 7.17 to 0.27, respectively; p 0.001), while WHOQOL-BREF scores increased statistically significantly (32.53 to 43.03; p 0.001). The degree of improvement was linked to initial caries severity. Therefore, the participants having more advanced caries at the start of the study demonstrated greater responsiveness, particularly in their scores on the OHIP-14 and WHOQOL-BREF.</p><p><strong>Conclusion: </strong>The restorative dental treatment of dental caries statistically significantly improves the oral health-related and general quality of life of adult patients. The responsiveness of the OHIP-14, OIDP, and WHOQOL-BREF instruments, as demonstrated by the current study findings, supports their application as robust patient-reported outcome measures (PROMs) in clinical dentistry. It is recommended that these PROMs should be integrated into practice to advance a more holistic and patient-centered approach to the provision of oral healthcare.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"519-525"},"PeriodicalIF":1.7,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Genetics on Caries Risk Assessment: MMP3 (rs679620) and VDR (rs731236) Gene Polymorphisms.","authors":"Seda Selvi, Pınar Yılmaz Atalı, Ömer Birkan Ağralı, Beste Tacal Aslan, Özlem Özge Yılmaz, Tolga Polat, Korkut Ulucan","doi":"10.3290/j.ohpd.c_2755","DOIUrl":"10.3290/j.ohpd.c_2755","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the impact of gene polymorphisms in VDR and MMP3 on caries and the efficacy of genetic factors in a novel caries risk model.</p><p><strong>Methods and materials: </strong>After oral examination of male individuals (aged 20-44), a diagnosis was made according to the decayed, missing and filled teeth (DMFT) index: Group 1 'high caries risk' (DMFT ≥ 14); Group 2 'low caries risk' (DMFT ≤ 5) (n = 162). Participants' detailed anamneses were recorded. Periodontal indices, saliva buffering capacity/BC, salivary quantity of Streptococcus mutans/SM and Lactobacillus spp./LB were measured. After DNA isolation, genotyping of the MMP3 (rs679620) and VDR (rs731236) genes was conducted using real-time polymerase chain reaction (PCR). A stepwise regression analysis was conducted to evaluate the explanatory contributions of independent variables to DMFT variability. The results were considered significant at p 0.05.</p><p><strong>Results: </strong>Significant differences were observed between the groups in terms of the plaque index, gingival index, probing depth, bleeding on probing, salivary flow rate, BC, salivary quantity of LB, frequency of consuming sugary foods/drinks, frequency of tooth brushing, and the use of preventive dental treatment (p 0.001). The MMP3 rs679620 polymorphism significantly affected caries risk (p 0.001), while the VDR polymorphism was not significant (p = 0.862). An explanatory regression model for caries experience, created by stepwise regression analysis, explained 61.1% of the DMFT.</p><p><strong>Conclusion: </strong>Adding genetic factors to the caries risk model may have a significant effect on the accuracy of the model.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"509-518"},"PeriodicalIF":1.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Resveratrol on Periodontal Disease Control and Treatment: A Systematic Review.","authors":"Octave Nadile Bandiaky, Camille Bechina, Marie Vanden Berghe, Assem Soueidan, Samuel Serisier, Xavier Struillou","doi":"10.3290/j.ohpd.c_2752","DOIUrl":"10.3290/j.ohpd.c_2752","url":null,"abstract":"<p><strong>Purpose: </strong>Resveratrol, a natural polyphenol with anti-inflammatory and antioxidant properties, has been proposed as an adjunctive agent in periodontal therapy. This systematic review aimed to evaluate the effectiveness of resveratrol in controlling periodontal inflammation and alveolar bone loss in preclinical and clinical studies.</p><p><strong>Methods and materials: </strong>A systematic review was conducted following PRISMA 2020 guidelines. Electronic databases (PubMed/MEDLINE, Cochrane Library, Lilacs, Wiley, ScienceDirect) were searched up to October 2025, complemented by manual searches of periodontal journals. Eligible studies included in vivo animal experiments and randomised clinical trials assessing the impact of resveratrol on periodontal outcomes. Three reviewers independently performed study screening, data extraction, and risk-of-bias assessment using SYRCLE and Cochrane tools.</p><p><strong>Results: </strong>Twenty-two studies met the inclusion criteria, including 16 preclinical and 6 clinical studies. In animal models, resveratrol consistently reduced alveolar bone loss (7.09% to 60.60%) and improved inflammatory and oxidative stress markers. Clinical trials reported variable but generally positive effects, including reductions in probing pocket depth, bleeding index, and plaque index, and improvements in clinical attachment level. Several studies also showed decreased systemic or local inflammatory cytokines. Clinical evidence remains limited by small sample sizes, methodological heterogeneity, and short follow-up periods. No clinical study evaluated radiographic bone loss.</p><p><strong>Conclusion: </strong>Preclinical studies suggest that resveratrol has anti-inflammatory, antioxidant and bone-protective effects, but clinical evidence is limited and heterogeneous. Resveratrol may be considered as an adjunct to nonsurgical periodontal therapy, particularly in aggressive periodontitis but further well-designed trials are needed to determine optimal dosage, duration, and delivery route to support its potential as a complementary therapy for periodontitis.