Nucleic Acids Research最新文献

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AsCas12a tolerates insertions in target DNA. AsCas12a耐受靶DNA的插入。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf887
Santosh R Rananaware, Grace M Shoemaker, Brianna L M Pizzano, Emma K Vesco, Luke Samuel W Sandoval, Jordan G Lewis, August P Bodin, Sarah J Flannery, Ian H Lange, Dheeraj Pedada, Anne Fang, Sydney G Antal, Daisy Aguilar, Noah R Rakestraw, Vedant N Karalkar, Katelyn S Meister, Long T Nguyen, Piyush K Jain
{"title":"AsCas12a tolerates insertions in target DNA.","authors":"Santosh R Rananaware, Grace M Shoemaker, Brianna L M Pizzano, Emma K Vesco, Luke Samuel W Sandoval, Jordan G Lewis, August P Bodin, Sarah J Flannery, Ian H Lange, Dheeraj Pedada, Anne Fang, Sydney G Antal, Daisy Aguilar, Noah R Rakestraw, Vedant N Karalkar, Katelyn S Meister, Long T Nguyen, Piyush K Jain","doi":"10.1093/nar/gkaf887","DOIUrl":"10.1093/nar/gkaf887","url":null,"abstract":"<p><p>CRISPR-Cas12a enzymes are RNA-guided nucleases widely used for programmable genome editing and diagnostics. Perfect complementarity between guide RNA and target DNA is essential for efficient binding and cleavage by Cas12a. However, we report that a particular ortholog of Cas12a, Acidaminococcus sp. Cas12a (AsCas12a), shows an unexpected tolerance to noncomplementary insertions at various positions in its DNA target. AsCas12a remains functional despite DNA bubbles or loops in the CRISPR-RNA (crRNA)-target DNA duplex, displaying both cis- and trans-cleavage activities even when the target harbors insertions of lengths 1-20 nucleotides in the crRNA-binding region. This activity is sequence-independent and works for ssDNA and is observed on dsDNA in vitro for specific insertion lengths/positions and DNA topologies but is strongly diminished in cells. Among 12 Cas12a orthologs tested, only AsCas12a exhibits this tolerance, making it a unique member of the Cas12a family. Structural analysis suggests a distinctive α-helix in AsCas12a's WED domain is required for this flexibility. Upon deleting this α-helix, AsCas12a loses its ability to tolerate insertions. This discovery can be utilized to detect single-nucleotide polymorphisms and enable protospacer adjacent motif (PAM)-flexible DNA cleavage with Cas12a. Our findings expand our fundamental understanding of CRISPR-Cas12a systems. In conclusion, we uncover and characterize a unique property of AsCas12a to tolerate insertions in its target.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A NanoLock-enabled, Craspase-based strategy for highly sensitive RNA detection. 一种基于craspase的高灵敏度RNA检测策略。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf907
Yumeng Xiao, Junyu Chen, Xincan Hou, Hongwei Wang, Kundi Zhang, Sujuan Xu, Tao Jiang, Yangao Huo, Fengyu Zhang, Lichuan Gu
{"title":"A NanoLock-enabled, Craspase-based strategy for highly sensitive RNA detection.","authors":"Yumeng Xiao, Junyu Chen, Xincan Hou, Hongwei Wang, Kundi Zhang, Sujuan Xu, Tao Jiang, Yangao Huo, Fengyu Zhang, Lichuan Gu","doi":"10.1093/nar/gkaf907","DOIUrl":"10.1093/nar/gkaf907","url":null,"abstract":"<p><p>Rapid and sensitive detection of RNA is important in fields such as biomedical research and clinical diagnostics. However, current methods typically involve an amplification process, require substantial time, and are susceptible to aerosol contamination. Herein, we introduce a NanoLock-powered, amplification-free assay based on the type III-E clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated system for rapid, highly sensitive, and specific RNA diagnostics. This innovative platform, designated CRISPR-guided caspase (Craspase)-NanoLock-Csx30 (CNC), harmoniously integrates the precise protease activity of Craspase with the remarkable luminescent sensitivity of NanoLock, creating a novel and streamlined approach for RNA detection. The CNC platform exhibited exceptional sensitivity in detecting severe acute respiratory syndrome coronavirus-2 N gene RNA through the integration of three guide RNAs, achieving a detection limit of 250 fM in just 10 min without amplification. Preliminary studies further revealed the platform's extended diagnostic potential for detecting influenza A virus and human immunodeficiency virus. These findings collectively establish the CNC platform as an appealing tool for infectious disease detection and significantly broaden the scope of CRISPR-based diagnostic applications.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-translational modification of H2B C-terminal helix regulates nucleosome interactions and chromatin signaling. H2B c端螺旋的翻译后修饰调节核小体相互作用和染色质信号传导。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf897
