Onkologie最新文献_第10页

Exploration of the role of radiotherapy in the management of early glottic cancer with complete carotid artery occlusion. 探讨放疗在早期声门癌合并颈动脉完全闭塞的治疗中的作用。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-07-08 DOI: 10.1159/000353750

Waleed F Mourad, Kenneth S Hu, Rania A Shourbaji, James Dolan, Dukagjin M Blakaj, Daniel Shasha, Louis B Harrison

{"title":"Exploration of the role of radiotherapy in the management of early glottic cancer with complete carotid artery occlusion.","authors":"Waleed F Mourad, Kenneth S Hu, Rania A Shourbaji, James Dolan, Dukagjin M Blakaj, Daniel Shasha, Louis B Harrison","doi":"10.1159/000353750","DOIUrl":"https://doi.org/10.1159/000353750","url":null,"abstract":"Background: The aim of this study was to compare intensity-modulated radiation therapy (IMRT) vs. 2D and 3D radiotherapy (RT) in the treatment of T1 glottic squamous cell carcinoma in an effort to highlight the advantages of IMRT in this particular clinical situation.Case report: We present the case of an 82-year-old female patient with T1 left true vocal cord squamous cell carcinoma and complete occlusion of the left carotid artery resulting in multiple strokes. The patient underwent definitive RT with 63 Gy (28 × 2.25 Gy). 3 plans were generated: 2D RT, 3D RT, and IMRT. The right carotid artery (Rt.CA) mean dose was 865, 2,065, and 4,268 cGy for IMRT, 3D RT, and 2D RT, respectively. The inferior pharyngeal constrictor (IPC) mean dose was 5,341, 6,456, and 6,451 cGy for IMRT, 3D RT, and 2D RT, respectively. IMRT provided the best homogeneity but at a higher cost and with prolonged treatment time.Conclusion: IMRT provided the finest planning target volume coverage with minimal Rt.CA and IPC doses. IMRT is recommended in certain clinical scenarios which are not manageable with other techniques.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 7-8","pages":"433-5"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000353750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31638496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Serum S100B levels correlate with clinical benefit in a metastatic melanoma patient treated by CTLA-4 blockade: a case report. 血清S100B水平与CTLA-4阻断治疗的转移性黑色素瘤患者的临床获益相关:一个病例报告。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-09-17 DOI: 10.1159/000355159

Carmen Loquai, Tina Müller-Brenne, Simin Schadmand-Fischer, Stephan Grabbe

{"title":"Serum S100B levels correlate with clinical benefit in a metastatic melanoma patient treated by CTLA-4 blockade: a case report.","authors":"Carmen Loquai, Tina Müller-Brenne, Simin Schadmand-Fischer, Stephan Grabbe","doi":"10.1159/000355159","DOIUrl":"https://doi.org/10.1159/000355159","url":null,"abstract":"Background: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells. In patients with metastatic melanoma, anti-CTLA-4 antibody therapy with ipilimumab achieves durable cancer regression in approximately 10-15% of patients. In the face of complex and sometimes delayed tumor response patterns, prognostic and predictive biomarkers are needed to monitor therapy outcomes and to identify early potential long-term survivors who might also benefit from therapy re-induction.Case report: The clinical case of a 49-year-old male patient with metastatic melanoma and unfavorable prognostic factors is presented. The time course of the serum biomarker S100B during initial anti-CTLA-4 therapy correlated very well with the clinical situation and, in the present case, proved its potential value as an early biomarker of a subsequently observed radiological response in this stage IV melanoma patient. The observed clinical response lasted for more than 24 months.Conclusions: Further efforts are required to better understand the patterns of response and the immunological tumor response in patients undergoing CTLA-4 blockade. A validation of S100B as a marker to identify early long-term responders among patients treated with ipilimumab is warranted.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 10","pages":"578-81"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000355159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31792071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Ubiquitin-proteasome pathway and prostate cancer. 泛素-蛋白酶体途径与前列腺癌。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-09-16 DOI: 10.1159/000355166

