Journal of Pharmacy & Bioresources最新文献_第3页

Comparative efficacy and safety investigation of eight antidiabetic herbal products distributed within South- Western Nigeria 尼日利亚西南部分布的8种抗糖尿病草药产品的疗效和安全性比较研究

Journal of Pharmacy & Bioresources Pub Date : 2023-02-19 DOI: 10.4314/jpb.v20i1.1

O. M. Adegbolagun, Olaoluwa Daniel Ibukun, Y. Ogunremi

{"title":"Comparative efficacy and safety investigation of eight antidiabetic herbal products distributed within South- Western Nigeria","authors":"O. M. Adegbolagun, Olaoluwa Daniel Ibukun, Y. Ogunremi","doi":"10.4314/jpb.v20i1.1","DOIUrl":"https://doi.org/10.4314/jpb.v20i1.1","url":null,"abstract":"Herbal preparations, often promoted as being natural and completely safe, are gaining popularity in the management of diabetes mellitus, despite lack of scientific data to confirm their efficacy and safety claims. This study investigated efficacy and safety of eight commercial antidiabetic herbal products. Antidiabetic activities were investigated in streptozotocin-induced diabetic rats at doses based on their labelled recommended dosages using metformin as reference drug. Body weights, blood glucose level (BGL), haematogical and biochemical parameters as well as histopathology of the kidney and lungs were assessed by standard procedures. All the samples demonstrated weight reduction (p<0.05), with accompanying BGL decrease ranging from 21.9 ±1.71 to 73.9 ±1.42% which was significant (p < 0.01) in three samples, when compared with metformin (37.9 ±7.41%). Of all the hematological indices, only WBC, platelet and eosinophil were affected by two of the samples, while for the biochemical parameters only alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels were increased (p<0.05) by one of the samples. Varied histopathological damages were observed with the liver, lungs and kidney tissues of treated groups. Hypoglycaemic activities were confirmed in all the samples, however, their deleterious effects on the liver, kidney and lungs calls for caution in their consumption.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134362924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated community case management of childhood illnesses; impact on training of community health workers in Vandeikya, North-East Zone of Benue State, Nigeria 儿童疾病的综合社区个案管理;对尼日利亚贝努埃州东北部地区Vandeikya社区卫生工作者培训的影响

Journal of Pharmacy & Bioresources Pub Date : 2023-02-19 DOI: 10.4314/jpb.v20i1.5

Uya John Abua, T. Igbudu, L. Egwuda, David Awua, Pius Enokela

{"title":"Integrated community case management of childhood illnesses; impact on training of community health workers in Vandeikya, North-East Zone of Benue State, Nigeria","authors":"Uya John Abua, T. Igbudu, L. Egwuda, David Awua, Pius Enokela","doi":"10.4314/jpb.v20i1.5","DOIUrl":"https://doi.org/10.4314/jpb.v20i1.5","url":null,"abstract":"Community health workers appropriately trained on Integrated Community Case Management (ICCM) of childhood illnesses can correctly treat children below 5 years who have pneumonia, diarrhoea and malaria. In Benue State, Nigeria, primary healthcare workers care for most children at community level, as such they need to be trained on ICCM. The objective of this study was to find out if training of primary healthcare workers in Vandeikya, North-East Zone of Benue State can improve their knowledge on ICCM. In Benue North-East, Vandeikya Local Government Area (LGA) was randomly selected out of seven LGAs. Health Officers’ in-charge of 30 Primary HealthCare Clinics were selected and trained based on our adapted ICCM training manual. The Pre- and Post-training assessment test for this study was designed based on the training manual. Paired sample t-test was conducted to find out if there was any significant difference in the knowledge of primary health care workers before and after receiving training. There was statistical difference in pre-training scores (X = 142.100, S1 = 25.925) and post-training scores (X =177.600, S2 =13.587) at (t=6.643, P=0.000). This result strongly indicated that the teaching intervention has improved the knowledge of the Primary Health Care workers on ICCM in Vandeikya LGA. ","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129510439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular docking and ADMET studies of the interaction of 4-carboxyl-2,6-dinitrophenylazohydroxynaphthalenes with bovine serum albumin 4-羧基-2,6-二硝基苯基偶羟基萘与牛血清白蛋白相互作用的分子对接和ADMET研究

Journal of Pharmacy & Bioresources Pub Date : 2023-02-19 DOI: 10.4314/jpb.v20i1.3

