Oxidative Medicine and Cellular Longevity最新文献

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The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High-Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2.
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.1155/omcl/8251896
Amin Mehrabi, Reza Nuori, Abbasali Gaeini, Maryam Amirazodi, Mohammad Mehrtash, Mohsen Abedini Esfahlani, Mina Bahrami, Mohammad Abbas Bejeshk, Mohammad Amin Rajizadeh
{"title":"The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High-Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2.","authors":"Amin Mehrabi, Reza Nuori, Abbasali Gaeini, Maryam Amirazodi, Mohammad Mehrtash, Mohsen Abedini Esfahlani, Mina Bahrami, Mohammad Abbas Bejeshk, Mohammad Amin Rajizadeh","doi":"10.1155/omcl/8251896","DOIUrl":"10.1155/omcl/8251896","url":null,"abstract":"<p><p><b>Introduction:</b> High-intensity interval training (HIIT) is a form of interval exercise that enhances capacity and benefits well-being. Resveratrol is a naturally occurring polyphenol prevalent in grapes and red wine, demonstrating significant health effects on the body. This study sought to evaluate the synergistic effects of swimming HIIT and resveratrol intake on the expression of SIRTs 4, SIRTs 5, and superoxide dismutases (SOD1 and SOD2) in the frontal lobe of elderly rats. <b>Materials and Methods:</b> Forty-five male Wistar rats, aged 22 months, were categorized into five groups: the control group (CTL), the swimming HIIT group (Ex: Exercise), the swimming HIIT with resveratrol group (R + Ex), the resveratrol group (R), and the solvent control group (vehicle). The R + Ex group engaged in high-intensity interval swimming and ingested resveratrol (10 mg/kg/day via gavage) for 6 weeks. During the initial and final sessions of each week, blood samples from the rats in the Ex and R + Ex groups were collected for lactate analysis. The proteins SIRTs 4 and 5, as well as SODs 1 and 2, were quantified using the western blot approach. <b>Results:</b> Integrating HIIT with resveratrol markedly enhanced the expression of SIRT4, SIRT5, and antioxidant enzymes in the frontal lobe of elderly rats. <b>Conclusion:</b> Resveratrol and HIIT, particularly their synergistic effects, provide antioxidant and antiaging benefits on the frontal lobe of aged rats.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2025 ","pages":"8251896"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prothrombotic State and Vascular Damage in Angiotensin II-Induced Hypertension: Influence of Waterpipe Smoke Exposure.
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.1155/omcl/2670738
Sumaya Beegam, Suhail Al-Salam, Nur Elena Zaaba, Ozaz Elzaki, Abderrahim Nemmar
{"title":"Prothrombotic State and Vascular Damage in Angiotensin II-Induced Hypertension: Influence of Waterpipe Smoke Exposure.","authors":"Sumaya Beegam, Suhail Al-Salam, Nur Elena Zaaba, Ozaz Elzaki, Abderrahim Nemmar","doi":"10.1155/omcl/2670738","DOIUrl":"10.1155/omcl/2670738","url":null,"abstract":"<p><p>Hypertension is a risk factor for vascular injury and thrombotic complications, and smoking tobacco is a risk factor for the development and exacerbation of hypertension. The influence of waterpipe smoke (WPS) on coagulation and vascular injury in hypertension is not fully understood. Here, we evaluated the effects of WPS in mice made hypertensive (HT) by infusing angiotensin II (Ang II) for 42 days. On day 14 of the infusion of Ang II or vehicle (normotensive; NT), mice were exposed either to air or WPS for four consecutive weeks. Each session was 30 min/day for 5 days/week. The concentrations of tissue factor, von Willebrand factor, fibrinogen, and plasminogen activator inhibitor-1 were elevated in the HT + WPS group versus either HT + air or NT + WPS groups. Similarly, in the HT + WPS group, thrombogenicity was increased both in vivo and in vitro, compared with either HT + air or NT + WPS groups. In aortic tissue, adhesion molecules including P-selectin, E-selectin, intercellular adhesion molecule-1, and vascular adhesion molecule-1 were increased in the HT + WPS group versus the controls. Likewise, various proinflammatory cytokines and markers of oxidative stress augmented in the HT + WPS group compared with either HT + air or NT + WPS. DNA damage, cleaved caspase-3, and cytochrome C were increased in the HT + WPS group versus the controls. The immunohistochemical expression of nuclear factor erythroid 2-related factor 2 was increased in the HT + WPS group versus either HT + air or NT + WPS. Taken together, our findings show that WPS exposure intensified thrombogenicity and vascular damage in experimentally induced hypertension. Our data suggest that vascular toxicity of WPS may be exaggerated in hypertensive patients.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2025 ","pages":"2670738"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise Stress Testing Enhances Plasma Protein Carbonyl Levels in Patients With Asymptomatic Moderate-to-Severe Aortic Stenosis. 运动应激试验提高无症状中重度主动脉瓣狭窄患者血浆蛋白羰基水平
