One Health最新文献

{"title":"Occurrence of extended- spectrum β-lactamases and ertapenem- mono- resistance in Escherichia coli isolated from diarrheal calves","authors":"Lívia Karahutová,&nbsp;Dobroslava Bujňáková","doi":"10.1016/j.onehlt.2025.101138","DOIUrl":"10.1016/j.onehlt.2025.101138","url":null,"abstract":"<div><div>The rise of antimicrobial resistance, particularly against last-resort antibiotics, is a major global health challenge. To address this crisis, implementation of the One Health concept, including surveillance across the environment, public and veterinary health sectors is strongly recommended. This study aimed to assess the antibiotic resistance of <em>Escherichia coli</em> strains isolated from faeces of diarrheal calves on eight farms in eastern Slovakia. We particularly focused on isolates carrying extended-spectrum beta-lactamases (ESBL), carbapenemases, fluoroquinolone resistance, and mobile colistin resistance genes<strong>.</strong></div><div>High resistance rates were observed for penicillins (ampicillin: 76 %; ampicillin + sulbactam: 50 %) and tetracycline (73 %), followed by quinolones (54 %), sulphonamides (46 %), aminoglycosides (tobramycin: 29 %; gentamicin: 44 %), and second and third generation cephalosporins (cefuroxime: 29 %; cefotaxime + clavulanic acid: 1 %; cefotaxime: 22 %). Sporadic resistance to fourth generation cephalosporins (2 %) and ertapenem mono-resistance (5 %) was also noted. Multidrug resistance (MDR) was observed in 71 % of the isolates. Automated interpretative reading of the antibiogram revealed six resistance mechanisms. The most concerning was the CTX-M type ESBL, with confirmed presence of the <em>bla</em>_CTX-M-1, <em>bla</em>_CTX-M-2, and <em>bla</em>_CTX-M-9 genes, along with MDR and mobile gene elements (<em>int</em>1 and <em>tn</em>3), which facilitate the horizontal spread of resistance genes. Additionally, two <em>bla</em>_CMY-2-positive isolates were observed with the <em>int</em>1 and <em>tn</em>3 genes. Genes responsible for resistance to other antimicrobial classes (such as tetracyclines, fluoroquinolones, and aminoglycosides) were also detected.</div><div>Our results suggest that calves may serve as a reservoir for MDR, ESBL/AmpC, and ertapenem-mono-resistant strains of <em>E. coli</em>, posing a potential public health risk through the horizontal spread of resistance genes.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101138"},"PeriodicalIF":4.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Global Health Security in Sub-Saharan Africa: The case for integrated One Health surveillance against zoonotic diseases and environmental threats","authors":"Pierre Gashema ,&nbsp;Placide Sesonga ,&nbsp;Patrick Gad Iradukunda ,&nbsp;Richard Muvunyi ,&nbsp;Jean Claude Mugisha ,&nbsp;Jerome Ndayisenga ,&nbsp;Tumusime Musafiri ,&nbsp;Richard Habimana ,&nbsp;Radjabu Bigirimana ,&nbsp;Alice Kabanda ,&nbsp;Misbah Gashegu ,&nbsp;Noel Gahamanyi ,&nbsp;Jonathan Izudi ,&nbsp;Emmanuel Edwar Siddig ,&nbsp;Jean Claude Semuto Ngabonziza ,&nbsp;Ayman Ahmed ,&nbsp;Tafadzwa Dzinamarira ,&nbsp;Leon Mutesa ,&nbsp;Claude Mambo Muvunyi","doi":"10.1016/j.onehlt.2025.101136","DOIUrl":"10.1016/j.onehlt.2025.101136","url":null,"abstract":"<div><div>Integrated One Health surveillance is pivotal to Africa's future health security, particularly in preventing and managing zoonotic and environmental health threats. The One Health strategy recognizes the interconnectedness of human, animal, and environmental health, allowing a holistic framework for tracking and responding to emerging and re-emerging pathogens. The One Health approach facilitates cross-sectoral data sharing and enhances surveillance, enabling the early detection and response to potential outbreaks. This proactive approach shifts the paradigm from reactive crisis management to preventive containment strategies. However, challenges such as funding gaps, limited infrastructure, limited diagnostic capacity, and weak multi-sectoral and cross-border collaborations remain. This perspective paper aims to 1) explore the effectiveness of integrated One Health surveillance in early detection and response to zoonotic diseases and environmental threats in Sub-Saharan Africa (SSA), and 2) identify key challenges and proposed solutions to strengthen regional health security. A multisectoral laboratory working group (MLWG) emerged as a pillar to enable active surveillance targeting humans, animals, and the environment. This paper highlighted essential strategies for enhancing One Health surveillance in SSA in light of the recent Marburg virus disease in Rwanda. It emphasizes environmental sampling through animal excreta and wastewater surveillance for early zoonotic detection, advocates for point-of-care polymerase chain reaction (PCR) testing platforms, and multiplex models to improve decentralized diagnostics. With 48 % of African nations incorporating One Health in national agendas, a unified continental framework is needed to support broader adoption and advance regional health security.