Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Open Chemistry Pub Date : 2024-03-06 DOI:10.1515/chem-2023-0199

Nureen Zahra, Aansa Mazhar, Beenish Zahid, Muhammad Ahsan Naeem, Abid Sarwar, Tariq Aziz, Metab Alharbi, Thamer H. Albekairi, Abdullah F. Alasmari

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引用次数: 0

Abstract

Butea monosperma is a deciduous tree, widely distributed throughout India, Burma, and Ceylon. The present study was intended to investigate the anti-inflammatory effects of Butea monosperma on the induced inflammatory model by evaluating pro-inflammatory biomarkers and their computational analysis. The anti-inflammatory activity may be attributed to the phyto-constituents for inhibitory effects on the two pro-inflammatory mediators (IL-8 and TNF-α). For this purpose, rats (n = 48) were equally divided in each group, i.e., 8 each in the negative and positive control and 32 in the experimental group with 8 rats for each dose, i.e., 50, 100, 200, and 400 mg/kg. TNF-α and IL-8 were tested by serum enzyme-linked immunosorbent assay (ELISA). The ELISA results showed 400 mg/kg dose as the potent anti-inflammatory. The binding sites of target proteins (TNF-α and IL-8) were docked with the active compounds (butrin and butein) of Butea monosperma. The butrin (target: TNF-α) and butein (target: IL-8) showed −8.4 and −6.0 kcal/mol binding energies, respectively, compared to the (diclofenac) standard drug with −6.8 kcal/mol binding energy. Hence, we concluded that Butea monosperma can be subjected to as a useful anti-inflammatory drug.

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评估艳紫铆花提取物对炎症生物标志物的影响

艳紫铆是一种落叶乔木，广泛分布于印度、缅甸和锡兰。本研究旨在通过评估促炎生物标志物及其计算分析，研究艳紫铆对诱导炎症模型的抗炎作用。抗炎活性可能归因于植物成分对两种促炎介质（IL-8 和 TNF-α）的抑制作用。为此，将大鼠（n = 48）平均分为两组，即阴性对照组和阳性对照组各 8 只，实验组 32 只，每个剂量（即 50、100、200 和 400 毫克/千克）各 8 只。用血清酶联免疫吸附试验（ELISA）检测 TNF-α 和 IL-8。酶联免疫吸附试验结果表明，400 毫克/千克的剂量具有强效抗炎作用。目标蛋白（TNF-α 和 IL-8）的结合位点与艳紫铆的活性化合物（丁炔素和丁素）进行了对接。与结合能为-6.8 kcal/mol的标准药物（双氯芬酸）相比，丁香素（靶标：TNF-α）和丁香苷（靶标：IL-8）的结合能分别为-8.4和-6.0 kcal/mol。因此，我们得出结论，艳紫铆可以作为一种有用的抗炎药物。

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来源期刊

Open Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

6 weeks

期刊介绍： Open Chemistry is a peer-reviewed, open access journal that publishes original research, reviews and short communications in the fields of chemistry in an ongoing way. The central goal is to provide a hub for researchers working across all subjects to present their discoveries, and to be a forum for the discussion of the important issues in the field. The journal is the premier source for cutting edge research in fundamental chemistry and it provides high quality peer review services for its authors across the world. Moreover, it allows for libraries everywhere to avoid subscribing to multiple local publications, and to receive instead all the necessary chemistry research from a single source available to the entire scientific community.