Open Chemistry最新文献

{"title":"Chemical composition and bioactivities of the methanol root extracts of Saussurea costus","authors":"Manal Abdulaziz Binobead, Ibrahim M. Aziz, Sobhy M. Ibrahim, Reem M. Aljowaie","doi":"10.1515/chem-2024-0002","DOIUrl":"https://doi.org/10.1515/chem-2024-0002","url":null,"abstract":"<jats:italic>Saussurea costus</jats:italic> (<jats:italic>S. costus</jats:italic>) is a medicinal plant from the <jats:italic>Asteraceae</jats:italic> family that is widely used in traditional medicine in Saudi Arabia. This study examines <jats:italic>S. costus</jats:italic> root extract for its chemical composition and its antioxidant, anti-cancer, and antibacterial properties. The results of the study on the methanol root extract of <jats:italic>S. costus</jats:italic> reveal a rich chemical composition, as identified by GC-MS/FID analysis. The extract also showed high levels of total phenolic content (188.2 ± 2.1 mg GAE/g DM) and total flavonoid content (129 ± 2.6 mg QE/g DM). In antioxidant tests, the extract exhibited strong activity, with the half-maximal inhibitory concentration (IC<jats:sub>50</jats:sub>) values of 137.15 μg/mL for ABTS and 175.5 μg/mL for DPPH as compared to positive control’s IC<jats:sub>50</jats:sub> values of 45.5 ± 0.3 μg/mL for ABTS and 55.3 ± 0.1 μg/mL for DPPH. The cytotoxic assessment against MCF-7 and A549 cell lines showed notable effects, particularly at higher concentrations. Additionally, the extract induced apoptosis in these cell lines, evidenced by changes in gene expression. Antibacterial tests revealed significant activity against various strains, with MIC values ranging from 7.81 to 125 μg/mL. The study underscores the importance of plant extracts in modern healthcare and suggests future research directions, including clinical applications and compound identification.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"45 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of essential oil and chemical composition of St. John’s Wort","authors":"Hülya Doğan, Hafize Fidan, Hatice Baş, Stanko Stankov, Albena Stoyanova, Sezai Ercisli, Amine Assouguem, Riaz Ullah, Ahmed Bari","doi":"10.1515/chem-2024-0001","DOIUrl":"https://doi.org/10.1515/chem-2024-0001","url":null,"abstract":"Considering it contains a variety of physiologically active compounds, including flavonoids, common phenols, and essential oils (EOs), St. John’s wort (<jats:italic>Hypericum perforatum</jats:italic> L.) is a common plant in Bulgaria that is predominantly used in folk medicine to cure various disorders. Determining the chemical makeup of St. John’s wort inflorescences that were gathered from northern Bulgaria was the purpose of this investigation. The antioxidant activity of <jats:italic>H. perforatum</jats:italic> L. extracts was assessed using 1,1-diphenyl-2-picrilhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and Trolox equivalent antioxidant capacity (TEAC) tests on methanol extract. The amount of EO obtained by water distillation was 0.08%, with its main components (over 3%) being <jats:italic>n</jats:italic>-nonane (27.46%), <jats:italic>β</jats:italic>-sesquiphellandrene (11.17%), heptanal dimethyl acetal (5.94%), ethyl hexyl ketone (5.93%), undecane (3.75%), sabinene (3.3%), and tridecyl alcohol (3.1%). Methanol extracts were obtained from the inflorescences, with the total flavonoid content determined as 8.66 mg quercetin equivalents (QE)/mg and total phenolic content as 271.33 mg Gallic acid equivalent/g. The FRAP assay yielded 493.07 µmol/L of antioxidant activity, while the TEAC assay yielded 106.39 µmol/L, respectively. Our findings enable a comprehensive characterization of <jats:italic>H. perforatum</jats:italic> from Bulgaria and an assessment of its oil suitability for potential industrial applications. Additionally, the results could guide the selection of specimens for future targeted breeding efforts.