Nutrients最新文献

{"title":"Zinc Supplementation, Inflammation, and Gut Integrity Markers in HIV Infection: A Randomized Placebo-Controlled Trial.","authors":"Jhony Baissary, Ziad Koberssy, Qian Wu, Abdus Sattar, Ornina Atieh, Joviane Daher, Kate Ailstock, Morgan Cummings, Danielle Labbato, Nicholas T Funderburg, Grace A McComsey","doi":"10.3390/nu17101671","DOIUrl":"10.3390/nu17101671","url":null,"abstract":"<p><p><b>Background:</b> Low levels of zinc are prevalent in patients living with HIV and are associated with higher morbidity. Zinc has major immunomodulatory effects. This study aimed to assess the effect of zinc supplementation on inflammatory and gut integrity markers and on zinc levels among HIV patients with zinc deficiency. <b>Methods:</b> This was a double-blind randomized placebo-controlled trial assessing the efficacy and safety of zinc supplementation on inflammation and gut markers in people with HIV (PWH) ≥ 18 years old, on stable antiretroviral therapy (ART) with undetectable HIV-1 viral load, and with zinc levels of ≤0.75 mg/L. Participants were randomized 2:1 to zinc gluconate tablets at a dose of 90 mg of elemental zinc or a matching placebo daily for 24 weeks. At baseline and at week 24, we measured plasma levels of zinc and markers of inflammation and gut barrier integrity. <b>Results:</b> Among the 95 participants enrolled in this study, 74% were male, and 65% were non-white, with a median CD4 count of 722 cells/μL. The primary analysis showed an increase in zinc levels in the active group. A decrease in the monocyte activation marker soluble CD14 was observed in the treatment group at -56.31 ng/mL (-263.24; 134.19), compared to an increase in the placebo group of 101.71 ng/mL (-90.50; 243.20); <i>p</i> = 0.021. The stratified analysis showed that the group with the lowest zinc levels at baseline had the greatest improvements in soluble CD14 levels during zinc supplementation. No changes were seen in other inflammation markers or gut integrity markers. <b>Conclusions:</b> This is the most comprehensive study on the effect of zinc supplementation in PWH on inflammatory and gut integrity markers. Decreases were seen in the monocyte activation marker sCD14. In the contemporary HIV era with potent effective therapies, suppressed viremia, and high CD4 cells, zinc supplementation does not offer consistent benefits on inflammation.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Level of Trimethylamine Oxide and the Risk of Recurrent Cardiovascular Events in Patients with Acute Myocardial Infarction.","authors":"Wenjun Ji, Bin Zhang, Jiahui Liu, Kaiyin Li, Jia Jia, Fangfang Fan, Jie Jiang, Xingang Wang, Yan Zhang","doi":"10.3390/nu17101664","DOIUrl":"10.3390/nu17101664","url":null,"abstract":"<p><p><b>Background:</b> This study investigated the value of trimethylamine oxide (TMAO) and its precursors in secondary prevention for patients with acute myocardial infarction (AMI). <b>Methods:</b> We retrospectively enrolled patients diagnosed with AMI. The associations of TMAO and its precursors with endpoint events were estimated by Cox proportional hazards models. <b>Results:</b> During a median follow-up of 6.4 years, 319 (32.0%) major adverse cardiovascular event (MACE) occurred in the 996 patients enrolled. After adjusting for traditional risk factors, the risk of MACE, cardiac death, and recurrent MI increased by 28% (HR 1.28, 95% CI 1.10-1.49), 44% (HR 1.44, 95% CI 1.12-1.84), and 27% (HR 1.27, 95% CI 1.04-1.55), respectively, per one increment in ln-transformed TMAO. After adjustment for the levels of its precursors, the relationship between TMAO and MACE was still significant. Choline was associated with MACEs, all-cause mortality, cardiac death, and risk of recurrent MI after adjusting for the levels of the remaining metabolites, in addition to traditional risk factors. The overall ability to predict all-cause mortality was better for the choline model than for the TMAO model (continuous NRI 0.185, <i>p</i> = 0.007; IDI 0.030, <i>p</i> = 0.020). Mediation effect analysis showed that the mediating effect of TMAO on choline and the risk of all-cause mortality was 11.39% (95% CI 0.0209-0.2200, <i>p</i> = 0.016), suggesting the existence of a choline activity pathway that is independent of the TMAO pathway. <b>Conclusions:</b> TMAO and choline were associated with an increased risk of MACE in patients with AMI, and choline had better predictive power.