{"title":"Looking through the Glass: Microspherophakia with LTBP2 Mutation in Siblings","authors":"","doi":"10.1016/j.ogla.2024.03.002","DOIUrl":"10.1016/j.ogla.2024.03.002","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Page e4"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140775017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing Outcomes of Tube Versus Trabeculectomy Among Patients with Angle-closure Glaucoma","authors":"","doi":"10.1016/j.ogla.2024.04.005","DOIUrl":"10.1016/j.ogla.2024.04.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Compare outcomes of tube shunt surgery (Tube) and trabeculectomy with mitomycin C (Trab-MMC) in patients with angle-closure glaucoma (ACG).</div></div><div><h3>Design</h3><div>Retrospective nonrandomized comparative study.</div></div><div><h3>Participants</h3><div>A total of 80 eyes from 80 patients with ACG who underwent either Tube (N = 50) or Trab-MMC (N = 30) between January 2015 and January 2022 at Massachusetts Eye and Ear.</div></div><div><h3>Methods</h3><div>Reviewed and analyzed 390 visits from patient charts.</div></div><div><h3>Main Outcome Measures</h3><div>Kaplan-Meier (KM) success rates, intraocular pressure (IOP), medication burden, best-corrected visual acuity (BCVA), adjusted hazard ratios (HRs), and complications.</div></div><div><h3>Results</h3><div>Baseline demographics were similar between both groups, except for a higher proportion of patients with pseudophakia and prior incisional ocular surgery in the Tube group. The Trab-MMC procedure had significantly higher KM complete success (CS) rates than the Tube procedure, but similar qualified success (QS) rates. Under QS, the cumulative probability of survival was 87% in the Tube group and 83% in the Trab-MMC group at year 1 (<em>P</em> = 0.77), and 75% in the Tube group and 58% in the Trab-MMC group at year 2 (<em>P</em> = 0.14). Under CS, the cumulative probability of survival was 13% in the Tube group and 59% in the Trab-MMC group at year 1 (<em>P</em> < 0.001), and 11% in the Tube group and 41% in the Trab-MMC group at year 2 (<em>P</em> < 0.001). Both Tube and Trab-MMC procedures resulted in significant patterns of IOP and medication reduction from baseline up to 2 years with mean IOP reduced to 12.6 ± 5.9 mmHg on 2.8 ± 1.4 medications after Tube and 12.1 ± 6.6 mmHg on 2.4 ± 1.7 medications after Trab-MMC. Patients who underwent Trab-MMC required less IOP-lowering medications at every follow-up visit up to year 1, but a similar number at year 2. No significant differences were found in IOP reduction, BCVA, or complication rates between groups.</div></div><div><h3>Conclusions</h3><div>We demonstrate that Trab-MMC confers similar IOP reduction and QS rates to Tube placement in patients with ACG. Trab-MMC, however, demonstrated greater medication burden reduction up to 1 year, and more favorable CS rates up to 2 years, while still maintaining similar complication rates to Tube.</div></div><div><h3>Financial Disclosure(s)</h3><div>The author(s) have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 476-484"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000681/pdfft?md5=ddab569973d879e52669a4a2fb9b409e&pid=1-s2.0-S2589419624000681-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Retrospective Comparison of Phaco-tube vs. Phaco-trabeculectomy in Glaucoma Patients","authors":"","doi":"10.1016/j.ogla.2024.04.008","DOIUrl":"10.1016/j.ogla.2024.04.008","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare surgical outcomes of phacoemulsification<span> combined with Baerveldt implantation (phaco-tube) or trabeculectomy with mitomycin-C (MMC) (phaco-trab) in patients without prior incisional ocular surgery.</span></div></div><div><h3>Design</h3><div>Single-center, retrospective, comparative case series.</div></div><div><h3>Participants</h3><div>A total of 90 patients underwent surgical treatment, including 45 patients in the phaco-tube group and 45 patients in the phaco-trab group.</div></div><div><h3>Methods</h3><div><span>Eligible patients were identified using current procedural terminology (CPT) codes, and their </span>medical records were retrospectively reviewed.