Ophthalmology. Glaucoma最新文献

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Validating and Updating the OHTS-EGPS Model Predicting 5-year Glaucoma Risk among Ocular Hypertension Patients Using Electronic Records 利用电子记录验证和更新预测眼压病患者 5 年青光眼风险的 OHTS-EGPS 模型。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.10.009
David M. Wright PhD , Augusto Azuara-Blanco PhD , Chris Cardwell PhD , Giovanni Montesano PhD , David P. Crabb PhD , Gus Gazzard MD , Anthony J. King MD , Rodolfo Hernández PhD , James E. Morgan DPhil , Bethany Higgins PhD , Yemisi Takwoingi PhD
{"title":"Validating and Updating the OHTS-EGPS Model Predicting 5-year Glaucoma Risk among Ocular Hypertension Patients Using Electronic Records","authors":"David M. Wright PhD ,&nbsp;Augusto Azuara-Blanco PhD ,&nbsp;Chris Cardwell PhD ,&nbsp;Giovanni Montesano PhD ,&nbsp;David P. Crabb PhD ,&nbsp;Gus Gazzard MD ,&nbsp;Anthony J. King MD ,&nbsp;Rodolfo Hernández PhD ,&nbsp;James E. Morgan DPhil ,&nbsp;Bethany Higgins PhD ,&nbsp;Yemisi Takwoingi PhD","doi":"10.1016/j.ogla.2024.10.009","DOIUrl":"10.1016/j.ogla.2024.10.009","url":null,"abstract":"<div><h3>Objective</h3><div>To validate and update the Ocular Hypertension Treatment Study-European Glaucoma Prevention Study (OHTS-EGPS) model predicting risk of conversion from ocular hypertension (OHT) to glaucoma using electronic medical records (EMR).</div></div><div><h3>Design</h3><div>Evaluation and update of a risk prediction algorithm using EMRs and linked visual field (VF) tests.</div></div><div><h3>Participants</h3><div>Newly diagnosed OHT patients attending hospital glaucoma services in England. Inclusion criteria are as follows: intraocular pressure (IOP) 22 to 32 mmHg (either eye); normal baseline VF test, defined as Glaucoma Hemifield Test (GHT) “within normal range” in a reliable VF test; at least 2 VF tests in total; no significant ocular comorbidities.</div></div><div><h3>Methods</h3><div>Risk factors are as follows: age, ethnicity, sex, IOP, vertical cup-to-disc ratio, central corneal thickness, VF pattern standard deviation, family history of glaucoma, systemic hypertension, diabetes mellitus, and glaucoma treatment. Glaucoma conversion was defined as 2 consecutive and reliable VF tests with GHT “outside normal limits” and/or need for glaucoma surgery. For validation, the OHTS-EGPS model was applied to predict a patient’s risk of developing glaucoma in 5 years. In the updating stage, the OHTS model was refitted by re-estimating the baseline hazard and regression coefficients. The updated model was cross-validated and several variants were explored.</div></div><div><h3>Main Outcome Measures</h3><div>Measures of discriminative ability (c-index) and calibration (calibration slope) were calculated and pooled across hospitals using random effects meta-analysis.</div></div><div><h3>Results</h3><div>From a total of 138 461 patients from 10 hospital glaucoma services in England, 9030 patients with OHT fitted the inclusion criteria. A total of 1530 (16.9%) patients converted to glaucoma during this follow-up period. The OHTS-EGPS model provided a pooled c-index of 0.61 (95% confidence interval: 0.60–0.63), ranging from 0.55 to 0.67 between hospitals. The pooled calibration slope was 0.45 (0.38–0.51), ranging from 0.25 to 0.64 among hospitals. The overall refitted model performed better than the OHTS-EGPS model, with a pooled c-index of 0.67 (0.65–0.69), ranging from 0.65 to 0.75 between hospitals.</div></div><div><h3>Conclusions</h3><div>We performed an external validation of the OHTS-EGPS model in a large English population. Refitting the model achieved modest improvements in performance. Given the poor performance of the OHTS-EGPS model in our population, one should use caution in its application to populations that differ from those in the OHTS and EGPS.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 143-151"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of Uveitis Following Initiation of Prostaglandin Analogs versus Other Glaucoma Medications 开始使用前列腺素类似物与其他青光眼药物后葡萄膜炎的发生率:来自 SOURCE 资料库的研究。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.10.010
Muhammad Z. Chauhan MD, MS , Abdelrahman M. Elhusseiny MD, MSc , Shikha Marwah MS , Ahmed B. Sallam MD, PhD , Joshua D. Stein MD, MS , Krishna S. Kishor MD
