Obesity Surgery最新文献

{"title":"The Performance of Artificial Intelligence in One Anastomosis Gastric Bypass Surgery: Comparative Efficacy of ChatGPT-4.0, ChatGPT-Omni, and Gemini AI.","authors":"Erkan Aksoy","doi":"10.1007/s11695-025-07794-9","DOIUrl":"10.1007/s11695-025-07794-9","url":null,"abstract":"<p><strong>Background: </strong>The integration of artificial intelligence (AI) into medical practice opens up new frontiers for decision support, especially in intricate surgical procedures like one-anastomosis gastric bypass (OAGB). This study was designed to showcase the potential and performance of three AI models-ChatGPT-4.0, ChatGPT-Omni, and Gemini AI-in tackling complex clinical queries related to OAGB, thereby paving the way for a more efficient and effective surgical practice.</p><p><strong>Methods: </strong>The study utilized a comprehensive query evaluation methodology comprising 180 questions for ChatGPT-4.0, ChatGPT-Omni, and Gemini AI models, equally divided among true/false, multiple-choice, open-ended, and case-scenario queries. These questions covered various aspects of OAGB surgery, including preoperative assessment, surgical technique, management of complications, and long-term outcomes.</p><p><strong>Results: </strong>ChatGPT-Omni showed higher accuracy rates than Gemini AI and ChatGPT-4.0 in most question formats and difficulty levels (p < 0.0001). However, the performance gap varied depending on the complexity and type of the queries. In true-false and multiple-choice formats, ChatGPT-Omni excelled, particularly in complex scenarios (p = 0.017). With a mean of 5.62 on a six-point scale, ChatGPT-Omni demonstrated exceptional capability in providing accurate and comprehensive answers to both open-ended and case scenarios. ChatGPT-Omni demonstrated the highest performance metrics, including precision (0.947), recall (0.857), and F1-score (0.9), although these values were dependent on the specific query format and type.</p><p><strong>Conclusions: </strong>While ChatGPT-Omni demonstrated superior accuracy in many clinical queries related to OAGB, especially in simpler decision-making scenarios, it is crucial to underscore the need for additional validation in complex clinical settings. This cautionary note serves as a reminder of the current limitations of AI in surgery and the importance of ongoing research and validation.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1469-1475"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years-Are the Initial Benefits Sustained?","authors":"Wahiba Elhag, Isra Elgenaied, Merilyn Lock, Walid El Ansari","doi":"10.1007/s11695-024-07664-w","DOIUrl":"10.1007/s11695-024-07664-w","url":null,"abstract":"<p><strong>Background: </strong>No previous study assessed the outcomes of sleeve gastrectomy (SG) beyond 5 years among adult patients with type 2 diabetes (T2DM). We appraised the evolution of 20 outcomes at 1, 3, 5, 7, and 9 years.</p><p><strong>Methods: </strong>This is a retrospective study of 361 consecutive T2DM patients who underwent SG at our institution (April 2011-December 2015). Postoperative data were compared to baseline and to previous time points using paired t tests. Diabetes status was also assessed at each time point.</p><p><strong>Results: </strong>The sample consisted of 65.37% females. The mean preoperative age was 44.38 ± 9.50 years and body mass index (BMI) was 43.81 ± 6.98 kg/m². Generally, most improvements occurred in the first year and were sustained on the long term. Postoperatively, there was a significant and sustained weight reduction, amounting to a mean decrease of 9 kg/m² in BMI at year 9 and associated excess weight loss between 59%_{year 1} and 46%_{year 9}. Fasting blood glucose decreased significantly across the five time points, from 9.27 ± 4.11_preop to 7.06 ± 2.70_{year 9} mmol/L. Mean HbA1c significantly decreased from 8.1%_preop to 6.77%_{year 9}. The prevalence of complete remission of T2DM was 20.45%, 19.44%, and 20% at 5, 7, and 9 years respectively, with significant reductions in percentages of patients using diabetes medications or insulin. Between 10% and 23% of patients experienced relapse of T2DM by 5-9 years. In comparison to baseline levels, mean blood pressure, triglycerides, high-density lipoprotein, low-density lipoprotein, total cholesterol, and hepatic enzymes levels all showed improvement in the long term.