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101136"},"PeriodicalIF":4.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHIP toolkit: Social mapping and transect walk for childhood infection and pollution – A comparative study across four cities (Jaipur, Jakarta, Antofagasta, and Istanbul)","authors":"Logan Manikam ,&nbsp;Kunal D. Kondhare ,&nbsp;Kalpita Shringarpure ,&nbsp;Margi Sheth ,&nbsp;Pam Factor-Livak ,&nbsp;Priti Parikh ,&nbsp;Hector Altamirano-Medina ,&nbsp;Dewi Nur Aisyah ,&nbsp;Radhika Sharma ,&nbsp;Darlington David Faijue ,&nbsp;Pradeep Kumar Srivastava ,&nbsp;Hein Min Tun ,&nbsp;Nancy H.L. Leung ,&nbsp;Chyntia Mayadewi ,&nbsp;Hemant Chaturvedi ,&nbsp;Kaushik Sarkar ,&nbsp;Monica Lakhanpaul ,&nbsp;Childhood Infection and Pollution (CHIP) Consortium","doi":"10.1016/j.onehlt.2025.101126","DOIUrl":"10.1016/j.onehlt.2025.101126","url":null,"abstract":"<div><h3>Background</h3><div>The Sustainable Development Goals Agenda 2030 underscores the value of sustainable cities, clean water, sanitation, and well-being. In-spite of several improvements, the under-five mortality rates remain quite high, especially in inadequately serviced peri-urban settlements, wherein the environmental conditions, poor sanitation, and limited healthcare exacerbate child health issues. Burdened by rapid urban migration and poor infrastructure, these settlements are prone to the spread of respiratory, gastrointestinal, and vector-borne diseases.</div></div><div><h3>Methods</h3><div>The Childhood Infection and Pollution (CHIP) consortium employed the Social Mapping and Transect Walk methodologies to assess the One Health factors influencing childhood infections in four cities: Jaipur (India), Jakarta (Indonesia), Antofagasta (Chile), and Istanbul (Turkey). The social mapping was to gain insights into the community structures and resources, while transect walks helped identify environmental and social pathways for infections.</div></div><div><h3>Results</h3><div>In-person interviews with slum households and key informants for providing essential context for intensive follow-on research and the opportunity to improve upon pre-existing research protocols prefaced based on the social mapping and transect interviews. The study found significant environmental and health disparities; Jaipur and Jakarta faced high rates of vector-borne diseases due to poor sanitation and flooding, respectively. Antofagasta experienced high respiratory disease rates linked to industrial pollution, while Istanbul struggled with gastrointestinal and respiratory infections due to waste management issues and industrial pollutants. The health challenges were compounded by faith in traditional medicine and lack of and/or irregular access to healthcare access.</div></div><div><h3>Conclusion</h3><div>The social mapping and transect walks could highlight specific environmental and social conditions in the selected cities. The One Health approach, that integrates human, environmental, and animal health, is essential in developing effective and sustainable solutions. Healthcare outcomes among children in vulnerable settings may be improved through addressing local environmental issues and improving community engagement.</div></div><div><h3>Disclaimer</h3><div>The term ‘slums’ is used as defined by the UN to describe areas lacking essential amenities, although we refer to them as “inadequately serviced peri-urban settlements” in our studies.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101126"},"PeriodicalIF":4.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the surveillance and control of mosquito-borne diseases in Europe and United States. The perspective from public health experts.","authors":"Luigi Sedda ,&nbsp;Elizabeth Wrench ,&nbsp;Thomas C. Moore ,&nbsp;Kaitlyn Wolfe ,&nbsp;Julie-Anne A. Tangena ,&nbsp;Heidi E. Brown","doi":"10.1016/j.onehlt.2025.101133","DOIUrl":"10.1016/j.onehlt.2025.101133","url":null,"abstract":"<div><div>The complexity of mosquito-borne diseases and the necessity for cross-sector collaboration present significant challenges, requiring changes in laws, policies, and inter-agency agreements. In this qualitative study we purposively selected and interviewed public health managers from the European Union and United States involved in vector-borne disease surveillance and control and asked them about the barriers currently faced when engaging in their activities. The interviewees highlighted the differences in surveillance and control guidelines