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"2016 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutraceutical potential of Mesembryanthemum forsskaolii Hochst. ex Bioss.: Insights into its nutritional composition, phytochemical contents, and antioxidant activity","authors":"Ahmed A. Qahtan, Abdulrahman A. Alatar","doi":"10.1515/chem-2023-0213","DOIUrl":"https://doi.org/10.1515/chem-2023-0213","url":null,"abstract":"<jats:italic>Mesembryanthemum forsskaolii</jats:italic> Hochst. ex Bioss is a resilient succulent plant in the Aizoaceae family. This plant has been recognized for its nutritional and metabolic benefits, but its potential remains underexplored. The aim of this research is to analyze the nutritional composition, phytochemical content, and antioxidant potential of <jats:italic>M</jats:italic>. <jats:italic>forsskaolii</jats:italic>. The protein content, total sugars, macro-, and micronutrients were estimated in seeds, leaves, and stems of the studied plant. To investigate the phytochemical profiles and antioxidant capacity, GC-MS analysis, determination of total phenolic, flavonoid, and tannin contents, ferric reducing antioxidant power (FRAP) and total antioxidant activity (TAC) tests, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assays were conducted. The soluble protein (147.55 mg g<jats:sup>−1</jats:sup> DW), total protein (341.23 mg g<jats:sup>−1</jats:sup> DW), total carbohydrate (0.258 mg mL<jats:sup>−1</jats:sup>), and nitrogen (26.152 mg g<jats:sup>−1</jats:sup>) contents of <jats:italic>M</jats:italic>. <jats:italic>forsskaolii</jats:italic> seeds were the highest. Phytochemical analysis revealed the presence of several compounds, such as β-sitosterol, phthalic acid, and phytol, which have potential antioxidative, anti-inflammatory, and antimicrobial properties. Seeds showed the greatest presence of phenols, flavonoids, and tannins, indicating high antioxidant activity in FRAP and TAC tests. The ABTS and DPPH scavenging assays showed that the antioxidant activity increased proportionally with concentration in all plant parts. However, seeds consistently demonstrated the greatest capacity. This study provides a detailed analysis on the dietary protein, carbohydrates, essential nutrients, and antioxidants that can be obtained from <jats:italic>M</jats:italic>. <jats:italic>forsskaolii</jats:italic>, highlighting its potential as a valuable source of nutrition and phytochemicals.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"51 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hollow mushroom nanomaterials for potentiometric sensing of Pb2+ ions in water via the intercalation of iodide ions into the polypyrrole matrix","authors":"Maha Abdallah Alnuwaiser, Mohamed Rabia","doi":"10.1515/chem-2024-0217","DOIUrl":"https://doi.org/10.1515/chem-2024-0217","url":null,"abstract":"Herein, the synthesis of a sensor for the determination of lead (Pb<jats:sup>2+</jats:sup>) ions via the intercalation of iodide ions into the polypyrrole matrix is performed. It demonstrated a Nernstian slope of 31.7 mV/decade, indicating a linear response within the concentration range of 10<jats:sup>−5</jats:sup>–10<jats:sup>−1 </jats:sup>M. The detection limit achieved is 9.10<jats:sup>−6 </jats:sup>M, indicating the sensor’s sensitivity to low concentrations of Pb<jats:sup>2+</jats:sup>. The effectiveness of the Ppy/I<jats:sup>−</jats:sup> sensor in Pb<jats:sup>2+</jats:sup> sensing is confirmed through cyclic voltammetry, where a peak potential of −0.2 V is observed. The sensitivity of the sensor for Pb<jats:sup>2+</jats:sup> detection is measured to be 2 µA/M. Moreover, the Ppy/I<jats:sup>−</jats:sup> sensor exhibits a negative response to interfering ions, which enhances its selectivity for Pb<jats:sup>2+</jats:sup> detection. Furthermore, when tested with natural water samples such as tap or underground water, which are typically free of lead ions, the sensor demonstrates a negative response to normal interfering ions commonly found in such samples. The Ppy/I<jats:sup>−</jats:sup> sensor offers several advantages, including the ability to detect Pb<jats:sup>2+</jats:sup> ions at very low concentrations, a flexible and adaptable design, and a cost-effective preparation technique. These features make it a promising tool for accurate and efficient detection of Pb<jats:sup>2+</jats:sup> ions.