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"499-508"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Severe Periodontitis using Exosome-Mediated Combination Therapies: A Retrospective Cohort Study.","authors":"Scott Froum, Nathan E Estrin, Hyun Jae Cho, Nima Farshidfar, Paras Ahmad, Richard J Miron","doi":"10.3290/j.ohpd.c_2745","DOIUrl":"10.3290/j.ohpd.c_2745","url":null,"abstract":"<p><strong>Purpose: </strong>This pilot retrospective case series aimed to evaluate the 6-month clinical outcomes and safety of a combined regenerative protocol utilizing exosomes specifically designed for periodontal regeneration (Periosomes), with 90% anorganic bovine bone/10% collagen (ABBMC), and horizontal platelet-rich fibrin (H-PRF) for the treatment of advanced periodontal osseous defects.</p><p><strong>Materials and methods: </strong>This study analyzed stage-III (severe) periodontitis patients (from poor to hopeless prognosis) who underwent periodontal surgery using Periosomes with an ABBC/H-PRF scaffold with a 6-month follow-up. Complete periodontal charting, including probing depth (PD), gingival margin (GM), bleeding on probing (BOP), clinical attachment loss (CAL), gingival index (GI), plaque index (PI), and tooth mobility, was assessed at baseline and the follow-up. The study included 13 patients (8 females and 5 males) aged 29 to 73 years, with 23 periodontal defects of one-walled (60.9%) and two-walled (39.1%) defect morphology.</p><p><strong>Results: </strong>The sites treated with Periosomes showed statistically significant reductions in PD from baseline to six months in one-walled defects (8.50 ± 2.41 mm to 3.14 ± 0.77; p 0.0001) and two-walled defects (7.56 ± 1.13 mm to 3.22 ± 0.44; p 0.0001) as well as in CAL from 9.14 ± 3.01 mm to 4.79 ± 2.17 (p 0.0001) in one-walled defects and from 7.22 ± 1.56 mm to 3.56 ± 1.01 (p 0.0001) in and two-walled defects. Furthermore, frequency distribution analysis found that 96% of sites attained residual PD 5 mm and 92% showed CAL gains ≥3 mm at the 6-month follow-up.</p><p><strong>Conclusion: </strong>The combined use of Periosomes, ABBMC, and H-PRF was associated with favorable short-term clinical improvements in advanced periodontal osseous defects with no reported adverse events. To our knowledge, this is the first human clinical study assessing the use of exosomes in periodontal regenerative therapy. However, controlled clinical trials with comparator groups and longer follow-up are necessary to evaluate the independent contribution of exosomes in periodontal regeneration.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"489-497"},"PeriodicalIF":1.7,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Ring Grafts Versus Non-Resorbable Membrane GBR for Vertical Ridge Augmentation: A Prospective Cohort Study.","authors":"Ammar Almarghlani, Hanin Alqurashy, Mohanad Alnahdi, Dalia Meisha, Ehab Azab, Hassan Abed, Rayan Sharka, Ali Alghamdi","doi":"10.3290/j.ohpd.c_2748","DOIUrl":"10.3290/j.ohpd.c_2748","url":null,"abstract":"<p><strong>Purpose: </strong>Vertical alveolar bone defects often require advanced augmentation techniques to enable successful implant placement. The aim of this study was to compare short-term vertical bone gain following two approaches: the bone-ring graft technique and guided bone regeneration (GBR) using a non-resorbable membrane in patients with vertical alveolar deficiencies.</p><p><strong>Materials and methods: </strong>A prospective cohort study was conducted involving 30 systemically healthy adult patients with posterior mandibular vertical bone defects measuring ≥4 mm. Participants were assigned to one of two treatment groups: Group A received the bone ring in conjunction with titanium implants and a resorbable collagen membrane; Group B was treated with allogeneic bone grafts and titanium-reinforced dense polytetrafluoroethylene (d-PTFE) membranes. Radiographic evaluations were performed at baseline, 1 week, 1 month, and 3 months postoperatively by cone-beam computed tomography (CBCT) and periapical radiographs. The primary outcome was vertical bone height gain. The data were analyzed using IBM SPSS Statistics Version 28.0.</p><p><strong>Results: </strong>Group A demonstrated statistically significantly greater vertical bone gain at all postoperative intervals: 9.1 mm at 1 week, 10.6 mm at 1 month, and 9.7 mm at 3 months, compared to 7.8 mm, 7.0 mm, and 6.9 mm, respectively, in Group B (p 0.0001). Plaque index scores were comparable between groups, with no statistically significant differences observed in postoperative swelling or infection rates. However, membrane exposure was statistically significantly more frequent in Group B at all follow-up visits (p ≤ 0.02).</p><p><strong>Conclusion: </strong>The bone-ring graft technique was associated with greater vertical bone gain and a lower incidence of membrane exposure compared to GBR using a non-resorbable membrane. Further studies with longer follow-up are required to confirm these findings.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"481-488"},"PeriodicalIF":1.7,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}