Yani Zhao, Anh Nguyen, Eyla C Arteaga, Aleksandra Skrajna, Krzysztof Krajewski, Dennis Goldfarb, Robert K McGinty
{"title":"Post-translational modification of H2B C-terminal helix regulates nucleosome interactions and chromatin signaling.","authors":"Yani Zhao, Anh Nguyen, Eyla C Arteaga, Aleksandra Skrajna, Krzysztof Krajewski, Dennis Goldfarb, Robert K McGinty","doi":"10.1093/nar/gkaf897","DOIUrl":"10.1093/nar/gkaf897","url":null,"abstract":"<p><p>Histone H2B contains a highly conserved C-terminal (H2B αC) helix that has been implicated in chromatin interactions and dynamics. The H2B αC helix comprising residues 105-125 is positioned adjacent to a major site of nucleosome interactions called the acidic patch. Despite individual structural studies highlighting interactions between chromatin proteins and the H2B αC helix, the general role of the helix in mediating nucleosome recognition has not been explored. Moreover, many post-translational modifications (PTMs) have been identified within the H2B αC helix, but significant gaps exist in our understanding of their regulatory potential. In this study, we employed nucleosome affinity proteomics using a library of nucleosomes with mutations or PTMs of the H2B αC helix to investigate contributions to nucleosome binding. Our work uncovers new spatial patterns of H2B αC helix engagement across the proteome. We also demonstrate that H2B K120 mono-ubiquitylation (H2B K120ub) within the H2B αC helix broadly disrupts nucleosome binding, phenocopying mutation of the acidic patch, while differentially regulating acidic patch-dependent chromatin functions. In contrast, lysine acetylation results in more subtle position-specific changes, highlighting a more general role of H2B αC helix PTMs in tuning acidic patch recognition.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The advantage of periodic over constant signalling in microRNA-mediated regulation. 在microrna介导的调控中,周期性信号优于恒定信号。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf867
Elsi Ferro, Candela L Szischik, Alejandra C Ventura, Carla Bosia
{"title":"The advantage of periodic over constant signalling in microRNA-mediated regulation.","authors":"Elsi Ferro, Candela L Szischik, Alejandra C Ventura, Carla Bosia","doi":"10.1093/nar/gkaf867","DOIUrl":"10.1093/nar/gkaf867","url":null,"abstract":"<p><p>Cells may exploit oscillatory gene expression to encode biological information. Temporal features of oscillations, such as pulse frequency and amplitude, are determinant for the outcome of signalling pathways. However, little effort has been devoted to unveiling the role of pulsatility in the context of post-transcriptional gene regulation, where microRNAs act by binding to RNAs and regulate their expression. Here, we study the effects of periodic against constant microRNA synthesis within minimal microRNA-target networks. We find that there is a repressive advantage of pulsatile over constant microRNA synthesis, and that the extent of repression depends on the frequency of pulses, thus uncovering frequency preference behaviours. We show that the preference for specific input frequencies is determined by relative microRNA and target kinetic rates and can lead to exclusive frequency-dependent repression on distinct RNA species, thereby highlighting a potential mechanism of selective dynamical target regulation. Moreover, we show that frequencies observed in periodically expressed microRNAs, such as those involved in circadian rhythms and development, can be selectively favored. Our findings might have implications for experimental studies aimed at understanding how periodic patterns drive biological responses through microRNA-mediated signalling and provide suggestions for validation in synthetic networks.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA G-quadruplexes emerge from a compacted coil-like ensemble via multiple pathways. RNA g -四联体通过多种途径从紧凑的线圈状集合中出现。
IF 14.9 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf872
Pavlína Pokorná,Vojtěch Mlýnský,Jiří Šponer,Petr Stadlbauer
