Oxidative Medicine and Cellular Longevity最新文献

{"title":"Correction to \"Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies\".","authors":"","doi":"10.1155/omcl/9757940","DOIUrl":"10.1155/omcl/9757940","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9757940"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress-Associated Alterations in Sperm ACTL7A Expression and Function in Men With Varicocele.","authors":"Sahar Tahamtan, Marziyeh Tavalaee, Mohsen Forouzanfar, Mojtaba Jafarinia, Mohammad H Nasr-Esfahani","doi":"10.1155/omcl/1776251","DOIUrl":"10.1155/omcl/1776251","url":null,"abstract":"<p><strong>Background: </strong>Actin-like 7A (ACTL7A) is a testis-specific cytoskeletal protein essential for spermiogenesis, acrosome formation, and oocyte activation. Given its critical role in sperm integrity and fertilization, ACTL7A protein may be particularly susceptible to oxidative and thermal stress associated with varicocele. This study aimed to evaluate ACTL7A gene, and protein expression in the sperm of infertile men with varicocele.</p><p><strong>Methods: </strong>Semen samples from infertile men with varicocele (n = 35) and fertile controls (n = 35) were assessed for standard sperm parameters (WHO 2021), redox status (2',7'-dichlorodihydrofluorescein diacetate [DCFH-DA] and BODIPY probes), chromatin packaging (Chromomycin A3 [CMA3] and Aniline Blue staining), DNA integrity (Sperm Chromatin Structure Assay [SCSA]), ACTL7A gene, and protein expression (quantitative real-time PCR and Western blotting).</p><p><strong>Results: </strong>Compared to fertile controls, the varicocele group exhibited significantly lower sperm quality, elevated oxidative stress, increased lipid peroxidation, and greater chromatin immaturity and DNA fragmentation (p < 0.01). Notably, ACTL7A gene and ACTL7A protein expression levels were significantly reduced (p < 0.05), with inverse correlations observed between ACTL7A gene and markers of chromatin packaging defects, including protamine deficiency and residual histones (p < 0.05).</p><p><strong>Conclusion: </strong>ACTL7A gene expression and ACTL7A protein are significantly reduced in sperm from men with varicocele, likely causing defective chromatin remodeling and abnormal sperm head formation. This study first links varicocele-associated oxidative stress to ACTL7A, suggesting its potential as a biomarker of testicular dysfunction. Future research should explore whether interventions like antioxidant therapy, varicocelectomy, or varicocele severity and duration improve sperm quality and reproductive outcomes.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e1776251"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: CO₂ Pneumoperitoneum Preserves β-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/omcl/9792742","DOIUrl":"10.1155/omcl/9792742","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9792742"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasciola hepatica-Derived Proteins Shield the Heart From Type 2 Myocardial Infarction in Rats by Modulating Oxidative Stress and Inflammatory Imbalance: Insights Relevant to the Hygiene Hypothesis.","authors":"Mohammadreza Ahmadi-Beni, Kobra Mokhtarian, Gholam Reza Mobini, Somayeh Najafi-Chaleshtori, Najmeh Salehi-Vanani, Maryam Anjomshoa, Fariba Houshmand","doi":"10.1155/omcl/3759583","DOIUrl":"10.1155/omcl/3759583","url":null,"abstract":"<p><p>Myocardial infarction (MI) remains a leading cause of mortality worldwide, with type 2 MI (T2MI) carrying a worse prognosis than type 1 MI (T1MI). The hygiene hypothesis suggests that reduced microbial exposure in sanitized environments contributes to immune dysregulation and inflammation-related diseases. While helminth therapy has shown potential in modulating the inflammatory responses in myocardial injury, its effects on oxidative stress remain underexplored. We hypothesize that Fasciola hepatica total protein extract (FhTE) attenuates myocardial injury in T2MI via immune modulation consistent with the hygiene hypothesis, affecting both inflammation and oxidative stress. To investigate this, male Wistar rats were pretreated with FhTE (2.5 mg/kg, intraperitoneally) daily for 6 days. MI was induced by subcutaneous isoproterenol (100 mg/kg) on days five and six. Electrocardiographic analysis 24 h post-final treatment revealed that FhTE pretreatment attenuated MI-induced changes. FhTE reduced cardiac hypertrophy and decreased serum cardiac injury markers. It enhanced antioxidant defense by increasing superoxide dismutase (SOD) and catalase (CAT) activities, lowering nitric oxide (NO) and malondialdehyde (MDA) levels, and modulating nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA levels. FhTE also reduced neutrophil and M1 macrophage activity, evidenced by decreased myeloperoxidase (MPO) levels and inducible nitric oxide synthase (iNOS) mRNA expression, and downregulated inflammatory cytokine genes (IL-1β, IL-6, TNF-⍺, and IL-33). FhTE demonstrates significant cardioprotective effects by modulating inflammation and oxidative stress, thereby preconditioning the myocardium against T2MI. These findings offer robust experimental support for the hygiene hypothesis in the context of ischemic heart disease, highlighting its potential for novel MI therapies.