O. E. Thomas

{"title":"Molecular docking and ADMET studies of the interaction of 4-carboxyl-2,6-dinitrophenylazohydroxynaphthalenes with bovine serum albumin","authors":"O. E. Thomas","doi":"10.4314/jpb.v20i1.3","DOIUrl":"https://doi.org/10.4314/jpb.v20i1.3","url":null,"abstract":"Previous spectrophotometric investigations revealed strong binding affinities between four potential monoazo colourants (code-named AZ-01 to 04) and bovine serum albumin (BSA) which could dictate the tissue distribution and toxicity of the additives. The molecular docking interactions of the dyes with BSA were analyzed using AutoDock vina and PatchDock in order to elucidate the functional groups involved in complex stabilization. Docking conformations confirmed the ligands preferentially inserted into the hydrophobic cavities of BSA site I. Structure-BSA binding relationships revealed the binding of AZ-02 was driven by hydrogen bond donation from its free phydroxynaphthalene substituent to Ser-479 while the predominantly hydrazone form of its positional isomer, AZ-01, increased its lipophilicity and tendency for hydrophobic interactions. The relatively higher C/H ratio of AZ-03 and - 04, which contain additional C-7 substituents, was responsible for their stronger binding and the extensive involvement of their aromatic rings in ligand-site I complex stabilization via Pi-Pi T-shaped, Pi-alkyl and alkyl-alkyl interactions. Moreso, AZ-01, -03 and -04 exist predominantly as hydrazone tautomers with an overall positive charge which provided complementary modes for interaction with negatively charged aspartic and glutamic acids. The structure-BSA binding relationships of the molecules, which can be employed in synthesis of safer congeners, have been elucidated. ","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131775200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteriological evaluation of instant noodles stored under sub-optimal conditions from selected markets in Sagamu- Ibafo axis of Ogun State, Nigeria 尼日利亚奥贡州Sagamu- Ibafo轴选定市场在次优条件下储存的方便面的细菌学评价

Journal of Pharmacy & Bioresources Pub Date : 2022-12-22 DOI: 10.4314/jpb.v19i3.1

O. Okunye, P. A. Idowu, B. Okanlawon, T. Lawal, O. Adejumo, O. Adeyemo, O. Oyinloye, W. Ojieabu

{"title":"Bacteriological evaluation of instant noodles stored under sub-optimal conditions from selected markets in Sagamu- Ibafo axis of Ogun State, Nigeria","authors":"O. Okunye, P. A. Idowu, B. Okanlawon, T. Lawal, O. Adejumo, O. Adeyemo, O. Oyinloye, W. Ojieabu","doi":"10.4314/jpb.v19i3.1","DOIUrl":"https://doi.org/10.4314/jpb.v19i3.1","url":null,"abstract":"This study evaluated 8 brands of 5 packets each of instant noodles for bacterial load, clinical status, and resistance of the isolates to conventional antibiotics, in addition to pH. These brands were cultured on plate count agar for bacterial enumeration while isolates were challenged on selective media for bacteria of clinical status. The antibiogram was determined using standard methods. The pH varied from acidic (4.92) as shown in GPJ 3 to closely neutral (6.94) as recorded in HWJ 2. TTJ1 had the lowest average bacteria count of 1.6 x 103 while BFJ5 with 6.3 x 105 counts was the highest. Prevalence of isolates of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa varied in the ratio 40:30:30. Of the 40 samples, 8 of the 16 Escherichia coli were resistant to gentamicin, ciprofloxacin, and Augmentin, 7 of the 12 Staphylococcus aureus elicited resistance to ampicillin and cotrimoxazole while 8 of the Pseudomonas aeruginosa were resistant to meropenem, cotrimoxazole, Augmentin, and cephalexin. Presence of bacteria of clinical status, in counts that exceeded recommended safe limits for ready-to-eat noodles and higher numbers of resistant isolates to the antibiotics appropriated, could be attributed to product storage under sub-optimal conditions which portend a public health risk.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123566303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical screening, acute toxicity and anti-ulcer activity of the stem bark of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) Anogeissus leiocarpus (DC.)茎皮的植物化学筛选、急性毒性及抗溃疡活性Guill。&穗青葱。(使君子科)

Journal of Pharmacy & Bioresources Pub Date : 2022-12-22 DOI: 10.4314/jpb.v19i3.5

T. Datok, D. G. Dafam, Abubakar Ahmed, L. Ior

{"title":"Phytochemical screening, acute toxicity and anti-ulcer activity of the stem bark of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae)","authors":"T. Datok, D. G. Dafam, Abubakar Ahmed, L. Ior","doi":"10.4314/jpb.v19i3.5","DOIUrl":"https://doi.org/10.4314/jpb.v19i3.5","url":null,"abstract":"Peptic ulcer disease constitutes a major health challenge resulting in morbidity and in some cases, mortality. This study evaluated the phytochemistry, acute toxicity, and anti-ulcer activity of the methanol extracts of the stem bark of Anogeissus leiocarpus (DC.) Guill. & Perr. Flavonoids, tannins and saponins are some phytochemicals found in the extracts. From the results, the LD50 of the aqueous and methanol extract was >5000 mg/kg and 3807 mg/kg. The mean ulcer indices for the aqueous extract was 0.38 ± 0.07, 0.38 ± 0.10 and 0.36 ± 0.07 respectively for the 100, 200 and 400 mg/kg), while those of the methanol extract were 0.32 ± 0.09, 0.10 ± 0.03 and 0.12 ± 0.10 respectively for 100, 200 and 400 mg/kg). These values were not significant at P>0.05 when compared with control. However, the percentage ulcer inhibition for methanol extract in group treated with 200 and 400 mg/kg, were both significantly (p<0.05) higher compared with 58.8% from omeprazole (20 mg/kg) treated group. These findings showed that the methanol extract at 200 mg/kg and 400 mg/kg. significantly (p<0.05) increased the anti-ulcer activity, suggesting that A. leiocarpus possesses anti-ulcer property which could be useful in the treatment of peptic ulcer disease.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125065487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality evaluation of Oral Rehydration Salt (ORS) products marketed in Abuja, Nigeria 尼日利亚阿布贾市售口服补液盐(ORS)产品的质量评价