Fang-Zhi Chen, Xiao-Kun Zhao

{"title":"Ubiquitin-proteasome pathway and prostate cancer.","authors":"Fang-Zhi Chen, Xiao-Kun Zhao","doi":"10.1159/000355166","DOIUrl":"https://doi.org/10.1159/000355166","url":null,"abstract":"Prostate cancer is one of the most common cancers in men. Various signaling pathways and proteins are involved in prostate carcinogenesis. Ubiquitination and deubiquitination of the related proteins contribute to the development of prostate cancer in various ways. The ubiquitin-proteasome (UPS) system is a common cellular process for protein degradation in eukaryotes. In this article we review recent advances related to the involvement of the UPS pathway in prostate cancer. The UPS pathway plays an important role in the regulation of cellular proteins with respect to cell cycle control, transcription, apoptosis, cell adhesion, angiogenesis, and tumor growth. It is involved in prostate cancer in various ways by modulating prostate cancer-related genes/proteins such as androgen receptor, cyclin-dependent kinase inhibitor P27, cyclin D1, and PTEN. Some ubiquitin-like modifier proteins have also been found to be associated with prostate cancer. The UPS pathway represents a potential therapeutic target for prostate cancer, and proteasome inhibitors represent a class of chemotherapeutic agents that inhibit tumor growth. The UPS pathway is related to prostate cancer in different ways. More research on that link is needed, as targeting the UPS pathway has led to some success in prostate cancer treatment.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 10","pages":"592-6"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000355166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31792074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer. microRNA-196a2多态性与结直肠癌易感性相关性的meta分析。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-09-16 DOI: 10.1159/000355158

Ke-Qing Shi, Zhuo Lin, De-Wei Li, Yu-Xiao Fang, Jian Gao, Zhu-Jun Deng, Li Chen, Gui-Ling Li, Jian-Min Wu, Kai-Fu Tang

{"title":"Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer.","authors":"Ke-Qing Shi, Zhuo Lin, De-Wei Li, Yu-Xiao Fang, Jian Gao, Zhu-Jun Deng, Li Chen, Gui-Ling Li, Jian-Min Wu, Kai-Fu Tang","doi":"10.1159/000355158","DOIUrl":"https://doi.org/10.1159/000355158","url":null,"abstract":"Background/aims: To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis.Methods: An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis.Results: 5 studies were used for analysis. The results showed a significant association between the miRNA-196a2 C/T polymorphism and CRC risk in the genetic models (C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001; CC vs. TT: OR = 1.368, 95% CI = 1.132-1.654, p = 0.001; TC/CC vs. TT: OR = 1.206, 95% = CI 1.035-1.405, p = 0.016; CC vs.Tc/tt: OR = 1.254, 95% CI = 1.077-1.461, p = 0.004), with the exception of the TC-versus-TT model (TC vs. TT: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138). In a subgroup analysis based on ethnicity, we identified a significant overrepresentation of the polymorphism in individuals of Asian ethnicity.Conclusion: This meta-analysis indicates a significant association between the miRNA-196a2 polymorphism and CRC risk.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 10","pages":"560-5"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000355158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31793718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation of cardiotoxicity via speckle-tracking echocardiography in patients treated with anthracyclines. 用斑点跟踪超声心动图评价蒽环类药物治疗患者的心脏毒性。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-11-20 DOI: 10.1159/000356850

Atalay Dogru, Devrim Cabuk, Tayfun Sahin, Ilhan Dolasik, Suleyman Temiz, Kazim Uygun

{"title":"Evaluation of cardiotoxicity via speckle-tracking echocardiography in patients treated with anthracyclines.","authors":"Atalay Dogru, Devrim Cabuk, Tayfun Sahin, Ilhan Dolasik, Suleyman Temiz, Kazim Uygun","doi":"10.1159/000356850","DOIUrl":"https://doi.org/10.1159/000356850","url":null,"abstract":"Background: The aim of this study was to examine the cardiac effects of anthracycline therapy based on speckle-tracking echocardiography (STE) and to identify patients at risk for cardiotoxicity.Patients and methods: The study included 35 breast cancer (BC) and 15 lymphoma patients who were treated with anthracycline-based chemotherapy. Conventional echocardiography and STE were performed 1 month prior to and 1 month after chemotherapy. Longitudinal strain analysis was performed via STE using automated functional imaging.Results: The ejection fraction (EF) and the fractional shortening values were significantly lower in the lymphoma group. There was a positive correlation between anthracycline dose and subclinical heart failure (p = 0.024). There was an increase in the myocardial performance index in both groups. After therapy, STE showed regional decreases in the longitudinal strain values in the BC group, but the global strain values did not differ. In the lymphoma group, the apical long-axis, the 4-chamber, and the global longitudinal strain values were significantly lower after therapy (p = 0.002, 0.041, and 0.004, respectively). The long-axis and global longitudinal strain values were significantly lower in the lymphoma patients with normal EF values (p = 0.01 and 0.05, respectively).Conclusion: Cardiotoxicity during the early phase of anthracycline treatment can be detected via STE prior to the observation of systolic function deterioration.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 12","pages":"712-6"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000356850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31971225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Severe disseminated coagulopathy caused by adenocarcinoma with bone marrow metastasis. 腺癌伴骨髓转移引起的严重播散性凝血功能障碍。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-04-02 DOI: 10.1159/000350327