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome measure was the rate of surgical failure (IOP ≤5 mmHg or >21 mmHg or reduced <20% from baseline on 2 consecutive study visits after 3 months, reoperations<span> for glaucoma, or experienced loss of light perception vision). Patients who had successful surgical outcomes without use of glaucoma medications<span> were classified as complete successes, while those who used glaucoma medications were classified as qualified successes. Secondary outcome measures were visual acuity (VA), visual field mean deviation (VFMD), intraocular pressure (IOP), glaucoma medication use, and complications.</span></span></div></div><div><h3>Results</h3><div>The cumulative probability of failure was 6.7% in the phaco-tube group and 32.8% in the phaco-trab group after 3 years (<em>P</em><span> = 0.005; Restricted Mean Survival Time = 5.9 months, 95% CI = 1.4–10.4 months). The IOP was 13.1 ± 3.4 mmHg in the phaco-tube group and 13.3 ± 6.2 mmHg in the phaco-trab group at 3 years (</span><em>P</em> = 0.90), and the number of glaucoma medications was 2.6 ± 1.5 in the phaco-tube group and 1.7 ± 1.3 in the phaco-trab group (<em>P</em> = 0.015). The logarithm of the minimum angle of resolution VA was 0.39 ± 0.58 in the phaco-tube group and 0.43 ± 0.73 in the phaco-trab group at 3 years (<em>P</em> = 0.82), and VFMD was −18.3 ± 9.0 dB in the phaco-tube group and −14.1 ± 7.0 dB in the phaco-trab group (<em>P</em><span> = 0.16). Postoperative complications developed in 21 patients (47%) in the phaco-tube group and 15 patients (33%) in the phaco-trab group (</span><em>P</em> = 0.28).</div></div><div><h3>Conclusions</h3><div>Phaco-tubes had a significantly lower rate of surgical failure compared to phaco-trabs after 3 years of follow-up. However, phaco-trabs used significantly fewer glaucoma medications at multiple postoperative timepoints and had a higher proportion of complete success.</div></div><div><h3>Financial Disclosure(s)</h3><div>The author(s) have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 466-475"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Systemic Use of Calcium Channel Blockers and Incidence of Primary Open-Angle Glaucoma","authors":"","doi":"10.1016/j.ogla.2024.06.003","DOIUrl":"10.1016/j.ogla.2024.06.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the association between the systemic use of calcium channel blockers (CCBs) and primary open-angle glaucoma (POAG) using a diverse nationwide dataset.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Subjects</h3><div>213 424 individuals aged 40 years and older in the National Institutes of Health <em>All of Us</em> dataset, notable for its demographic, geographic, and medical diversity and inclusion of historically underrepresented populations. Patients with a diagnosis of POAG prior to use of any kind of antihypertensive medication were excluded.</div></div><div><h3>Methods</h3><div>Bivariate and multivariable regression analyses were performed to evaluate associations between CCB use and POAG. Calcium channel blocker use was further divided into exposure to dihydropyridine CCBs and nondihydropyridine CCBs, and subgroup analyses were performed using chi-square and Fisher tests.</div></div><div><h3>Main Outcome Measures</h3><div>Diagnosis of POAG.</div></div><div><h3>Results</h3><div>Within our cohort, 2772 participants (1.3%) acquired a diagnosis of POAG, while 210 652 (98.7%) did not. Among patients who developed POAG, the mean age was 73.3 years, 52.5% were female, and 48.2% identified as White. Among patients with POAG, 32.6% used 1 or more CCB, 28.2% used a dihydropyridine CCB, and 2.2% used a nondihydropyridine CCB. In bivariate analysis, use of any CCBs was associated with an increased risk of POAG (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.27–1.31, <em>P</em> < 0.001). In multivariable analysis adjusting for age, gender, race, ethnicity, and comorbidities such as diabetes, hyperlipidemia, and hypertension, use of any CCBs remained associated with an increased risk of developing POAG (OR: 1.52, 95% CI: 1.33–1.74, <em>P</em> < 0.001). When stratified by type of CCB, the use of dihydropyridine CCBs (OR: 1.31, 95% CI: 1.14–1.50, <em>P</em> < 0.001) was associated with increased POAG risk.</div></div><div><h3>Conclusions</h3><div>Use of dihydropyridine CCBs was associated with a significantly higher risk of developing POAG, both before and while adjusting for demographic factors and comorbid medical conditions.