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OECD Series on Testing and Assessment最新文献

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Fish Short-Term Reproduction Assay (FSTRA) (OECD TG 229) 鱼类短期繁殖试验(FSTRA) (OECD TG 229)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-6-en
Tg
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引用次数: 1
Daphnia magna Reproduction Test (OECD TG 211) 大水蚤繁殖试验(OECD TG 211)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-12-en
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引用次数: 2
OECD mammalian screens and tests (Conceptual Framework Levels 3-5) 经合组织哺乳动物筛选和试验(概念框架3-5级)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/g27e23fefd-en
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引用次数: 0
Subchronic Dermal Toxicity: 90-Day Study (OECD TG 411) 亚慢性皮肤毒性:90天研究(OECD TG 411)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-29-en
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引用次数: 3
Chironomid Toxicity Test Using Spiked Sediment (OECD TG 218) or Spiked Water (OECD TG 219) 使用加尖沉淀物(OECD TG 218)或加尖水(OECD TG 219)的螯合剂毒性试验
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-11-en
Tg
{"title":"Chironomid Toxicity Test Using Spiked Sediment (OECD TG 218) or Spiked Water (OECD TG 219)","authors":"Tg","doi":"10.1787/9789264304741-11-en","DOIUrl":"https://doi.org/10.1787/9789264304741-11-en","url":null,"abstract":"358. Modality detected/endpoints: This medium-term in vivo assay with the dipteran insect Chironomus spp. is responsive to juvenile hormone (JH) (ant)agonists and ecdysteroid (Ec) (ant)agonists which can interfere with such processes as metamorphosis, moulting and growth (e.g. Hahn, Liess and Schulz [2001]; Taenzler et al. [2007]; Jungmann et al. [2009]; Tassou and Schulz [2009, 2013]). It exposes the test organisms over a single generation. It is important to note, however, that none of the endpoints in this apical test are specifically responsive to JHor Ec-active chemicals, and the assay will give positive results with many other substances. The lack of internationally validated mechanistic assays for endocrine activity in insects may prevent firm conclusions about whether test chemicals are endocrine disrupters (EDs) in this taxon, although in vitro assays for JH and estrogen (E) activity are available in the literature. However, the data from the test may nevertheless be of value for classification and hazard identification/characterisation.","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84683083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
28-Day (Subacute) Inhalation Toxicity Study (OECD TG 412) 28天(亚急性)吸入毒性研究(OECD TG 412)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-30-en
Tg
{"title":"28-Day (Subacute) Inhalation Toxicity Study (OECD TG 412)","authors":"Tg","doi":"10.1787/9789264304741-30-en","DOIUrl":"https://doi.org/10.1787/9789264304741-30-en","url":null,"abstract":"882. This assay determines the subchronic inhalation toxicity of chemicals to provide data for quantitative inhalational hazard identification/characterisation. It is primarily used to derive regulatory concentrations for assessing worker risk in occupational settings. It may also be used to assess human residential, transportation and environmental risk. Dosing duration is 28 days and the preferred species is the rat. Animals are exposed to test substance in inhalation chambers for six hours per day on a five day per week basis. The preferred mode of exposure is nose only, but whole body exposure may also be used. OECD TG 412 was first adopted in 1981, revised in 2009 and 2017. Although it has not been validated for the detection of endocrine active substances (EASs), this assay contains several endpoints that are suitable for the determination of endocrine effects. As all the endpoints are apical, it is difficult to discern mechanism of action from this test alone. Information on mechanism of action may need to be obtained from in vitro estrogen/androgen/thyroid/steroidogenesis (E,A,T,S) assays or in vivo lower tier tests such as the Uterotrophic Bioassay (UT – OECD TG 440) and the Hershberger Bioassay (H – OECD TG 441). Hormone measurements are not included in this assay.","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73016819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Potamopyrgus antipodarum Reproduction Test (OECD TG 242) 黄颡鱼生殖试验(OECD TG 242)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-9-en
{"title":"Potamopyrgus antipodarum Reproduction Test (OECD TG 242)","authors":"","doi":"10.1787/9789264304741-9-en","DOIUrl":"https://doi.org/10.1787/9789264304741-9-en","url":null,"abstract":"","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77619535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
OECD non-mammalian screens and tests (Conceptual Framework Levels 3-5) 经合组织非哺乳动物筛选和试验(概念框架3-5级)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/g27e1ac658-en
{"title":"OECD non-mammalian screens and tests (Conceptual Framework Levels 3-5)","authors":"","doi":"10.1787/g27e1ac658-en","DOIUrl":"https://doi.org/10.1787/g27e1ac658-en","url":null,"abstract":"","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77798121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-OECD in vitro screens (Conceptual Framework Level 2) 非经合组织体外筛选(概念框架2级)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-5-en
{"title":"Non-OECD in vitro screens (Conceptual Framework Level 2)","authors":"","doi":"10.1787/9789264304741-5-en","DOIUrl":"https://doi.org/10.1787/9789264304741-5-en","url":null,"abstract":"","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79447200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproduction/Developmental Toxicity Screening Test (OECD TG 421) and Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD TG 422) 生殖/发育毒性筛选试验(OECD TG 421)和结合重复剂量毒性研究与生殖/发育毒性筛选试验(OECD TG 422)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-25-en
Tg
{"title":"Reproduction/Developmental Toxicity Screening Test (OECD TG 421) and Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD TG 422)","authors":"Tg","doi":"10.1787/9789264304741-25-en","DOIUrl":"https://doi.org/10.1787/9789264304741-25-en","url":null,"abstract":"Weights of: (parents only) testes, epididymides, prostate and seminal vesicles with coagulating glands (OECD TG 421 and TG 422), plus adrenals (OECD TG 422 only). Optional organ weights could include levator ani plus bulbocavernosus muscle complex, Cowper’s glands and glans penis in males, and paired ovaries and uterus (including cervix). Thyroid gland weight could be measured (after fixation) in all adults and PND 13 pups (OECD TG 421 and TG 422).","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"21 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83491212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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