{"title":"Incidence of Uveitis Following Initiation of Prostaglandin Analogs versus Other Glaucoma Medications","authors":"Muhammad Z. Chauhan MD, MS ,&nbsp;Abdelrahman M. Elhusseiny MD, MSc ,&nbsp;Shikha Marwah MS ,&nbsp;Ahmed B. Sallam MD, PhD ,&nbsp;Joshua D. Stein MD, MS ,&nbsp;Krishna S. Kishor MD","doi":"10.1016/j.ogla.2024.10.010","DOIUrl":"10.1016/j.ogla.2024.10.010","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the risk of incidence rates of uveitis among patients starting topical glaucoma therapy.</div></div><div><h3>Design</h3><div>Retrospective database study utilizing the Sight Outcomes Research Collaborative (SOURCE) Ophthalmology Data Repository.</div></div><div><h3>Participants</h3><div>Adult glaucoma patients who were recently started on topical glaucoma therapy.</div></div><div><h3>Methods</h3><div>Using data from 10 health systems contributing data to the SOURCE data repository, we identified all adult glaucoma patients who had been newly started on a topical glaucoma medication (prostaglandin analogs [PGAs], beta-blockers [BBs], alpha agonists [AAs], and carbonic anhydrase inhibitors [CAIs]). Patients with pre-existing documentation of uveitis were excluded.</div></div><div><h3>Main Outcome Measures</h3><div>Incidence of uveitis within 3 months of initiating therapy with different topical glaucoma medications.</div></div><div><h3>Results</h3><div>We included 67 517 patients who were newly prescribed a topical glaucoma medication. The mean age of the patients was 67.3 ± 13.2 years and ∼59% were females. A total of 567 patients (0.87%) developed uveitis within 3 months of initiating the therapy. The incidence of uveitis was 0.32%, 1.95%, 1.63%, and 1.68% for users of PGAs, BBs, AAs, and CAIs, respectively. After adjusting for sociodemographic factors, individuals using topical BBs, AAs, and CAIs had significantly higher odds of developing uveitis versus those using PGAs (<em>P</em> &lt; 0.001 for all comparisons).</div></div><div><h3>Conclusions</h3><div>The use of PGAs was not associated with higher odds of developing uveitis compared with other classes of topical glaucoma medications.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 126-132"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries 加利福尼亚州医疗保险受益人青光眼严重程度与髋部骨折之间的关系。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.10.002
Sayan K. Chatterjee MPH , Ramin Talebi BS , Ken Kitayama MD, PhD , Andrew G. Young MD , Fei Yu PhD , Victoria L. Tseng MD, PhD , Anne L. Coleman MD, PhD
{"title":"The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries","authors":"Sayan K. Chatterjee MPH ,&nbsp;Ramin Talebi BS ,&nbsp;Ken Kitayama MD, PhD ,&nbsp;Andrew G. Young MD ,&nbsp;Fei Yu PhD ,&nbsp;Victoria L. Tseng MD, PhD ,&nbsp;Anne L. Coleman MD, PhD","doi":"10.1016/j.ogla.2024.10.002","DOIUrl":"10.1016/j.ogla.2024.10.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the association between glaucoma severity and hip fractures in older adults.</div></div><div><h3>Design</h3><div>Retrospective cross-sectional study.</div></div><div><h3>Subjects</h3><div>California (CA) Medicare beneficiaries in 2019 with Parts A &amp; B coverage.</div></div><div><h3>Methods</h3><div>Multivariable logistic regression was used to analyze the association between glaucoma severity (mild, moderate, and severe vs. no glaucoma) and hip fracture, after adjusting for age, sex, race and ethnicity, and Charlson Comorbidity Index score. A subgroup analysis was performed only in individuals with glaucoma to examine the odds of hip fracture for those with moderate and severe glaucoma compared to those with mild glaucoma.</div></div><div><h3>Main Outcome Measures</h3><div>The variations in the odds of hip fractures for patients with and without glaucoma and for patients with moderate and severe glaucoma compared to those with mild glaucoma.</div></div><div><h3>Results</h3><div>Of the 2 717 346 beneficiaries in the study population, 220 662 (8.1%) had glaucoma. In multivariable regression analysis, those with mild (odds ratio [OR]: 0.83; 95% confidence interval [CI]: 0.78–0.88) and moderate glaucoma (OR: 0.88; 95% CI: 0.84–0.92) had reduced odds of hip fracture compared with those with no glaucoma. There was no statistically significant association between severe vs. no glaucoma and hip fracture (OR: 0.96; 95% CI: 0.91–1.02). Among individuals with glaucoma, the odds of hip fracture were higher for those with severe glaucoma (OR: 1.17; 95% CI: 1.08–1.27), compared with those with mild glaucoma.