Open Life Sciences最新文献_第8页

A de novo meningioma with rapid growth: A possible malignancy imposter? 新生快速生长的脑膜瘤：可能是恶性肿瘤的骗子？

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1118

Zhenjiang Pan, Jing Bao, Shepeng Wei

{"title":"A de novo meningioma with rapid growth: A possible malignancy imposter?","authors":"Zhenjiang Pan, Jing Bao, Shepeng Wei","doi":"10.1515/biol-2025-1118","DOIUrl":"10.1515/biol-2025-1118","url":null,"abstract":"Meningiomas, accounting for approximately 33% of primary central nervous system tumors, are the most prevalent type in this category. Advanced age is frequently viewed as a barrier to surgical intervention, yet recent cases have challenged this perception by demonstrating successful outcomes in elderly patients. This case report aims to illustrate the feasibility and benefits of surgical treatment in older individuals. An 84-year-old patient presented with a newly diagnosed meningioma and underwent surgical tumor removal at age 88. Following a comprehensive preoperative evaluation that excluded significant comorbidities, the procedure utilized advanced surgical techniques and optimized postoperative care to ensure safety and recovery. Pathology revealed a World Health Organization grade 1 fibrous meningioma, confirming its benign nature. The patient tolerated the surgery well and recovered successfully, marking her as the oldest reported individual to undergo such treatment. This case demonstrates that advanced age does not inherently limit tumor growth or preclude surgical intervention. Through meticulous patient assessment and personalized treatment strategies, elderly patients can achieve positive outcomes. It highlights the value of a tailored approach, prioritizing overall health and specific medical needs, and supports proactive surgical management to enhance quality of life and clinical results. This challenges traditional assumptions about age-related restrictions on surgical feasibility.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251118"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report. 使用下一代测序诊断无症状老年癌症继发结核感染：病例报告。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1123

Jiahuan Huang, Wenbo Ren, Weishang Hu, Jianfang Ni

引用次数: 0

Oncolytic bacteria: A revolutionary approach to cancer therapy. 溶瘤细菌：一种革命性的癌症治疗方法。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-06-10 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1076

Mohsen A Khormi, Saleh M Al-Maaqar, Abdulaziz R Al Johni, Nasser A Al-Tayyar, Jafar Abdullah Alhamad, Abdullah A Ghyathuddin, Zakia Alblawi, Sabreen M Behairy, Mohammed A Alghamdi, Wael A Alsubhi, Mikiyas D Teklemariam

{"title":"Oncolytic bacteria: A revolutionary approach to cancer therapy.","authors":"Mohsen A Khormi, Saleh M Al-Maaqar, Abdulaziz R Al Johni, Nasser A Al-Tayyar, Jafar Abdullah Alhamad, Abdullah A Ghyathuddin, Zakia Alblawi, Sabreen M Behairy, Mohammed A Alghamdi, Wael A Alsubhi, Mikiyas D Teklemariam","doi":"10.1515/biol-2025-1076","DOIUrl":"10.1515/biol-2025-1076","url":null,"abstract":"Cancer is one of the most devastating diseases all over the globe, and it is the second worldwide cause of death, exceeded only by cardiovascular diseases. The therapeutic approach to human cancer has evolved significantly and has varied depending on the type and stage of cancer, as well as the general health status of the patient. Despite the advancements in cancer treatment, various challenges persist in the treatment of cancer, including side effects, drug resistance, and incomplete eradication of tumors. The use of oncolytic bacteria (cancer targeting and destroying bacteria) has been identified to have several advantages over the traditional methods of cancer treatment. Several bacterial species have been identified to be used in the treatment of different types of cancers. Oncolytic therapy can be achieved through the use of a naturally occurring and/or genetically modified bacterial species, including Clostridium, Salmonella, Escherichia coli, and Listeria spp. with their toxins, enzymes, biofilms, and secondary metabolites as well as their spores that leads to direct or indirect killing of cancer cells. This review provides some highlights about the biology and therapeutic potential of oncolytic bacteria individually or in combination with other therapeutic approaches against different types of cancers. Besides, the current challenges and future perspectives will be explored.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251076"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CEBPB promotes ulcerative colitis-associated colorectal cancer by stimulating tumor growth and activating the NF-κB/STAT3 signaling pathway. CEBPB通过刺激肿瘤生长和激活NF-κB/STAT3信号通路促进溃疡性结肠炎相关结直肠癌的发生。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2022-1012

