Oxidative Medicine and Cellular Longevity最新文献

{"title":"Coadministration of Monophosphoryl Lipid and Curcumin Modulates Neuroprotective Effects in LPS Stimulated Rat Primary Microglial Cells.","authors":"Maryam Hooshmand, Ahmad Asoodeh","doi":"10.1155/omcl/9422312","DOIUrl":"10.1155/omcl/9422312","url":null,"abstract":"<p><p>Lipopolysaccharide (LPS)-induced activation of microglia triggers the release of neuroinflammatory molecules, contributing to the progression of neurodegenerative diseases. Targeting these neuroinflammatory molecules could serve as a potential therapeutic strategy. Given the evidence supporting the immune-boosting properties of curcumin (Curc) and the protective effects of monophosphoryl lipid A (MPL) in the central nervous system (CNS) related to Alzheimer's disease (AD), this study aimed to assess the anti-inflammatory effects of these compounds on primary rat microglial cells, which are crucial in the response to neuroinflammation. This in vitro study investigated the effects of Curc, MPL, and their coadministration (Curc + MPL) on inflammatory cytokine levels in activated microglial cells. Primary microglial cells were isolated from 1-day-old rats and treated with various concentrations of Curc, MPL, and Curc + MPL prior to LPS stimulation. Cell viability was assessed using the MTT assay, followed by the Griess assay to evaluate nitric oxide (NO) production. The levels of inflammatory cytokines interleukin-1<i>β</i> (IL-1<i>β</i>), tumor necrosis factor-alpha (TNF-<i>α</i>), and interleukin-6 (IL-6), as well as the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), were analyzed via real-time PCR. Additionally, enzyme-linked immunosorbent assay (ELISA) was employed to quantify the protein levels of IL-1<i>β</i>, TNF-<i>α</i>, and IL-6. Our findings demonstrate that Curc and MPL possess antineuroinflammatory properties in LPS-stimulated microglial cells. Notably, the coadministration of Curc and MPL (Curc + MPL) significantly inhibited the production of pro-inflammatory cytokines IL-1<i>β</i>, TNF-<i>α</i>, and IL-6. Furthermore, Curc + MPL suppressed the expression of iNOS and COX-2. These results strongly suggest that Curc + MPL is a promising neuroprotective agent for the treatment of neurodegenerative disorders by mitigating neuroinflammatory responses.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"9422312"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on the Neuroprotective Effect of <i>Moringa oleifera</i>.","authors":"Beniam Worku, Nafyad Tolossa","doi":"10.1155/2024/7694516","DOIUrl":"10.1155/2024/7694516","url":null,"abstract":"<p><p><i>Moringa oleifera</i>, which is known as a drumstick tree in different areas of the world, is well-known for many health benefits, which are attributed to the abundance of flavonoids, phenolic chemicals, and thiocyanates it contains. This review focuses on <i>M. oleifera</i>'s potential for neuroprotection, emphasizing its anti-inflammatory, antioxidant, and neurotransmitter-modulating qualities. Different parts of <i>M. oleifera</i> include leaves, roots, bark, and gum. Flowers, seeds, and seed oil are used for many health purposes, most notably in the treatment of neurological diseases. Neurodegeneration, which is characterized by the progressive death of nerve cells, is a major concern with an aging population, leading to disorders such as dementia and movement disorders. <i>M. oleifera</i> bioactive compounds improve the antioxidant defense activities of the brain, reduce inflammation, and improve neurotransmitter levels, showing potential therapeutic applications for neurodegenerative disorders. This review emphasizes the importance of further research, especially clinical trials, to fully understand and utilize <i>M. oleifera</i>'s neuroprotective capabilities.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"7694516"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Opuntiol Prevents Photoaging of Mouse Skin <i>via</i> Blocking Inflammatory Responses and Collagen Degradation.