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DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer. BDNF和RASA2基因的DNA甲基化与绝经后乳腺癌妇女的认知功能有关
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.349-360
Myeong-Ga Cho, Susan M Sereika, Meredith H Cummings, Kirk I Erickson, Catherine M Bender, Yvette P Conley
{"title":"DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer.","authors":"Myeong-Ga Cho, Susan M Sereika, Meredith H Cummings, Kirk I Erickson, Catherine M Bender, Yvette P Conley","doi":"10.1188/24.ONF.349-360","DOIUrl":"10.1188/24.ONF.349-360","url":null,"abstract":"<p><strong>Objectives: </strong>To determine associations among DNA methylation of brain-derived neurotrophic factor (BDNF) and RAS p21 protein activator 2 (RASA2) genes with processing speed and perceived cognitive function.</p><p><strong>Sample & setting: </strong>This was a cross-sectional, secondary analysis of baseline data from a randomized controlled trial, the Exercise Program in Cancer and Cognition Study.</p><p><strong>Methods & variables: </strong>Data included M values for DNA methylation of the BDNF and RASA2 genes; processing speed, objectively measured using the Grooved Pegboard and Digit Vigilance Test scores; and perceived cognitive function, self-reported using the Patient Assessment of Own Functioning Inventory. Regression analysis was conducted.</p><p><strong>Results: </strong>Greater methylation of cg21291635 of the BDNF gene (p = 0.01) and cg20247102 of the RASA2 gene (p = 0.013) were associated with poorer processing speed, whereas greater methylation of cg20108357 of the BDNF gene (p < 0.001) and cg00567892 of the RASA2 gene (p = 0.019) were associated with better perceived cognitive function.</p><p><strong>Implications for nursing: </strong>Gene methylation variations were demonstrated, suggesting the genes' potential roles and two possible distinct mechanisms of cognitive function in cancer.&nbsp.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"349-360"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal and Neuropsychological Symptoms Are Associated With Distinct Vomiting Profiles in Patients Receiving Chemotherapy. 化疗患者的胃肠道症状和神经心理学症状与不同的呕吐特征有关。
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.361-380
Komal P Singh, Bruce A Cooper, Steven M Paul, Kathryn Ruddy, Amrit B Singh, Jun Chen, Keenan A Pituch, Tom E Grys, Parminder Singh, Felipe Batalini, Marilyn J Hammer, Jon D Levine, Christine Miaskowski
{"title":"Gastrointestinal and Neuropsychological Symptoms Are Associated With Distinct Vomiting Profiles in Patients Receiving Chemotherapy.","authors":"Komal P Singh, Bruce A Cooper, Steven M Paul, Kathryn Ruddy, Amrit B Singh, Jun Chen, Keenan A Pituch, Tom E Grys, Parminder Singh, Felipe Batalini, Marilyn J Hammer, Jon D Levine, Christine Miaskowski","doi":"10.1188/24.ONF.361-380","DOIUrl":"https://doi.org/10.1188/24.ONF.361-380","url":null,"abstract":"<p><strong>Objectives: </strong>To identify subgroups of patients with distinct chemotherapy-induced vomiting (CIV) profiles; determine how these subgroups differ on several demographic, clinical, and symptom characteristics; and evaluate factors associated with chemotherapy-induced nausea and CIV profiles.</p><p><strong>Sample & setting: </strong>Adult patients (N = 1,338) receiving cancer chemotherapy.</p><p><strong>Methods & variables: </strong>Data were collected on demographic, clinical, and symptom characteristics. Differences among subgroups of patients with distinct CIV profiles were evaluated using parametric and nonparametric tests.</p><p><strong>Results: </strong>Three CIV profiles (None, Decreasing, and Increasing) were identified. Compared with the None class, Decreasing and Increasing classes were more likely to have lower household income and a higher comorbidity burden, as well as to report higher rates of dry mouth, nausea, diarrhea, depression, anxiety, sleep disturbance, morning fatigue, and pain interference.</p><p><strong>Implications for nursing: </strong>Clinicians need to assess common and distinct risk factors for CIV and chemotherapy-induced nausea.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"361-380"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distress, Pain, and Nausea on Postoperative Days 1 and 14 in Women Recovering From Breast-Conserving Surgery: A Repeated-Measures Study. 保乳手术术后第 1 天和第 14 天妇女的苦恼、疼痛和恶心:重复测量研究
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.381-390
Jennifer Ross Majumdar, Petra Goodman, Margaret Barton-Burke, Jaime Gilliland, Nalini Jairath
