Operative dentistry最新文献

{"title":"Impact of Aging on the Optical and Mechanical Properties of Universal Resin Composites.","authors":"Ö D Özbilgi, S Tuncer, M Demirci, M Berkman, F Karabay, N Tekçe, B Dikmen, C Baydemir","doi":"10.2341/24-160-L","DOIUrl":"10.2341/24-160-L","url":null,"abstract":"<p><strong>Purpose: </strong>The clinical use of universal resin composites for direct restorations has increased significantly in recent years due to their versatility and simplified shade-matching approach. However, limited long-term data exist on their stability under aging conditions. This study evaluated the optical and mechanical properties of six universal resin composites (Omnichroma, Charisma Topaz One, Vittra APS Unique, OptiShade, G-aenial A'Chord, and Neo Spectra ST) after six months of artificial saliva aging, while examining the influence of spectrophotometer type and inorganic filler composition on their performance.</p><p><strong>Methods: </strong>Color differences [CIEDE2000 (ΔE00)], translucency (TP00), gloss (GU), surface roughness (Ra, μm), and flexural strength (MPa) were measured before and after six months of artificial saliva aging. Statistical analysis was performed using non-parametric tests, including Kruskal Wallis, Mann Whitney U, and Wilcoxon signed-rank tests, with a significance level set at α < 0.05.</p><p><strong>Results: </strong>Statistically significant differences were observed in color differences (ΔE00), translucency (TP00), gloss (GU) and flexural strength among the tested resin composites following aging (p < 0.05). Vittra APS Unique exhibited the highest translucency (TP00 = 55.35) and flexural strength (initial = 140.0 MPa, aged = 99.7 MPa), while G-aenial A'Chord demonstrated the lowest surface roughness (Ra = 0.124 μm) and highest gloss (56 GU). The type of spectrophotometer used significantly impacted the color differences (p < 0.05).</p><p><strong>Conclusions: </strong>Optical and mechanical properties of universal resin composites varied significantly after six months of artificial saliva aging. Moreover, this study showed that the type of spectrophotometer utilized had a significant effect on color differences.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"51 1","pages":"80-96"},"PeriodicalIF":2.2,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuspal Coverage Direct Resin Composite Restorations for Cracked Teeth: A Five-Year Clinical Study.","authors":"A Malentacca, C Rupe, F Zaccheo, C Lajolo","doi":"10.2341/24-172-C","DOIUrl":"10.2341/24-172-C","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The restorative strategies for cracked teeth vary considerably, and both direct and indirect restorations, with and without cuspal coverage have been proposed. However, the literature has shown no consensus among authors, and long-term clinical studies focusing on the direct restorative treatment of cracked teeth remain limited. This five-year retrospective clinical study aimed to evaluate the survival rate of teeth affected by coronal cracks, treated with cuspal coverage direct resin composite restorations, and to evaluate the risk factors associated with tooth loss.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods and materials: &lt;/strong&gt;The study was conducted following the principle of the Declaration of Helsinki and good clinical practice after the approval by the Ethics Committee of the University. Clinical charts, photographs, and videos of 321 patients were retrospectively evaluated. The inclusion criteria were as follows: only posterior cracked teeth with at least five-year follow-up and no pre-existing endodontic treatment. The patients were treated in a private practice between January 1991 and December 2018. Two types of direct resin composite restorative techniques were performed based on the fracture and tooth type. One approach involved a cavity design with full cusp coverage; the other utilized partial cusp coverage, in which only the cracked cusp was covered, and box-shaped restorations were performed to reinforce the opposing walls. No indirect restorations were performed in any of the groups. All treatments were provided by a single operator. The primary outcome was to assess tooth survival at five years. Stepwise logistic regression analysis was performed to identify variables as potential predictors of tooth loss.