between the European Centre for Disease Prevention and Control and the US Centers for Disease Control and Prevention which reflect structural political differences between the European Union and United States. The lack of centralisation increases uncertainty in applying mosquito surveillance and control guidance. In addition, limited resources and modelling capabilities hinder effective surveillance and control. The public health agents recognised that community engagement and transparent communication are critical for gaining public support and to succeed in interventions, thus recognition of the values of these collaborations need to be accounted for in disease preparedness. Effective mosquito surveillance and control requires strong organisational bases, coordination among stakeholders, and sufficient resources, as advocate by one health frameworks. Addressing these challenges is urgent due to global trends like climate change and increased international travel, which may heighten the risk of mosquito-borne disease outbreaks.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101133"},"PeriodicalIF":4.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastitis in goat: A review of etiology, epidemiology, economic impact, and public health concerns","authors":"Abebe Tibebu ,&nbsp;Yechale Teshome ,&nbsp;Habtamu Tamrat ,&nbsp;Adane Bahiru","doi":"10.1016/j.onehlt.2025.101131","DOIUrl":"10.1016/j.onehlt.2025.101131","url":null,"abstract":"<div><div>Mastitis is a multifactorial disease of mammals that has substantial implications on production, welfare, and public health, but it is far less studied in goats. This study reviewed the causes, diagnostic tests, economic and public health impacts, and prevalence of mastitis in goats. The review revealed that mastitis in goats could be clinical (CM) or subclinical (SCM). Bacteria, such as <em>Staphylococcus</em>, <em>Streptococcus</em>, <em>E. coli</em>, and <em>Mycoplasma</em>, are the main cause of mastitis in goats. Mastitis in goats is influenced by intrinsic factors like breed, parity, age, and lactation stage, and extrinsic factors like pathogens, environment, and management. Somatic cell count and the California mastitis test are common diagnostic tests for SCM, but their reliability is questionable due to the broader range of somatic cells in goat milk. Dry period therapy and early interventions are the best options for mastitis treatment and control methods, while temporal milking stops can enhance immunity. Mastitis can affect animal welfare, milk yield, quality, marketability, and public health due to disease transmission and intoxication. The pooled prevalence of mastitis was found to be 36 % (95 % CI: 25–50). The prevalence of CM was often less than 5 % and occurred sporadically. In contrast, SCM was the most prevalent form (prevalence ranges from 30 % to 50 %). In conclusion, despite goats being the foundation of financial stability and food security in rural households, and with an estimated prevalence comparable to cows, mastitis research is frequently overlooked. Given goats' importance in rural households' economies, there is a need to shift research priorities and strengthen multidisciplinary collaborations to address zoonotic diseases associated with mastitis, at the intersection of animal, environmental, and human health.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101131"},"PeriodicalIF":4.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecology and epidemiology of multidrug-resistant Salmonella in synanthropic small mammals in Bangladesh","authors":"Md Aftabuddin Rumi ,&nbsp;Injamamul Hasnine ,&nbsp;Md Abu Sayeed ,&nbsp;Monjurul Islam ,&nbsp;Pronesh Dutta ,&nbsp;Md Helal Uddin ,&nbsp;Farhana Rahman ,&nbsp;Mohammed Abdus Samad ,&nbsp;Jade K. Forwood ,&nbsp;Mohammad Mahmudul Hassan ,&nbsp;Ariful Islam","doi":"10.1016/j.onehlt.2025.101135","DOIUrl":"10.1016/j.onehlt.2025.101135","url":null,"abstract":"<div><div>Multidrug resistant (MDR) organisms pose a significant global concern, affecting both human and animal health. Synanthropic small mammals, such as rodents and shrews can serve as environmental reservoirs and vectors for MDR organisms, including <em>Salmonella</em> spp. Hence, a cross-sectional study was conducted to estimate the prevalence, risk factors, and MDR patterns of <em>Salmonella</em> spp. in wild rodents and shrews across diverse ecological settings in Bangladesh. Throat and rectal/fecal swab samples were collected from a total of 350 mammals (203 wild rodents and 147 shrews) and tested for <em>Salmonella</em> spp. using selective culturing, biochemical properties and PCR. All isolates were tested for culture susceptibility using the Kirby-Bauer disc diffusion method for 17 antimicrobials. Our findings revealed the