Ophthalmology. Glaucoma最新文献

{"title":"Agreement of Serial iCare HOME2 and Goldmann Applanation Tonometry","authors":"","doi":"10.1016/j.ogla.2024.04.007","DOIUrl":"10.1016/j.ogla.2024.04.007","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess agreement of iCare HOME2 and Goldmann applanation tonometry over a wide range of intraocular pressure (IOP).</div></div><div><h3>Design</h3><div>A prospective, observational cohort study.</div></div><div><h3>Subjects</h3><div>Twenty-six adult patients undergoing intravitreal injection, which temporarily raises IOP, were recruited from the Palo Alto Medical Foundation Retina Clinic between October 2022 and February 2023.</div></div><div><h3>Methods</h3><div>Subjects had serial iCare HOME2 (IOP_I) and Goldmann applanation (IOP_G) IOP measurements before and at 0 and 5 to 10 minutes after injection. Baseline IOPs and pachymetry were taken in both eyes.</div></div><div><h3>Main Outcome Measures</h3><div>Correlation between IOP_I and IOP_G was tested by within-subjects intraclass correlation coefficient (ICC) for repeated measures. Agreement between IOP_I and IOP_G was evaluated by a Bland–Altman plot with correction for multiple measurements. The difference between IOP_I and IOP_G was evaluated between eyes at baseline (Pearson’s <em>r</em>) and within the injected eye over different timepoints (ICC for absolute agreement). Linear regression was used to evaluate the effects of age, sex, glaucoma, and corneal thickness.</div></div><div><h3>Results</h3><div>The mean IOP_I and IOP_G were 25.3 (range: 9–55) and 23.5 (range: 8–56) mmHg, respectively. The correlation between IOP_I and IOP_G was 0.99 (<em>P</em> &lt; 0.001). The mean difference (IOP_G − IOP_I) was 2.2 mmHg (95% limits of agreement: −3.4 to 7.8 mmHg). The bias in measurements was correlated between eyes (<em>r</em>, 0.68; <em>P</em> &lt; 0.001) and in the injected eye across all timepoints (ICC, 0.86; 95% CI, 0.75–0.93), but did not show a relationship with age, sex, glaucoma, or corneal thickness.</div></div><div><h3>Conclusions</h3><div>IOP_I and IOP_G showed excellent correlation; however, there was a stable bias toward IOP_G being higher than IOP_I over a large range of IOP.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 440-444"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000711/pdfft?md5=fc3c2c08e518d4425589fd4f26b26a1f&pid=1-s2.0-S2589419624000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitomycin C 0.2 mg/ml versus Mitomycin C 0.4 mg/ml during the Implantation of an Ab Externo Polystyrene-isobutylene-styrene Microshunt","authors":"","doi":"10.1016/j.ogla.2024.06.001","DOIUrl":"10.1016/j.ogla.2024.06.001","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the effectiveness and adverse event profile of standalone polystyrene-isobutylene-styrene (SIBS) microshunt implantation with adjunct mitomycin C (MMC) 0.2 mg/ml and MMC 0.4 mg/ml.</div></div><div><h3>Design</h3><div>Mega-analysis using individual patient data from international prospective and retrospective clinical studies.</div></div><div><h3>Participants</h3><div>Patients with glaucoma who underwent implantation of a SIBS microshunt with MMC as a standalone procedure.</div></div><div><h3>Methods</h3><div>A comparison of eyes that received MMC 0.2 mg/ml or 0.4 mg/ml.</div></div><div><h3>Main Outcomes Measures</h3><div>Primary outcome was complete success defined as the proportion of eyes at 1 year with all of the following: (1) no 2 consecutive intraocular pressures (IOPs) &gt; 17 mmHg; (2) no clinical hypotony; (3) ≥ 20% IOP reduction from baseline; and (4) no use of glaucoma medications. Secondary outcomes included IOP thresholds of 12 mmHg, 14 mm Hg, and 21 mmHg, median IOP, number of medications, risk factors for failure, interventions, adverse events, and reoperations.</div></div><div><h3>Results</h3><div>At 1 year, the complete success rate was significantly higher (71.3% vs. 50.46%; P &lt; 0.001) and the median IOP was significantly lower (13.0 vs 14.2 mmHg; <em>P</em> &lt; 0.05) in the MMC 0.4 mg/ml group. Mitomycin C 0.2 mg/ml was found to be a significant risk factor for failure (hazard ratio 1.75; 95% confidence interval 1.14–2.67). Needling and surgical revision occurred at a lower rate in the MMC 0.4 mg/ml group (7% vs 18.8%; <em>P</em> = 0.002 and 4.3% vs 13.7% <em>P</em> = 0.0087, respectively). Adverse events occurred at a similar frequency in both groups (26.6% MMC 0.2 mg/ml vs 29.6% MMC 0.4 mg/ml; <em>P</em> = 0.46), most of which were early and transient.