Chemical composition and bioactivities of the methanol root extracts of Saussurea costus

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Open Chemistry Pub Date : 2024-03-21 DOI:10.1515/chem-2024-0002

Manal Abdulaziz Binobead, Ibrahim M. Aziz, Sobhy M. Ibrahim, Reem M. Aljowaie

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Abstract

Saussurea costus (S. costus) is a medicinal plant from the Asteraceae family that is widely used in traditional medicine in Saudi Arabia. This study examines S. costus root extract for its chemical composition and its antioxidant, anti-cancer, and antibacterial properties. The results of the study on the methanol root extract of S. costus reveal a rich chemical composition, as identified by GC-MS/FID analysis. The extract also showed high levels of total phenolic content (188.2 ± 2.1 mg GAE/g DM) and total flavonoid content (129 ± 2.6 mg QE/g DM). In antioxidant tests, the extract exhibited strong activity, with the half-maximal inhibitory concentration (IC50) values of 137.15 μg/mL for ABTS and 175.5 μg/mL for DPPH as compared to positive control’s IC50 values of 45.5 ± 0.3 μg/mL for ABTS and 55.3 ± 0.1 μg/mL for DPPH. The cytotoxic assessment against MCF-7 and A549 cell lines showed notable effects, particularly at higher concentrations. Additionally, the extract induced apoptosis in these cell lines, evidenced by changes in gene expression. Antibacterial tests revealed significant activity against various strains, with MIC values ranging from 7.81 to 125 μg/mL. The study underscores the importance of plant extracts in modern healthcare and suggests future research directions, including clinical applications and compound identification.

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木犀草根甲醇提取物的化学成分和生物活性

木贼（Saussurea costus）是一种菊科药用植物，在沙特阿拉伯的传统医学中被广泛使用。本研究考察了木贼根提取物的化学成分及其抗氧化、抗癌和抗菌特性。通过 GC-MS/FID 分析，对 S. costus 根甲醇提取物的研究结果表明其化学成分丰富。提取物还显示出较高的总酚含量（188.2 ± 2.1 mg GAE/g DM）和总黄酮含量（129 ± 2.6 mg QE/g DM）。在抗氧化测试中，该提取物表现出很强的活性，ABTS 的半最大抑制浓度 (IC50) 值为 137.15 μg/mL，DPPH 的半最大抑制浓度 (IC50) 值为 175.5 μg/mL，而阳性对照的半最大抑制浓度 (IC50) 值为 45.5 ± 0.3 μg/mL（ABTS）和 55.3 ± 0.1 μg/mL（DPPH）。对 MCF-7 和 A549 细胞系进行的细胞毒性评估显示了显著的效果，尤其是在浓度较高的情况下。此外，提取物还能诱导这些细胞株的细胞凋亡，基因表达的变化就是证明。抗菌测试显示，萃取物对各种菌株具有显著的抗菌活性，MIC 值从 7.81 到 125 μg/mL 不等。这项研究强调了植物提取物在现代医疗保健中的重要性，并提出了未来的研究方向，包括临床应用和化合物鉴定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

6 weeks

期刊介绍： Open Chemistry is a peer-reviewed, open access journal that publishes original research, reviews and short communications in the fields of chemistry in an ongoing way. The central goal is to provide a hub for researchers working across all subjects to present their discoveries, and to be a forum for the discussion of the important issues in the field. The journal is the premier source for cutting edge research in fundamental chemistry and it provides high quality peer review services for its authors across the world. Moreover, it allows for libraries everywhere to avoid subscribing to multiple local publications, and to receive instead all the necessary chemistry research from a single source available to the entire scientific community.