overall prevalence of MDR <em>Salmonella</em> spp. was 38.6 % (95 % CI: 33.5–44.0). Prevalence was highest in <em>S. murinus</em> (61.2 %), followed by <em>B. bengalensis</em> (35.9 %), <em>M. musculus</em> (29.4 %) and <em>R. rattus</em> (29.0 %). The resistance of the isolated Salmonella strains in descending order was: 100 % to ampicillin and oxytetracycline, followed by 94 % to sulfamethoxazole-trimethoprim, 92.0 % to doxycycline, and 89.0 % to ciprofloxacin. Shrews had significantly higher odds of carrying MDR <em>Salmonella</em> (OR = 3.8, <em>p</em> &lt; 0.01) compared to rodents. Moreover, small mammals from human dwellings had greater odds (OR = 2.4, p &lt; 0.01) of carrying MDR <em>Salmonella</em> than agricultural lands. Resistance to ceftriaxone and azithromycin is particularly concerning, as these are critical for treating human infections with third generation cephalosporin and macrolides. These findings underscore the importance of enhanced reduced environmental contamination and judicious use of antibiotics to prevent spillovers of MDR organisms from wildlife to people and livestock.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101135"},"PeriodicalIF":4.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the prevalence and antimicrobial resistance landscape of Pantoea genus in veterinary clinical strains: Insights from a cohort study","authors":"Ondrej Holy ,&nbsp;Vladimir Sladecek ,&nbsp;Jaroslav Bzdil ,&nbsp;Monika Zouharova ,&nbsp;Julio Parra-Flores ,&nbsp;Cátia Caneiras","doi":"10.1016/j.onehlt.2025.101130","DOIUrl":"10.1016/j.onehlt.2025.101130","url":null,"abstract":"<div><div>The genus <em>Pantoea</em>, of which <em>Pantoea agglomerans</em> is the most common species, is an emerging Gram-negative facultative anaerobic bacillus that causes a wide range of opportunistic infections. To date, the prevalence, antibiotic resistance, and pathogenic potential of this bacterium in animals remains largely unexplored. The aim of this work was to describe the prevalence of microorganisms of the genus <em>Pantoea</em> in clinical samples obtained from animals during the period 2015–2017 and to define their susceptibility to antimicrobial agents. In the monitored period, a total of 23,739 clinical samples obtained from animals in the Czech Republic with symptoms of disease were tested, from which 151 <em>Pantoea</em> genus were isolated (prevalence 0.63 %). Cultivation and incubation were carried out under aerobic conditions by culture methods using massopeptone blood agar, Endo's agar and xylose lysine deoxycholate agar at 37 ± 1 °C for 24 h. Suspect strains were confirmed by matrix-assisted laser desorption/ionization coupled to time-of-flight mass spectrometry (MALDI-TOF MS). Susceptibility testing was performed by the standard disk diffusion method using Mueller-Hinton agar. <em>Pantoea</em> strains were recovered from domestic horses, carnivores (dogs, cats) and rodents (prevalence of 6.78, 1.64 and 1.12 % respectively). Resistance to beta-lactam antimicrobials was detected in 12 strains. In addition to beta-lactams, resistance to co-trimoxazole was detected in 1 case and to co-trimoxazole and chloramphenicol in 1 case, highlights the need to monitor the emergence of this strain in the context of the One Health approach.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101130"},"PeriodicalIF":4.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household risk factors associated with canine leishmaniasis in Fortaleza, northeastern Brazil: Environmental, social, dog characteristics, and exposure to canine Ehrlichia spp","authors":"Adam Leal-Lima ,&nbsp;Diana Celia Sousa Nunes-Pinheiro ,&nbsp;Filipe Dantas-Torres ,&nbsp;Társilla Mara Vieira Ferreira ,&nbsp;Christine A. Petersen ,&nbsp;Angela J. Toepp ,&nbsp;Marie V. Ozanne","doi":"10.1016/j.onehlt.2025.101127","DOIUrl":"10.1016/j.onehlt.2025.101127","url":null,"abstract":"<div><div>Canine leishmaniasis (CanL) and canine monocytic ehrlichiosis (CME) are enzootic in Brazil. Although studies have identified risk factors associated with <em>Leishmania</em> seropositivity, very few have combined environmental, social, and dog characteristics, including exposure to other vector-borne pathogens such as <em>Ehrlichia canis</em>, the primary agent of CME in Brazil. In this cross-sectional study, we assessed risk factors associated with <em>Leishmania</em> seropositivity in Fortaleza, Brazil, including dog characteristics, exposure to <em>E. canis</em>, family socioeconomic status, and environmental factors, using univariate chi-squared tests for independence and multivariable random forest models. Antibodies to <em>Leishmania</em> and <em>Ehrlichia</em> were assessed using a chromatographic immunoassay and a rapid ELISA, respectively. In total, 