Shan Gao, Wei Wang, Xu-Dong Tong, Dao-Rong Wang, Ai-Xia Tian, Wei Yang, Jin-Min Chen

{"title":"CEBPB promotes ulcerative colitis-associated colorectal cancer by stimulating tumor growth and activating the NF-κB/STAT3 signaling pathway.","authors":"Shan Gao, Wei Wang, Xu-Dong Tong, Dao-Rong Wang, Ai-Xia Tian, Wei Yang, Jin-Min Chen","doi":"10.1515/biol-2022-1012","DOIUrl":"10.1515/biol-2022-1012","url":null,"abstract":"Ulcerative colitis-associated colorectal cancer (UCCRC) represents a significant complication of ulcerative colitis. CEBPB has been shown to promote the invasion of colon cancer cells. In this study, we aimed to investigate the role of CEBPB in the progression of cancers associated with colitis. The wild-type (WT) mice, transfected with a vector expressing CEBPB and siRNA targeting CEBPB, along with their littermate controls, were subjected to a challenge using azoxymethane and dextran sodium sulfate to establish a model of UCCRC. Colon tissues and blood samples were collected for analysis through hematoxylin and eosin staining and enzyme linked immunosorbent assay. Immunohistochemical staining was employed to assess protein expression. In the UCCRC model, mice transfected with vectors expressing CEBPB exhibited a reduction in weight loss and colorectal stenosis, as well as disordered colonic gland structure. Additionally, these mice demonstrated an increased number and size of tumors compared to WT controls. Furthermore, transfection with CEBPB resulted in a decrease in both the quantity and dimensions of tumors. NF-κB was found to enhance the phosphorylation level of STAT3 based on Western blot assay. The activation of NF-κB and STAT3 subsequently promoted the proliferation, invasion, and migration of colon cancer cells by clone formation assays, transwell assays, and scratch-wound assays. Moreover, rescue experiments indicated that CEBPB induced UCCRC through the NF-κB/STAT3 signaling pathway. CEBPB mediated colonic injury in UCCRC mice by activating the NF-κB/STAT3 pathway. This finding reveals a previously unrecognized link between CEBPB and colitis-related tumorigenesis and provides new insight into UCCRC pathogenesis.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20221012"},"PeriodicalIF":1.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on individualized drug sensitivity detection technology based on bio-3D printing technology for precision treatment of gastrointestinal stromal tumors. 基于生物3d打印技术的个体化药敏检测技术在胃肠道间质瘤精准治疗中的研究。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1108

