Oxidative Medicine and Cellular Longevity最新文献

{"title":"RETRACTION: Shear-Induced ITGB4 Promotes Endothelial Cell Inflammation and Atherosclerosis.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/omcl/9828461","DOIUrl":"10.1155/omcl/9828461","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9828461"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/omcl/9789810","DOIUrl":"10.1155/omcl/9789810","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9789810"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate-Induced Liver Injury.","authors":"Bushra Zia, Mouza Hasan Alqaishi Alshehhi, Azimullah Sheikh, Samir Mirza, Sandeep B Subramanya, Shreesh K Ojha","doi":"10.1155/omcl/9407932","DOIUrl":"10.1155/omcl/9407932","url":null,"abstract":"<p><p>Methotrexate (MTX) is a widely used chemotherapeutic and immunosuppressive agent for treating various malignancies, autoimmune diseases (AIDs), and inflammatory disorders. Despite its therapeutic efficacy, long term or high-dose MTX treatment is associated with a significant risk of hepatotoxicity, leading to MTX-induced liver injury (MTX-LI). The pathogenesis of MTX-LI involves multiple mechanisms, including oxidative stress, mitochondrial dysfunction, inflammation, and altered metabolic processes, which collectively contribute to hepatocellular damage and fibrosis. Clinically, MTX-LI manifests as elevated liver enzymes, hepatic steatosis, and, in severe cases, cirrhosis, posing a challenge to treatment regimens. To mitigate MTX-LI, a growing body of research has focused on exploring therapeutic and/or preventive potential and pharmacological mechanisms of phytochemicals and pharmaceuticals. Phytochemicals, including flavonoids, terpenoids, alkaloids, and polyphenols, exhibit hepatoprotective effects attributed to their antioxidant, anti-inflammatory, and antiapoptotic properties that can counteract MTX-induced hepatic damage. Additionally, various pharmaceutical agents possessing antioxidants and anti-inflammatory properties and favorably modulate metabolic pathways have shown promise in reducing the severity or progression of of MTX-LI. The phytochemicals or pharmaceuticals showed beneficial in MTX-LI primarily act by scavenging reactive oxygen species (ROS), modulating inflammatory pathways, and improving liver regeneration. Integrated together, its apparent that naturally occurring many phytochemicals as well as synthetic agents of pharmaceutical relevance are capable of preventing or alleviating MTX-LI. However, the optimal strategies for integrating these agents into clinical practice require further investigations to highlight safety and efficacy in humans followed by pharmacological rationale of their possible use in therapeutics. Future directions should focus on elucidating the precise molecular mechanisms, establish safety and efficacy in humans, conducting regulatory toxicology studies and randomized clinical trials, and developing combination therapies for promotion as protective agents or adjuvants to maximize efficacy and minimize adverse effects.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9407932"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer, Antitumor, and Antioxidant Microbial Lipids: Mechanism of Action, Production, and Clinical Application.","authors":"Morteza Nadeb, Seyed Soheil Aghaei, Tahereh Komeili-Movahed, Hamed Afkhami","doi":"10.1155/omcl/5525367","DOIUrl":"10.1155/omcl/5525367","url":null,"abstract":"<p><p>The present document highlights the significance of microbial lipids as new generation anticancer, antitumor, and antioxidant compounds. It focuses on the diverse nature of the action of these lipids in cancer treatment, especially polyunsaturated fatty acids (PUFAs). These mechanisms include membrane disruption, apoptosis/necrosis, DNA damage modifying histone and gene expression, angiogenesis inhibition, cell proliferation/cycle regulation, migration, invasion, metastasis, differentiation, reversal of drug resistance, and immune system modulation. The text also discusses the economical biosynthesis of these lipids via microbial fermentation, chemosynthesis, and other synthesis techniques. The versatility of PUFAs is described in detail in the following areas of study including signal transduction and inflammation. While microbial lipids offer potential cost-effectiveness due to scalable fermentation processes, it is important to note that specific clinical dosage regimens and comprehensive pharmacoeconomic comparisons with standard chemotherapeutic agents are still under investigation. Current estimates suggest lower long-term costs if optimized dosing is achieved, but further clinical trials are required to validate these economic benefits.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e5525367"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles\".","authors":"","doi":"10.1155/omcl/9857537","DOIUrl":"10.1155/omcl/9857537","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9857537"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study\".","authors":"","doi":"10.1155/omcl/9767860","DOIUrl":"10.1155/omcl/9767860","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9767860"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Roles of Natural Products in Regulating Ferroptosis in Acute and Chronic Liver Diseases: A Review.","authors":"Farshad Niazpour, Reza Meshkani","doi":"10.1155/omcl/9874221","DOIUrl":"https://doi.org/10.1155/omcl/9874221","url":null,"abstract":"<p><p>Liver diseases, both acute and chronic, are a major global health burden with limited therapeutic options. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a key contributor to liver pathology and a potential therapeutic target. This review examines how plant-derived natural products modulate ferroptosis across acute liver failure (ALF), nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma (HCC). These compounds show dual effects, suppressing ferroptosis to protect hepatocytes in ALF, NAFLD, and NASH, and inducing ferroptosis to eliminate activated hepatic stellate cells and cancer cells in liver fibrosis and HCC. Mechanistically, they act on major ferroptosis regulators, including nuclear factor erythroid 2-related factor 2 (NRF2), solute carrier family 7 member 11 (SLC7A11), glutathione (GSH) peroxidase 4 (GPX4), heme oxygenase 1 (HMOX1), acyl-CoA synthetase long-chain family member 4 (ACSL4), lipid metabolism enzymes including arachidonate lipoxygenases (ALOXs) and lysophosphatidylcholine acyltransferase 3 (LPCAT3), and tumor protein p53 (p53). They influence transcriptional and epigenetic programs to regulate gene expression related to ferroptosis. Some natural products modulate noncoding RNAs and chromatin-modifying enzymes to suppress genes promoting ferroptosis, while others affect RNA methylation to stabilize antioxidant defenses. Additionally, these compounds regulate iron metabolism and impact key upstream signaling pathways, collectively shaping ferroptosis control. Despite promising preclinical results, translation to clinical use is challenged by context-dependent effects, bioavailability limitations, and potential toxicity. Further mechanistic studies, in vivo validation, and clinical trials are warranted. Overall, natural product-based modulation of ferroptosis offers a promising therapeutic avenue in liver disease.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9874221"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson's Disease.","authors":"","doi":"10.1155/omcl/9828315","DOIUrl":"10.1155/omcl/9828315","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9828315"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13359022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passiflora edulis f. flavicarpa Extract Prevents Muscle Atrophy and Insulin Resistance in High-Fat Diet-Induced Obese Rats via Regulating the Nrf2, NF-κB, and IRS-1/PI3K/AKT Signaling Pathways.","authors":"Nrarat Chobsuay, Pennapa Chonpathompikunlert, Jukkarin Srivilai, Wachirawadee Malakul, Nanteetip Limpeanchob, Sathid Aimjongjun, Sakara Tunsophon","doi":"10.1155/omcl/5709962","DOIUrl":"10.1155/omcl/5709962","url":null,"abstract":"<p><p>High-fat diets (HFDs) are a key contributor to obesity and promote oxidative stress and inflammation, which are associated with muscle atrophy and insulin resistance (IR). Passiflora edulis exhibits anti-obesity, antioxidant, and anti-inflammatory effects. The study aimed to investigate the potential benefit of P. edulis f. flavicarpa (PF) extract in preventing obesity-associated muscle atrophy and IR. The PF extract effectively inhibited cholesterol micelle solubility with an IC₅₀ of 3431 µg/mL and decreased fat accumulation in 3T3-L1 adipocytes. Furthermore, this study investigated a model of HFD-induced IR and muscle atrophy in rats. Thirty-five male Sprague-Dawley (SD) rats were induced with obesity by HFD and were administered 250 and 500 mg/kg/day of PF extract. Rats fed with an HFD were associated with fat accumulation and oxidative stress, which promoted inflammation, muscle damage, muscle atrophy, and IR in obese rats. However, administration of PF extract effectively mitigated these effects. The PF extract decreased fat accumulation in white adipose tissues and gastrocnemius (GAS) muscle by inhibiting fat absorption and synthesis, particularly Cd36 and Hmgcr. The PF extract also notably reduced oxidative stress-induced muscle inflammation and damage via elevating nuclear factor erythroid 2-related factor 2 (Nrf2) and reducing nuclear factor kappa B (NF-κB) expressions. Additionally, PF extract was found to mechanistically prevent muscle atrophy by inhibiting Fbxo32, Trim63, and B-cell lymphoma 2 (BCL2)-associated X (Bax) expressions, while enhancing Bcl2 expression. We also found that PF extract mitigated muscle IR by upregulation of the insulin receptor substrate-1/phosphatidylinositol-3 kinase/protein kinase B (IRS-1/PI3K/AKT) pathway and Slc2a4 expression. The findings indicate that PF extract can prevent skeletal muscle loss and IR in obesity by modulating oxidative stress, inflammation, and activating IRS-1/PI3K/AKT signaling pathway.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e5709962"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Methanol Extract of Ocimum Gratissimum Protects Murine Peritoneal Macrophages from Nicotine Toxicity by Decreasing Free Radical Generation, Lipid and Protein Damage and Enhances Antioxidant Protection.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/omcl/9876960","DOIUrl":"10.1155/omcl/9876960","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9876960"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}