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"56 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of gamma radiation on 5-hydroxymethylfurfural conversion in water and dimethyl sulfoxide","authors":"Nurulsafeelanaria Benwannamas, Phongphak Sataman, Somprasong Thongkham, Wilasinee Kingkam, Wiranee Sriwiang, Sakchai Laksee, Nicha Prigyai, Tanagorn Sangtawesin, Threeraphat Chutimasakul","doi":"10.1515/chem-2023-0206","DOIUrl":"https://doi.org/10.1515/chem-2023-0206","url":null,"abstract":"5-Hydroxymethylfurfural (HMF) is a biomass-based chemical platform that can undergo many feasible reactions. One of the most important reactions is the oxidation to 2,5-furandicarboxylic acid (FDCA), which is the monomer for bioplastic production. In this work, the radiation method was used to investigate the conversion of HMF in both aqueous (DI) and dimethyl sulfoxide (DMSO) solutions. The effects of media solvents, atmospheric gases, HMF concentrations, additive bases, and absorbed doses of gamma radiation were studied. The results showed that the media solvent played a crucial role in HMF conversion under gamma irradiation. At 30 kGy, the HMF conversions in DI and DMSO were 92.1 and 24.1%, respectively, and the oxidation products were only found in the irradiated samples under DMSO. The HMF conversion and oxidation product formation increased with the gamma radiation dose. Moreover, it was found that FDCA stability toward gamma irradiation is highly sensitive in aqueous solution but relatively stable in DMSO. The results implied the alternative promising choice of radiation method compared with traditional methods. To join the bridge, the use of a mixture solvent DI/DMSO seems considerable in the future.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"26 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140129854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers","authors":"Nureen Zahra, Aansa Mazhar, Beenish Zahid, Muhammad Ahsan Naeem, Abid Sarwar, Tariq Aziz, Metab Alharbi, Thamer H. Albekairi, Abdullah F. Alasmari","doi":"10.1515/chem-2023-0199","DOIUrl":"https://doi.org/10.1515/chem-2023-0199","url":null,"abstract":"<jats:italic>Butea monosperma</jats:italic> is a deciduous tree, widely distributed throughout India, Burma, and Ceylon. The present study was intended to investigate the anti-inflammatory effects of <jats:italic>Butea monosperma</jats:italic> on the induced inflammatory model by evaluating pro-inflammatory biomarkers and their computational analysis. The anti-inflammatory activity may be attributed to the phyto-constituents for inhibitory effects on the two pro-inflammatory mediators (IL-8 and TNF-α). For this purpose, rats (<jats:italic>n</jats:italic> = 48) were equally divided in each group, i.e., 8 each in the negative and positive control and 32 in the experimental group with 8 rats for each dose, i.e., 50, 100, 200, and 400 mg/kg. TNF-α and IL-8 were tested by serum enzyme-linked immunosorbent assay (ELISA). The ELISA results showed 400 mg/kg dose as the potent anti-inflammatory. The binding sites of target proteins (TNF-α and IL-8) were docked with the active compounds (butrin and butein) of <jats:italic>Butea monosperma</jats:italic>. The butrin (target: TNF-α) and butein (target: IL-8) showed −8.4 and −6.0 kcal/mol binding energies, respectively, compared to the (diclofenac) standard drug with −6.8 kcal/mol binding energy. Hence, we concluded that <jats:italic>Butea monosperma</jats:italic> can be subjected to as a useful anti-inflammatory drug.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140053917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study","authors":"Rafik El-Mernissi, Naoual El Menyiy, Rania Moubachir, Aziz Zouhri, Yahya El-Mernissi, Farhan Siddique, Sumaira Nadeem, Hind Ibork, Azeddin El Barnossi, Gezahign Fentahun Wondmie, Mohammed Bourhia, Yousef A. Bin Jardan, Oualid Abboussi, Lhoussain Hajji","doi":"10.1515/chem-2023-0214","DOIUrl":"https://doi.org/10.1515/chem-2023-0214","url":null,"abstract":"This study evaluated the volatile components of <jats:italic>Cannabis sativa</jats:italic> L. essential oils (CSEOs) and their pharmacological potential <jats:italic>in