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the Dinner Tonight Healthy Cooking School on Participants' Nutrition Knowledge and Cooking Confidence.","authors":"Sumathi Venkatesh, Odessa E Keenan, Morium B Bably","doi":"10.3390/nu17101668","DOIUrl":"10.3390/nu17101668","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Nearly three-quarters of American adults are overweight or obese, leading to serious health challenges. Poor nutrition is a major contributor, highlighting the need for effective nutrition education and cooking interventions. This study evaluated the impact of the Dinner Tonight Healthy Cooking School (DTHCS) on improving nutrition knowledge and cooking confidence among participants. <b>Methods</b>: A secondary data analysis was conducted on self-reported retrospective surveys collected from 7932 individuals across 64 Texas counties between September 2017 and March 2024. The surveys assessed changes in participants' understanding of key nutrition concepts (rated using a four-point scale from poor to excellent) and their confidence in cooking healthy meals (rated using a four-point scale from none to high) before and after attending the program. <b>Results</b>: The findings showed significant improvements in both nutrition knowledge (from fair to good <i>p</i> < 0.001) and cooking confidence (from low to moderate <i>p</i> < 0.001) following program participation. <b>Conclusions</b>: These results highlight the vital role of nutrition and culinary education in addressing the growing obesity epidemic and reducing the risk of diet-related chronic conditions. Given the positive program outcomes, DTHCS has the potential to inform future studies and guide successful planning and implementation of community-based cooking programs for adults to promote healthier eating behaviors.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interplay Between Psychological and Neurobiological Predictors of Weight Regain: A Narrative Review.","authors":"Małgorzata Moszak, Justyna Marcickiewicz, Marta Pelczyńska, Paweł Bogdański","doi":"10.3390/nu17101662","DOIUrl":"10.3390/nu17101662","url":null,"abstract":"<p><p><b>Introduction</b>: Obesity is a global health problem requiring effective interventions to achieve weight loss and maintain it in the long term. A major challenge for clinicians is weight regain (WR), defined as progressive weight gain following successful weight loss. WR is affected by multiple factors, including psychological traits linked to specific brain alterations. Understanding these mechanisms is crucial in developing strategies to prevent WR and to ensure effective weight control. <b>Objectives</b>: This narrative review aims to gather current findings on the psychological and neurobiological determinants of WR and to discuss the interplay between these factors. <b>Methods</b>: A literature search was conducted on PubMed, Medline, and Web of Science for English-language studies published between December 1990 and November 2024. <b>Results</b>: WR is driven by interconnected psychological and neurobiological factors that influence eating behavior and the regulation of body weight. Certain personality traits and emotional patterns are associated with specific changes in brain activity, which together affect vulnerability to WR. Although distinct mechanisms can be identified, the complexity of homeostatic and nonhomeostatic appetite control suggests that no single factor predominates. <b>Conclusions</b>: This review highlights the dynamic interplay between psychological and neurobiological predictors of WR. However, due to the narrative nature of this review, the focus on selected determinants, and the limited quality and size of the available studies, further research is needed to comprehensively understand causality and to improve relapse prevention strategies.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Vitamin D Status in Religious and Intermittent Fasting: A Comparative Study in Orthodox Nuns and Women from the General Population.","authors":"Spyridon N Karras, Konstantinos Michalakis, Maria Kypraiou, Antonios Vlastos, Marios Anemoulis, Georgios Koukoulis, Zadalla Mouslech, Filotas Talidis, Costas Haitoglou, Georgios Michos, Evangelos G Papanikolaou, Dimitrios Skoutas, Neoklis Georgopoulos, Georgios Tzimagiorgis","doi":"10.3390/nu17101656","DOIUrl":"10.3390/nu17101656","url":null,"abstract":"<p><p><b>Background:</b> Vitamin D plays a key role in bone metabolism and immune regulation. Populations with restricted sun exposure or limited dietary intake are particularly vulnerable to vitamin D deficiency. Orthodox Christian nuns represent a unique group in this regard, due to traditional clothing, limited outdoor activity, and prolonged religious fasting. However, few studies have compared them with lay individuals following similar dietary practices. <b>Objective:</b> This study aimed to investigate predictors of serum 25-hydroxyvitamin D [25(OH)D] concentrations in two female populations: Orthodox Christian nuns and women from the general population practicing intermittent (religious or non-religious) fasting. We also aimed to develop predictive models of vitamin D status for each group based on lifestyle and biochemical parameters. <b>Methods:</b> A total of 85 women (40 Orthodox nuns and 45 laywomen), aged 30-50 years, were enrolled. Serum 25(OH)D, parathyroid hormone (PTH), calcium levels, and anthropometric indices, including body mass index (BMI), total body fat, and visceral fat, were measured. Dietary calcium and vitamin D intake, as well as sun exposure, were assessed using validated questionnaires. Separate