</p><p><strong>Conclusion: </strong>Patients with T2DM experienced substantial improvements in most anthropometric and cardiometabolic outcomes within the first year, and these were sustained in the long term.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1253-1264"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Changes in the Structure, Function, and Fat Content of the Heart in Patients with Obesity After Bariatric Surgery-A Prospective Magnetic Resonance Imaging Study.","authors":"Jinquan Bai, Xiaolu Li, Zhenzhou Shi, Hong Pan, Shuting Wang, Chao Gao, Min Zhao, Xiuzheng Yue, Kai Yang, Xia Zhang, Chang Liu, Wei Wang, Tong Zhang","doi":"10.1007/s11695-024-07662-y","DOIUrl":"10.1007/s11695-024-07662-y","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1575"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Bariatric Surgery Outcomes and Socioeconomic Deprivation.","authors":"Midhuna Jomon, James Lucocq, Georgios Geropoulos, Andrew de Beaux, Bruce Tulloh, Brian Joyce, Beverly Wallace, Gillian Drummond, Peter J Lamb, Andrew G Robertson","doi":"10.1007/s11695-025-07747-2","DOIUrl":"10.1007/s11695-025-07747-2","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a multifaceted problem for global healthcare, influenced by socioeconomic factors. Bariatric surgery is an effective treatment where less invasive management has been unsuccessful. The impact of socioeconomic deprivation on surgical outcomes is a novel area of research. The present study aims to investigate the effect of socioeconomic deprivation on bariatric surgery outcomes.</p><p><strong>Methods: </strong>Data was prospectively collected at a regional bariatric centre in Scotland. The study included patients who received either a Roux-en-Y Gastric Bypass (RYGB) or Sleeve Gastrectomy (SG) (2008-2022). Follow-up occurred postoperatively at 6 months, 1 year and annually thereafter. Socioeconomic deprivation was measured using the Scottish Index of Multiple Deprivation (SIMD) using residential postcodes to generate a deprivation quintile (Q1-5). The primary outcome was percentage total weight loss (%TWL). Secondary outcomes included postoperative complications, comorbidity status, nutritional status, length of stay and re-admissions. Grouped analysis was conducted to represent a more deprived group (Q1-3) and a less deprived group (Q4-5). Statistical analysis was carried out of the data. The study was carried out using the STROBE principles.</p><p><strong>Results: </strong>316 patients were included (median follow-up, 7 years; median %TWL, 23.8%). There was no significant difference in median %TWL (p = 0.528), short-term (p = 0.619) or long-term (p = 0.164) complications and resolution (p = 0.472), improvement (p = 0.282) or exacerbation of comorbidities (p = 0.717) between socioeconomic quintiles.</p><p><strong>Conclusion: </strong>Socioeconomic deprivation does not limit bariatric surgery outcomes and should not be a barrier to surgery.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1316-1325"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Preoperative Eating Habits on Weight Loss After Metabolic Bariatric Surgery.","authors":"Muhammer Ergenç, Tevfik Kıvılcım Uprak, Hale Feratoğlu, Ömer Günal","doi":"10.1007/s11695-025-07766-z","DOIUrl":"10.1007/s11695-025-07766-z","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders and disordered eating habits are frequently identified among metabolic and bariatric surgery (MBS) patients. However, how these factors may affect postsurgical outcomes has not been adequately addressed. The aim of this study was to investigate the associations between patients' eating habits and optimal clinical response after MBS.</p><p><strong>Methods: </strong>The study analyzed data from patients who underwent MBS at Marmara University Hospital between 2015 and 2023. Patient demographics, body mass index, obesity-associated medical problems, follow-up periods, surgical procedures (laparoscopic sleeve gastrectomy-SG, laparoscopic Roux-en-Y gastric bypass-RYGB), and eating habits (binge eating, carbohydrate craving, night eating, and sweet eating) were analyzed. Patients were divided into two groups: the optimal clinical response group (%TWL ≥ 20) and the suboptimal clinical response group (%TWL < 20) after surgery, and the groups were compared.