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 491-498"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Agreement of Serial iCare HOME2 and Goldmann Applanation Tonometry","authors":"","doi":"10.1016/j.ogla.2024.04.007","DOIUrl":"10.1016/j.ogla.2024.04.007","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess agreement of iCare HOME2 and Goldmann applanation tonometry over a wide range of intraocular pressure (IOP).</div></div><div><h3>Design</h3><div>A prospective, observational cohort study.</div></div><div><h3>Subjects</h3><div>Twenty-six adult patients undergoing intravitreal injection, which temporarily raises IOP, were recruited from the Palo Alto Medical Foundation Retina Clinic between October 2022 and February 2023.</div></div><div><h3>Methods</h3><div>Subjects had serial iCare HOME2 (IOP<sub>I</sub>) and Goldmann applanation (IOP<sub>G</sub>) IOP measurements before and at 0 and 5 to 10 minutes after injection. Baseline IOPs and pachymetry were taken in both eyes.</div></div><div><h3>Main Outcome Measures</h3><div>Correlation between IOP<sub>I</sub> and IOP<sub>G</sub> was tested by within-subjects intraclass correlation coefficient (ICC) for repeated measures. Agreement between IOP<sub>I</sub> and IOP<sub>G</sub> was evaluated by a Bland–Altman plot with correction for multiple measurements. The difference between IOP<sub>I</sub> and IOP<sub>G</sub> was evaluated between eyes at baseline (Pearson’s <em>r</em>) and within the injected eye over different timepoints (ICC for absolute agreement). Linear regression was used to evaluate the effects of age, sex, glaucoma, and corneal thickness.</div></div><div><h3>Results</h3><div>The mean IOP<sub>I</sub> and IOP<sub>G</sub> were 25.3 (range: 9–55) and 23.5 (range: 8–56) mmHg, respectively. The correlation between IOP<sub>I</sub> and IOP<sub>G</sub> was 0.99 (<em>P</em> < 0.001). The mean difference (IOP<sub>G</sub> − IOP<sub>I</sub>) was 2.2 mmHg (95% limits of agreement: −3.4 to 7.8 mmHg). The bias in measurements was correlated between eyes (<em>r</em>, 0.68; <em>P</em> < 0.001) and in the injected eye across all timepoints (ICC, 0.86; 95% CI, 0.75–0.93), but did not show a relationship with age, sex, glaucoma, or corneal thickness.</div></div><div><h3>Conclusions</h3><div>IOP<sub>I</sub> and IOP<sub>G</sub> showed excellent correlation; however, there was a stable bias toward IOP<sub>G</sub> being higher than IOP<sub>I</sub> over a large range of IOP.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 440-444"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000711/pdfft?md5=fc3c2c08e518d4425589fd4f26b26a1f&pid=1-s2.0-S2589419624000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitomycin C 0.2 mg/ml versus Mitomycin C 0.4 mg/ml during the Implantation of an Ab Externo Polystyrene-isobutylene-styrene Microshunt","authors":"","doi":"10.1016/j.ogla.2024.06.001","DOIUrl":"10.1016/j.ogla.2024.06.001","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the effectiveness and adverse event profile of standalone polystyrene-isobutylene-styrene (SIBS) microshunt implantation with adjunct mitomycin C (MMC) 0.2 mg/ml and MMC 0.4 mg/ml.</div></div><div><h3>Design</h3><div>Mega-analysis using individual patient data from international prospective and retrospective clinical studies.</div></div><div><h3>Participants</h3><div>Patients with glaucoma who underwent implantation of a SIBS microshunt with MMC as a standalone procedure.</div></div><div><h3>Methods</h3><div>A comparison of eyes that received MMC 0.2 mg/ml or 0.4 mg/ml.</div></div><div><h3>Main Outcomes Measures</h3><div>Primary outcome was complete success defined as the proportion of eyes at 1 year with all of the following: (1) no 2 consecutive intraocular pressures (IOPs) > 17 mmHg; (2) no clinical hypotony; (3) ≥ 20% IOP reduction from baseline; and (4) no use of glaucoma medications. Secondary outcomes included IOP thresholds of 12 mmHg, 14 mm Hg, and 21 mmHg, median IOP, number of medications, risk factors for failure, interventions, adverse events, and reoperations.</div></div><div><h3>Results</h3><div>At 1 year, the complete success rate was significantly higher (71.3% vs. 50.46%; P < 0.001) and the median IOP was significantly lower (13.0 vs 14.2 mmHg; <em>P</em> < 0.05) in the MMC 0.4 mg/ml group. Mitomycin C 0.2 mg/ml was found to be a significant risk factor for failure (hazard ratio 1.75; 95% confidence interval 1.14–2.67). Needling and surgical revision occurred at a lower rate in the MMC 0.4 mg/ml group (7% vs 18.8%; <em>P</em> = 0.002 and 4.3% vs 13.7% <em>P</em> = 0.0087, respectively). Adverse events occurred at a similar frequency in both groups (26.6% MMC 0.2 mg/ml vs 29.6% MMC 0.4 mg/ml; <em>P</em> = 0.46), most of which were early and transient.