{"title":"RNA G-quadruplexes emerge from a compacted coil-like ensemble via multiple pathways.","authors":"Pavlína Pokorná,Vojtěch Mlýnský,Jiří Šponer,Petr Stadlbauer","doi":"10.1093/nar/gkaf872","DOIUrl":"https://doi.org/10.1093/nar/gkaf872","url":null,"abstract":"RNA G-quadruplexes (rG4s) are emerging as vital structural elements involved in processes like gene regulation, translation, and genome stability. Found in untranslated regions of messenger RNAs (mRNAs), they influence translation efficiency and mRNA localization. Additionally, rG4s of long noncoding RNAs and telomeric RNA play roles in RNA processing and cellular aging. Despite their significance, the atomic-level folding mechanisms of rG4s remain poorly understood due to their complexity. We studied the folding of the r(GGGA)3GGG and r(GGGUUA)3GGG (TERRA) sequences into parallel-stranded rG4 using all-atom enhanced-sampling molecular dynamics simulations, applying well-tempered metadynamics coupled with solute tempering. The obtained folding pathways suggest that RNA initially adopts a compacted coil-like ensemble characterized by dynamic guanine stacking and pairing. The three-quartet rG4 gradually forms from this compacted coil ensemble via diverse routes involving strand rearrangements and guanine incorporations. While the folding mechanism is multipathway, various two-quartet rG4 structures appear to be a common transitory ensemble along most routes. Thus, the process seems more complex than previously predicted, as G-hairpins or G-triplexes do not act as distinct intermediates, even though some are occasionally sampled. We also discuss the challenges of applying enhanced sampling methodologies to such a multidimensional free-energy surface and address the force-field limitations.","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"32 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesizing supercoiled circular DNA molecules in vitro. 体外合成超螺旋环状DNA分子。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf889
Sepideh Rezaei, Monica Moncada-Restrepo, Sophia Leng, Jeremy W Chambers, Fenfei Leng
{"title":"Synthesizing supercoiled circular DNA molecules in vitro.","authors":"Sepideh Rezaei, Monica Moncada-Restrepo, Sophia Leng, Jeremy W Chambers, Fenfei Leng","doi":"10.1093/nar/gkaf889","DOIUrl":"10.1093/nar/gkaf889","url":null,"abstract":"<p><p>Supercoiled (Sc) circular DNA, such as plasmids, are essential in molecular biology and hold strong therapeutic potential. However, they are typically produced in Escherichia coli, resulting in bacterial methylations, unnecessary sequences, and contaminants that hinder certain applications including clinical uses. These limitations could be avoided by synthesizing plasmids entirely in vitro, but synthesizing high-purity Sc circular DNA biochemically remains a significant technical challenge. To overcome this challenge, we have developed two novel biochemical methods for in vitro synthesis of Sc circular DNA. Linear DNA with two loxP sites in the same orientation is generated by polymerase chain reaction or rolling circle amplification. Cre recombinase efficiently converts the linear DNA into relaxed circular DNA. T5 exonuclease is then used to digest unwanted linear DNA, and topoisomerases are employed to generate Sc circular DNA. Using this approach, we synthesized EGFP-FL, a 2 kb mini-circular DNA encoding essential EGFP expression elements. EGFP-FL transfected HeLa and C2C12 cells with significantly higher efficiency than its E. coli-derived counterpart. These methods enable the efficient production of Sc circular DNA from 196 bp to several kb, and in quantities from micrograms to milligrams, providing a versatile, scalable, and bacteria-free platform for basic research and therapeutic applications.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoter-proximal transcription-translation coupling controls early transcription in Escherichia coli. 启动子-近端转录-翻译偶联控制大肠杆菌的早期转录。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf896
Soojin Park, Jina Yang, Sora Yang, Yong Hee Han, Giho Kim, Sang Woo Seo, Nam Ki Lee
{"title":"Promoter-proximal transcription-translation coupling controls early transcription in Escherichia coli.","authors":"Soojin Park, Jina Yang, Sora Yang, Yong Hee Han, Giho Kim, Sang Woo Seo, Nam Ki Lee","doi":"10.1093/nar/gkaf896","DOIUrl":"10.1093/nar/gkaf896","url":null,"abstract":"<p><p>The functional coupling of transcription and translation contributes significantly to maintaining messenger RNA (mRNA) expression in bacterial cells. Premature transcription termination and fast mRNA decay are known to limit the expression of mRNAs when transcription is decoupled from translation. Here, we report that inhibiting the generation of untranslatable mRNAs from the promoter-proximal region is a newly identified but essential pathway of mRNA quality control by transcription-translation decoupling. The promoter-proximal region of mRNAs, the amount of which reflects early transcription in the 5'-untranslated region, is not generated without translation. The decoupling between transcription and translation results in RNA polymerase (RNAP) traffic within 250 bp from the transcription start site, hindering productive early transcription. The limited processivity of RNAP without a coupled ribosome in the promoter-proximal region is further supported by the observation that decoupled RNAP elongates mRNA by only 80-90 bp on average in vivo. Our results demonstrate that ribosome coupling near the promoter-proximal region is critical for the efficient synthesis of translatable mRNAs by RNAPs.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural mechanism of RECQ1 helicase in unfolding G-quadruplexes compared with duplex DNA. RECQ1解旋酶展开g -四联体与双链DNA的结构机理比较。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf877