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/2024/9806462","DOIUrl":"https://doi.org/10.1155/2024/9806462","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"9806462"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Modulatory Effect of an Ethanolic Extract of <i>Anredera cordifolia</i> (Ten.) on the Proliferation and Migration of Hyperglycemic Fibroblasts in an <i>In Vitro</i> Diabetic Wound Model.","authors":"Elisa Vanessa Heisler, Bárbara Osmarim Turra, Nathália Cardoso de Afonso Bonotto, Ivana Beatrice Mânica da Cruz, Marco Aurélio Echart Montano, Verônica Farina Azzolin, Jacir Dal Magro, Felipe Zaniol, Juliano Perottoni, Maria Eduarda Chelotti, Fernanda Dos Santos Trombini, Ednea A Maia-Ribeiro, Fernanda Barbisan, Maria Denise Schimith","doi":"10.1155/2024/2812290","DOIUrl":"https://doi.org/10.1155/2024/2812290","url":null,"abstract":"<p><p>Diabetes mellitus is associated with chronic wound-healing problems that significantly impact patients' quality of life and substantially increase expenditure on healthcare. Therefore, the identification of compounds that can aid healing is justified. <i>Anredera cordifolia</i> (Ten.) has been used in folk medicine for curative purposes; however, the causal mechanisms underlying its healing effects remain to be elucidated. In this study, the effect of the ethanolic extract of <i>A. cordifolia</i> was evaluated in an <i>in vitro</i> healing model using fibroblasts cultivated under normoglycemic and hyperglycemic environments. The extract was predominantly composed of phytol and exhibited genoprotective activity. Fibroblast migration attenuated the adverse effects of hyperglycemia, favoring cell proliferation. Collagen levels were significantly increased in ruptured fibroblasts under both standard and hyperglycemic environments. The phytogenomic effect of the extract on three genes related to extracellular matrix formation, maintenance, and degradation showed that <i>A. cordifolia</i> increased the expression of genes related to matrix synthesis and maintenance in both normoglycemic and hyperglycemic individuals. Furthermore, it reduced the expression of genes related to matrix degradation. Overall, this is the first study to demonstrate the effectiveness of <i>A. cordifolia</i> in wound healing, elucidating possible causal mechanisms that appear to be based on the genoprotective effect of this plant on the migratory and proliferative phases of the wound healing process; these effects are probably related to phytol, its main constituent.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"2812290"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combined Effect of Green Tea, Saffron, Resveratrol, and Citicoline against Neurodegeneration Induced by Oxidative Stress in an <i>In Vitro</i> Model of Cognitive Decline.","authors":"Simone Mulè, Sara Ferrari, Giorgia Rosso, Rebecca Galla, Stefania Battaglia, Valeria Curti, Claudio Molinari, Francesca Uberti","doi":"10.1155/2024/7465045","DOIUrl":"https://doi.org/10.1155/2024/7465045","url":null,"abstract":"<p><p>During ageing, the brain is vulnerable to a growing imbalance of the antioxidant defence system, resulting in increased oxidative stress. This condition may be mainly responsible for cognitive decline, resulting in synaptic transmission disruptions and the onset of neuronal dysfunction. In this context, developing efficient preventive and therapeutic strategies against increased oxidative stress and decreased antioxidant defence mechanisms should be considered a public health priority to promote healthy ageing. Therefore, the current study explored the benefits of a novel combination of green tea, saffron, trans-Reveratrol, and citicoline, called MIX, on improving intracellular processes to ameliorate the mechanisms linked to cognitive decline under oxidative stress conditions. First, the ability of MIX to cross the blood-brain barrier (BBB) was evaluated in an <i>in vitro</i> model, analysing TEER value and the specific tight junctions; second, the CCF-STTG1 cell line was pretreated with 200 <i>µ</i>M H₂O₂ for 30 min to explore the effects of the single active compounds and their combination under oxidative stress conditions. Our results demonstrated for the first time the synergistic effects of the new combination to improve the absorption rate of individual agents through the BBB and maintain its integrity. Subsequently, further research was done to assess the positive role of