{"title":"Distress, Pain, and Nausea on Postoperative Days 1 and 14 in Women Recovering From Breast-Conserving Surgery: A Repeated-Measures Study.","authors":"Jennifer Ross Majumdar, Petra Goodman, Margaret Barton-Burke, Jaime Gilliland, Nalini Jairath","doi":"10.1188/24.ONF.381-390","DOIUrl":"10.1188/24.ONF.381-390","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the incidence and trajectory of distress, pain, and nausea and vomiting at postoperative day (POD) 1 and at POD 14 following breast-conserving surgery.</p><p><strong>Sample & setting: </strong>75 women aged 18 years or older receiving breast-conserving surgery with sentinel lymph node biopsy for treatment of early-stage primary breast cancer at an ambulatory surgery center.</p><p><strong>Methods & variables: </strong>This prospective, repeated-measures study assessed distress, pain, and nausea and vomiting using the National Comprehensive Cancer Network Distress Thermometer and Problem List on POD 1 and POD 14.</p><p><strong>Results: </strong>Pain and distress scores were highest on POD 1. The number of women who reported depression increased from POD 1 to POD 14. Thematic analysis revealed that family concerns, fears and worries, and postoperative issues contributed to pain and distress.</p><p><strong>Implications for nursing: </strong>Women experience pain and distress during recovery at home after breast-conserving surgery. Nurses can use these results to apply evidence-based practice to reduce this symptom burden. Future nursing research should focus on targeted interventions outside of the hospital setting.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"381-390"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer. 早期乳腺癌妇女核因子 E2 相关因子 2 抗氧化反应元件通路中的基因与癌症相关疲劳之间的关系
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.404-416
Tara S Davis, Theresa A Koleck, Margaret Q Rosenzweig, Christine Miaskowski, Kirk I Erickson, Susan M Sereika, Catherine M Bender, Yvette P Conley
{"title":"Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer.","authors":"Tara S Davis, Theresa A Koleck, Margaret Q Rosenzweig, Christine Miaskowski, Kirk I Erickson, Susan M Sereika, Catherine M Bender, Yvette P Conley","doi":"10.1188/24.ONF.404-416","DOIUrl":"10.1188/24.ONF.404-416","url":null,"abstract":"<p><strong>Objectives: </strong>To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer.</p><p><strong>Sample & setting: </strong>Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania.</p><p><strong>Methods & variables: </strong>Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.</p><p><strong>Results: </strong>The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.</p><p><strong>Implications for nursing: </strong>Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"404-416"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palpitations in Women With Breast Cancer Are Associated With Polymorphisms for Neurotransmitter Genes. 乳腺癌妇女的心悸与神经递质基因的多态性有关。
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.332-348
Ying Sheng, Yvette P Conley, Steven M Paul, Bruce A Cooper, Janet S Carpenter, Marilyn J Hammer, Jon D Levine, Christine Miaskowski
{"title":"Palpitations in Women With Breast Cancer Are Associated With Polymorphisms for Neurotransmitter Genes.","authors":"Ying Sheng, Yvette P Conley, Steven M Paul, Bruce A Cooper, Janet S Carpenter, Marilyn J Hammer, Jon D Levine, Christine Miaskowski","doi":"10.1188/24.ONF.332-348","DOIUrl":"https://doi.org/10.1188/24.ONF.332-348","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate for associations between the occurrence of palpitations reported by women prior to breast cancer surgery and single nucleotide polymorphisms (SNPs) for neurotransmitter genes.</p><p><strong>Sample & setting: </strong>A total of 398 women, who were scheduled for unilateral breast cancer surgery, provided detailed information on demographic and clinical characteristics and the occurrence of palpitations prior to breast cancer surgery.</p><p><strong>Methods & variables: </strong>The occurrence of palpitations was assessed using a single item (i.e., \"heart races/pounds\" in the past week [\"yes\"/\"no\"]). Blood samples were collected for genomic analyses. Multiple logistic regression analyses were used to identify associations between the occurrence of palpitations and variations in neurotransmitter genes.</p><p><strong>Results: </strong>Nine SNPs and two haplotypes among 11 candidate genes were associated with the occurrence of palpitations. These genes encode for a number of neurotransmitters and/or their receptors, including serotonin, norepinephrine, dopamine, gamma-amino butyric acid, Substance P, and neurokinin.</p><p><strong>Implications for nursing: </strong>These findings suggest that alterations in a variety of neurotransmitters contribute to the development of this symptom.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"332-348"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Psychoneurologic Symptom Cluster and Its Association With Breast Cancer Genomic Instability. 精神神经症状群及其与乳腺癌基因组不稳定性的关系