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1155/omcl/4852300
Magdalena Kopytek, Renata Kolasa-Trela, Krzysztof Piotr Malinowski, Michał Ząbczyk, Joanna Natorska, Anetta Undas
{"title":"Exercise Stress Testing Enhances Plasma Protein Carbonyl Levels in Patients With Asymptomatic Moderate-to-Severe Aortic Stenosis.","authors":"Magdalena Kopytek, Renata Kolasa-Trela, Krzysztof Piotr Malinowski, Michał Ząbczyk, Joanna Natorska, Anetta Undas","doi":"10.1155/omcl/4852300","DOIUrl":"10.1155/omcl/4852300","url":null,"abstract":"<p><p><b>Background:</b> Exercise stress test-induced hypofibrinolysis and changes in circulating levels of several interleukins have been observed in aortic stenosis (AS). However, it is unknown whether the pattern of exercise-induced changes in oxidative stress differs between AS patients and controls and if the differences are associated with changes in fibrinolysis and inflammation. <b>Methods:</b> We studied 32 asymptomatic patients with moderate-to-severe AS and 32 controls of similar age, sex, and body mass index. We assessed plasma protein carbonyl (PC) concentrations, a marker of oxidative stress, in relation to interleukin (IL)-10 and -6 levels and fibrinolysis capacity, expressed as plasma clot lysis time (CLT) at four time points: at baseline, at peak exercise, 1 and 24 h after a symptom-limited exercise test. <b>Results:</b> AS patients had 12.8% and 27% higher PC concentrations 1 and 24 h after exercise than controls (both <i>p</i>  < 0.05), with no differences at baseline and peak exercise. In AS patients, PC concentration was 8.3% higher at peak exercise compared to baseline followed by further PC increase (+12.8% at 1 h and +20.5% at 24 h) compared to peak exercise (all <i>p</i>  < 0.05). In controls, PC concentrations increased during exercise, reaching the highest values 1 h after exercise (+21.9%). In the AS group, PC concentrations at baseline correlated with AS severity measured as peak transvalvular velocity (<i>V</i> <sub>max</sub>: <i>r</i> = 0.49, <i>p</i>  < 0.05), mean (PG<sub>mean</sub>: <i>r</i> = 0.42, <i>p</i>  < 0.05), and maximal transvalvular pressure gradients (PG<sub>max</sub>: <i>r</i> = 0.41, <i>p</i>  < 0.05). PC concentrations correlated with IL-10 levels 1 h (<i>r</i> = 0.37, <i>p</i>  < 0.05) and 24 h (<i>r</i> = 0.38, <i>p</i>  < 0.05) post exercise in AS patients, whereas in controls only at baseline (<i>r</i> = 0.42, <i>p</i>  < 0.05). No associations between PC levels and IL-6 or CLT were observed at any time point. <b>Conclusions:</b> Our findings show that AS patients respond differently to exercise in terms of PC compared to controls, which suggests a novel effect of hemodynamic abnormalities in this disease on intensity of oxidative stress.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"4852300"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Overview of the Biological Complexity of Vitiligo. 白癜风的生物学复杂性综述。
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI: 10.1155/omcl/3193670
Paola Matarrese, Rossella Puglisi, Gianfranco Mattia, Tonia Samela, Damiano Abeni, Walter Malorni
{"title":"An Overview of the Biological Complexity of Vitiligo.","authors":"Paola Matarrese, Rossella Puglisi, Gianfranco Mattia, Tonia Samela, Damiano Abeni, Walter Malorni","doi":"10.1155/omcl/3193670","DOIUrl":"10.1155/omcl/3193670","url":null,"abstract":"<p><p>Vitiligo is a skin disease that affects all ethnicities and genders and is characterized by the loss of pigment essentially due to the selective loss of melanocytes. Although it is generally considered a systemic disease associated with polymorphisms in genes involved in the immune response, vitiligo is also considered an oxidative imbalance-associated disease. It represents a multifactorial pathology in which some genetic predisposition and epigenetic factors coupled with some critical biochemical and molecular pathways could play a pivotal role. The aim of this work was thus to review some of the fine cellular mechanisms involved in the etiopathogenesis of vitiligo, mainly focusing on the nonimmunological ones, extensively highlighted elsewhere. We took into consideration, in