</div></div><div><h3>Conclusions</h3><div>In the CA Medicare population, the presence of glaucoma was associated with decreased likelihood of hip fracture. However, in those with glaucoma, increased glaucoma severity was associated with an increased likelihood of hip fracture. Potential mediating mechanisms requiring further study include fear of falls and physical inactivity in patients with glaucoma.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 167-174"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Multifaceted Nongenetic Risk Factors for Primary Open-angle Glaucoma 原发性开角型青光眼的多方面非遗传风险因素--系统综述。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.10.004
Jens Rovelt MSc, PhD , Josefine Freiberg MD, PhD , Augusto Azuara-Blanco MD, PhD , Gianni Virgili MD , Miriam Kolko MD, PhD
{"title":"The Multifaceted Nongenetic Risk Factors for Primary Open-angle Glaucoma","authors":"Jens Rovelt MSc, PhD ,&nbsp;Josefine Freiberg MD, PhD ,&nbsp;Augusto Azuara-Blanco MD, PhD ,&nbsp;Gianni Virgili MD ,&nbsp;Miriam Kolko MD, PhD","doi":"10.1016/j.ogla.2024.10.004","DOIUrl":"10.1016/j.ogla.2024.10.004","url":null,"abstract":"<div><h3>Topic</h3><div>A synthesis of the current knowledge on risk factors for primary open-angle glaucoma (POAG).</div></div><div><h3>Clinical Relevance</h3><div>This review advances understanding, guides future research, and informs strategies for preventing and treating POAG.</div></div><div><h3>Method</h3><div>We conducted a systematic search of PubMed, Embase, Web of Science, and the Cochrane Library to identify relevant systematic reviews (SRs) published in English after 2012. The inclusion criteria focused on SRs investigating risk factors for POAG. We registered the study prospectively in the PROSPERO database (CRD42022351372) and used Covidence and the Risk of Bias in Systematic Reviews tool to manage article selection and assess the risk of bias in the included SRs. Data was extracted independently by 2 authors.</div></div><div><h3>Results</h3><div>After removing duplicate SRs, we assessed 2542 SRs. Of these, 2396 were determined to be irrelevant, leaving 138 for a full-text review. Following this, 78 were excluded with reasons, resulting in 60 SRs. Of these, 30 had a low risk of bias. In our bias assessment, SRs categorized as high risk of bias were characterized by 1) lack of sufficient detail in the bias assessment of the SR and 2) insufficient information or missing calculations of heterogeneity among the included studies. In our study, we identified 22 risk factors associated with POAG. The SRs covered a wide range of risk factors for POAG. Among these, the strongest associations with POAG, based on effect size, were observed in 2 SRs related to obstructive sleep apnea (OSA), with a pooled odds ratio (OR) of 3.66 (95% confidence interval [CI]: 1.70–7.90) and an adjusted OR of 2.46 (95% CI: 1.32–4.59). Similarly, 2 SRs investigating <em>Helicobacter pylori</em> (<em>H. pylori</em>) infections showed significant associations, with pooled ORs of 2.08 (95% CI: 1.48–2.93) and 2.08 (95% CI: 1.42–3.04), respectively.</div></div><div><h3>Conclusion</h3><div>This article summarizes the current knowledge on risk factors for POAG from published SRs. Our findings highlight the complexity of the disease and the nature of the factors that may affect various populations. Among the reported associations with low risk of bias, we found the highest effect estimates for OSA and <em>H. pylori</em> infections in relation to POAG. Our review helps advance understanding, guide future research, and inform strategies for the prevention and treatment of POAG.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 188-198"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost in the Angle: The Mystery of the Missing XEN 迷失在角度:失踪的XEN之谜。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.12.005
Miguel Santos MD, Telma Gala, Luís Abegão Pinto MD, PhD
{"title":"Lost in the Angle: The Mystery of the Missing XEN","authors":"Miguel Santos MD,&nbsp;Telma Gala,&nbsp;Luís Abegão Pinto MD, PhD","doi":"10.1016/j.ogla.2024.12.005","DOIUrl":"10.1016/j.ogla.2024.12.005","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Page e4"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