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 321 teeth and 321 patients were included (mean follow-up: 63 months, mean age: 53.9 years). The sample consisted of 79 maxillary and 21 mandibular premolars and 78 maxillary and 143 mandibular molars. At the five-year follow-up, the survival rate was 94.1% (302/321 teeth), with only 19 teeth extracted; 126 root canal treatments were performed (39.2%), and 41 teeth (12.8%) developed periodontal lesions during the follow-up, due to the deepening of the crack. Endodontic treatment (OR: 2.67, 95% CI 1.04-6.89, p = 0.04) and development of a periodontal lesion (OR: 10.52, 95% CI 4.1-27.1, p &lt; 0.0001) were independent risk factors for tooth loss. The type of fracture and other tooth-related factors (ie, pulp calcification, tooth vitality, apical periodontitis) were not statistically significant (p &gt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The different restorations exhibited similar clinical performance. Our results suggest that the treatment of coronal cracks with direct resin composite restorations may achieve the remission of symptoms and stop the progression of the crack pattern, improving long-term durability. However, when endodontic treatment is required for a cr","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"51 1","pages":"20-35"},"PeriodicalIF":2.2,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academy of Operative Dentistry: Award of Excellence.","authors":"Jeffrey A Platt","doi":"10.2341/1559-2863-51-1-5","DOIUrl":"https://doi.org/10.2341/1559-2863-51-1-5","url":null,"abstract":"","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"51 1","pages":"5"},"PeriodicalIF":2.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Management of Opacities and Enamel Hypoplasia: Case Study.","authors":"B Doğu Kaya, P Yılmaz Atalı, B Tarçın, D Tağtekin, B Kargül, F Wong","doi":"10.2341/25-116-C","DOIUrl":"10.2341/25-116-C","url":null,"abstract":"<p><p>Developmental enamel defects can negatively affect esthetics and patient satisfaction. Minimally invasive treatments have emerged as alternatives to conventional restorations, but quantitative evaluation of their outcomes is limited. The objective of this case report was to assess the efficacy of a combined minimally invasive approach in improving enamel appearance using objective color and fluorescence measurements. A 23-year-old male patient presented with enamel hypoplasia and opacities on 24 teeth. The treatment protocol included: (1) three weeks of at-home bleaching with 16% carbamide peroxide using a custom tray; (2) micro-abrasion with 6.6% hydrochloric acid and silicon carbide slurry followed by 5% sodium fluoride varnish; and (3) applications of 15% hydrochloric acid etching, drying, and resin infiltration. The patient was advised to use a remineralization agent for one month. Fluorescence measurements and color contact-spectrophotometer readings were recorded at baseline, after each treatment stage, and during six- and 12-month follow-ups. Marked improvements in enamel color and fluorescence were observed after bleaching and resin infiltration, and despite a slight decline over time, values remained superior to initial measurements during follow-ups. This multistage minimally invasive approach achieved substantial improvements in enamel appearance, demonstrating its effectiveness for managing enamel opacities.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"51 1","pages":"6-19"},"PeriodicalIF":2.2,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Experimental Polymer-Based Fluoride Varnishes Against Erosive Tooth Wear.","authors":"T M de Andrade Santos, M G Augusto, J B Fernandes, V C Bottesini, I V Aoki, T Scaramucci, Crg Torres, A B Borges","doi":"10.2341/25-041-L","DOIUrl":"10.2341/25-041-L","url":null,"abstract":"<p><strong>Objectives: </strong>The addition of film-forming polymers to fluoride varnishes may enhance their protective effect against erosive tooth wear. This study evaluated experimental varnishes combining fluoride with polymethacrylate copolymers for controlling enamel wear under erosive-abrasive conditions.</p><p><strong>Methods and materials: </strong>Polished bovine enamel specimens were demineralized (0.3% citric acid, pH 2.6, 5 minutes) and assigned to six groups (n = 15) based on treatment: amino methacrylate copolymer (AMC); methyl methacrylate copolymer (MMC); AMC with sodium fluoride (AMC+NaF); MMC with sodium fluoride (MMC+NaF); ultrapure water (negative control, NC); and a commercial varnish (positive control; Duraphat, Colgate-Palmolive Company). Experimental varnishes contained 15% polymer, and fluoride-containing groups had 5% NaF. Specimens underwent nine-day erosive-abrasive cycling consisting of five minutes immersion in 0.3% citric acid, 60 minutes in artificial saliva, repeated four times daily, combined with toothbrushing for 15 seconds twice daily. Surface loss (SL) was measured after treatment to confirm varnish thickness standardization and at the end of cycling using contact profilometry. KOH-soluble fluoride (µg/cm2) on enamel was also quantified. Data were analyzed using One-way ANOVA for surface loss, and Kruskal-Wallis and Dunn post hoc tests for KOH-soluble fluoride (α = 0.05).</p><p><strong>Results: </strong>AMC+NaF, MMC+NaF, and the commercial varnish (Duraphat) significantly reduced SL compared to the negative control and polymer-only varnishes (p = 0.001). No significant differences were observed between Duraphat and AMC+NaF (p = 0.139) or MMC+NaF (p = 0.166). For KOH-soluble fluoride, AMC+NaF showed lower values than MMC+NaF (p = 0.001), while Duraphat did not differ significantly from either.