Outcomes of Bariatric Surgery in Patients With Bipolar and Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.

IF 2.9 3区 医学 Q1 SURGERY
Obesity Surgery Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI:10.1007/s11695-025-07889-3
Túlio Pimentel, Maria Clara Florêncio, Ivo Queiroz, Mariano Gallo Ruelas, Roberta De Lorenzi Steiger Ferraz, Álvaro Antônio Bandeira Ferraz
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Abstract

Psychiatric disorders, particularly bipolar disorder (BD) and schizophrenia spectrum disorders (SCZ), are associated with high rates of obesity and metabolic diseases. This systematic review and meta-analysis evaluates the efficacy of bariatric surgery in BD/SCZ patients, aiming to inform clinical decisions and optimize treatment strategies for this population. MEDLINE, Embase, and Cochrane databases were searched up to September 2024. A restricted maximum likelihood random-effects model with mean differences (MD) for continuous outcomes and odds ratios (ORs) for binary outcomes, along with 95% confidence intervals (CI), was used. 13 studies involving 19,662 patients, of whom 1,117 (5.7%) were diagnosed with BD or SCZ, were included. The analysis revealed no significant differences in %TWL or BMI change at 6 months, 1 year, and 2 years. BD/SCZ patients showed a significantly smaller %EWL at 6 months; however, the differences at 1 and 2 years were no longer statistically significant. Similarly, no differences were found between BD/SCZ patients and controls regarding adherence to 6-month, 1-year, and 2-year follow-up, as well as 1-year remission rates of type 2 diabetes mellitus, hypertension, obstructive sleep apnea syndrome, dyslipidemia, or 30-day readmission and reoperation rates. Data from included studies also indicated no exacerbation of psychiatric disorders after surgery. This study suggests that bariatric surgery may be similarly effective in patients with BD and SCZ, offering potential benefits for a population burdened with both psychiatric and physical health challenges.

双相情感障碍和精神分裂症谱系障碍患者减肥手术的结果:系统回顾和荟萃分析。
精神疾病,特别是双相情感障碍(BD)和精神分裂症谱系障碍(SCZ),与肥胖和代谢疾病的高发率相关。本系统综述和荟萃分析评估了BD/SCZ患者减肥手术的疗效,旨在为该人群的临床决策提供信息并优化治疗策略。检索截止到2024年9月的MEDLINE、Embase和Cochrane数据库。使用限制最大似然随机效应模型,连续结果的平均差异(MD)和二元结果的优势比(ORs)以及95%置信区间(CI)。纳入13项研究,涉及19662例患者,其中1117例(5.7%)被诊断为BD或SCZ。分析显示,6个月、1年和2年的TWL百分比或BMI变化无显著差异。BD/SCZ患者在6个月时EWL的百分比明显较小;然而,1年和2年的差异不再具有统计学意义。同样,BD/SCZ患者与对照组在6个月、1年和2年随访依从性以及1年2型糖尿病、高血压、阻塞性睡眠呼吸暂停综合征、血脂异常或30天再入院和再手术率方面也没有差异。纳入研究的数据也表明手术后精神疾病没有恶化。这项研究表明,减肥手术可能对BD和SCZ患者同样有效,为精神和身体健康都有负担的人群提供潜在的益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Obesity Surgery
Obesity Surgery 医学-外科
CiteScore
5.80
自引率
24.10%
发文量
567
审稿时长
3-6 weeks
期刊介绍: Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.
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