vitro</jats:italic>, in animal, and <jats:italic>in silico</jats:italic>. The anti-oxidant capacities of volatile compounds were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), total anti-oxidant capacity (TAC), and gas chromatography-mass spectrometry (GC-MS). Anti-microbial activity against bacterial and fungal strains was assessed using disk diffusion and micro-dilution, and acute toxicity was examined on mice using OECD 423 criteria. The results indicate that the main components were β-caryophyllene (31.54%), α-humulene (12.62%), β-myrcene (4.83%), and α-pinene (4.69%). The essential oil showed high anti-oxidant ability (IC<jats:sub>50</jats:sub> = 0.981 ± 0.059 mg/ml for DPPH, EC<jats:sub>50</jats:sub> = 1.74 ± 0.05 for FRAP), and TAC of 0.101 ± 0.001 mg AAE/g. Additionally, it showed significant antibacterial action against Gram-negative organisms, such as <jats:italic>Escherichia coli</jats:italic> (11.33 ± 0.00 mm), <jats:italic>Klebsiella pneumonia</jats:italic> (9 ± 0.00 mm), and <jats:italic>Pseudomonas aeruginosa</jats:italic> (9.34 ± 0.00), with MICs ranging from 0.0052 to 0.0208 mg/CSEO demonstrated antifungal activity against <jats:italic>Candida albicans</jats:italic> and <jats:italic>Fusarium proliferatum</jats:italic>, with activity levels of 18.66 ± 0.88 mm, 41.89 ± 3.60%, and MICs of 0.39 and 0.013 mg/ml, respectively. In toxicological studies, CSEO proved to be safe for animals. Docking identified bioactive components and explored anti-oxidant and antibacterial properties. Docking proved that bulnesol and champacol caused indicated actions.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"154 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140053923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo protective effects of vitamin C against cyto-genotoxicity induced by Dysphania ambrosioides aqueous extract","authors":"Laila El-Bouzidi, Ahmed khadra, Manal Zefzoufi, Saida Sissi, Abdelilah El-Abbassi, Khalid Bekkouche, Souad Sellami, Hanane Rais","doi":"10.1515/chem-2023-0207","DOIUrl":"https://doi.org/10.1515/chem-2023-0207","url":null,"abstract":"<jats:italic>Dysphania ambrosioides</jats:italic> (L.) holds a prominent place in Moroccan folk medicine due to its therapeutic attributes. Despite its widespread use, instances of inadvertent intoxication linked to its consumption have been reported. This study aims to evaluate the potential cytogenotoxic effects of <jats:italic>D. ambrosioides</jats:italic> leaf aqueous extract (DAAE) and explore the prospective protective role of vitamin C (<jats:sc>l</jats:sc>-ascorbic acid) through the micronucleus test conducted on (1) <jats:italic>Vicia faba</jats:italic> root-tip meristem and (2) mouse bone marrow cells. In addition, antioxidant enzyme activities, specifically superoxide dismutase (SOD) and catalase (CAT), were evaluated in <jats:italic>V. faba</jats:italic> treated with DAAE. After a 7-day daily administration of DAAE to mice, serum biochemical parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine, and uric acid) were measured, and histological examination of liver and kidney tissues was performed. The results indicated that DAAE had dose-dependent cytotoxic and genotoxic effects on both biological models. Furthermore, <jats:italic>V. faba</jats:italic> treated with DAAE showed significant increases in the activities of SOD and CAT enzymes. Mice treated with DAAE exhibited significant elevations in serum biochemical parameters compared to the control group. Histological examination of liver and kidney tissues revealed hepatic degeneration, glomerular shrinkage, and distinct vacuolated tubular epithelial cells. The cotreatment with vitamin C demonstrated a significant protective effect against DAAE-induced cytogenotoxicity. These findings underscore the importance of vitamin C as a protective agent against oxidative stress and cytogenotoxicity induced by DAAE and recommend its use in any DAAE-based preparation.