American Glaucoma Society-American Academy of Ophthalmology Position Statement on Nicotinamide Use for Glaucoma Neuroprotection 美国青光眼学会-美国眼科学会关于尼古丁酰胺用于青光眼神经保护的立场声明。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2025.01.002
Aakriti Garg Shukla MD, MSc, George A. Cioffi MD, Simon W.M. John PhD, Qing Wang MD, PhD, Jeffrey M. Liebmann MD, American Glaucoma Society and American Academy of Ophthalmology
{"title":"American Glaucoma Society-American Academy of Ophthalmology Position Statement on Nicotinamide Use for Glaucoma Neuroprotection","authors":"Aakriti Garg Shukla MD, MSc,&nbsp;George A. Cioffi MD,&nbsp;Simon W.M. John PhD,&nbsp;Qing Wang MD, PhD,&nbsp;Jeffrey M. Liebmann MD,&nbsp;American Glaucoma Society and American Academy of Ophthalmology","doi":"10.1016/j.ogla.2025.01.002","DOIUrl":"10.1016/j.ogla.2025.01.002","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 112-116"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifiable Historic and Observable Factors May Predict Progression to Exfoliation Glaucoma in Newly Diagnosed Exfoliation Patients 可识别的历史因素和可观察到的因素可预测新诊断的剥脱性青光眼患者向剥脱性青光眼的发展。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.10.006
Karen Curtin PhD , Joshua D. Stein MD, MS , Brian C. Stagg MD, MS , Nora Fino MS , Matthew Conley MD , Taylor Johnson BS , Ayesha Patil MD , Chase Paulson MD , Christian Pompoco BS , Barbara M. Wirostko MD, FARVO
{"title":"Identifiable Historic and Observable Factors May Predict Progression to Exfoliation Glaucoma in Newly Diagnosed Exfoliation Patients","authors":"Karen Curtin PhD ,&nbsp;Joshua D. Stein MD, MS ,&nbsp;Brian C. Stagg MD, MS ,&nbsp;Nora Fino MS ,&nbsp;Matthew Conley MD ,&nbsp;Taylor Johnson BS ,&nbsp;Ayesha Patil MD ,&nbsp;Chase Paulson MD ,&nbsp;Christian Pompoco BS ,&nbsp;Barbara M. Wirostko MD, FARVO","doi":"10.1016/j.ogla.2024.10.006","DOIUrl":"10.1016/j.ogla.2024.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>To identify clinical factors associated with conversion to exfoliation glaucoma (XFG) in exfoliation syndrome (XFS) patients who are most at risk of progression to XFG within 3 years for increased surveillance and early preventive interventions.</div></div><div><h3>Design</h3><div>A retrospective patient cohort study design was employed.</div></div><div><h3>Subjects</h3><div>A source population of XFS patients ≥ 50 years was identified from electronic medical records in the Utah Population Database. From this, 487 study patients with one or more dilated eye examinations before chart-confirmed XFS onset in 2011 or later and ≥ 3 years of subsequent eye examinations were selected for study.</div></div><div><h3>Methods</h3><div>We implemented binomial linear mixed models with L1-penalized estimation to select variables associated with conversion. Models included a random intercept to account for within-patient correlation for eye-level data. Candidate demographic, lifestyle, systemic, and ocular comorbidities data were obtained, and diagnoses were categorized as binary (history or no history). These potential factors between conversion and nonconversion patients were used in model selection of variables jointly predictive of conversion. Odds ratios and confidence intervals were calculated using the link logit.</div></div><div><h3>Main Outcome Measures</h3><div>To determine the main outcome of conversion to XFG following an index diagnosis of XFS compared with nonconversion within 3 years, clinical records of each subject’s left and right eyes were assessed to confirm XFS and date of onset and date of XFG onset, if conversion occurred. Clinical measurements (e.g., intraocular pressure [IOP], cup-to-disc ratio, provider notes, and IOP-lowering procedures and medications) were used to corroborate conversion status.</div></div><div><h3>Results</h3><div>Eighteen variables jointly predicted XFG conversion within 3 years correctly in 71% of patient eyes. The odds of conversion were the highest for exudative age-related macular degeneration (AMD), 2.3-fold (<em>P</em> = 0.004). Other predictive variables included nonexudative AMD (<em>P</em> = 0.05), primary open angle glaucoma (<em>P</em> &lt; 0.001), obstructive sleep apnea (<em>P</em> = 0.03), and ocular hypertension (<em>P</em> = 0.003) diagnosed before XFS onset.</div></div><div><h3>Conclusions</h3><div>We determined a set of clinically relevant factors that predicted which newly diagnosed XFS patients progressed to XFG within 3 years. A planned validation will independently confirm if these prognostic indicators hold promise in other settings.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 133-142"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of the Handheld IC200 and Slit Lamp-mounted ST500 Rebound Tonometers with Goldmann Applanation Tonometry 手持式 IC200 和装在裂隙灯上的 ST500 回弹式眼压计与戈德曼眼压计的比较研究。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.10.008