Yang-Yang Tu, Zhong-Ting Huang, Zhi-Yong Zhang, Dong-Liang Liu, Hai-Long Qian

{"title":"Research on individualized drug sensitivity detection technology based on bio-3D printing technology for precision treatment of gastrointestinal stromal tumors.","authors":"Yang-Yang Tu, Zhong-Ting Huang, Zhi-Yong Zhang, Dong-Liang Liu, Hai-Long Qian","doi":"10.1515/biol-2025-1108","DOIUrl":"10.1515/biol-2025-1108","url":null,"abstract":"This study aims to analyze and explore whether tumor biological three-dimensional printing (3DP) models can serve as reliable preclinical model research tools and assist in the personalized treatment of gastrointestinal stromal tumor (GIST) patients. Ten GIST cases admitted to our hospital from May 2024 to September 2024 were included in the personalized treatment group. Patient-derived GIST 3DP models were established, and treatment plans were selected based on the results of drug sensitivity tests. The progression-free survival (PFS) of the personalized treatment group was compared with that of GIST patients who had progressed after first-line treatment and were admitted to our hospital before the study. Treatment safety was also assessed. Immunofluorescence staining technology was used to observe tumor markers in the 3DP tumor models and their corresponding parent tumor tissues, revealing a high degree of consistency, which indicates that the 3DP tumor models highly retain the histological characteristics of the parent tumor tissues. The median PFS of patients in the personalized treatment group was 6.1 months, compared to 5.3 months in the previous treatment group, with a statistically significant difference (P-value <0.05). The individualized drug sensitivity detection technology based on bio-3D printing technology, used for the personalized treatment of GIST patients who have progressed after first-line treatment, can benefit patients.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251108"},"PeriodicalIF":1.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasticity of the anatomical traits of Rhododendron L. (Ericaceae) leaves and its implications in adaptation to the plateau environment. 杜鹃花叶片解剖特征的可塑性及其对高原环境的适应意义

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1116

Wenwen Guo, Mecao Zhuo, Youzhi Bai, Jiangping Fang

{"title":"Plasticity of the anatomical traits of Rhododendron L. (Ericaceae) leaves and its implications in adaptation to the plateau environment.","authors":"Wenwen Guo, Mecao Zhuo, Youzhi Bai, Jiangping Fang","doi":"10.1515/biol-2025-1116","DOIUrl":"10.1515/biol-2025-1116","url":null,"abstract":"There is a variety of Rhododendron plants in the Tibetan plateau; yet, little is known about their variations in leaf anatomical traits and the implications for environmental adaptation. In this study, we investigated the anatomical traits of leaves in five Rhododendron L. species from Shergyla Mountain on the Tibetan plateau. The results showed that the five species have notable intraspecific and interspecific differences in the thickness of leaves, cuticle thickness, adaxial epidermis thickness, palisade parenchyma thickness, spongy parenchyma thickness, and tightness of leaf palisade parenchyma (P < 0.05). There are autocorrelations among these anatomical traits of the leaves, indicating the existence of synergistic changes. The interspecific variations in leaves' anatomical structures illustrated their spectrum of plasticity to habitat heterogeneity. Our findings demonstrated that Rhododendron plants have developed typical ectopic leaves to adapt to harsh conditions of the Tibetan plateau.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251116"},"PeriodicalIF":1.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of metabolites related to microbiota-gut-brain axis in plasma of colon cancer, esophageal cancer, stomach cancer, and lung cancer patients. 结肠癌、食管癌、胃癌和肺癌患者血浆中微生物-肠-脑轴相关代谢物的改变

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1115

Yuqin Zhao, Kangwei Shen, Qing Lu, Wei Huang, Xuejun Kang, Li Xie

{"title":"Alterations of metabolites related to microbiota-gut-brain axis in plasma of colon cancer, esophageal cancer, stomach cancer, and lung cancer patients.","authors":"Yuqin Zhao, Kangwei Shen, Qing Lu, Wei Huang, Xuejun Kang, Li Xie","doi":"10.1515/biol-2025-1115","DOIUrl":"10.1515/biol-2025-1115","url":null,"abstract":"Co-occurring symptoms such as depression, anxiety, fatigue, and sleep disorders are frequently comorbid with cancer. The causes of these cancer-related symptom clusters are hypothesized sharing a common biological mechanism. This study explored pattern differences of some gut metabolites (glucocorticoids, short-chain fatty acids, gut microbial metabolites from tryptophan) in plasma samples from patients with four types of cancer. Metabolomics analysis was performed to indicate the differences of metabolites. Discrimination model and diagnostic model were constructed using orthogonal partial least squares discriminant analysis, and differential metabolites were screened, then receiver-operating characteristic curve analysis was performed to evaluate the performance of these models. Melatonin (MLT), indole propionic, and skatole were screened as the common differential metabolites shared by four types of cancer, indicating that the intestinal microbial metabolic pathway of tryptophan plays a key role in the occurrence and development of malignant tumors. The area under the curve values for the potential candidate biomarker predictors in univariate analysis ranged from 0.771 to 0.989, and in multivariate analysis ranged from 0.985 to 1.00. The sensitivity and specificity of the multivariable model were 94.7-100 and 96.4-100%, respectively. These biomarkers also had good performance in discriminating different pairs of cancer. The analysis of gut microbiota metabolites allows us to characterize the common metabolic characteristics of patients with various cancers. The intestinal microbial metabolic pathway of tryptophan plays a key role in the occurrence and development of malignant tumors.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251115"},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological qualities and detoxification trends of fruit by-products for valorization: A review. 水果加工副产物的毒理学特性及脱毒趋势综述。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1105