656 dogs were included, with 21.6 % of them being positive for <em>Leishmania</em>. Large dogs and dogs from families in social stratum 7 were more likely to be exposed to <em>Leishmania</em>. Random forest classification models with acceptable discrimination (∼0.65) consistently showed that sleeping outside and household social class had the highest variable importance, regardless of the methods used to impute missing explanatory data. <em>Ehrlichia</em> exposure status, along with environmental (backyard type and presence of cats) and dog variables (fur length, deworming frequency, and tick infestation), ranked among the top ten variables in all models. In conclusion, sleeping outdoors and lower social strata were the most relevant risk factors for <em>Leishmania</em> seropositivity in dogs from Fortaleza. Large-scale studies are needed to evaluate whether these variables are risk factors for L. <em>infantum</em> exposure in other areas where CanL is endemic, possibly also incorporating more human and vector data.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101127"},"PeriodicalIF":4.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific cooperation among Europe's One Health agencies","authors":"Stefania Tampach ,&nbsp;Ana Vidal ,&nbsp;Ian Marnane ,&nbsp;Wim De Coen ,&nbsp;Ole Heuer ,&nbsp;Carlos G. das Neves ,&nbsp;Kerstin Gross-Helmert ,&nbsp;Gorgias Garofalakis ,&nbsp;Stef Bronzwaer","doi":"10.1016/j.onehlt.2025.101129","DOIUrl":"10.1016/j.onehlt.2025.101129","url":null,"abstract":"<div><div>Over the years, the five EU agencies (ECDC, ECHA, EEA, EFSA, and EMA) dealing with One Health matters, have established scientific cooperation on a range of cross-cutting topics, including zoonoses, emerging risks, and antimicrobial resistance. Effective cooperation requires coordination of efforts, clear communication, and joint management of activities to achieve shared objectives. This publication analyses various “cooperation tools” that are indicated in Memoranda of Understanding (MoUs) and working arrangements among the five agencies and identifies joint publications on subjects on which agencies have been cooperating. Finally, the paper recommends that building on the success of the longstanding collaboration among the EU Agencies, additional scientific cooperation mechanisms should be explored to support multi-sectoral approaches and to further the One Health implementation in the EU.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101129"},"PeriodicalIF":4.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological insights into canine rabies in Chennai: Trends, forecasting and One Health implications","authors":"Viswanathan Naveenkumar ,&nbsp;Mangalanathan Vijaya Bharathi ,&nbsp;Porteen Kannan ,&nbsp;B.S. Pradeep Nag ,&nbsp;Sureshkannan Sundaram ,&nbsp;Nithya Quintoil Mohanadasse ,&nbsp;Raghavendra G. Amachawadi ,&nbsp;Muskan Dubey ,&nbsp;Charley A. Cull ,&nbsp;Chandan Shivamallu ,&nbsp;Shiva Prasad Kollur ,&nbsp;Ravindra P. Veeranna","doi":"10.1016/j.onehlt.2025.101128","DOIUrl":"10.1016/j.onehlt.2025.101128","url":null,"abstract":"<div><div>Eliminating canine-mediated human rabies deaths by 2030 is a global priority, necessitating a data-driven approach to understand rabies dynamics and implement effective prevention strategies. This study provides epidemiological insights into canine rabies in Chennai, analyzing nine years of surveillance data (<em>n</em> = 428, March 2010 – February 2019) to assess trends, seasonality and predictive patterns. Change point and time series analyses were conducted and forecasting models were evaluated using Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE) and Mean Absolute Scaled Error (MASE) metrics. No significant seasonality was detected, but change point analysis identified two key shifts, segmenting the data into three phases and revealing an overall declining trend. Among the models tested, the Prophet model demonstrated the best predictive performance (RMSE: 1.88, MAE: 1.55, MAPE: 45.44 %, MASE: 3.52), outperforming the Generalized Additive Model (GAM), Bayesian Structural Time Series (BSTS) and Seasonal Trend decomposition using Loess combined with ARIMA (STL + ARIMA (0,0,2)). This study offers critical epidemiological insights for strengthening One Health-based rabies control strategies, particularly in urban settings where canine rabies plays a major role in human exposure risk. By providing longitudinal data and predictive modelling, these findings guide targeted preventive interventions, inform evidence-based policy decisions and support global efforts to eliminate dog-mediated human rabies deaths by 2030.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101128"},"PeriodicalIF":4.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}