stepwise multiple regression models were constructed for each group to identify independent predictors of 25(OH)D concentrations. An additional combined model, including all participants, was also explored. <b>Results:</b> PTH was the most significant predictor, negatively correlating with 25(OH)D concentrations in both groups (<i>p</i> = 0.038), highlighting its regulatory role in vitamin D metabolism. When analyzed separately, the model for Orthodox nuns showed stronger explanatory power (adjusted R² = 0.718; <i>p</i> = 0.013) compared with the control group (adjusted R² = 0.362; <i>p</i> = 0.038), with PTH emerging as a key predictor in both. <b>Conclusions:</b> Distinct predictors of vitamin D status were identified in each group, reflecting the complex interplay between lifestyle and physiological factors. These findings suggest that targeted interventions, such as addressing PTH regulation in fasting populations or enhancing sun exposure in the general population, may be more effective in preventing vitamin D deficiency depending on the context.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Micronutrient Intake in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation.","authors":"Louise Lindkvist Pedersen, Maria Ebbesen Sørum, Anne Nissen, Tina Gerbek, Karin Kok, Kaspar Sørensen, Martin Kaj Fridh, Christian Mølgaard, Klaus Gottlob Müller","doi":"10.3390/nu17101663","DOIUrl":"10.3390/nu17101663","url":null,"abstract":"<p><strong>Background: </strong>Survivors of hematopoietic stem cell transplantation (HSCT) during childhood face significant late effects. This study aimed to map the dietary micronutrient intake of long-term survivors of pediatric HSCT and explore its associations with transplant outcomes, body composition, and physical capacity.</p><p><strong>Methods: </strong>We included 85 long-term survivors of HSCT (median age 30 years) The median time since HSCT was 19.9 years, reflecting a long-term survivor population. Dietary intake was assessed using a 3-day food record. Body composition was measured by DXA, and physical capacity was evaluated through cardiorespiratory fitness and physical performance tests.</p><p><strong>Results: </strong>We observed an inadequate intake of several vitamins and minerals including vitamins A, C, D, E, selenium, and potassium, with a median intake below recommendations. While dietary intake of vitamin D was reduced in patients with chronic graft versus host disease (cGvHD), the occurrence of cGvHD was not associated with overall micronutrient intake. Twelve percent of the participants had reduced skeletal muscle mass and 16% displayed a low bone mass density during DXA scans. These conditions were not related to the micronutrient intake. Likewise, reduced cardiorespiratory fitness and physical performance were unrelated to micronutrient intake. Total energy intake was found to significantly influence micronutrient intake (<i>p</i> = 0.001), explaining 66% of the variation.</p><p><strong>Conclusions: </strong>Long-term survivors of pediatric HSCT demonstrated inadequate intake of multiple micronutrients. These findings suggest that inclusion of comprehensive micronutrient assessment and nutritional guidance should be considered for inclusion in follow-up care protocols.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Nutrition Strategies for Patients in the Intensive Care Unit: A Narrative Review on the Future of Critical Care Nutrition.","authors":"Mircea Stoian, Adina Andone, Sergiu Rareș Bândilă, Danusia Onișor, Dragoș-Florin Babă, Raluca Niculescu, Adina Stoian, Leonard Azamfirei","doi":"10.3390/nu17101659","DOIUrl":"10.3390/nu17101659","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Introduction:&lt;/b&gt; Critically ill patients in intensive care units (ICUs) are at high risk of malnutrition, which can result in muscle atrophy, polyneuropathy, increased mortality, or prolonged hospitalizations with complications and higher costs during the recovery period. They often develop ICU-acquired weakness, exacerbated by sepsis, immobilization, and drug treatments, leading to rapid muscle mass loss and long-term complications. Studies indicate that adequate protein and calorie intake can decrease mortality and improve prognosis and recovery. However, optimal implementation remains a critical challenge. &lt;b&gt;Objectives:&lt;/b&gt; This narrative review aims to summarize recent advances in nutritional strategies for critically ill patients. It highlights the benefits and limitations of current approaches including enteral (EN) and parenteral nutrition (PN) and examines their impact on clinical outcomes and overall mortality. Additionally, the review explores the emerging role of precision nutrition in critical care using technologies such as metabolomics and artificial intelligence (AI) to provide valuable insights into optimizing nutritional care in critically ill patients. &lt;b&gt;Methods:&lt;/b&gt; A comprehensive literature search was conducted to identify recent studies, clinical