Zenebe Tadesse Tsegay, Slim Smaoui, Theodoros Varzakas

{"title":"Toxicological qualities and detoxification trends of fruit by-products for valorization: A review.","authors":"Zenebe Tadesse Tsegay, Slim Smaoui, Theodoros Varzakas","doi":"10.1515/biol-2025-1105","DOIUrl":"10.1515/biol-2025-1105","url":null,"abstract":"The abundant and renewable resources from fruit by-products are getting emphasis on their valorization. These by-products may contain toxic substances due to factors such as cultivation, harvesting, transportation, preservation, or processing. Hence, presenting scientific overviews of the toxicological qualities and detoxification trends of these by-products are critical for implicating their possible valorization. The present demand for valorization of fruit by-products requires emphasis and methodologies for the detoxification of any toxicants to develop healthier products. This review emphasized the toxicological qualities of by-products from fruits for which the maximum global production occurred in 2022. In this review, heavy metals (arsenic, cadmium, cobalt, chromium, nickel, lead, and mercury), mycotoxins, toxicant organic compounds, anti-nutritional factors, and pesticide/fungicide residues of the selected fruit byproducts were discussed. Current trends to reduce possible toxicants of these by-products during their valorization were emphasized. Novel functional foods valorized from these fruit by-products and future perspectives of detoxification were also focused on in this review.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251105"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine tumor resembling ovarian sex cord tumor with extensive rhabdoid differentiation: A case report. 类似卵巢性索瘤伴广泛横纹肌分化的子宫肿瘤1例。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1104

Rumeng Yang, Liwei Liu

引用次数: 0

Correlation analysis between semen routine parameters and sperm DNA fragmentation index in patients with semen non-liquefaction: A retrospective study. 精液非液化患者精液常规参数与精子DNA断裂指数的相关性分析：回顾性研究。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2022-1020

Fengqing Ji, Junying Chen, Liyun Lin

{"title":"Correlation analysis between semen routine parameters and sperm DNA fragmentation index in patients with semen non-liquefaction: A retrospective study.","authors":"Fengqing Ji, Junying Chen, Liyun Lin","doi":"10.1515/biol-2022-1020","DOIUrl":"10.1515/biol-2022-1020","url":null,"abstract":"This research investigated the correlation between routine semen parameters and the sperm DNA fragmentation index (DFI) in infertile males with non-liquefying semen, aiming to provide insights for infertility management. We conducted a retrospective analysis of 152 infertile males at our Andrology Department from March 2023 to March 2024, assessing differences in semen parameters and DFI based on liquefaction times and identifying influential factors on DFI. Participants were divided into two groups based on their semen liquefaction times: less than 60 min (111 patients) and 60 min or more (41 patients). The group with normal liquefaction times demonstrated significantly better forward and total sperm motility, and lower sperm morphology indices and DFI values. A positive correlation was found between DFI and liquefaction time, while a negative correlation was observed with motility and normal sperm ratio. Specifically, each additional minute of liquefaction time increased DFI by 0.13, and a 1% decrease in normal sperm ratio increased DFI by 0.73. The findings indicate that delayed semen liquefaction correlates with poorer sperm motility and morphology and higher DFI, underscoring the importance of comprehensive semen assessment in evaluating male fertility.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20221020"},"PeriodicalIF":1.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0