</p><p><strong>Conclusions: </strong>Varnishes formulated with polymethacrylate copolymers and sodium fluoride provided in vitro protection against enamel erosive-abrasive wear, with efficacy comparable to the commercial varnish tested.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"50 6","pages":"612-626"},"PeriodicalIF":2.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Comparison of Four Resin Composite Matrix Systems.","authors":"M Balci, G A Sabah, M G Kanmaz, G Eyici, K Ayan, N Saklakoğlu","doi":"10.2341/25-008-L","DOIUrl":"10.2341/25-008-L","url":null,"abstract":"<p><strong>Objective: </strong>To address the limited evidence regarding the performance of various matrix systems, this study investigated proximal contact quality and surface characteristics across systems differing in structural design and component configuration.</p><p><strong>Methods and materials: </strong>Forty Frasaco mandibular left first molars (ANKA-4 ZE 100, Frasaco GmbH, Tettnang, Germany) were used to prepare mesial proximal box cavities with standard dimensions. Cavities were restored with a bulk-fill light-cured resin composite using four different matrix systems (n = 10): precontoured stainless steel (Palodent V3, Dentsply Sirona, York, PA, USA), copper (TECCI Copper, TECCI Dental, Istanbul, Turkey), and polyester (TECCI Transparent, TECCI Dental) sectional, and non-dead soft steel circumferential (SuperMat Adapt SuperCap, KerrHawe, Bioggio, Switzerland) matrix systems. Pre- and post-operative scans were obtained using an intraoral scanner (Trios 3, 3Shape, Copenhagen, Denmark). Mesiodistal (MD) diameters were measured on the scans. Proximal contour and marginal adaptation were assessed by two blinded examiners. Surface roughness was evaluated using a profilometer (Mitutoyo SJ 301, Mitutoyo Corp., Kawasaki-shi, Kanagawa, Japan). Data were analyzed using One-Way ANOVA with Tukey's post hoc test for parametric comparisons, and Wilcoxon Signed-Ranks, Kruskal-Wallis with Dunn's post hoc test, Fisher's Exact test with Bonferroni correction, and Cohen's kappa for nonparametric analyses, with significance set at α = 0.05.</p><p><strong>Results: </strong>Significant differences were observed among matrix systems for MD diameters, proximal contour, marginal adaptation, and surface roughness (all p < 0.049). The stainless steel sectional matrix system produced the greatest MD diameter change and the highest incidence of cervical and lateral overhang. Only stainless steel and copper sectional matrix systems generated convex contours. Copper and stainless steel sectional matrices also exhibited greater surface roughness than the other systems (both p < 0.03).</p><p><strong>Conclusion: </strong>Precontoured metal sectional matrices with rings achieve proper proximal contours and increase MD diameter. However, they require precise placement to avoid distortion, which may compromise surface smoothness.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"50 6","pages":"639-653"},"PeriodicalIF":2.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of HEMA-Containing and HEMA-Free Adhesives on the Integrity of Deep Proximal Margin Restorations.","authors":"Y A Zainel, B M Zeidan","doi":"10.2341/25-043-L","DOIUrl":"10.2341/25-043-L","url":null,"abstract":"<p><strong>Objective: </strong>Resin composite restorations in deep subgingival cavities involving cementum margins often exhibit early adhesive debonding and marginal failure. Conventional resin adhesive systems are prone to hydrolysis in these situations. However, evidence on the optimal adhesive systems for deep margins is limited. Therefore, this study evaluated the effect of HEMA-containing and HEMA-free adhesives in deep proximal margin restorations after simulated long-term aging.</p><p><strong>Methods and materials: </strong>Class II box-only cavities were prepared on the distal surfaces of 48 extracted upper premolars, with the gingival margins placed 2 mm apical to the cemento-enamel junction. The teeth were randomly divided into three study groups (n = 16) based on the type of adhesive system: two-step HEMA-containing, two-step HEMA-free, and one-step HEMA-containing. Cavities were restored using a preheated nanohybrid resin composite and cured using a polywave LED light at 1200 mW/cm2. Each group was subdivided into an immediate subgroup (n = 8), in which teeth were examined after 24 hours, and a delayed subgroup (n = 8), in which teeth were examined after an aging process comprising 10,000 thermal cycles (5-55°C). Resin composite/cementum interfaces were evaluated quantitatively by scanning electron microscopy at 200× magnification. Marginal integrity was statistically analyzed by the percentage of continuous margin (%CM).</p><p><strong>Results: </strong>The Kruskal-Wallis test revealed that the two-step HEMA-containing and two-step HEMA-free adhesive systems showed significantly better marginal integrity than the one-step HEMA-containing system for both the immediate and aged groups (all p < 0.005). A Wilcoxon rank-sum test showed that the aging process affected the one-step HEMA-containing adhesive system (p = 0.002), but not the two-step systems (p < 0.05).