Oxidative Medicine and Cellular Longevity最新文献

{"title":"Correction to \"Antiosteoporotic Effect of Combined Extract of <i>Morus alba</i> and <i>Polygonum odoratum</i>\".","authors":"","doi":"10.1155/omcl/9864725","DOIUrl":"https://doi.org/10.1155/omcl/9864725","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2014/579305.].</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"9864725"},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway\".","authors":"","doi":"10.1155/omcl/9783010","DOIUrl":"https://doi.org/10.1155/omcl/9783010","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2022/2188145.].</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"9783010"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-κB Signaling\".","authors":"","doi":"10.1155/omcl/9789842","DOIUrl":"https://doi.org/10.1155/omcl/9789842","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2019/5294105.].</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"9789842"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative and Inflammatory Damage by Environmental Polyethylene Microplastics in Caco-2 Cells Is Prevented by Polyphenol-Rich Limoncella Apple Extract.","authors":"Stefania Lama, Massimo Venditti, Alessandra Biasi, Carmen Lenti, Hana Najahi, Mohamed Banni, Gian Carlo Tenore, Ettore Novellino, Paola Stiuso","doi":"10.1155/omcl/3136395","DOIUrl":"10.1155/omcl/3136395","url":null,"abstract":"<p><strong>Background: </strong>Humans are constantly exposed to environmental microplastic (MP) particles, which can be absorbed through the gut and exert adverse health effects. This study aimed to investigate the harmful effects of environmental polyethylene MPs (PE, 2.6 μm) on differentiated Caco-2 (D-Caco-2) intestinal epithelial cells and to assess the protective potential of <i>Limoncella</i> apple polyphenol extract (LAPE).</p><p><strong>Methods: </strong>D-Caco-2 cells were exposed to PE, LAPE, or their combination. Cell viability and lipid peroxidation were evaluated using MTT and TBARS assays, respectively. The organization of F-actin and alkaline phosphatase proteins was evaluated by immunofluorescence, whereas occludin and NF-κB were evaluated by Western blot analysis.</p><p><strong>Results: </strong>PE reduced D-Caco-2 viability and impaired cell differentiation by increasing lipid peroxidation. In addition, PE destructured F-actin organization and altered the expression of occludin, a tight-junction protein.</p><p><strong>Conclusions: </strong>Our findings show that PE increases oxidative stress, triggering epithelial-mesenchymal transition and dedifferentiation in Caco-2 cells. Interestingly, LAPE, owing to its antioxidant and anti-inflammatory properties, counteracted the harmful effects of PE, suggesting its potential as a nutraceutical strategy to prevent MP-induced damage in the gastrointestinal (GI) tract.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"3136395"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12932969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota\".","authors":"","doi":"10.1155/omcl/9853756","DOIUrl":"https://doi.org/10.1155/omcl/9853756","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2021/9424582.].</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"9853756"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Functional Ingredient Derived From a Mixture of Mulberry (<i>Morus alba</i> L.) Leaves and Butterfly Pea (<i>Clitoria ternatea</i> L.) Flowers Enhances Rapid Eye Movement Sleep, Cognitive Function, and Anxiolytic Behavior via GABA_A Receptor-Dependent Mechanism in Rats.","authors":"Jakkrit Nukitram, Aonvara Kanjanavattana, Panlekha Rungruang, Nattaporn Yotyatthai, Pannita Kaewudom, Pichayapa Promkasikorn, Patharakan Kaowsuwan, Nobuhiro Zaima, Dania Cheaha, Wipawee Thukhammee, Jintanaporn Wattanathorn","doi":"10.1155/omcl/2305848","DOIUrl":"10.1155/omcl/2305848","url":null,"abstract":"<p><p>The neuropharmacological benefits for sleep quality and mental health from the extracts of <i>Morus alba</i> L. leaves (MA) and <i>Clitoria ternatea</i> L. flowers (CT) have been revealed previously. However, due to synergistic interactions of polyherbal ingredients, the positive effects of MA mixed with CT are still controversial. Preliminary outcomes from in vitro assessment exposed that a 3:1 ratio of MA:CT (MACT) yielded the highest antioxidant capacity and gamma-aminobutyric acid (GABA)-promoting activity among seven combination ratios: 0MA:1CT, 1MA:0CT, 1MA:1CT, 1MA:2CT, 1MA:3CT, 2MA:1CT, and 3MA:1CT. Male Wistar rats (<i>n</i> = 6/group) were electroencephalographically and electromyographically monitored to confirm the sedative-hypnotic function of the assigned ingredients over 3 h after oral administration. Cognitive and anxiolytic effects were also evaluated thereafter. Following drug administration, it was found that MACT exhibited positive influences in a dose-dependent manner (125, 250, and 500 mg/kg), and in a significantly better manner than either 500 mg/kg MA or CT alone. Interestingly, a majority of these effects, including sedative-hypnotic parameters, that is, decreasing of latency to rapid eye movements (REMs) sleep and wake duration, increasing of REM sleep duration, number of REM sleep bouts, as well as elevating of cognitive function and anxiolytic parameters was reversed by pretreatment with bicuculline methiodide (2 mg/kg), a GABA_A receptor antagonist. Overall, the advantages of MACT-based polyherbal drugs, which act preferentially on GABA_A receptors, may pave the way for further development of MACT as an alternative drug or food supplement for neuropharmacological improvements in GABA_A receptor-related disorders.