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.391-403
Susan C Grayson, Susan M Sereika, Yvette P Conley, Adrian V Lee, Steffi Oesterreich, Theresa A Koleck, Margaret Q Rosenzweig, Tiantong Liu, Susan W Wesmiller
{"title":"The Psychoneurologic Symptom Cluster and Its Association With Breast Cancer Genomic Instability.","authors":"Susan C Grayson, Susan M Sereika, Yvette P Conley, Adrian V Lee, Steffi Oesterreich, Theresa A Koleck, Margaret Q Rosenzweig, Tiantong Liu, Susan W Wesmiller","doi":"10.1188/24.ONF.391-403","DOIUrl":"https://doi.org/10.1188/24.ONF.391-403","url":null,"abstract":"<p><strong>Objectives: </strong>To phenotype the psychoneurologic (PN) symptom cluster in individuals with metastatic breast cancer and associate those phenotypes with individual characteristics and cancer genomic variables from circulating tumor DNA.</p><p><strong>Sample & setting: </strong>This study included 201 individuals with metastatic breast cancer recruited in western Pennsylvania.</p><p><strong>Methods & variables: </strong>A descriptive, cross-sectional design was used. Symptom data were collected via the MD Anderson Symptom Inventory, and cancer genomic data were collected via ultra-low-pass whole-genome sequencing of circulating tumor DNA from participant blood.</p><p><strong>Results: </strong>Three distinct PN symptom phenotypes were described in a population with metastatic breast cancer: mild symptoms, moderate symptoms, and severe mood-related symptoms. Breast cancer TP53 deletion was significantly associated with membership in a moderate to severe symptoms phenotype (p = 0.013).</p><p><strong>Implications for nursing: </strong>Specific cancer genomic changes associated with increased genomic instability may be predictive of PN symptoms. This finding may enable proactive treatment or reveal new therapeutic targets for symptom management.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"391-403"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fertility Preservation in Individuals With Cancer. 保留癌症患者的生育能力。
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.294-296
{"title":"Fertility Preservation in Individuals With Cancer.","authors":"","doi":"10.1188/24.ONF.294-296","DOIUrl":"https://doi.org/10.1188/24.ONF.294-296","url":null,"abstract":"<p><p>The position statement on fertility preservation was produced through collaborative efforts among the Association of Pediatric Hematology/Oncology Nurses, Canadian Association of Nurses in Oncology/Association canadienne des.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"294-296"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower Income, Smoking, Cardiopulmonary Comorbidities, and Higher Symptom Burden Influence the Occurrence of Cough in Patients Receiving Chemotherapy. 较低的收入、吸烟、心肺合并症和较高的症状负担会影响化疗患者的咳嗽发生率。
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.E4-E24
Joosun Shin, Marilyn J Hammer, Mary E Cooley, Bruce A Cooper, Steven M Paul, Yvette P Conley, Kord M Kober, Jon D Levine, Christine Miaskowski
{"title":"Lower Income, Smoking, Cardiopulmonary Comorbidities, and Higher Symptom Burden Influence the Occurrence of Cough in Patients Receiving Chemotherapy.","authors":"Joosun Shin, Marilyn J Hammer, Mary E Cooley, Bruce A Cooper, Steven M Paul, Yvette P Conley, Kord M Kober, Jon D Levine, Christine Miaskowski","doi":"10.1188/24.ONF.E4-E24","DOIUrl":"https://doi.org/10.1188/24.ONF.E4-E24","url":null,"abstract":"<p><strong>Objectives: </strong>To identify subgroups of patients with distinct cough occurrence profiles and evaluate for differences among these subgroups.</p><p><strong>Sample & setting: </strong>Outpatients receiving chemotherapy (N = 1,338) completed questionnaires six times over two chemotherapy cycles.</p><p><strong>Methods & variables: </strong>Occurrence of cough was assessed using the Memorial Symptom Assessment Scale. Latent class analysis was used to identify subgroups with distinct cough occurrence profiles. Parametric and nonparametric tests were used to evaluate for differences.</p><p><strong>Results: </strong>Four distinct cough profiles were identified (None, Decreasing, Increasing, and High). Risk factors associated with membership in the High class included lower annual household income; history of smoking; self-reported diagnoses of lung disease, heart disease, and back pain; and having lung cancer.</p><p><strong>Implications for nursing: </strong>Clinicians need to assess all patients with cancer for cough and provide targeted interventions.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"E4-E24"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antineoplastic Therapy Administration Safety Standards for Adult and Pediatric Oncology: ASCO-ONS Standards. 成人和儿童肿瘤抗肿瘤治疗管理安全标准》:ASCO-ONS 标准。