addition to oxidative stress, both the cause and the hallmark of the pathology, some less investigated aspects such as the role of epigenetic factors, e.g., microRNAs, of receptors of catecholamines, and the more recently recognized role of the mitochondria. Sex differences associated with vitiligo have also been investigated starting from sex hormones and the receptors through which they exert their influence. From literature analysis, a picture seems to emerge in which vitiligo can be considered not just a melanocyte-affecting disease but a systemic pathology that compromises the homeostasis of a complex tissue such as the skin, in which different cell types reside playing multifaceted physiological roles for the entire organism. The exact sequence of cellular and subcellular events associated with vitiligo is still a matter of debate. However, the knowledge of the individual biological factors implicated in vitiligo could help physicians to highlight useful innovative markers of progression and provide, in the long run, new targets for more tailored treatments based on individual manifestations of the disease.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"3193670"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial-Mesenchymal Transition Induced by a Metal Mixture in Liver Cells With Antioxidant Barrier Decreased. 金属混合物诱导具有抗氧化屏障的肝细胞上皮-间质转化降低。
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI: 10.1155/omcl/6983256
M Valverde, P Rosales-Cruz, E Torrejon-Gonzalez, A Ponce-Ortiz, M A Rodriguez-Sastre, E Rojas
{"title":"Epithelial-Mesenchymal Transition Induced by a Metal Mixture in Liver Cells With Antioxidant Barrier Decreased.","authors":"M Valverde, P Rosales-Cruz, E Torrejon-Gonzalez, A Ponce-Ortiz, M A Rodriguez-Sastre, E Rojas","doi":"10.1155/omcl/6983256","DOIUrl":"10.1155/omcl/6983256","url":null,"abstract":"<p><p>Occupational exposure to arsenic (As), cadmium (Cd), and lead (Pb) affects many sectors, necessitating research to understand their transformation mechanisms. In this study, we characterized the process of epithelial-mesenchymal transition (EMT) in a rat hepatic epithelial cell line with decreased expression of catalase and glutamate cysteine ligase catalytic (GCLC) subunit that was exposed to a mixture of As, Cd, and Pb at equimolar occupational exposure concentrations. We evaluated the expression of genes and proteins involved in EMT. Our findings revealed that cells with a decreased antioxidant barrier showed a decreased expression and abundance of epithelial genes when exposed to a mixture of metals. Additionally, we observed alterations in the expression of transcription factors (TFs) associated with EMT and an increase in the expression and abundance of mesenchymal genes. Specifically, we found that E-cadherin expression decreased by ~50% at both the gene and protein levels. In contrast, the expression of <i>vimentin</i>, <i>α-smooth muscle actin</i>, and <i>N-cadherin</i> genes increased by ~70%, whereas their corresponding protein levels increased by nearly 100%. Furthermore, the TFs zinc finger e-box binding homeobox 1 and snail family transcriptional repressor 1 showed a 30% increase in gene expression and an ~80% increase in protein expression. These changes enable the cells to acquire migratory capabilities. Our results confirmed that exposure to this mixture of As, Cd, and Pb can induce EMT in cells with a decreased antioxidant barrier.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"6983256"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative Stress and Cancer Risk in Schistosomiasis. 血吸虫病的氧化应激与癌症风险。
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-12-17 eCollection Date: 2024-01-01 DOI: 10.1155/omcl/9701021
Justice Afrifa, Eric Gyamerah Ofori, Yeboah Kwaku Opoku, Kwame Kumi Asare, Rosemary Doe Sorkpor, Ibrahim W Naveh-Fio, Richard Armah, Sandra Ofori, Richard K D Ephraim
{"title":"Oxidative Stress and Cancer Risk in Schistosomiasis.","authors":"Justice Afrifa, Eric Gyamerah Ofori, Yeboah Kwaku Opoku, Kwame Kumi Asare, Rosemary Doe Sorkpor, Ibrahim W Naveh-Fio, Richard Armah, Sandra Ofori, Richard K D Ephraim","doi":"10.1155/omcl/9701021","DOIUrl":"10.1155/omcl/9701021","url":null,"abstract":"<p><p><b>Background:</b> Schistosomiasis is considered one of the most devastating parasitic diseases globally, coming second only to malaria in terms of morbidity. The disease-causing parasite can inhabit the body for over a decade, leading to imbalances in the host's metabolic systems. The flukes and their eggs can illicit various immunological and metabolic complications resulting