Oriental Journal Of Chemistry最新文献_第2页

Analysis of Forced Degradation Products in Rilpivirine using RP-HPLC and Peak Purity Evaluation 利用 RP-HPLC 和峰值纯度评估分析利匹韦林中的强制降解产物

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390613

Abburi Ramarao, Guttikonda Venkata Rao, S. Chinnamaneni, Komati Navya Sri, Mandava Bhagya Tej, Gollammudi Padma Rao, V. Abbaraju, Mandava Venkata Basaveswarao RaoBasaveswarao Rao

{"title":"Analysis of Forced Degradation Products in Rilpivirine using RP-HPLC and Peak Purity Evaluation","authors":"Abburi Ramarao, Guttikonda Venkata Rao, S. Chinnamaneni, Komati Navya Sri, Mandava Bhagya Tej, Gollammudi Padma Rao, V. Abbaraju, Mandava Venkata Basaveswarao RaoBasaveswarao Rao","doi":"10.13005/ojc/390613","DOIUrl":"https://doi.org/10.13005/ojc/390613","url":null,"abstract":"The primary objective of this research was to delve into the forced degradation products of Rilpivirine hydrochloride (RLP HCl), a crucial non-nucleoside reverse transcriptase inhibitor employed inmanagement of epidemic disease named HIV-1. The investigation utilised the probable of RP-HPLC in tandem with peak purity assessment .In order to simulate conceivable degradation pathways, the study encompassed a gamut of stress conditions like acidic, alkaline, oxidative , thermal and photolytic environments. Authors used Agilent zorbaxEclipse XDB C18 column (150x2.1mm, 1.8µm), RLP and impurities were separated. Buffer as pH of 3.0 and acetonitrile in gradient mode (68:32v/v), flow rate of 0.55ml/min. Volume injected is 3µL and detection wavelength is 220 nm. Temperature is maintained at 55oC by 70:30v/v mixture of water and acetonitrile.System suitability was erect to be within the limits. The average percentage recoveries for impurities were 98% to 101%.The outcomes of this meticulous study unveiled the susceptibilities of RLP to a spectrum of stress factors, in the generation of impurity profile RLP-Amide A, RLP-Amide Band Z-RLP with peak purities. The forced degradation tests demonstrate that the peak of RP-HPLC is spectroscopically pure in all stressed conditions. All degradation products are separated from the main peak and do not interfere with main substance. This exploration not only augments the comprehension of RLP’s stability profile but also underscores the pivotal role of analytical techniques in upholding the safety and efficacy benchmarks of pharmaceutical formulations.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"50 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and Functional Dynamics of Secondary Metabolite from Actinokineospora cibodasensis against Pseudomonas aeruginosa Biofilm cibodasensis 放线菌次生代谢物抗铜绿假单胞菌生物膜的结构和功能动力学研究

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390619

Sreelakshmi K.S, U. R

{"title":"Structural and Functional Dynamics of Secondary Metabolite from Actinokineospora cibodasensis against Pseudomonas aeruginosa Biofilm","authors":"Sreelakshmi K.S, U. R","doi":"10.13005/ojc/390619","DOIUrl":"https://doi.org/10.13005/ojc/390619","url":null,"abstract":"Biofilm formation has incredible detrimental effects and has brought huge issue to our daily life. Pseudomonas aeruginosa is recognized as an opportunistic pathogen and its one of the antibiotic resistance mechanisms includes biofilm formation. To survive against harsh environmental conditions the microorganisms form an extracellular polymeric substance matrix. Natural products, particularly, marine natural products have been established useful in providing new chemical entities to mark biofilm inhibition and dole out as a rich source of privileged frames for studying chemical as well as biological applications. In the present study, antibiofilm potential of bioextract from Actinokineospora cibodasensis (MW513387) is tested against Pseudomonas aeruginosa (ATCC 27853) biofilm. The analysis of the quorum sensing modulation was done using exopolysaccharide (EPS) quantification and Cytotoxicity assays were performed to check toxicity. Scanning electron microscopy (SEM) was also conducted to visualize the mitigation of biofilm using the biocontrol agent. All the assays conducted evidently indicated that the potential bioactive compound from Actinokineospora cibodasensis has greater inhibition effect against pathogenic biofilm. In the near-term years it is expected that these pharmaceutical compounds from natural source be translated into antibiofilm drugs.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"21 8","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Characterization of Organosiloxanes with A Liquid Crystalline Trans-4-Pentylcyclohexanoate Moiety 具有液晶反式-4-戊基环己酸酯分子的有机硅氧烷的制备与表征

