Colorectal cancer and associated genetic, lifestyle, cigarette, nargileh-hookah use and alcohol consumption risk factors: a comprehensive case-control study.

IF 3.1 Q2 ONCOLOGY
Oncology Reviews Pub Date : 2024-10-11 eCollection Date: 2024-01-01 DOI:10.3389/or.2024.1449709
Abdulbari Bener, Ahmet Emin Öztürk, Muhammed Furkan Dasdelen, Cem Cahit Barisik, Zehra Betul Dasdelen, Ahmet F Agan, Jean De La Rosette, Andrew S Day
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引用次数: 0

Abstract

Aim: This study aimed to investigate the causes and risk factors of colorectal cancer (CRC) in a Turkish population, focusing on various modifiable and non-modifiable risk factors.

Methods: A hospital-based case-control design was employed to compare individuals with CRC (cases) to individuals without CRC (controls). Male and female participants were recruited from the surgery, internal medicine, and out-patient departments. The study encompassed socio-demographic data, clinical information, radiological diagnoses, and biochemical measurements. Univariable and multivariable logistic regressions were used to determine associated risk factors of CRC.

Results: The study included 704 individuals with CRC and 704 controls. Significant socio-demographic disparities were observed between the groups, with over 30% of the cases having lower levels of education and income compared to the controls. Lifestyle factors such as obesity, higher rates of smoking (cigarettes and hookah) and alcohol consumption were more prevalent among cases than controls. Further significant associations were identified with intestinal inflammation, obesity, processed food consumption, and symptoms such as abdominal pain, cramps, diarrhea, constipation, blood in stool, bloating, irritable bowel syndrome, nausea/vomiting, anemia, stress, fatigue, weakness, and weight loss. Diet analysis revealed that individuals with CRC consumed more red meat, processed and fast foods along with less pulses and vegetables. Genetic predispositions and exposure to chemicals also correlated strongly with increased CRC risk. Multivariable regression analysis identified, nausea/vomiting, constipation, intestinal disease, genetics factor, hookah-nargileh use, history of any cancer, family history of bowel cancer, constipation, cigarette smoking, stress, milk-yogurt consumption, obesity and red meat consumption as significant determinants for CRC.

Conclusion: CRC risk is influenced by dietary, lifestyle, and genetic factors. Awareness of hereditary risk and participation in screening are crucial. Lifestyle changes, such as avoiding smoking, hookah, and alcohol use, and adopting a healthy diet, are essential for prevention.

结肠直肠癌与相关遗传、生活方式、吸烟、吸食大麻和饮酒等风险因素:一项综合病例对照研究。
目的:本研究旨在调查土耳其人群中结肠直肠癌(CRC)的病因和风险因素,重点关注各种可改变和不可改变的风险因素:方法: 采用基于医院的病例对照设计,将患有 CRC 的个体(病例)与未患有 CRC 的个体(对照)进行比较。男女参与者分别从外科、内科和门诊部招募。研究内容包括社会人口学数据、临床信息、放射学诊断和生化测量。研究采用单变量和多变量逻辑回归来确定与 CRC 相关的风险因素:研究包括 704 名 CRC 患者和 704 名对照者。研究发现,两组之间存在明显的社会人口差异,超过 30% 的病例与对照组相比教育和收入水平较低。与对照组相比,肥胖、吸烟(香烟和水烟)和饮酒等生活方式因素在病例中更为普遍。此外,肠道炎症、肥胖、食用加工食品以及腹痛、痉挛、腹泻、便秘、便血、腹胀、肠易激综合征、恶心/呕吐、贫血、压力、疲劳、虚弱和体重下降等症状之间也存在明显的关联。饮食分析表明,CRC 患者食用较多的红肉、加工食品和快餐,较少食用豆类和蔬菜。遗传倾向和接触化学物质也与 CRC 风险的增加密切相关。多变量回归分析表明,恶心/呕吐、便秘、肠道疾病、遗传因素、使用水烟、任何癌症病史、肠癌家族史、便秘、吸烟、压力、饮用牛奶-酸奶、肥胖和食用红肉是导致 CRC 的重要决定因素:结论:CRC 风险受饮食、生活方式和遗传因素的影响。对遗传风险的认识和参与筛查至关重要。改变生活方式,如避免吸烟、酗酒和采用健康饮食,对于预防至关重要。
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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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