</p><p><strong>Conclusion: </strong>Two-step adhesive systems had better performance at cementum margins than the one-step adhesive system. The presence of HEMA in the two-step adhesive did not degrade marginal quality compared to the two-step HEMA-free adhesive systems.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"50 6","pages":"599-611"},"PeriodicalIF":2.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstrain in Maxillary Premolars With Noncarious Cervical Lesions Before and After Restoration: A Randomized Clinical Trial.","authors":"S Yadav, Pka Rajasekaran, S Krishnamoorty, A Kishen","doi":"10.2341/23-075-C","DOIUrl":"10.2341/23-075-C","url":null,"abstract":"<p><strong>Objectives: </strong>Loss of cervical tooth structure due to noncarious cervical lesions (NCCLs) can weaken teeth and increase tooth strain. Therefore, the aim of this study was to evaluate the in vivo microstrain variations in human maxillary premolars with NCCLs before and after restoration with resin composite (RC) and resin-modified glass ionomer cement (RMGIC).</p><p><strong>Methods and materials: </strong>This study was a split-mouth, randomized controlled clinical trial. Twenty patients aged 40-60 years with NCCLs in maxillary premolars were selected. Bite force was measured bilaterally. In Stage I, 10 patients with unilateral NCCLs were randomized and restored with RC and RMGIC. In Stage II, 10 patients with bilateral NCCLs received RC and RMGIC restorations after maxillary quadrant randomization. Bonded strain gauges recorded the coronal buccal microstrain after maximum intercuspation before and after restoration and at the six-month recall visit. Data were analyzed with the Wilcoxon signed-rank test, Mann-Whitney test, Fisher exact test, and Friedman test.</p><p><strong>Results: </strong>In Stage I, there was a significant reduction in mean coronal buccal microstrain immediately after restoration with RMGIC and RC (both p = 0.048) to values similar to that of intact control teeth (p = 0.486, p = 0.686); this reduction remained evident at the six-month recall (RMGIC: p = 0.014, RC: p = 0.040). In Stage II, there was a bilateral, significant reduction in mean coronal buccal microstrain immediately after restoration with RMGIC (p = 0.022) and RC (p = 0.011), which remained evident at the six-month recall visit (both p < 0.001).</p><p><strong>Conclusion: </strong>Coronal buccal microstrain in teeth with NCCLs was significantly reduced after restoration with RMGIC and RC.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"50 6","pages":"563-575"},"PeriodicalIF":2.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Current Literature in Operative Dentistry: An Annual Report from the Research Committee of the Academy of Operative Dentistry.","authors":"T A Sulaiman, T Alsahafi, R G Stevenson, A Elgreatly, R Alkattan, S Alhalees, M Tajik, Mas Melo, I Garcia, A Agnihotry, S Wade, M Hamdan, Z Badr, E J Swift","doi":"10.2341/25-198-LIT","DOIUrl":"10.2341/25-198-LIT","url":null,"abstract":"<p><p>This report from the Research Committee of the Academy of Operative Dentistry brings together the most important research and clinical progress from 2024 to 2025. The review presents an evidence-based assessment of current advancements in research methodology, cariology, adhesion, materials science, and digital technologies. Methodological enhancements concentrate on the application of standardized reporting frameworks, including SPIRIT/CONSORT-Outcomes 2022 and CRIME-Q, to enhance the reproducibility and clinical applicability of restorative trials. In cariology, the biological paradigm shift underscores minimally invasive, risk-oriented management, with substantial evidence advocating for selective caries removal and vital pulp therapy to maintain pulpal vitality in permanent teeth. Materials research shows how resin composites have changed over time to include bioactive, universal-shade, and bulk-fill formulations that are meant to be efficient in the clinic and release therapeutic ions. The addition of digital workflows, such as intraoral scanning, artificial intelligence (AI) to help with diagnosis, and objective spectrophotometric shade mapping, is also changing traditional restorative protocols. Additive manufacturing (3D printing) introduces new ways to fabricate ceramics, but subtractive milling is still superior for making high-load restorations. These findings collectively highlight a pivotal shift towards precision-oriented, biologically integrated restorative care aimed at enhancing long-term clinical outcomes.</p>","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"50 6","pages":"576-598"},"PeriodicalIF":2.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Now That We Have CODA'S Attention….","authors":"Gordon K Jones","doi":"10.2341/1559-2863-50-5-463","DOIUrl":"https://doi.org/10.2341/1559-2863-50-5-463","url":null,"abstract":"","PeriodicalId":19502,"journal":{"name":"Operative dentistry","volume":"50 5","pages":"463-465"},"PeriodicalIF":2.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}