the combination to counteract oxidative damage; as expected, MIX restored the neurodegenerative state activated by 200 <i>µ</i>M H₂O₂, reducing mitochondrial damage, and improving survival pathways. Additionally, MIX acted as a regulator of both cellular energy metabolism and apoptosis, reducing the inflammatory state activated by oxidative stress. Finally, MIX can balance neurotrophin production to prevent mitochondrial disruption. In conclusion, MIX counteracted the adverse effects of brain oxidative stress, suggesting that this new proposed formulation prevents the molecular mechanisms underlying the onset of cognitive decline, even in support of conventional therapy.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"7465045"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Silymarin on Calcium Chloride-Induced Arrhythmia in Male Rat.","authors":"Fereshteh Toghroli, Mohammad Foad Noorbakhsh, Javad Sajedianfard","doi":"10.1155/2024/6720138","DOIUrl":"10.1155/2024/6720138","url":null,"abstract":"<p><p>Antioxidants play an important role in protecting cardiac arrhythmias. Silymarin, strong antioxidant, is effective in reducing the complications caused by arrhythmias. This study was conducted to determine the effect of silymarin on the prevention and treatment of calcium chloride-induced arrhythmia. In total, 48 male rats were randomly divided into six groups: the first control group for acute administration received intravenous injection of 0.2 mL of dimethylsulfoxide, a cosolvent, immediately after induction of arrhythmia; the second control group for chronic administration, daily gavage of dimethylsulfoxide for 2 weeks before induction of arrhythmia; acute silymarin group, 100 mg/kg intravenous, immediately after the occurrence of arrhythmia; chronic silymarin group, daily gavage of 50 mg/kg for 2 weeks before induction of arrhythmia; amiodarone standard treatment, 5 mg/kg intravenous, immediately after induction of arrhythmia; and quinidine standard treatment, 10 mg/kg intravenous, immediately after induction of arrhythmia. Calcium chloride (140 mg/kg, i.v.) was used to induce arrhythmia. Electrocardiogram was recorded and monitored by PowerLab™ system. The incidence rates of premature ventricular beat (PVB), ventricular tachycardia (VT), and ventricular fibrillation (VF) were calculated. The antiarrhythmic effect of silymarin was observed with a significant decrease in the incidence of premature ventricular beat (22.56 ± 1.04%, <i>P</i> < 0.001), ventricular tachycardia (34.150 ± 1.59%, <i>P</i> < 0.001), and ventricular fibrillation (24.31 ± 1.02%, <i>P</i> < 0.001) compared with the control group (100%). These effects were comparable to antiarrhythmic drugs such as quinidine (29.23% ± 1.24%, 52.23% ± 1.13%, 66.31% ± 1.81%) and amiodarone (22.91% ± .72%, 41.09% ± 1.66%, 61.59% ± 1.11%). Silymarin exerts a potent antioxidant effect, thereby mitigating the risk of VT, VF, and PVC.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"6720138"},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effects of Trimetazidine against Cisplatin-Induced Peripheral Neuropathy: Involvement of AMPK-Mediated PI3K/mTOR, Nrf2, and NF-<i>κ</i>B Signaling Axes.","authors":"Marawan A Elbaset, Sherif M Afifi, Tuba Esatbeyoglu, Sahar S Abdelrahman, Dalia O Saleh","doi":"10.1155/2024/6612009","DOIUrl":"10.1155/2024/6612009","url":null,"abstract":"<p><p>Cisplatin-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cisplatin chemotherapy used in cancer treatment. This study explored the neuroprotective effects of Trimetazidine (TRI) against CIPN by preserving nerve integrity, reducing neuro-oxidative stress, and alleviating neuroinflammation. Using a rat model of CIPN, we evaluated TRI's impact on motor coordination, pain sensitivity, and peripheral nerve histopathology. Also, its effects on neuro-oxidative stress and neuroinflammatory markers were assessed. The findings showed that rats with CIPN had worse motor coordination and increased sensitivity to pain but that these symptoms were alleviated by TRI therapy in a dose-dependent way. Nerve conduction velocities were normalized, and expression of genes involved in neuropathy signaling was suppressed after TRI therapy. Antioxidant benefits