</p><p><strong>Results: </strong>A total of 426 patients, including 197 patients who underwent SG and 229 patients who underwent RYGB, were included. The mean age of all patients was 40.9 ± 10.7 years. During the preoperative period, binge eating, carbohydrate craving, night eating, and sweet eating habits were detected in 55.9%, 67.6%, 47.7%, and 60.6% of the patients, respectively. The mean follow-up period was 24 months (1-60 months). Eighty percent of the patients achieved an optimal clinical response. The preoperative eating habits and %TWL values of the patients were analyzed. There was no statistically significant effect of eating habits on the optimal clinical response in all patients or in the SG vs RYGB groups.</p><p><strong>Conclusions: </strong>This study investigated the effect of preoperative disordered eating habits on weight loss after MBS and revealed no significant difference between those with these habits and those without these habits. It is difficult to predict weight loss after MBS on the basis of preoperative eating behavior. However, further studies are needed to evaluate this factor in combination with other factors before or after surgery.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1407-1414"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Landscape of Obesity Education Worldwide - Are We Doing Enough? Scoping Review of Content of Obesity Educational Interventions in Medical Schools and Residency Programs.","authors":"Wahiba Elhag, Walid El Ansari","doi":"10.1007/s11695-024-07654-y","DOIUrl":"10.1007/s11695-024-07654-y","url":null,"abstract":"<p><p>No study appraised the curricular content of published obesity education interventions (OEI) delivered to medical students, residents, or fellows. This scoping review identified and described the curricular content of published OEI, examined the specific obesity-related domains addressed, and proposed potential directions for future intervention development. We searched PubMed and Web of Science databases. Original articles on OEI delivered to medical students, residents, or fellows were included. Data extraction was guided by the Obesity Medicine Education Collaborative's framework and the Accreditation Council for Graduate Medical Education-International (ACGME-I) competencies framework. The curricular content of OEI was categorized and visually mapped to identify trends and gaps. A total of 490 studies were identified, and 60 were included. Conceptually, twelve obesity domains emerged: epidemiology, health policy, prevention; basic sciences; nutrition; physical activity; behavioral aspects; counseling; pharmacotherapy; metabolic/bariatric surgery (MBS); weight stigma; ethics/professionalism; health literacy; and practice guidelines. Geographically, most OEI (88.3%) were implemented in North America. Three-quarters of OEI were for medical students, less OEI were for residents, and none for fellows. Content-wise, the OEI for medical students and for residents exhibited strikingly limited coverage of all obesity domains, although those for residency programs had more limited coverage than those for medical schools. Across medical schools, the most common domains addressed were basic sciences (48.3%), counseling, and nutrition (45% each); the least included were pharmacotherapy (13.3%), ethics/professionalism (3.3%), and health literacy (1.6%). For residency programs, the most common domains addressed were basic sciences and counseling (21.6% for each); the least were pharmacotherapy and MBS (6.6% each), weight stigma (5%), ethics/professionalism (3.3%) and health literacy (1.6%). Many critical domains of obesity remain inadequately addressed in the education provided in medical schools and residency programs. Future OEI should incorporate these to equip future physicians with knowledge, skills, and attitudes to care for patients with obesity.