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Management of Neuroendocrine Breast Carcinoma (NEBC): Review of Literature 神经内分泌性乳腺癌（NEBC）的治疗：文献综述
IF 3.6
Oncology Reviews Pub Date : 2024-02-09 DOI: 10.3389/or.2024.12114
A. Mohamed, J. Zeidalkilani, S. L. Asa, M. Trybula, Alberto J. Montero
{"title":"Management of Neuroendocrine Breast Carcinoma (NEBC): Review of Literature","authors":"A. Mohamed, J. Zeidalkilani, S. L. Asa, M. Trybula, Alberto J. Montero","doi":"10.3389/or.2024.12114","DOIUrl":"https://doi.org/10.3389/or.2024.12114","url":null,"abstract":"Extra pulmonary high-grade poorly differentiated neuroendocrine carcinomas (EP-NECs) are rare tumors that usually arise in the gastrointestinal and genitourinary tracts. Primary neuroendocrine carcinoma of the breast (NEBC) is extremely rare, representing less than 0.1% of all breast cancers and less than 1% of neuroendocrine neoplasms. Consequently, they can be misdiagnosed as other types of breast cancer, however, proper immunohistochemical (IHC) studies can assist with making the correct diagnosis. Management of NEBC can be challenging given the paucity of evidence-based literature and should not routinely follow the therapeutic guidelines of other breast cancers. In this article, we review the current literature regarding the management of NEBC.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Neuroendocrine Breast Carcinoma (NEBC): Review of Literature 神经内分泌性乳腺癌（NEBC）的治疗：文献综述
IF 3.6
Oncology Reviews Pub Date : 2024-02-09 DOI: 10.3389/or.2024.12114
A. Mohamed, J. Zeidalkilani, S. L. Asa, M. Trybula, Alberto J. Montero
{"title":"Management of Neuroendocrine Breast Carcinoma (NEBC): Review of Literature","authors":"A. Mohamed, J. Zeidalkilani, S. L. Asa, M. Trybula, Alberto J. Montero","doi":"10.3389/or.2024.12114","DOIUrl":"https://doi.org/10.3389/or.2024.12114","url":null,"abstract":"Extra pulmonary high-grade poorly differentiated neuroendocrine carcinomas (EP-NECs) are rare tumors that usually arise in the gastrointestinal and genitourinary tracts. Primary neuroendocrine carcinoma of the breast (NEBC) is extremely rare, representing less than 0.1% of all breast cancers and less than 1% of neuroendocrine neoplasms. Consequently, they can be misdiagnosed as other types of breast cancer, however, proper immunohistochemical (IHC) studies can assist with making the correct diagnosis. Management of NEBC can be challenging given the paucity of evidence-based literature and should not routinely follow the therapeutic guidelines of other breast cancers. In this article, we review the current literature regarding the management of NEBC.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139850355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Pancreatic Cancer: Where Are We? 转移性胰腺癌：我们在哪里？
IF 3.6
Oncology Reviews Pub Date : 2024-01-18 DOI: 10.3389/or.2023.11364
Abraham Hernández-Blanquisett, Valeria Quintero-Carreño, M. C. Martínez-Ávila, María Porto, María Carolina Manzur-Barbur, Emiro Buendía
{"title":"Metastatic Pancreatic Cancer: Where Are We?","authors":"Abraham Hernández-Blanquisett, Valeria Quintero-Carreño, M. C. Martínez-Ávila, María Porto, María Carolina Manzur-Barbur, Emiro Buendía","doi":"10.3389/or.2023.11364","DOIUrl":"https://doi.org/10.3389/or.2023.11364","url":null,"abstract":"Pancreatic cancer is one of the most lethal neoplasms worldwide; it is aggressive in nature and has a poor prognosis. The overall survival rate for pancreatic cancer is low. Most patients present non-specific symptoms in the advanced stages, which generally leads to late diagnosis, at which point there is no option for curative surgery. The treatment of metastatic pancreatic cancer includes systemic therapy, in some cases radiotherapy, and more recently, molecular targeted therapies, which can positively impact cancer control and improve quality of life. This review provides an overview of the molecular landscape of pancreatic cancer based on the most recent literature, as well as current treatment options for patients with metastatic pancreatic cancer.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139615150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palliative Care for Cancer Patients in Asia: Challenges and Countermeasures 亚洲癌症患者的姑息治疗：挑战与对策
IF 3.6
Oncology Reviews Pub Date : 2024-01-16 DOI: 10.3389/or.2023.11866
Yu Wang, Xinqing Zhang, Yilin Huang, Xiangyu Ma