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390601

Li-Chuan Wu, Chih-Hung Lin

引用次数: 0

Discovery of New Isoniazid Derivatives As Anti-tubercular Agents: In silico Studies, Synthesis, and In vitro Activity Evaluation 发现新的异烟肼衍生物作为抗结核药物：硅学研究、合成和体外活性评估

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390610

Abida Ash Mohd, Mohd Imran, Noura Yousif Alnaser, Shams Saud Altimyat, Nawaf M. Al-Otaibi, A. Bawadekji

{"title":"Discovery of New Isoniazid Derivatives As Anti-tubercular Agents: In silico Studies, Synthesis, and In vitro Activity Evaluation","authors":"Abida Ash Mohd, Mohd Imran, Noura Yousif Alnaser, Shams Saud Altimyat, Nawaf M. Al-Otaibi, A. Bawadekji","doi":"10.13005/ojc/390610","DOIUrl":"https://doi.org/10.13005/ojc/390610","url":null,"abstract":"This research aimed to discover novel isoniazid (INH) derivatives as anti-tubercular (anti-TB) agents. The chemical structures of isoniazid-based pyridazinone (IBP) derivatives were designed, and their toxicity and pharmacokinetic properties were predicted using the ProTox II and Swiss-ADME databases. The molecular docking of non-toxic IBPs was also performed concerning INH, pyrazinamide (PYZ), ethionamide (ETH), macozinone (MCZ), and BTZ043 utilizing DprE1 enzyme’s proteins (PDB IDs: 4F4Q, 4NCR and 6HEZ). Based on the in silico study results, IBP19, IBP21, IBP22, and IBP29 were selected for their synthesis, and the spectral analysis confirmed their chemical structures. In vitro, anti-TB activity against Mtb H37Rv strain and MTT assay (against HepG2 and Vero cell lines) of IBP19, IBP21, IBP22, and IBP29 were also carried out. A total of eleven non-toxic IBPs were identified with promising pharmacokinetic parameters. The docking score (DS in kcal/mol against 6HEZ protein) of IBP19 (-9.52), IBP21 (-8.78), IBP22 (-9.07), and IBP29 (-9.99) was better than MCZ (-8.76) and BTZ043 (-8.56) revealing their DprE1 enzyme inhibitory action. The in vitro anti-TB activity evaluation (MIC values) confirmed that IBP19 (1.562 µg/ml), IBP21 (1.562 µg/ml), IBP22 (1.562 µg/ml), and IBP29 (1.562 µg/ml) had almost double potency than INH (3.125 µg/ml), and PYZ (3.125 µg/ml). IBP19, IBP21, IBP22, and IBP29 also displayed a CC50 value of > 300 µg/ml against HCL and VCL cell lines. This effect was better than INH (> 200 µg/ml), ETH (> 150 µg/ml), and PYZ (> 200 µg/ml). Accordingly, IBP19, IBP21, IBP22, and IBP29 provide a new template for developing safe and effective novel DprE1 inhibitors.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"33 10","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Sn-incorporation on the Structural and Optical Properties of ZnO Thin Films Prepared by Sol-Gel Method 掺入锡对溶胶-凝胶法制备的氧化锌薄膜的结构和光学特性的影响

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390614

Hansraj Sharma, Sunil Kumar, Jagavendra Yadav, Jagdish Prasad, Mangej Singh

引用次数: 0

Adaptive Paramagnetism and Photoluminescence in Nitrogen Co-doped Mn: CdS Composite Quantum Dots 氮共掺杂 Mn.CdS 复合量子点中的自适应顺磁性和光致发光CdS 复合量子点