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e3759583"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Thiol Oxidation State of Albumin Is Associated With Training Load Across an Australian Football Pre-Season.","authors":"Christopher James, Jason Weber, Corrin Boyd, Paul A Fournier, Peter G Arthur","doi":"10.1155/omcl/5534194","DOIUrl":"10.1155/omcl/5534194","url":null,"abstract":"<p><p>Australian football is a demanding contact sport where high training loads during the pre-season have been identified as a potential cause of non-contact injuries. The level of thiol-oxidised albumin, a marker of oxidative stress, might be related to the training load, and thus could be used to indirectly quantify the impact of training loads upon an athlete. The aim of this study was to investigate whether the level of thiol-oxidised albumin was affected by the pre-season training load in a team of professional Australian Football League (AFL) athletes and compare the effect of lower pre-season training loads caused by COVID-19 restrictions on the level of thiol-oxidised albumin. Forty-five participants collected daily dried blood spots in the morning prior to each training session to measure thiol-oxidised albumin using a novel methodology (OxiDx). Training load, which was operationally defined as the total distance covered during training as well as distance at certain velocities, and change of direction (COD), was measured using global positioning units. There was an association (R² = 0.12) between the level of thiol-oxidised albumin with; (1) total distance covered (p  < 0.0001), (2) distance covered at 10-20 km/h (p  < 0.0001) and 20-25 km/h (p = 0.0082) and (3) COD running (p = 0.0025). Training loads and the level of thiol-oxidised albumin were highest in the early pre-season and lowest at the conclusion of the pre-season, when training loads were reduced as a consequence of COVID-19. The measurement of the level of thiol-oxidised albumin may provide a means to indirectly quantify the impact of training loads upon an athlete, especially given the simplicity of the OxiDx methodology for fingertip blood sample collection.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e5534194"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats\".","authors":"","doi":"10.1155/omcl/9784046","DOIUrl":"10.1155/omcl/9784046","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9784046"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Role of Holothuria leucospilota Extract Against Amyloid-β Toxicity via Autophagy and Antioxidant Mechanisms in Caenorhabditis elegans Model.","authors":"Chanathip Kamonnat, Salinthip Thongdechsri, Pichnaree Kraokaew, Nakorn Niamnont, Prasert Sobhon, Krai Meemon","doi":"10.1155/omcl/1471919","DOIUrl":"10.1155/omcl/1471919","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a major global health challenge characterized by cognitive decline and neuronal degeneration driven by amyloid-β (Aβ) aggregation and oxidative stress. Given the limited efficacy and adverse effects of current pharmacological therapies, food-derived bioactive compounds have gained increasing attention as potential preventive strategies against neurodegenerative disorders. In this study, we investigated the neuroprotective effects of Holothuria leucospilota extracts using a transgenic Caenorhabditis elegans model of AD. Our results demonstrated that H. leucospilota hexane extract (HLHE) at 500 µg/mL significantly delayed Aβ-induced paralysis and improved chemotaxis behavior. Consistently, HLHE treatment reduced Aβ deposition and decreased both high- and low-molecular weights of Aβ oligomers, as determined by automated Western blot analysis. Additionally, HLHE also reduced reactive oxygen species (ROS) levels. Transcriptomic and RT-qPCR analyses revealed that HLHE enhanced autophagic activity through the upregulation of bec-1 (autophagy initiation) and lysosomal genes (cpr-1, cpr-2, and cpr-5). Furthermore, HLHE activated antioxidant defense pathways via the insulin/IGF-1 signaling (IIS) axis, specifically upregulating genes associated with SKN-1 pathway (pmk-1, skn-1, gst-4, and gst-10) and HSF-1 pathway (hsf-1, hsp-16.1, hsp-12.6, and mtl-1). HLHE also promoted nuclear localization of SKN-1 and increased expression of its downstream target gst-4. Chemical analysis revealed that HLHE contained arachidonic acid (21.12%) and other bioactive lipid compounds as major constituents, suggesting a synergistic role in promoting autophagy and antioxidant responses. Collectively, this study suggests that HLHE confers neuroprotection against Aβ-induced toxicity by activating autophagy and oxidative stress defense mechanisms, supporting its potential development as a food-derived preventive or therapeutic agent for AD.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e1471919"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/omcl/9820439","DOIUrl":"https://doi.org/10.1155/omcl/9820439","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9820439"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma\".","authors":"","doi":"10.1155/omcl/9853912","DOIUrl":"10.1155/omcl/9853912","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9853912"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress\".","authors":"","doi":"10.1155/omcl/9847903","DOIUrl":"10.1155/omcl/9847903","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 1","pages":"e9847903"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}