Ryo Tomita MD, Glen P. Sharpe MSc, Devin Betsch MD, Rodolfo Bonatti MD, Balwantray C. Chauhan PhD
{"title":"A Comparative Study of the Handheld IC200 and Slit Lamp-mounted ST500 Rebound Tonometers with Goldmann Applanation Tonometry","authors":"Ryo Tomita MD,&nbsp;Glen P. Sharpe MSc,&nbsp;Devin Betsch MD,&nbsp;Rodolfo Bonatti MD,&nbsp;Balwantray C. Chauhan PhD","doi":"10.1016/j.ogla.2024.10.008","DOIUrl":"10.1016/j.ogla.2024.10.008","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the agreement and repeatability of intraocular pressure (IOP) measured with the slit lamp-mounted ST500 rebound tonometer (iCare Finland Oy), the hand-held IC200 rebound tonometer (iCare Finland Oy), and Goldmann applanation tonometry (GAT).</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Participants</h3><div>Glaucoma patients and staff of the Eye Care Centre, Nova Scotia Health.</div></div><div><h3>Methods</h3><div>Intraocular pressure was measured twice each with the IC200, ST500, and GAT. Bland-Altman analysis was used to compare each pair of tonometers and whether the difference between tonometers depended on mean IOP. Intraclass correlation coefficients were also computed. Repeatability of the measurements with each tonometer was assessed by calculating the mean and variance of the difference between the first and second measurements. The relationship between IOP and central corneal thickness was also evaluated.</div></div><div><h3>Main Outcome Measures</h3><div>Agreement and repeatability of IOP measurements with the IC200, ST500, and GAT.</div></div><div><h3>Results</h3><div>One eye of 157 participants (64 men and 93 women) with a median (interquartile range) age and central corneal thickness of 62 (45–72) years and 553 (533–572) μm, respectively, were enrolled. Median IOP with the IC200, ST500, and GAT was 17.1 (14.3–21.0), 16.5 (14.0–20.8), and 17.0 (14.0–20.5) mmHg, respectively, while the range of IOP (measured with GAT) was 8.5 to 53.0 mmHg. Measurements with the 3 tonometers were not statistically different from each other, and in neither of the 3 paired comparisons was the difference in IOP between 2 tonometers dependent on mean IOP. The intraclass correlation coefficient values (0.97–0.98) showed excellent agreement between the tonometers. The variance of the difference between the first and second measurements of the ST500 was significantly lower than that of GAT (<em>P</em> = 0.04) and IC200 (<em>P</em> &lt; 0.01). Intraclass correlation coefficients for intratonometer repeatability were also excellent (0.97–0.99).</div></div><div><h3>Conclusions</h3><div>The ST500 shows good agreement with GAT over a large range of IOP and significantly higher repeatability compared to the IC200 and GAT, suggesting it may be advantageous in clinical settings where topical anesthesia or skilled staff are unavailable.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 2","pages":"Pages 152-156"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective Management of Ahmed Valve Obstruction by Iris Using Only Mydriatic Drops 静脉滴注治疗艾哈迈德瓣膜梗阻的有效方法。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.11.005
David Oliver-Gutiérrez MD, Laura Sánchez MD, Marta Castany PhD
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引用次数: 0
Association between Device Manufacturer Payments to Surgeons and Minimally Invasive Glaucoma Surgery Utilization in the United States 美国设备制造商向外科医生支付的费用与 MIGS 使用率之间的关联。
IF 2.8
Ophthalmology. Glaucoma Pub Date : 2025-03-01 DOI: 10.1016/j.ogla.2024.11.002
Patrick C. Demkowicz BS, Christopher C. Teng MD, MBA, Ji Liu MD, MS, Soshian Sarrafpour MD
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引用次数: 0
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