were also shown in TRI, with oxidative damage being reduced and the cellular energy balance being restored. By inhibiting the production of inflammatory markers, it also demonstrated anti-inflammatory properties. Histopathological examination revealed that TRI, especially when administered at a higher dose, inhibited the degeneration and demyelination of nerve fibers. The anti-inflammatory properties of TRI in the sciatic nerves were further shown by the fact that its administration reduced iNOS expression. In conclusion, AMPK-mediated PI3K/mTOR, Nrf2, and NF-<i>κ</i>B signaling pathways may all be involved in the therapeutic benefits of TRI for CIPN. These results indicate that TRI may be useful for reducing the side effects of CIPN and enhancing patient outcomes during cisplatin chemotherapy.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"6612009"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of <i>Nigella sativa</i> Oil and Whole Seeds on STZ-Induced Diabetic Rats: A Biochemical and Immunohistochemical Study.","authors":"Naif AlSuhaymi","doi":"10.1155/2024/5594090","DOIUrl":"10.1155/2024/5594090","url":null,"abstract":"<p><strong>Background: </strong>Type II diabetes mellitus (DM) is an increasing health problem that has negative impacts on patients and healthcare systems, worldwide. The development of new therapies with better efficacy, fewer side effects, and lower prices are urgently needed to treat this disease.</p><p><strong>Aim: </strong>To evaluate and compare the therapeutic effects of <i>Nigella sativa</i> (<i>N. sativa</i>) seed and oil on the biochemical parameters and regeneration of pancreatic islets (or islets of Langerhans) of streptozotocin (STZ)-induced diabetic rats.</p><p><strong>Materials and methods: </strong>The diabetic rat model was prepared by administering a single dose of STZ (35 mg/kg body weight). The whole seed or the oil of <i>N. sativa</i> was administered to the diabetic and control groups for a period of 28 days, but not to the negative and STZ controls. Serum blood glucose, liver enzymes, lipid profile, and renal function tests (uric acid, albumin, total protein, urea, and creatinine) were measured in all groups. After the rats were euthanized, their pancreases were extracted, and then sectioned and fixed on slides in preparation before staining with H&E stain and immunohistochemical study.</p><p><strong>Results: </strong>Treatment of STZ-diabetic rats with <i>N. sativa</i> seeds or oil significantly improved their serum glucose levels, lipid profiles, and liver and renal functions as well as preserved the integrity of pancreatic <i>β</i> cells.</p><p><strong>Conclusion: </strong><i>N. sativa</i> seeds and oil demonstrate significant therapeutic improvement effects on DM and its related complications including effective protection of islets of Langerhans. The therapeutic benefits of <i>N. sativa</i> seeds and oil on DM and its related complications are comparable.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"5594090"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin Increases Growth Performance and Decreases Incidence of Diarrhea and Mechanism of Action in Weaned Piglets.","authors":"Yanjun Mao, Qinglin Yang, Junhong Liu, Yuxin Fu, Shuaishuai Zhou, Jiayan Liu, Linlin Ying, Yao Li","doi":"10.1155/2024/5632260","DOIUrl":"10.1155/2024/5632260","url":null,"abstract":"<p><p>This study aimed to investigate the mechanism of quercetin increasing growth performance and decreasing incidence of diarrhea in weaned piglets. Forty-eight Duroc × Landrace × Large White weaned piglets with similar body weight (7.48 ± 0.20 kg, 28 days of age) were randomly divided into four treatments (control, 250 mg/kg quercetin, 500 mg/kg quercetin, and 750 mg/kg quercetin treatments) and fed with basal diet or experimental diet supplemented with quercetin. Performance, diarrhea rate and index, and content of serum anti-inflammatory factors were determined and calculated in weaned piglets; colonic flora and signaling pathways related to anti-inflammation were measured using 16S rDNA sequencing and RNA-seq, respectively. The results showed that compared with control, feed-to-gain ratio and content of serum interferon gamma (IFN-<i>γ</i>) were significantly