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"8 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140044364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of multi-template molecularly imprinted polymers (MT-MIPs) for isolating ethyl para-methoxycinnamate and ethyl cinnamate from Kaempferia galanga L., extract with methacrylic acid as functional monomer","authors":"Ike Susanti, Anastasya Leatemia Triadenda, Niky Murdaya, Driyanti Rahayu, Rimadani Pratiwi, Yudi Rosandi, Aliya Nur Hasanah","doi":"10.1515/chem-2023-0202","DOIUrl":"https://doi.org/10.1515/chem-2023-0202","url":null,"abstract":"<jats:italic>Kaempferia galanga</jats:italic> L. extract contains ethyl p-methoxycinnamate (EPMC) and ethyl cinnamate (EC), which have several pharmacological activities. EPMC and EC have been successfully isolated, but the %yield was low. Therefore, developing an isolation method to increase the %yield result of EPMC and EC is essential. The molecularly imprinted polymers have been applied to separate lot of active compounds from natural products with excellent results. MIP synthesis is usually performed using a single template with high selectivity for the target analyte but only detect single chemical compounds. Hence, this study synthesized multi-template molecularly imprinted polymers (MT-MIPs) for isolating EPMC and EC simultaneously using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate or trimethyl propane trimethacrylate (TRIM) as a crosslinker. The study results indicate that MT-MIP produced with TRIM is more effective in separating EPMC and EC simultaneously in <jats:italic>K. galanga</jats:italic> L. extracts. However, the yields of EPMC and EC were still low. The yields of EPMC and EC in <jats:italic>n</jats:italic>-hexane extracts were 1.557 and 1.929%, with purity of 66.330 and 61.510%, respectively. Further research is necessary to determine the ideal functional monomer and its ratio to template molecules to obtain the excellent selectivity of the MT-MIPs used for simultaneously isolating EPMC and EC.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"127 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140044199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and physicochemical studies of different apple varieties grown in Morocco","authors":"Kara Mohammed, Hamza Saghrouchni, Youness El Abdali, Assouguem Amine, Nouha Haoudi, Mohamed El fadili, Aya Amar, Tareq Hamijo, Isil Var, Riaz Ullah, Zerhouni Abdou Rachid, Bahhou Jamila","doi":"10.1515/chem-2023-0205","DOIUrl":"https://doi.org/10.1515/chem-2023-0205","url":null,"abstract":"The apple is an important part of the human diet and is one of the most popular fruits in Morocco, with varieties that are now suitable for human consumption. This study aims to clarify several aspects of apples, such as their physical and chemical compositions and nutrient profiles. Total polyphenols, flavonoids, tannins, and anthocyanins were determined using spectrophotometer and organic acid compounds were identified by high-performance liquid chromatography-ultraviolet. The results show a significant difference between the several varieties under study in terms of their physico-chemical and phyto-chemical characteristics. In general, the studied apples are juiciness, with a percentage ranging from 60 to 71%. The pH values demonstrate how acidic the apples are. The Brix parameter denotes values greater than 13°Brix. Total polyphenols and condensed tannins (1154.65 ± 13.54 µg EAG/g and 514.09 ± 32.40 µg EAT/g, respectively) are more present in the Ahjjani variety than they are in other varieties. This demonstrates their good nutritional quality while not being consumable. However, the Story variety has a predominance of flavonoids (75.074 ± 2.309 µg QE/g) and flavones (45.074 ± 2.09 µg QE/g). The detection of organic acids has shown that the acid succinic is the most abundant in all the varieties of studied apple fruits. These results allow us to infer that non-consumable varieties are also important dietary sources of bioactive molecules, notably for polyphenols. The fact that these kinds can be used to produce other byproducts is therefore highly intriguing.","PeriodicalId":19520,"journal":{"name":"Open Chemistry","volume":"73 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140016809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}