Anne F Klenner, Andreas Greinacher, Anna Kuvikova, Gottfried Dölken, Christoph Busemann

{"title":"Severe disseminated coagulopathy caused by adenocarcinoma with bone marrow metastasis.","authors":"Anne F Klenner, Andreas Greinacher, Anna Kuvikova, Gottfried Dölken, Christoph Busemann","doi":"10.1159/000350327","DOIUrl":"https://doi.org/10.1159/000350327","url":null,"abstract":"Background: Patients with mucin-producing adenocarcinoma have an increased risk for venous and arterial thrombosis. When these patients present with thrombocytopenia, disseminated intravascular coagulopathy (DIC) is often the underlying cause.Case report: We report 2 patients who were admitted due to bleeding symptoms of unknown cause, in whom further workup revealed adenocarcinoma-induced DIC.Conclusion: In elderly patients presenting with signs of DIC, such as reduced fibrinogen levels, elevated prothrombin time, elevated D-dimer, and thrombocytopenia, without any obvious reason (e.g., sepsis), adenocarcinoma-associated coagulopathy should be considered as the underlying cause. Paradoxically, in these patients bleeding symptoms improve when the patient is sufficiently anti-coagulated with low molecular weight heparin. Treatment of the underlying disease is of central importance in controlling acute or chronic DIC associated with malignant diseases and chemotherapy should be started as soon as possible.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 5","pages":"292-4"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000350327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31443256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Thyroid incidentalomas on FDG PET/CT in patients with non-thyroid cancer - a large retrospective monocentric study. 非甲状腺癌患者的FDG PET/CT甲状腺偶发瘤-一项大型回顾性单中心研究

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-04-15 DOI: 10.1159/000350305

Heeyoung Kim, Seong-Jang Kim, In-Joo Kim, Keunyoung Kim

{"title":"Thyroid incidentalomas on FDG PET/CT in patients with non-thyroid cancer - a large retrospective monocentric study.","authors":"Heeyoung Kim, Seong-Jang Kim, In-Joo Kim, Keunyoung Kim","doi":"10.1159/000350305","DOIUrl":"https://doi.org/10.1159/000350305","url":null,"abstract":"Background: The purpose of this study was to compare the incidence of thyroid cancer among patients with primary non-thyroid cancer, who showed focal thyroid uptake in (18)F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT).Material and methods: We reviewed a total of 22,674 FDG PET/CTs performed at our institution between March 2005 and June 2011. A retrospective review was conducted on 433 non-thyroid cancer patients (male: n = 90, female: n = 343) who had thyroid incidentaloma on FDG PET/CT. In 286 patients, diagnostic confirmation was done by ultrasound-guided fine needle aspiration biopsy (FNAB).Results: Among 22,674 FDG PET/CT scans, 483 subjects (2.1%) showed focal thyroid uptake. Among the 286 patients who underwent FNAB, 280 were included in the study. Of those, 68 patients (24.3%) demonstrated papillary thyroid carcinoma on the final pathologic findings. We divided patients into 7 groups depending on the primary cancer.Conclusion: In patients with cancer of non-thyroid origin, incidental FDG uptake in the thyroid gland was observed in 2.1% and associated with a 24.3% risk for well-differentiated thyroid carcinoma. However, there was no statistically significant difference in the malignant risk of focal FDG uptake of the thyroid gland according to the underlying primary non-thyroid cancer type.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 5","pages":"260-4"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000350305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31443362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

A phase I study of the oral platinum agent satraplatin in combination with oral vinorelbine in patients with advanced solid malignancies. 口服铂制剂沙特铂联合口服长春瑞滨治疗晚期实体恶性肿瘤的I期研究。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-01-28 DOI: 10.1159/000346671

Elisa Gallerani, Richard Cathomas, Cristiana Sessa, Tiziana Digena, Anna Amalia Bartosek, Laura Dal Zotto, Roger von Moos