</div></div><div><h3>Conclusion</h3><div>Polystyrene-isobutylene-styrene microshunt implantation with MMC 0.4 mg/ml resulted in a higher success rate with greater IOP reduction compared with MMC 0.2 mg/ml. Higher MMC concentration was not associated with increased serious adverse events.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 454-465"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000851/pdfft?md5=b85e8a7f2b431b99a937e28f01a84bd7&pid=1-s2.0-S2589419624000851-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141294000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of a Novel Head-Mounted Objective Auto-perimetry (Gaze Analyzing Perimeter) and Humphrey Field Analyzer","authors":"","doi":"10.1016/j.ogla.2024.05.003","DOIUrl":"10.1016/j.ogla.2024.05.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the agreement between 24-2 visual field (VF) test results obtained using the gaze analyzing perimeter (GAP; Findex) and the Humphrey field analyzer (HFA; Carl Zeiss Meditec).</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Participants</h3><div>Patients underwent HFA 24-2 for suspected or confirmed VF loss and were treated at the Kyoto University Hospital between December 2022 and July 2023.</div></div><div><h3>Methods</h3><div>Patients underwent consecutive VF tests on the same eye using HFA and GAP 24-2 tests. Bland–Altman analysis was used to compare GAP and HFA results. Examination points where the sensitivity measured using GAP was ≥ 10 dB higher than that measured using HFA were re-evaluated by referring back to the original gaze data; 2 ophthalmologists assessed whether the gaze moved linearly toward the new test target.</div></div><div><h3>Main Outcome Measures</h3><div>Mean deviation (MD) and elapsed time on an individual basis and sensitivity on an examination point basis.</div></div><div><h3>Results</h3><div>Forty-seven eyes of 47 patients were analyzed. The correlation coefficient of the MD using HFA and GAP was 0.811 (95% confidence interval [CI]: 0.683–0.891). Bland–Altman analysis showed good agreement between HFA and GAP tests. The mean difference (95% limits of agreement) in MD between HFA and GAP results was −0.63 dB (−5.81 to 4.54 dB). Although no statistically significant differences were observed in the elapsed time (<em>P</em> = 0.99), measurements completed within 200 seconds were observed only in the GAP group (11 cases, 23.4%), who had significantly better HFA MD value than others (<em>P</em> = 0.001). On an examination point basis for sensitivity, the correlation coefficient between HFA and GAP was 0.691 (95% limits of agreement, 0.670–0.711). Original gaze data assessment revealed that the gaze moved linearly toward the new test target for 70.2% of the examination points with a sensitivity discrepancy.</div></div><div><h3>Conclusions</h3><div>The results indicate that the GAP provides VF assessment outcomes comparable to those of the HFA. The GAP exhibited advantages in terms of testing time, particularly in patients with minimal VF impairment. Furthermore, the GAP records all eye movements, enabling the objective determination of VF abnormalities based on gaze patterns and facilitating easy posthoc verification.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 445-453"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258941962400084X/pdfft?md5=995ada057c89360ca541325143132a44&pid=1-s2.0-S258941962400084X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-Like Peptide 1 Receptor Agonists: A Role in Glaucoma?","authors":"","doi":"10.1016/j.ogla.2024.03.005","DOIUrl":"10.1016/j.ogla.2024.03.005","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 419-421"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publication Rate of Abstracts Presented at American Glaucoma Society Annual Meetings","authors":"","doi":"10.1016/j.ogla.2024.05.001","DOIUrl":"10.1016/j.ogla.2024.05.001","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Pages 512-513"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Depths of Glaucomatous