decreased in the 500 and 750 mg/kg quercetin treatments (<i>P</i> < 0.05); quercetin significantly decreased diarrhea rate and diarrhea index (<i>P</i> < 0.05) and significantly increased the content of serum transforming growth factor (TGF-<i>β</i>) in weaned piglets (<i>P</i> < 0.05); the content of serum NF-<i>κ</i>B was significantly decreased in the 750 mg/kg quercetin treatment (<i>P</i> < 0.05); moreover, quercetin significantly increased diversity of colonic flora (<i>P</i> < 0.05), and at the phylum level, the relative abundance of Actinobacteria in the 500 and 750 mg/kg treatments was significantly increased (<i>P</i> < 0.05), and the relative abundance of Proteobacteria in the three quercetin treatments were significantly decreased (<i>P</i> < 0.05) in the colon of weaned piglets; at the genus level, the relative abundance of <i>Clostridium-sensu-stricto-1</i>, <i>Turicibacter</i>, <i>unclassified_f_Lachnospiraceae</i>, <i>Phascolarctobacterium</i>, and <i>Family_XIII _AD3011_group</i> was significantly increased (<i>P</i> < 0.05); the relative abundance of <i>Subdollgranulum</i> and <i>Blautia</i> was significantly decreased in the 500 and 750 mg/kg treatments (<i>P</i> < 0.05); the relative abundance of <i>Eschericha-Shigella</i>, <i>Terrisporobacter</i>, and <i>Eubacterium-coprostanoligenes</i> was significantly increased (<i>P</i> < 0.05); the relative abundance of <i>Streptocococcus</i>, <i>Sarcina</i>, <i>Staphylococcus</i>, and <i>Ruminococcaceae_UCG-008</i> was significantly decreased in the three quercetin treatments (<i>P</i> < 0.05); the relative abundance of <i>Ruminococcaceae_UCG_014</i> was significantly increased in the 250 mg/kg quercetin treatment in the colon of weaned piglets (<i>P</i> < 0.05). The results of Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that differentially expressed genes (DEGs) from the quercetin treatments were significantly enriched in nuclear transcription factor-<i>κ</i>B (NF-<i>κ</i>B) signal pathway (<i>P</i> < 0.05); mRNA expression of tumor necrosis factor-<i>α</i> (TNF-<i>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"5632260"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke.","authors":"Zhanylsyn U Urasheva, Gulnar B Kabdrakhmanova, Aigul P Yermagambetova, Aigerim B Utegenova, Nazgul A Seitmaganbetova, Ondassyn M Aliyev, Saulesh S Kurmangaliyeva, Nazym K Kenzhina, Yergen Z Kurmambayev, Alima A Khamidulla","doi":"10.1155/2024/2121733","DOIUrl":"10.1155/2024/2121733","url":null,"abstract":"<p><p>Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000-2023, shedding light on the global scientific contributions, collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significant contributors, underscoring their prominence in advancing our understanding of tight junction proteins. Occludin, identified as a linchpin in regulating BBB integrity, proves to be a pivotal player, with implications extending to the diagnosis of hemorrhagic transformation in ischemic stroke. This study identifies occludin as a potential biomarker, offering promise for early diagnosis and paving the way for novel diagnostic strategies. The analysis highlights the necessity for a more comprehensive exploration of tight junction proteins, including occludin and claudin-5, particularly in the context of acute cerebral ischemia. The unique healthcare landscape in Kazakhstan adds urgency to the call for further scientific research in this region, emphasizing the need for tailored investigations to address specific regional challenges. This comprehensive overview not only delineates the current state of occludin research but also signals the direction for future investigations. The identified knowledge gaps and emerging trends provide a roadmap for researchers and policymakers alike, with implications for both scientific discourse and clinical practice. Moving forward, a deeper understanding of tight junction proteins, informed by the insights gleaned from this study, holds the potential to shape targeted therapeutic interventions and diagnostic strategies, ultimately contributing to advancements in global stroke care.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"2121733"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}