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1201-1222"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Excision of Gastrointestinal Stromal Tumor (GIST) After Sleeve Gastrectomy: Highlighting a Sleeve-Preserving Surgical Approach.","authors":"Haseeb Javed Khan, Tahir Yunus, Abdul Kamil Ghumman, Abdelrahman Nimeri","doi":"10.1007/s11695-025-07775-y","DOIUrl":"10.1007/s11695-025-07775-y","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal stromal tumors (GISTs) are relatively rare, accounting for approximately 0.1-3% of all gastrointestinal tumors. Their incidence is higher in individuals aged 50 to 70 years, with an equal gender distribution. Due to their diverse clinical presentations, including upper gastrointestinal (GI) bleeding and gastric discomfort, along with an indolent growth pattern, GISTs can remain undetected for extended periods. This delay in diagnosis can lead to complications. Diagnosis involves upper GI endoscopy, computed tomography (CT) scan, biopsy with histologic grading, and immunohistochemical testing for CD-117 and CD34. The higher incidence of GISTs in patients with obesity underscores the need for preoperative upper GI endoscopic screening.</p><p><strong>Case presentation: </strong>A 31-year-old female with a history of sleeve gastrectomy (SG) for obesity (BMI 38 kg/m²) presented 13 months postoperatively with recurrent hematemesis, epigastric fullness, and pain radiating to the back. Despite medical management, including proton pump inhibitors (PPIs), her symptoms persisted. Upper GI endoscopy revealed a polypoidal mass at the gastroesophageal junction (GEJ). Endoscopic ultrasound (EUS) indicated that the lesion originated from the muscularis propria. A contrast-enhanced CT scan confirmed the presence of a polypoid mass without extra-luminal extension, raising suspicion of GIST. The patient underwent laparoscopic resection of the tumor using a sleeve-preserving approach. The tumor was excised with a 1-cm margin of normal tissue, ensuring complete resection with negative margins confirmed by the frozen section. The gastric defect was closed with interrupted sutures, and a 38-Fr gastric tube was placed to maintain luminal patency. The patient had an uneventful recovery, with minimal drain output, and was discharged on postoperative day 3 with continued PPI therapy. Histopathological examination confirmed a low-risk GIST. At 1-year follow-up, the patient remained asymptomatic with no recurrence.</p><p><strong>Conclusion: </strong>Early detection and sleeve-preserving resection of GISTs in post-sleeve gastrectomy patients ensure effective tumor management while maintaining gastric integrity. This case highlights the importance of preoperative evaluation and long-term follow-up in these patients.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1571-1574"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic Factors Associated with Postoperative Complications in Primary Bariatric Surgery: A Rapid Review.","authors":"Jocelin Hon, Paul Fahey, Mohammad Ariya, Milan Piya, Alex Craven, Evan Atlantis","doi":"10.1007/s11695-025-07784-x","DOIUrl":"10.1007/s11695-025-07784-x","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery is highly effective for the management of severe obesity, but its safety profile is not completely understood. This review aimed to synthesise evidence linking demographic factors to postoperative complications and mortality following primary bariatric surgery.</p><p><strong>Methods: </strong>We searched Medline for observational studies of adult patients linking demographic factors to postoperative complications of primary bariatric surgery published from 2017 to 2022. Risk ratios (RR) with 95% confidence intervals (95% CI) were calculated and pooled using random effect meta-analysis. Heterogeneity was quantified using the I² statistic and tested for statistical significance using the Q-statistic. Sensitivity analyses were used to explore potential sources of heterogeneity.</p><p><strong>Results: </strong>A total of 71 observational studies (69 cohort, 2 case-control) were reviewed and appraised. Older age was consistently associated with increased risks of postoperative mortality (RR = 2.62, 95% CI 1.63-4.23, I² = 42.04%), serious complications (RR = 1.76, 95% CI 1.09-2.82, I² = 93.24%), anastomotic leak (RR = 1.64, 95% CI 1.04-2.58, I² = 61.09%), and haemorrhage (RR = 1.44, 95% CI 1.07-1.94, I² = 45.25%). Male sex was associated with increased anastomotic leak (RR = 1.39, 95% CI 1.04-1.87, I² = 72.36%). Sensitivity analyses did not identify sources of bias. Socioeconomic factors, including Black/African American race, low financial status, and marital status (mixed results), were linked to higher complication risks in some studies.