IF 1.6 4区 医学
Oncology nursing forum Pub Date : 2024-06-14 DOI: 10.1188/24.ONF.297-320
Robert D Siegel, Kristine B LeFebvre, Sarah Temin, Amy Evers, Lisa Barbarotta, Ronda M Bowman, Alexandre Chan, David W Dougherty, Michael Ganio, Therese Marie Mulvey, Amanda Ouzts, Martha Polovich, Maritza Salazar-Abshire, Elaine Stenstrup, Christine Marie Sydenstricker, Susan Tsai, MiKaela Olsen
{"title":"Antineoplastic Therapy Administration Safety Standards for Adult and Pediatric Oncology: ASCO-ONS Standards.","authors":"Robert D Siegel, Kristine B LeFebvre, Sarah Temin, Amy Evers, Lisa Barbarotta, Ronda M Bowman, Alexandre Chan, David W Dougherty, Michael Ganio, Therese Marie Mulvey, Amanda Ouzts, Martha Polovich, Maritza Salazar-Abshire, Elaine Stenstrup, Christine Marie Sydenstricker, Susan Tsai, MiKaela Olsen","doi":"10.1188/24.ONF.297-320","DOIUrl":"10.1188/24.ONF.297-320","url":null,"abstract":"<p><strong>Purpose: </strong>To update the American Society of Clinical Oncology (ASCO)-Oncology Nursing Society (ONS) standards for antineoplastic therapy administration safety in adult and pediatric oncology and highlight current standards for antineoplastic therapy for adult and pediatric populations with various routes of administration and location.</p><p><strong>Methods: </strong>ASCO and ONS convened a multidisciplinary Expert Panel with representation of multiple organizations to conduct literature reviews and add to the standards as needed. The evidence base was combined with the opinion of the ASCO-ONS Expert Panel to develop antineoplastic safety standards and guidance. Public comments were solicited and considered in preparation of the final manuscript.</p><p><strong>Results: </strong>The standards presented here include clarification and expansion of existing standards to include home administration and other changes in processes of ordering, preparing, and administering antineoplastic therapy; the advent of immune effector cellular therapy; the importance of social determinants of health; fertility preservation; and pregnancy avoidance. In addition, the standards have added a fourth verification.</p><p><strong>Standards: </strong>Standards are provided for which health care organizations and those involved in all aspects of patient care can safely deliver antineoplastic therapy, increase the quality of care, and reduce medical errors.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"297-320"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Chemotherapy-Related Cognitive Impairment on Social Roles and Well-Being in Breast Cancer Survivors. 化疗导致的认知障碍对乳腺癌幸存者的社会角色和幸福感的影响。
IF 1.9 4区 医学
Oncology nursing forum Pub Date : 2024-02-19 DOI: 10.1188/24.ONF.153-162
Lisa R Bailey, Melissa Craft, Shannon S C Bert, Barbara W Carlson
{"title":"The Impact of Chemotherapy-Related Cognitive Impairment on Social Roles and Well-Being in Breast Cancer Survivors.","authors":"Lisa R Bailey, Melissa Craft, Shannon S C Bert, Barbara W Carlson","doi":"10.1188/24.ONF.153-162","DOIUrl":"10.1188/24.ONF.153-162","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the impact of disruptions in information processing (DIPs) on social roles, well-being, and quality of life (QOL) in breast cancer survivors after chemotherapy.</p><p><strong>Participants & setting: </strong>Experiences of DIPs were explored in eight breast cancer survivors aged 53-70 years, 12-60 months post-treatment, referred from a National Cancer Institute-designated cancer center and a nonprofit breast cancer support organization from January 6 to August 31, 2020.</p><p><strong>Methodologic approach: </strong>This study used a mixed-methods approach. Participants journaled and answered questionnaires sent via mail that asked them about changes in their cognition, QOL, and social roles. Qualitative data were thematically analyzed using constant comparative analysis, and questionnaire scores were compared with qualitative data.</p><p><strong>Findings: </strong>Journals revealed problems with functioning in occupational roles and increased stress, anxiety, and frustration. Women with more DIPs tended to have lower role satisfaction and QOL. Greater role satisfaction was associated with higher QOL and social role participation.</p><p><strong>Implications for nursing: </strong>Mitigating the effects of DIPs on social function may allow women to continue in important roles, which has the potential to affect QOL.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 2","pages":"153-162"},"PeriodicalIF":1.9,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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