{"title":"A phase I study of the oral platinum agent satraplatin in combination with oral vinorelbine in patients with advanced solid malignancies.","authors":"Elisa Gallerani, Richard Cathomas, Cristiana Sessa, Tiziana Digena, Anna Amalia Bartosek, Laura Dal Zotto, Roger von Moos","doi":"10.1159/000346671","DOIUrl":"https://doi.org/10.1159/000346671","url":null,"abstract":"Background: The broad spectrum of antitumor activity of the oral platinum satraplatin (S) and vinorelbine (V) were the rationale for performing a phase I trial to define the maximum tolerated (MTD) and the recommended (RD) dose in adult patients with advanced solid tumors.Patients and methods: 4 dose levels (DLs) of S (mg/m(2)/day, days 1-5) and V (mg/m(2)/day, days 1, 8, 15, and 22) every 28 days were explored: S60/V60 on days 1, 8 and 15 only; S60/V60; S70/V60; and S80/V60. Subsequently, 3 further DLs were evaluated with V omitted on day 22: S70/V60, S80/V60, and S80/V80.Results: Treating 27 patients, the MTD was S80/V80 on days 1, 8, and 15, with 2 dose-limiting toxicities in 2 patients (nausea and vomiting grade (G) 3 with skipping of V on day 15, and neutropenia G4 with infection). The RD was S80/V60 on days 1, 8, and 15. The most frequent toxicities (any G) were nausea (70%), diarrhea (59%), anorexia (37%), vomiting (33%), asthenia (26%), constipation (26%), and paresthesia (18%). Partial responses were observed in 2 platinum-sensitive ovarian cancer patients and in 1 prostate cancer patient.Conclusion: The combination of S and V is tolerable at a DL of S80/V60 on days 1, 8, and 15; further evaluations in platinum- and V-sensitive tumor types would be of interest.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 1-2","pages":"40-5"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000346671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31255953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Frequency of computed tomography examinations in the follow-up care of testicular cancer patients - an evaluation of patterns of care in Germany. 睾丸癌患者随访护理中计算机断层扫描检查的频率——德国护理模式的评估。

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-03-18 DOI: 10.1159/000349952

Carsten Rusner, Andreas Stang, Klaus-Peter Dieckmann, Heiko Friedel

{"title":"Frequency of computed tomography examinations in the follow-up care of testicular cancer patients - an evaluation of patterns of care in Germany.","authors":"Carsten Rusner, Andreas Stang, Klaus-Peter Dieckmann, Heiko Friedel","doi":"10.1159/000349952","DOIUrl":"https://doi.org/10.1159/000349952","url":null,"abstract":"Background: Exposure to radiation resulting from diagnostic imaging procedures probably increases late cancer risk. Patterns of care regarding the application of computed tomography (CT) imaging in testicular cancer patients were investigated.Methods: The database of a large German health insurance company comprising 850,000 insured men was searched for cases of testicular cancer arising in the years 2005 and 2006. The number of CT scans applied during a 3-year period of follow-up was noted for each individual patient and the resulting cumulative radiation dose was estimated. The number of CT scans actually observed was compared to guideline recommendations.Results: 177 patients were identified. Within the 3-year observation period, patients received a mean of 4.4 CT scans (standard error: 0.4) whereas a number of 6.2 would have been expected according to contemporary guidelines. Patients were exposed to an estimated total median diagnostic radiation dose of 30 millisieverts (mSv) (interquartile range: 10-54 mSv).Conclusion: There is a considerable gap between recommendation and actual performance regarding the number of CT scans applied to testicular cancer patients. Unfamiliarity of clinicians with guidelines as well as poor acceptance of high numbers of CT scans scheduled may have contributed to create this particular pattern of care.","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 4","pages":"188-92"},"PeriodicalIF":0.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000349952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40242510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Panitumumab-induced interstitial lung disease in a case of metastatic colorectal cancer. 帕尼单抗诱导的转移性结直肠癌间质性肺疾病1例

IF 0.3 4区医学

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-03-18 DOI: 10.1159/000349959

Takeshi Yamada, Toshikazu Moriwaki, Kenji Matsuda, Yoshiyuki Yamamoto, Akinori Sugaya, Daisuke Akutsu, Tetsuya Murashita, Shinji Endo, Ichinosuke Hyodo

引用次数: 6