Disc","authors":"","doi":"10.1016/j.ogla.2024.03.001","DOIUrl":"10.1016/j.ogla.2024.03.001","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Page e3"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Starstruck Lens: Iatrogenic Rosette Cataract and Its Spontaneous Resolution","authors":"","doi":"10.1016/j.ogla.2024.02.006","DOIUrl":"10.1016/j.ogla.2024.02.006","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 5","pages":"Page e1"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Peripapillary Choroidal Thickness Between Primary Open-angle Glaucoma, Normal Tension Glaucoma, and Normal Eyes","authors":"","doi":"10.1016/j.ogla.2024.02.008","DOIUrl":"10.1016/j.ogla.2024.02.008","url":null,"abstract":"<div><h3>Topic</h3><p>To investigate differences in peripapillary choroidal thickness (PPCT) between primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and healthy eyes, additionally comparing differences between POAG and NTG eyes.</p></div><div><h3>Clinical Relevance</h3><p>Peripapillary choroidal thickness is a well-established OCT parameter in eyes with glaucoma and other ocular pathologies. The relationship between PPCT and glaucoma, if better understood, may facilitate the development of PPCT as a potential diagnostic and monitoring metric for glaucoma. In particular, there has yet to be a synthesis that directly compares PPCT between POAG eyes and NTG eyes.</p></div><div><h3>Methods</h3><p>A comprehensive literature search was performed on PubMed, EMBASE, and Cochrane Library, identifying studies from inception to December 2022. We included studies that measured PPCT using OCT in POAG, NTG, and healthy eyes. Mean difference (MD) among groups was calculated. Statistical analysis was performed using R version 4.2.0. Risk of bias of included studies was assessed using the Newcastle Ottawa Scale (NOS).</p></div><div><h3>Results</h3><p>Eighteen studies were included in this meta-analysis, with a pooled total of 935 healthy control eyes, 446 NTG eyes, and 934 POAG eyes. There was a significant reduction of PPCT in POAG eyes compared with healthy eyes [MD = −16.32; 95% confidence interval (CI) (−27.55 to −5.09)]. Reduction in PPCT was also significant in NTG eyes compared with healthy eyes [MD = −34.96; 95% CI (−49.97 to −19.95)]. NTG eyes had significantly reduced PPCT compared with POAG eyes [MD = −26.64; 95% CI (−49.00 to −4.28)].</p></div><div><h3>Conclusions</h3><p>Glaucomatous eyes appear to have significantly reduced PPCT compared with normal healthy eyes. In addition, PPCT in NTG eyes appear significantly thinner compared with that in POAG eyes.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 4","pages":"Pages 359-371"},"PeriodicalIF":2.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000358/pdfft?md5=8ca71efef5ad22c91b181ca2905cc56f&pid=1-s2.0-S2589419624000358-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Analysis of Intraocular Pressure Measurement Accuracy With Reused iCare Probes","authors":"","doi":"10.1016/j.ogla.2024.02.005","DOIUrl":"10.1016/j.ogla.2024.02.005","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess the accuracy of reused iCare probes after disinfection with 70% isopropyl alcohol and ethylene oxide gas compared to new iCare probes and Goldmann applanation tonometry (GAT).</p></div><div><h3>Design</h3><p>Prospective comparative analysis.</p></div><div><h3>Participants</h3><p>A total of 118 eyes from 59 patients recruited from the Aravind Eye Hospital glaucoma clinic in Tirupati, South India.</p></div><div><h3>Methods</h3><p>Intraocular pressure (IOP) was measured on each eye using a new iCare tonometer probe, an iCare probe previously used and disinfected 1 time prior (once used probe) and 5 times prior (multiply used probe), as well as with GAT. Probes were disinfected after each use with 70% isopropyl alcohol swabs and ethylene oxide sterilization.</p></div><div><h3>Main Outcome Measures</h3><p>Agreement demonstrated with intraclass correlation coefficients (ICCs), mean difference in IOP values with limits of agreement, and Bland-Altman plots among IOP measurement approaches.