guidelines, and expert consensus papers on nutritional support for ICU patients. The investigation focused on critical aspects such as the optimal timing for intervention, the route of administration, specific protein and energy targets, and technological innovations to support personalized nutrition, ensuring that each patient receives tailored support based on their unique needs. &lt;b&gt;Results:&lt;/b&gt; Guidelines recommend initiating EN or PN nutrition within the first 48 h of admission, using indirect calorimetry (IC) to estimate energy needs, and supplementing protein up to 1.2 g/kg/day after stabilization. IC has gained importance in assessing energy needs but is still underused in the ICU. EN is preferred because it maintains intestinal integrity, reduces the risk of infections, and is recommended within the first 48 h of ICU admission. PN is used when EN is infeasible, but it increases the risk of infection. By integrating metabolomics with transcriptomic and genomic data, we can gain a deeper understanding of the effect of nutrition on cellular homeostasis, facilitating personalized treatments and enhancing the recovery of critically ill patients. &lt;b&gt;Conclusions:&lt;/b&gt; AI is becoming increasingly important in monitoring and evaluating artificial nutrition, providing a more accurate and efficient alternative to traditional methods. AI can assist in identifying and managing malnutrition and is effective for estimating caloric and nutrient intake. AI minimizes human error, enables continuous monitoring, and integrates various data sources. The nutritional care of critically ill patients requires collaboration among specialists from diverse fields, including physicians, nutri","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers in Age-Related Diseases and Nutritional Interventions.","authors":"Caiziyu Yu, Lili Qiu, Xiaoyu Wang","doi":"10.3390/nu17101658","DOIUrl":"10.3390/nu17101658","url":null,"abstract":"<p><p>The aging population presents one of the greatest challenges to sustainable development, progressing at an unprecedented rate in recent years [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Italian ObGyn Residents Have Enough Knowledge to Counsel Women About Nutritional Facts? Results of an On-Line Survey.","authors":"Laura Sarno, Dario Colacurci, Eleonora Ranieri, Rossella E Nappi, Maurizio Guida","doi":"10.3390/nu17101654","DOIUrl":"10.3390/nu17101654","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Nutrition plays a key role in gynecologic conditions, pregnancy, and perinatal outcomes; therefore, nutritional counseling is essential in obstetric and gynecologic care. The present study aimed to delineate Italian Obstetrics and Gynecology (ObGyn) residents' awareness of women's nutrition and supplementation in different stages of life. <b>Methods</b>: We conducted a cross-sectional online survey about women's nutrition and supplementation use throughout their lifetime. A 31-item survey questionnaire was distributed to Italian ObGyn Residents. <b>Results</b>: 258 Italian ObGyn Residents completed the online survey. About 40% of the responders considered their knowledge of women's nutritional needs poor or very poor. A total of 226 residents (88%) declared that there is not enough time dedicated to women's nutrition during their specialty program, and almost all the trainees would consider training in this area helpful for achieving a better professional profile. A total of 128 participants (49.6%) demonstrated insufficient knowledge in this field. Most (97.1%) of the responding trainees recommend supplementation during different stages of women's lives. <b>Conclusions</b>: Italian ObGyn residents are not very skilled in women's nutrition. There is an urgent need to develop specific training and interventions to educate our ObGyn residents about the importance of improving nutritional habits in patient care.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) and Vitamin Metabolism: A Nutritional Perspective on an Emerging Environmental Health Issue.","authors":"Chen Liu, Biao Zhou, Lichun Huang, Dan Han, Mengjie He, Mengyi Zhou, Peiwei Xu, Ronghua Zhang","doi":"10.3390/nu17101660","DOIUrl":"10.3390/nu17101660","url":null,"abstract":"<p><p>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals characterized by exceptional stability and potential for bioaccumulation. Ubiquitous in the environment, PFAS can enter the human body through water, air, and dietary sources. Exposure to PFAS has been linked to various adverse health effects, including cancer, endocrine disruption, and reproductive and developmental toxicities. Emerging evidence suggests potential interactions between PFAS exposure and vitamin levels in the human body. This review provides a comprehensive understanding of the associations between PFAS and various vitamins, elucidates potential underlying mechanisms, and offers insights for the development of targeted nutritional interventions.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}