Reproduction/Developmental Toxicity Screening Test (OECD TG 421) and Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD TG 422)

Abstract

Weights of: (parents only) testes, epididymides, prostate and seminal vesicles with coagulating glands (OECD TG 421 and TG 422), plus adrenals (OECD TG 422 only). Optional organ weights could include levator ani plus bulbocavernosus muscle complex, Cowper’s glands and glans penis in males, and paired ovaries and uterus (including cervix). Thyroid gland weight could be measured (after fixation) in all adults and PND 13 pups (OECD TG 421 and TG 422).