</p></div><div><h3>Results</h3><p>Compared to new iCare probes, both once used probes (ICC = 0.989, 95% confidence interval [CI] 0.985–0.993) and multiply used probes (ICC = 0.989, 95% CI 0.984–0.992) showed excellent agreement, and the mean difference in IOP was minimal for both once used probes (0.70 mmHg, 95% CI 0.29–1.11) and multiply used probes (0.75 mmHg, 95% CI 0.66–0.82) compared to new probes. Bland-Altman plots demonstrated minimal differences between new and reused probes across the spectrum of IOP. When comparing multiply used probes to once used probes, there was a high level of agreement (0.993) (95% CI 0.990–0.995) and negligible mean IOP difference 0.04 mmHg (95% CI 0.32–0.40). Additionally, ICC values for new probes (0.966, 95% CI 0.951–0.976), once used probes (0.958, 95% CI 0.940–0.971), and multiply used probes (0.957, 95% CI 0.938–0.970) compared to GAT were similar and all showed excellent agreement. Both new and reused iCare probes underestimated IOP by 2 to 3 mmHg compared to GAT.</p></div><div><h3>Conclusions</h3><p>In this prospective comparative analysis, we found that reusing iCare probes up to 5 times does not compromise the accuracy of IOP measurements when disinfected with 70% isopropyl alcohol swabs and ethylene oxide. Reusing iCare probes has the potential to transform care by reducing cost, decreasing environmental waste, and allowing for glaucoma screening camps and increased glaucoma monitoring in low resource settings leading to earlier identification and treatment of glaucoma.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 4","pages":"Pages 352-358"},"PeriodicalIF":2.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Outcomes of Hypertensive Phase After Glaucoma Drainage Device Surgery","authors":"","doi":"10.1016/j.ogla.2024.03.006","DOIUrl":"10.1016/j.ogla.2024.03.006","url":null,"abstract":"<div><h3>Purpose</h3><p>To describe the incidence, risk factors, clinical characteristics, and long-term outcomes of a hypertensive phase (HP) after glaucoma drainage device (GDD) implantation.</p></div><div><h3>Design</h3><p>Retrospective cohort study.</p></div><div><h3>Participants</h3><p>Eyes that underwent implantation of their first GDD from January 2010 to October 2020 at a tertiary care center.</p></div><div><h3>Methods</h3><p>Hypertensive phase was defined as intraocular pressure (IOP) &gt;21 mmHg occurring at 2 consecutive visits in the first 90 days after the date of surgery for Ahmed Glaucoma Valve (AGV) or in the first 90 days after tube opening for Baerveldt Glaucoma Implant (BGI). Generalized estimating equations and Fisher exact tests were used to evaluate risk factors for HP and risk factors for failure of GDD surgery after occurrence of a HP.</p></div><div><h3>Main Outcome Measures</h3><p>Incidence and risk factors for HP. Overall surgical success rates, defined as the absence of failure criteria: IOP &gt;21 mmHg, ≤5 mmHg, or &lt;20% reduction below baseline IOP after 3 months for 2 consecutive visits, with or without adjunctive ocular hypotensive therapy; additional glaucoma surgery; or loss of light perception.</p></div><div><h3>Results</h3><p>Among 419 eyes of 360 patients that underwent GDD implantation, 42 (10.0%) eyes developed HP. Onset of HP was 20.8 ± 10.5 days after AGV and 11.7 ± 20.3 days from the date of tube opening after BGI. Mean IOP during HP was 26.5 ± 3.2 mmHg with peak IOP of 30.0 ± 5.9 mmHg. Median follow-up duration was 21.5 months after onset of HP. Younger age and neovascular glaucoma were significant risk factors for HP occurrence in a multivariable model. Resolution of HP occurred in 32 eyes (76.2%) after a mean duration of 48.0 ± 53.0 days. Additional surgery with a second GDD or cyclophotocoagulation was performed for 12 eyes (28.6%). The overall success rate among eyes with a HP was 52.6% at 2 years, which was significantly lower than that observed among control eyes that did not experience HP (76.3%), <em>P</em> &lt; 0.01.</p></div><div><h3>Conclusions</h3><p>The incidence of HP was 10.0%. Younger age and neovascular glaucoma were significant risk factors for HP in the multivariable model. The risk of surgical failure after HP is significantly higher compared to eyes that did not experience HP.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 4","pages":"Pages 345-351"},"PeriodicalIF":2.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589419624000619/pdfft?md5=a0c552019d6c084da9340d82e01027b0&pid=1-s2.0-S2589419624000619-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}