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005//ojc/390603

Surya Sekhar Reddy M, Kishore Kumar Y B

{"title":"Adaptive Paramagnetism and Photoluminescence in Nitrogen Co-doped Mn: CdS Composite Quantum Dots","authors":"Surya Sekhar Reddy M, Kishore Kumar Y B","doi":"10.13005//ojc/390603","DOIUrl":"https://doi.org/10.13005//ojc/390603","url":null,"abstract":"Manganese-doped cadmium sulfide quantum dots (QDs), co-doped with nitrogen, were synthesized using the chemical co-precipitation method (CPM). Surfactant 2-mercaptoethanol (ME) was used to efficiently regulate the size of these QDs. X-ray diffraction (XRD) analyses verified that the particles fell within the nano-dimension, measuring between 1-2 nm. A Rietveld analysis with X’pert high score software (XPHS) proved that these synthesized QDs contained many phases. The energy dispersive X-ray spectroscopy (EDX) technique confirmed the successful incorporation of both manganese and nitrogen dopants into the CdS. Ultraviolet-visible analysis (UV-Vis) demonstrated a noticeable shift towards the blue end in the energy gap, indicating the presence of a quantum-confinement effect. The photoluminescence (PL) investigations revealed a significant emission peak at λ = 634 nm, linked to the transition from 4T1 to 6A1, attributed to the incorporation of Mn2+ within the CdS core. Electron paramagnetic spectroscopy (EPR) demonstrated paramagnetic characteristics. EPR assessments of the g factor (1.995) and hyperfine splitting constant (A) values (7 mT) verified the existence of nitrogen and manganese ions in the tetrahedral positions of the CdS core. The notable alterations noticed in the magnetic and optical characteristics of the fabricated quantum dots imply promising uses in optoelectronic and magneto-luminescent applications.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"57 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization, Density Functional Theory Studies and Antioxidant Activity of Novel Hydrazone Ligands and their Metal Complexes 新型腙配体及其金属复合物的合成、表征、密度泛函理论研究和抗氧化活性

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390624

V. Suleman, Abdul Ghany Mohammed Al-Daher

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Evaluation of Lead Removal by Activated Citrus Sinensis Biochar Impregnated with Calcium Alginate Beads 海藻酸钙珠浸渍的活性柑橘生物炭除铅效果评估

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390615

Vandana Kachhwaha, Pooja Kumari, Naresh Giri, P. Mishra

{"title":"Evaluation of Lead Removal by Activated Citrus Sinensis Biochar Impregnated with Calcium Alginate Beads","authors":"Vandana Kachhwaha, Pooja Kumari, Naresh Giri, P. Mishra","doi":"10.13005/ojc/390615","DOIUrl":"https://doi.org/10.13005/ojc/390615","url":null,"abstract":"This study introduces an innovative method of using activated carbon derived from orange peels incorporated into calcium alginate beads to remove lead from synthetic water efficiently. This novel approach demonstrates remarkable effectiveness in addressing lead pollution in water. Established techniques such as SEM and FTIR were employed to characterize the adsorbents created in the laboratories. Batch studies confirmed the lead adsorbed were conducted to evaluate the efficiency of lead removal, with the highest removal efficiencies achieved at pH 6.5 (90.3%), an adsorbent dose of 2 mg (90.3%), a contact time of 50 minutes (92.3%), and an initial lead solution concentration of 20 ppm (93.2%). The study employed various adsorption models, including Langmuir, Freundlich, and Tempkin models. The Langmuir model exhibited an excellent fit to the adsorption isotherm at 60 °C, as indicated by a high linear regression correlation coefficient. For the bioadsorption process, pseudo-second-order kinetics fits well (R2 = 0.9992). The analytical results verify that activated carbon from discarded orange peels and calcium alginate beads effectively removes Pb, offering an encouraging solution for water purification challenges.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"3 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Efficient Adsorption of Trivalent Rare Earth Elements Using Nano Copper Ferrite: Kinetics, Isotherms and Thermodynamics 使用纳米铜铁氧体高效吸附三价稀土元素：动力学、等温线和热力学

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390628

Sudha Thotakura

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Rheology of Cottonseed (Gossypium hirsutum) Oil used as Biodegradable Lubricant 用作生物可降解润滑剂的棉籽油的流变性能

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Oriental Journal Of Chemistry Pub Date : 2023-12-27 DOI: 10.13005/ojc/390633

Ioana Stanciu

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