in the generation of reactive oxygen species (ROS). These are known to have several devastating effects on the host through increased oxidative stress, DNA mutation, and gene modifications, which can lead to fibrosis and cancer. <b>Main Body:</b> Here, we discuss oxidative stress and cancer risk in Schistosoma infection. The concept of ROS generation and the complex antioxidant systems that enable the parasite to evade oxidant insults and prolong its life span in the host are explored. Further, the various roles of ROS during the initiation and progression of schistosomiasis and its influence on the host are discussed. Finally, mechanisms linked to the risk of bladder cancer in <i>Schistosoma haematobium</i> (<i>S. haematobium</i>) infections are elucidated. <b>Conclusion:</b> Finally, we provide an opinion on how some of these mechanisms could give directions for future studies as well as provide a springboard for diagnostics and drug targeting in schistosomiasis.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"9701021"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coadministration of Monophosphoryl Lipid and Curcumin Modulates Neuroprotective Effects in LPS Stimulated Rat Primary Microglial Cells. 单磷脂酰脂和姜黄素共同给药调节LPS刺激大鼠初级小胶质细胞的神经保护作用。
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.1155/omcl/9422312
Maryam Hooshmand, Ahmad Asoodeh
{"title":"Coadministration of Monophosphoryl Lipid and Curcumin Modulates Neuroprotective Effects in LPS Stimulated Rat Primary Microglial Cells.","authors":"Maryam Hooshmand, Ahmad Asoodeh","doi":"10.1155/omcl/9422312","DOIUrl":"10.1155/omcl/9422312","url":null,"abstract":"<p><p>Lipopolysaccharide (LPS)-induced activation of microglia triggers the release of neuroinflammatory molecules, contributing to the progression of neurodegenerative diseases. Targeting these neuroinflammatory molecules could serve as a potential therapeutic strategy. Given the evidence supporting the immune-boosting properties of curcumin (Curc) and the protective effects of monophosphoryl lipid A (MPL) in the central nervous system (CNS) related to Alzheimer's disease (AD), this study aimed to assess the anti-inflammatory effects of these compounds on primary rat microglial cells, which are crucial in the response to neuroinflammation. This in vitro study investigated the effects of Curc, MPL, and their coadministration (Curc + MPL) on inflammatory cytokine levels in activated microglial cells. Primary microglial cells were isolated from 1-day-old rats and treated with various concentrations of Curc, MPL, and Curc + MPL prior to LPS stimulation. Cell viability was assessed using the MTT assay, followed by the Griess assay to evaluate nitric oxide (NO) production. The levels of inflammatory cytokines interleukin-1<i>β</i> (IL-1<i>β</i>), tumor necrosis factor-alpha (TNF-<i>α</i>), and interleukin-6 (IL-6), as well as the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), were analyzed via real-time PCR. Additionally, enzyme-linked immunosorbent assay (ELISA) was employed to quantify the protein levels of IL-1<i>β</i>, TNF-<i>α</i>, and IL-6. Our findings demonstrate that Curc and MPL possess antineuroinflammatory properties in LPS-stimulated microglial cells. Notably, the coadministration of Curc and MPL (Curc + MPL) significantly inhibited the production of pro-inflammatory cytokines IL-1<i>β</i>, TNF-<i>α</i>, and IL-6. Furthermore, Curc + MPL suppressed the expression of iNOS and COX-2. These results strongly suggest that Curc + MPL is a promising neuroprotective agent for the treatment of neurodegenerative disorders by mitigating neuroinflammatory responses.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"9422312"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on the Neuroprotective Effect of Moringa oleifera. 辣木的神经保护作用综述
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7694516
Beniam Worku, Nafyad Tolossa
{"title":"A Review on the Neuroprotective Effect of <i>Moringa oleifera</i>.","authors":"Beniam Worku, Nafyad Tolossa","doi":"10.1155/2024/7694516","DOIUrl":"10.1155/2024/7694516","url":null,"abstract":"<p><p><i>Moringa oleifera</i>, which is known as a drumstick tree in different areas of the world, is well-known for many health benefits, which are attributed to the abundance of flavonoids, phenolic chemicals, and thiocyanates it contains. This review focuses on <i>M. oleifera</i>'s potential for neuroprotection, emphasizing its anti-inflammatory, antioxidant, and neurotransmitter-modulating qualities. Different parts of <i>M. oleifera</i> include leaves, roots, bark, and gum. Flowers, seeds, and seed oil are used for many health purposes, most notably in the treatment of neurological diseases. Neurodegeneration, which is characterized by the progressive death of nerve cells, is a major concern with an aging population, leading to disorders such as dementia and movement disorders. <i>M. oleifera</i> bioactive compounds improve the antioxidant defense activities of the brain, reduce inflammation, and improve neurotransmitter levels, showing potential therapeutic applications for neurodegenerative disorders. This review emphasizes the importance of further research, especially clinical trials, to fully understand and utilize <i>M. oleifera</i>'s neuroprotective capabilities.