{"title":"Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer.","authors":"Ke-Qing Shi, Zhuo Lin, De-Wei Li, Yu-Xiao Fang, Jian Gao, Zhu-Jun Deng, Li Chen, Gui-Ling Li, Jian-Min Wu, Kai-Fu Tang","doi":"10.1159/000355158","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis.</p><p><strong>Methods: </strong>An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis.</p><p><strong>Results: </strong>5 studies were used for analysis. The results showed a significant association between the miRNA-196a2 C/T polymorphism and CRC risk in the genetic models (C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001; CC vs. TT: OR = 1.368, 95% CI = 1.132-1.654, p = 0.001; TC/CC vs. TT: OR = 1.206, 95% = CI 1.035-1.405, p = 0.016; CC vs.</p><p><strong>Tc/tt: </strong>OR = 1.254, 95% CI = 1.077-1.461, p = 0.004), with the exception of the TC-versus-TT model (TC vs. TT: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138). In a subgroup analysis based on ethnicity, we identified a significant overrepresentation of the polymorphism in individuals of Asian ethnicity.</p><p><strong>Conclusion: </strong>This meta-analysis indicates a significant association between the miRNA-196a2 polymorphism and CRC risk.</p>","PeriodicalId":19684,"journal":{"name":"Onkologie","volume":"36 10","pages":"560-5"},"PeriodicalIF":0.3000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000355158","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Onkologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000355158","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/9/16 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 5
Abstract
Background/aims: To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis.
Methods: An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis.
Results: 5 studies were used for analysis. The results showed a significant association between the miRNA-196a2 C/T polymorphism and CRC risk in the genetic models (C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001; CC vs. TT: OR = 1.368, 95% CI = 1.132-1.654, p = 0.001; TC/CC vs. TT: OR = 1.206, 95% = CI 1.035-1.405, p = 0.016; CC vs.
Tc/tt: OR = 1.254, 95% CI = 1.077-1.461, p = 0.004), with the exception of the TC-versus-TT model (TC vs. TT: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138). In a subgroup analysis based on ethnicity, we identified a significant overrepresentation of the polymorphism in individuals of Asian ethnicity.
Conclusion: This meta-analysis indicates a significant association between the miRNA-196a2 polymorphism and CRC risk.
背景/目的:通过荟萃分析准确评估microRNA (miRNA)-196a2 C/T多态性对结直肠癌(CRC)风险的影响。方法:在PubMed、EMBASE、ISI Web of Science和Cochrane Library中进行电子检索。合并优势比(OR)及其95%置信区间(CI)通过meta分析来评估相关性。结果:共纳入5项研究进行分析。结果显示，在遗传模型中，miRNA-196a2 C/T多态性与结直肠癌风险之间存在显著相关性(C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001;CC vs. TT: OR = 1.368, 95% CI = 1.132 ~ 1.654, p = 0.001;TC/CC vs. TT: OR = 1.206, 95% = CI 1.035 ~ 1.405, p = 0.016;CC vs. TC /tt: OR = 1.254, 95% CI = 1.077-1.461, p = 0.004)， TC vs. tt模型除外(TC vs. tt: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138)。在基于种族的亚组分析中，我们发现了亚洲种族个体中多态性的显著过度代表。结论:该荟萃分析表明miRNA-196a2多态性与结直肠癌风险之间存在显著相关性。
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