</div></div><div><h3>Conclusion</h3><div>Polystyrene-isobutylene-styrene microshunt implantation with MMC 0.4 mg/ml resulted in a higher success rate with greater IOP reduction compared with MMC 0.2 mg/ml. Higher MMC concentration was not associated with increased serious adverse events.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 454-465"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000851/pdfft?md5=b85e8a7f2b431b99a937e28f01a84bd7&pid=1-s2.0-S2589419624000851-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141294000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of a Novel Head-Mounted Objective Auto-perimetry (Gaze Analyzing Perimeter) and Humphrey Field Analyzer","authors":"","doi":"10.1016/j.ogla.2024.05.003","DOIUrl":"10.1016/j.ogla.2024.05.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the agreement between 24-2 visual field (VF) test results obtained using the gaze analyzing perimeter (GAP; Findex) and the Humphrey field analyzer (HFA; Carl Zeiss Meditec).</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Participants</h3><div>Patients underwent HFA 24-2 for suspected or confirmed VF loss and were treated at the Kyoto University Hospital between December 2022 and July 2023.</div></div><div><h3>Methods</h3><div>Patients underwent consecutive VF tests on the same eye using HFA and GAP 24-2 tests. Bland–Altman analysis was used to compare GAP and HFA results. Examination points where the sensitivity measured using GAP was ≥ 10 dB higher than that measured using HFA were re-evaluated by referring back to the original gaze data; 2 ophthalmologists assessed whether the gaze moved linearly toward the new test target.</div></div><div><h3>Main Outcome Measures</h3><div>Mean deviation (MD) and elapsed time on an individual basis and sensitivity on an examination point basis.</div></div><div><h3>Results</h3><div>Forty-seven eyes of 47 patients were analyzed. The correlation coefficient of the MD using HFA and GAP was 0.811 (95% confidence interval [CI]: 0.683–0.891). Bland–Altman analysis showed good agreement between HFA and GAP tests. The mean difference (95% limits of agreement) in MD between HFA and GAP results was −0.63 dB (−5.81 to 4.54 dB). Although no statistically significant differences were observed in the elapsed time (<em>P</em> = 0.99), measurements completed within 200 seconds were observed only in the GAP group (11 cases, 23.4%), who had significantly better HFA MD value than others (<em>P</em> = 0.001). On an examination point basis for sensitivity, the correlation coefficient between HFA and GAP was 0.691 (95% limits of agreement, 0.670–0.711). Original gaze data assessment revealed that the gaze moved linearly toward the new test target for 70.2% of the examination points with a sensitivity discrepancy.</div></div><div><h3>Conclusions</h3><div>The results indicate that the GAP provides VF assessment outcomes comparable to those of the HFA. The GAP exhibited advantages in terms of testing time, particularly in patients with minimal VF impairment. Furthermore, the GAP records all eye movements, enabling the objective determination of VF abnormalities based on gaze patterns and facilitating easy posthoc verification.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 445-453"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258941962400084X/pdfft?md5=995ada057c89360ca541325143132a44&pid=1-s2.0-S258941962400084X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glucagon-Like Peptide 1 Receptor Agonists: A Role in Glaucoma?","authors":"","doi":"10.1016/j.ogla.2024.03.005","DOIUrl":"10.1016/j.ogla.2024.03.005","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 419-421"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Publication Rate of Abstracts Presented at American Glaucoma Society Annual Meetings","authors":"","doi":"10.1016/j.ogla.2024.05.001","DOIUrl":"10.1016/j.ogla.2024.05.001","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 512-513"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}