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"7694516"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXPRESSION OF CONCERN: Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. 表达关切:Opuntiol 通过阻止炎症反应和胶原降解防止小鼠皮肤光老化。
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9806462
Oxidative Medicine And Cellular Longevity
{"title":"EXPRESSION OF CONCERN: Opuntiol Prevents Photoaging of Mouse Skin <i>via</i> Blocking Inflammatory Responses and Collagen Degradation.","authors":"Oxidative Medicine And Cellular Longevity","doi":"10.1155/2024/9806462","DOIUrl":"https://doi.org/10.1155/2024/9806462","url":null,"abstract":"","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"9806462"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Modulatory Effect of an Ethanolic Extract of Anredera cordifolia (Ten.) on the Proliferation and Migration of Hyperglycemic Fibroblasts in an In Vitro Diabetic Wound Model. Anredera cordifolia(Ten.)乙醇提取物对体外糖尿病伤口模型中高血糖成纤维细胞增殖和迁移的调节作用。
2区 生物学
Oxidative Medicine and Cellular Longevity Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2812290
Elisa Vanessa Heisler, Bárbara Osmarim Turra, Nathália Cardoso de Afonso Bonotto, Ivana Beatrice Mânica da Cruz, Marco Aurélio Echart Montano, Verônica Farina Azzolin, Jacir Dal Magro, Felipe Zaniol, Juliano Perottoni, Maria Eduarda Chelotti, Fernanda Dos Santos Trombini, Ednea A Maia-Ribeiro, Fernanda Barbisan, Maria Denise Schimith
{"title":"The Modulatory Effect of an Ethanolic Extract of <i>Anredera cordifolia</i> (Ten.) on the Proliferation and Migration of Hyperglycemic Fibroblasts in an <i>In Vitro</i> Diabetic Wound Model.","authors":"Elisa Vanessa Heisler, Bárbara Osmarim Turra, Nathália Cardoso de Afonso Bonotto, Ivana Beatrice Mânica da Cruz, Marco Aurélio Echart Montano, Verônica Farina Azzolin, Jacir Dal Magro, Felipe Zaniol, Juliano Perottoni, Maria Eduarda Chelotti, Fernanda Dos Santos Trombini, Ednea A Maia-Ribeiro, Fernanda Barbisan, Maria Denise Schimith","doi":"10.1155/2024/2812290","DOIUrl":"https://doi.org/10.1155/2024/2812290","url":null,"abstract":"<p><p>Diabetes mellitus is associated with chronic wound-healing problems that significantly impact patients' quality of life and substantially increase expenditure on healthcare. Therefore, the identification of compounds that can aid healing is justified. <i>Anredera cordifolia</i> (Ten.) has been used in folk medicine for curative purposes; however, the causal mechanisms underlying its healing effects remain to be elucidated. In this study, the effect of the ethanolic extract of <i>A. cordifolia</i> was evaluated in an <i>in vitro</i> healing model using fibroblasts cultivated under normoglycemic and hyperglycemic environments. The extract was predominantly composed of phytol and exhibited genoprotective activity. Fibroblast migration attenuated the adverse effects of hyperglycemia, favoring cell proliferation. Collagen levels were significantly increased in ruptured fibroblasts under both standard and hyperglycemic environments. The phytogenomic effect of the extract on three genes related to extracellular matrix formation, maintenance, and degradation showed that <i>A. cordifolia</i> increased the expression of genes related to matrix synthesis and maintenance in both normoglycemic and hyperglycemic individuals. Furthermore, it reduced the expression of genes related to matrix degradation. Overall, this is the first study to demonstrate the effectiveness of <i>A. cordifolia</i> in wound healing, elucidating possible causal mechanisms that appear to be based on the genoprotective effect of this plant on the migratory and proliferative phases of the wound healing process; these effects are probably related to phytol, its main constituent.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"2024 ","pages":"2812290"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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