{"title":"Palliative Care for Cancer Patients in Asia: Challenges and Countermeasures","authors":"Yu Wang, Xinqing Zhang, Yilin Huang, Xiangyu Ma","doi":"10.3389/or.2023.11866","DOIUrl":"https://doi.org/10.3389/or.2023.11866","url":null,"abstract":"With the increasing incidence of cancer worldwide, palliative care has become an effective intervention to relieve cancer patients’ pain and improve their quality of life, although the present development of palliative medicine and hospice care in many Asian countries remains insufficient. To this end, this review comprehensively discussed the main challenges that influence the promotion of palliative medicine, from the perspective of both healthcare professionals and cancer patients. We further proposed and summarized a series of potentially effective countermeasures and solutions, including the shared decision-making modal, multidisciplinary professional cooperation, application of modern science and technology, standardization training for medical workers, personalized palliative treatment regimens, and others, aiming to improve the clinical quality of palliative care practice for cancer patients and promote the development of palliative medicine in Asian regions.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139527929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplantable Murine Tumors in the Studies of Peptide Antitumor Vaccines 多肽抗肿瘤疫苗研究中的可移植小鼠肿瘤
IF 3.6
Oncology Reviews Pub Date : 2024-01-08 DOI: 10.3389/or.2023.12189
Aleksandr V. Ponomarev, Irina Zh. Shubina, Zinaida A. Sokolova, M. Baryshnikova, V. Kosorukov
{"title":"Transplantable Murine Tumors in the Studies of Peptide Antitumor Vaccines","authors":"Aleksandr V. Ponomarev, Irina Zh. Shubina, Zinaida A. Sokolova, M. Baryshnikova, V. Kosorukov","doi":"10.3389/or.2023.12189","DOIUrl":"https://doi.org/10.3389/or.2023.12189","url":null,"abstract":"Numerous studies have shown that antitumor vaccines based on synthetic peptides are safe and can induce both CD8+ and CD4+ tumor-specific T cell responses. However, clinical results are still scarce, and such approach to antitumor treatment has not gained a wide implication, yet. Recently, particular advances have been achieved due to tumor sequencing and the search for immunogenic neoantigens caused by mutations. One of the most important issues for peptide vaccines, along with the choice of optimal adjuvants and vaccination regimens, is the search for effective target antigens. Extensive studies of peptide vaccines, including those on murine models, are required to reveal the effective vaccine constructs. The review presents transplantable murine tumors with the detected peptides that showed antitumor efficacy as a vaccine compound.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal Management of Colorectal Liver Metastases: State of the Art 结直肠肝转移的多模式治疗：最新技术
IF 3.6
Oncology Reviews Pub Date : 2024-01-04 DOI: 10.3389/or.2023.11799
Elisabetta Filoni, Vittoria Musci, Alessia Di Rito, Riccardo Inchingolo, Riccardo Memeo, Francesco Mannavola
{"title":"Multimodal Management of Colorectal Liver Metastases: State of the Art","authors":"Elisabetta Filoni, Vittoria Musci, Alessia Di Rito, Riccardo Inchingolo, Riccardo Memeo, Francesco Mannavola","doi":"10.3389/or.2023.11799","DOIUrl":"https://doi.org/10.3389/or.2023.11799","url":null,"abstract":"Liver is the most common site of colorectal cancer (CRC) metastases. Treatment of CRC liver metastases (CRLM) includes different strategies, prevalently based on the clinical and oncological intent. Valid approaches in liver-limited or liver-prevalent disease include surgery, percutaneous ablative procedures (radiofrequency ablation, microwave ablation), intra-arterial perfusional techniques (chemo-embolization, radio-embolization) as well as stereotactic radiotherapy. Systemic treatments, including chemotherapy, immunotherapy and other biological agents, are the only options for patients with no chance of locoregional approaches. The use of chemotherapy in other settings, such as neoadjuvant, adjuvant or conversion therapy of CRLM, is commonly accepted in the clinical practice, although data from several clinical trials have been mostly inconclusive. The optimal integration of all these strategies, when applicable and clinically indicated, should be ever considered in patients affected by CRLM based on clinical evidence and multidisciplinary experience. Here we revised in detail all the possible therapeutic approaches of CRLM focusing on the current evidences, the studies still in progress and the often contradictory data.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139386483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges of FGFR2 Testing in Gastric Cancer 胃癌 FGFR2 检测面临的挑战