</p><p><strong>Conclusions: </strong>Older age and certain demographic factors (male sex, Black/African American race, low financial status, marital status) were associated with increased risks of postoperative complications following primary bariatric surgery.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1456-1468"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Anastomosis Gastric Bypass Versus Roux‑en‑Y Gastric Bypass for Obesity: An Updated Meta‑analysis and Systematic Review of Randomized Controlled Trials.","authors":"Yusuf Ahmed, Karim Ataya, Abdulla Almubarak, Isa Almubarak, Manar Ali, Walaa Yusuf, Mostafa Mohammed Saad Mahran, Stefan Simeonovski, Almoutuz Aljaafreh, Wah Yang","doi":"10.1007/s11695-025-07776-x","DOIUrl":"10.1007/s11695-025-07776-x","url":null,"abstract":"<p><strong>Background: </strong>Roux-en-Y gastric bypass (RYGB) is widely regarded as a cornerstone intervention for individuals afflicted with metabolic syndromes and severe obesity. However, one anastomosis gastric bypass (OAGB) emerged after RYGB as a more straightforward and less technically demanding operation. This systematic review and meta-analysis aims to compare both procedures and update the currently existing evidence.</p><p><strong>Methods: </strong>We systematically searched PubMed, Scopus, and the Cochrane Central Register for randomized controlled trials (RCTs) that compared OAGB with RYGB as primary operations.</p><p><strong>Results: </strong>Twelve studies were included in this meta-analysis, with a total of 904 patients. Total weight loss percentage (TWL%) was statistically higher in the OAGB group at 6 months (95% CI 0.80 to 2.94; P = 0.006) with no differences in 12, 24, and 36 months compared to RYGB. On the other hand, OAGB exhibited a significantly higher excess weight loss percentage (EWL%) compared to RYGB at 12 months (95% CI 3.08 to 9.73; P = 0.0002). EWL% was comparable in both procedures at 6, 24, and 60 months of follow-up. There were no statistically significant differences in terms of the resolution of comorbidities related to obesity. De novo gastro-esophageal reflux disease (GERD) (RR 2.58; 95% CI 1.55 to 4.3; P = 0.0003) and marginal ulcers (RR 2.7; 95% CI 1.07 to 6.84; P = 0.04) were significantly higher in patients who underwent OAGB in comparison to RYGB.</p><p><strong>Conclusions: </strong>In conclusion, OAGB is comparable to RYGB in terms of weight loss parameters and comorbidity resolution. However, OAGB can lead to a higher risk of development of marginal ulcers and de novo GERD.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1438-1446"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Metabolic Bariatric Surgery on Intra-pancreatic Fat Deposition and Total Pancreas Volume: a Systematic Review and Meta-analysis.","authors":"Yaochen Wang, Yutong Liu, Maxim S Petrov","doi":"10.1007/s11695-025-07778-9","DOIUrl":"10.1007/s11695-025-07778-9","url":null,"abstract":"<p><p>Bariatric procedures are common interventions for weight loss and metabolic improvements; yet, their effects on the pancreas-a key metabolic organ-are largely unknown. This systematic review aimed to summarise data on changes in intra-pancreatic fat deposition (IPFD) and total pancreas volume (TPV) following metabolic bariatric surgery and endoscopic bariatric therapy. The literature search was conducted in MEDLINE and Embase databases. Studies in humans were included if they reported on changes in IPFD and/or TPV from before to after bariatric procedure. Random effects meta-analysis was conducted. Fourteen studies (all involving metabolic bariatric surgery) met the eligibility criteria. Metabolic bariatric surgery resulted in a mean absolute IPFD reduction of 3.9% (p = 0.003) and a mean TPV decrease of 10.7 cm³ (p < 0.001). The mean relative IPFD reduction after metabolic bariatric surgery was 35.9%. Sleeve gastrectomy led to a higher mean relative IPFD reduction than Roux-en-Y gastric bypass (39.9% vs. 20.6%), though this difference was not statistically significant. Analysis of follow-up duration showed a mean relative IPFD reduction of 8.8% in patients with follow-ups of less than 3 months. Metabolic bariatric surgery leads to significant reductions in IPFD and TPV. Follow-up should take place no earlier than 3 months for the full benefits of bariatric procedures on the pancreas to manifest.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"1513-1524"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}