Ze-Yu Song, Xin Zhang, Xia Ai, Ling-Yun Huang, Xi-Miao Hou, Philippe Fossé, Na-Nv Liu, Olivier Mauffret, Stéphane Réty, Xu-Guang Xi
{"title":"Structural mechanism of RECQ1 helicase in unfolding G-quadruplexes compared with duplex DNA.","authors":"Ze-Yu Song, Xin Zhang, Xia Ai, Ling-Yun Huang, Xi-Miao Hou, Philippe Fossé, Na-Nv Liu, Olivier Mauffret, Stéphane Réty, Xu-Guang Xi","doi":"10.1093/nar/gkaf877","DOIUrl":"10.1093/nar/gkaf877","url":null,"abstract":"<p><p>RECQ1, the most abundant RecQ helicase in human cells, is involved in telomere maintenance in ALT cells and plays a critical role in maintaining genomic integrity and stability. Here, we present five high-resolution crystal structures that systematically reveal a novel mechanism by which the RECQ1 helicase recognizes and regulates G-quadruplex (G4) DNA structures. Our results demonstrate that DNA binding induces intra-subunit rearrangement in RECQ1, transitioning it from a closed to an open conformation. This rearrangement alters the stability of the dimer interface. G4 recognition and unwinding are driven by coordinated interactions between the D1/D2 domains and the single-stranded DNA (ssDNA)-binding channel. This dual engagement aligns the G4 tetrad in a geometry favorable for unwinding. ATP hydrolysis facilitates ssDNA translocation, positioning the β-hairpin to disrupt hydrogen bonds-unraveling G4 structures in a manner analogous to the unwinding of dsDNA. This study proposes a mechanistic model for RECQ1-mediated G4 unwinding and elucidates how RECQ1 recognizes and unwinds distinct DNA structures.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure. 鸟嘌呤- ii核开关三级结构揭示的配体特异性和适应性。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf884
Hongcheng Li, Xin Shen, Xiaochen Xu, Xiaoqing Tai, Mengqi He, Jinzhu Zhang, Aiming Ren
{"title":"Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure.","authors":"Hongcheng Li, Xin Shen, Xiaochen Xu, Xiaoqing Tai, Mengqi He, Jinzhu Zhang, Aiming Ren","doi":"10.1093/nar/gkaf884","DOIUrl":"10.1093/nar/gkaf884","url":null,"abstract":"<p><p>A comprehensive understanding of the fundamental principles governing RNA-small molecule interactions is crucial for advancing RNA-targeting therapeutics with small molecules. Riboswitches, a class of noncoding RNAs, regulate gene expression by direct interaction with small-molecule metabolites. In this work, we report an in-depth structure-based investigation of a newly identified riboswitch, Guanine-II, which, despite sharing a conserved scaffold with the Guanine-I riboswitch, exhibits strikingly distinct small molecule ligand-binding characteristics. Through a comprehensive structural analysis of the Guanine-II riboswitch bound to various guanine analogs, combined with comparative studies of other guanine riboswitch variants, including Guanine-I and Xanthine-II riboswitches, as well as isothermal titration calorimetry, we reveal local structural rearrangements that precisely modulate small-molecule ligand adaptability. We further demonstrate that subtle differences in the composition and peripheral architecture of the binding pocket are key determinants of ligand-binding specificity. Additionally, based on the similarity in ligand recognition patterns with the tetrahydrofolate-II riboswitch, we identified additional compounds that bind to the Guanine-II riboswitch through a structure-guided rational search, providing valuable structural insights for the discovery of small molecules targeting RNA.</p>","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to 'Structure of the nucleosome-bound human BCL7A'. 更正“核小体结合的人BCL7A的结构”。
IF 13.1 2区 生物学
Nucleic Acids Research Pub Date : 2025-09-05 DOI: 10.1093/nar/gkaf948
{"title":"Correction to 'Structure of the nucleosome-bound human BCL7A'.","authors":"","doi":"10.1093/nar/gkaf948","DOIUrl":"10.1093/nar/gkaf948","url":null,"abstract":"","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":"53 17","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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