IF 3.6
Oncology Reviews Pub Date : 2023-12-14 DOI: 10.3389/or.2023.11790
Ilya Tsimafeyeu, G. Raskin
{"title":"Challenges of FGFR2 Testing in Gastric Cancer","authors":"Ilya Tsimafeyeu, G. Raskin","doi":"10.3389/or.2023.11790","DOIUrl":"https://doi.org/10.3389/or.2023.11790","url":null,"abstract":"","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138974668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Checkpoint Inhibitors and Their Cardiovascular Adverse Effects. 免疫检查点抑制剂及其心血管不良反应。
IF 3.6
Oncology Reviews Pub Date : 2023-11-17 eCollection Date: 2023-01-01 DOI: 10.3389/or.2023.11456
Ravi Kumar Paluri, Yochitha Pulipati, Dileep Kumar Reddy Regalla
{"title":"Immune Checkpoint Inhibitors and Their Cardiovascular Adverse Effects.","authors":"Ravi Kumar Paluri, Yochitha Pulipati, Dileep Kumar Reddy Regalla","doi":"10.3389/or.2023.11456","DOIUrl":"10.3389/or.2023.11456","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have reshaped and have become a well-established treatment modality for multiple advanced-stage malignancies. ICIs block the immune system regulatory checkpoints, namely CTLA-4 and PD-1/PDL1, which provokes excess immune response against self-antigens. Immune modulation with ICIs can result in diverse immune-related adverse events targeting organ systems. Several cases of ICI-related cardiotoxicity were reported, while the actual incidence was likely underestimated due to heterogeneous clinical presentation. These include, but are not limited to, myocarditis, pericarditis, atherosclerosis, and arrhythmia. EKG, Troponin, Echocardiogram (TTE), and Cardiac MRI (CMRI) are indispensable diagnostic tools to aid in the management of cardiac adverse effects. Herein, we review the ICI-mediated cardiovascular adverse events, diagnosis, treatment strategies, and reintroduction of ICIs post-cardiotoxicity.</p>","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Polymorphisms Involved in Bladder Cancer: A Global Review 膀胱癌基因多态性研究综述
Oncology Reviews Pub Date : 2023-11-06 DOI: 10.3389/or.2023.10603
Hampig Raphael Kourie, Joseph Zouein, Bahaa Succar, Avedis Mardirossian, Nizar Ahmadieh, Eliane Chouery, Cybel Mehawej, Nadine Jalkh, Joseph kattan, Elie Nemr
{"title":"Genetic Polymorphisms Involved in Bladder Cancer: A Global Review","authors":"Hampig Raphael Kourie, Joseph Zouein, Bahaa Succar, Avedis Mardirossian, Nizar Ahmadieh, Eliane Chouery, Cybel Mehawej, Nadine Jalkh, Joseph kattan, Elie Nemr","doi":"10.3389/or.2023.10603","DOIUrl":"https://doi.org/10.3389/or.2023.10603","url":null,"abstract":"Bladder cancer (BC) has been associated with genetic susceptibility. Single peptide polymorphisms (SNPs) can modulate BC susceptibility. A literature search was performed covering the period between January 2000 and October 2020. Overall, 334 articles were selected, reporting 455 SNPs located in 244 genes. The selected 455 SNPs were further investigated. All SNPs that were associated with smoking and environmental exposure were excluded from this study. A total of 197 genes and 343 SNPs were found to be associated with BC, among which 177 genes and 291 SNPs had congruent results across all available studies. These genes and SNPs were classified into eight different categories according to their function.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135634435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Research, Diagnosis, and Treatment of Neuroendocrine Cervical Carcinoma: A Review 神经内分泌宫颈癌的研究、诊断和治疗进展综述
Oncology Reviews Pub Date : 2023-11-01 DOI: 10.3389/or.2023.11764
Xiaoyan Ren, Wenjuan Wu, Qiufan Li, Wen Li, Gang Wang
{"title":"Advances in Research, Diagnosis, and Treatment of Neuroendocrine Cervical Carcinoma: A Review","authors":"Xiaoyan Ren, Wenjuan Wu, Qiufan Li, Wen Li, Gang Wang","doi":"10.3389/or.2023.11764","DOIUrl":"https://doi.org/10.3389/or.2023.11764","url":null,"abstract":"Neuroendocrine neoplasms (NENs) were classified separately in the 5th edition (2020) of the World Health Organization (WHO) classification of female genital malignancies. Cervical neuroendocrine carcinoma (NEC) is distinguished by its low incidence, high invasiveness, early local dissemination, and distant metastases. The purpose of this review is to outline the achievements in pathology, diagnostics, gene sequencing, and multi-modality treatment of cervical NEC.","PeriodicalId":19487,"journal":{"name":"Oncology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135321257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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