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"2305848"},"PeriodicalIF":0.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12906349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development\".","authors":"","doi":"10.1155/omcl/9871853","DOIUrl":"10.1155/omcl/9871853","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2020/2641461.].</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"9871853"},"PeriodicalIF":0.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormetic Effects of 7-Ketocholesterol in Preventing Ferroptosis in Hepatocytes.","authors":"Sarit Anavi, Nicole Giltman, Haim Zeigerman, Zecharia Madar, Oren Tirosh","doi":"10.1155/omcl/7958511","DOIUrl":"10.1155/omcl/7958511","url":null,"abstract":"<p><strong>Background and aims: </strong>Ferroptosis, a form of cell death marked by iron dysregulation and lipid peroxidation, has been implicated in liver and neurodegenerative diseases. 7-ketocholesterol (7KC), a cholesterol oxidation product, induces oxidative stress and inflammation at high concentrations. However, the effects of low, subtoxic levels of 7KC are unclear. This study investigates the potential hormetic effects of low concentrations of 7KC on hepatocytes and neuronal cells during ferroptosis.</p><p><strong>Method: </strong>Ferroptosis was induced in AML12 hepatocytes using 20 µM Erastin, with cells co-treated with varying concentrations of 7KC. Cell death was assessed, and gene expression was analyzed via RNA sequencing (RNA-seq) and real-time PCR. HT4 hippocampal neuronal cells were treated with glutamate to induce ferroptosis, both with and without 7KC.</p><p><strong>Results: </strong>Low, nontoxic concentrations of 7KC protected both hepatocytes and neuronal cells from ferroptosis induced by Erastin and glutamate, respectively. In contrast, higher concentrations of 7KC increased cell death. 7KC's protective effects in hepatocytes were linked to lower malondialdehyde (MDA) levels and reduced peroxidation of polyunsaturated fatty acids (PUFAs). The cholesterol synthesis pathway, as well as lipid accumulation, was suppressed by 7KC. Conversely, these processes were upregulated by Erastin. Notably, 7KC showed a stronger anti-ferroptotic effect than 7-dehydrocholesterol (7DHC) at low concentrations, possibly through Nrf2-independent upregulation of the gamma-glutamylcysteine ligase catalytic (GCLC) unit.</p><p><strong>Conclusion: </strong>This study reveals that 7KC can have a hormetic effect on ferroptosis at low concentrations, suggesting a potential advantage. Further research is needed to clarify the underlying mechanisms, particularly regarding GCLC upregulation.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"7958511"},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Caloric Restriction and Resistance Training on Weight Management, Insulin Sensitivity, and Adipose Tissue Protein Dynamics.","authors":"Mohammad Mehrtash, Mohsen Salesi, Farhad Daryanoosh, Nader Tanideh, Iman Jamhiri","doi":"10.1155/omcl/6888340","DOIUrl":"10.1155/omcl/6888340","url":null,"abstract":"<p><strong>Background/aims: </strong>Obesity and insulin resistance induced by excessive calorie intake remain major health challenges. Caloric restriction (CR) and resistance training (RT) are known strategies to improve metabolic health, but their combined effects on lipid droplet-associated proteins and metabolic regulators remain unclear. This study aimed to evaluate the impact of CR and RT, alone and in combination (CR + RT), on lipid droplet-associated proteins and signaling pathways in rats exposed to a high-fat diet (HFD).</p><p><strong>Methods: </strong>Fifty male Sprague-Dawley rats were fed HFD for 8 weeks and were then randomly assigned to five groups: HFD, normal-fat diet (NFD), CR, RT, and CR + RT. Each intervention was performed for 8 weeks following the initial 8-week HFD induction. Body weight, insulin resistance index (HOMA-IR), and mRNA expression of perilipin 1 was measured in both adipose and skeletal muscle tissues, whereas perilipin 5, fat-specific protein 27 (FSP-27), adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1<i>α</i>), sirtuin 1 (SIRT1), and AMP-activated protein kinase (AMPK) were measured only in skeletal muscle after the subsequent 8-week intervention period.</p><p><strong>Results: </strong>At baseline, no significant differences in body weight were observed among the groups (<i>p</i>  > 0.05). After 16 weeks, rats in HFD group exhibited the highest body weight (509.8 ± 6.0g), whereas CR + RT group showed the most pronounced reduction (292.2 ± 1.8 g; <i>p</i>  < 0.001). Insulin resistance (HOMA-IR) was significantly elevated in the HFD group (5.55 ± 0.21) compared to all other groups, while the CR + RT group demonstrated the lowest value (1.24 ± 0.05), comparable to the normal diet group (<i>p</i>  > 0.05). At the molecular level, CR + RT downregulated perilipin 1 and FSP-27, while significantly upregulating ATGL, AMPK, SIRT1, and PGC-1<i>α</i> compared to HFD (all <i>p</i>  < 0.05).</p><p><strong>Conclusion: </strong>Combined CR and RT produced superior benefits over either intervention alone, improving insulin sensitivity and lipid metabolism through coordinated regulation of lipid droplet proteins and metabolic signaling pathways. These findings suggest CR+RT as an effective strategy against diet-induced obesity.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"6888340"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/omcl/9893408","DOIUrl":"https://doi.org/10.1155/omcl/9893408","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2020/7046923.].</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2026 ","pages":"9893408"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}