Journal of Pharmacy & Bioresources Pub Date : 2022-12-22 DOI: 10.4314/jpb.v19i3.4

N. Ibekwe, O. Obodozie-Ofoegbu, O. Adigwe

{"title":"Quality evaluation of Oral Rehydration Salt (ORS) products marketed in Abuja, Nigeria","authors":"N. Ibekwe, O. Obodozie-Ofoegbu, O. Adigwe","doi":"10.4314/jpb.v19i3.4","DOIUrl":"https://doi.org/10.4314/jpb.v19i3.4","url":null,"abstract":"Medicine security remains one of the public health challenges in Sub-Saharan Africa as the report by World Health Organization (WHO) shows that 10.5% of medicines in low and middle-income countries worldwide are falsified or substandard. The study aimed to evaluate the quality of Oral Rehydration Salt (ORS) products sold in pharmacy outlets in Abuja, Nigeria. Seventeen different commercial brands of WHO recommended low-osmolarity ORS finished pharmaceutical products (FPP) were randomly selected from pharmacy outlets in the Federal Capital Territory (FCT) and Gwagwalada Area Council in Abuja. They were assessed for quality based on physicochemical properties and the content of active pharmaceutical ingredients in accordance with the International Pharmacopeia (IP) guidelines. The shelf lives of all the samples were valid, and they all met the visual inspection test, labelling, pH (7.4‒8.0 between23.3‒23.9°C) and moisture content (1‒9 mg/g) requirements. The content assay revealed 88.2%, 88.2%, 64.7%, 47.1%, and 35.3% compliance of the samples for glucose, chloride, citrate, sodium and potassium, respectively. Twelve (76.5%) of the brands failed at least one content assay and 8 (47%) had zero potassium content. The study underscores the need for regular, periodic post-market surveillance on essential medicines sold in the Nigerian market.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114298767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of cytotoxic effect of Tetrapleura tetraptera (Mimosaceae) pod, root and stem bark extracts on AU565 breast cancer cells 四胸草豆荚、根、茎皮提取物对AU565乳腺癌细胞的细胞毒作用研究

Journal of Pharmacy & Bioresources Pub Date : 2022-12-22 DOI: 10.4314/jpb.v19i3.2

R. Imade, B. Ayinde, Anam Alam

{"title":"Evaluation of cytotoxic effect of Tetrapleura tetraptera (Mimosaceae) pod, root and stem bark extracts on AU565 breast cancer cells","authors":"R. Imade, B. Ayinde, Anam Alam","doi":"10.4314/jpb.v19i3.2","DOIUrl":"https://doi.org/10.4314/jpb.v19i3.2","url":null,"abstract":"Tetrapleura tetraptera is a medicinal plant used to treat a variety of diseases, including tumor-related ailments in ethnomedical practice. This study was undertaken to assess its pod, root, and stem bark extracts for cytotoxicity against AU 565 human breast cancer cell line. The plant parts were extracted with methanol and organic solvent partitioning carried out on the pod extract using hexane and chloroform. Preliminary screening was conducted on the extracts and fractions with brine shrimp of Artemia salina nauplii (10-1000 g/mL) and growth inhibition test with Sorghum bicolor seed radicles (5 mg/mL). Antiproliferation effect on AU565 was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay at 50 μg/mL. The extracts showed moderate cytotoxic activity with A. salina nauplii. T. tetraptera root extract produced the highest antiproliferative activity, with +99.79 % inhibition on AU 565 cell line. No cytotoxic action was observed with the pod extract on the cell line but its chloroform fraction had high growth inhibitory action on S. bicolor radicles and high cytotoxic effect on the cancer cell line, with 81.98 and 82.27% inhibitions realized respectively. The root bark extract and chloroform fraction of the pod extract demonstrated potent cytotoxic activity on the cell line and seem to justify the use of the plant in preparation of recipes for tumor-related ailments.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115054215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiproliferative, antioxidant and antiplasmodial activities of the root bark of Adenodolichos paniculatus (Hua) Hutch (Fabaceae) Fabaceae(豆科)Adenodolichos paniculatus (Hua) Hutch根皮的抗增殖、抗氧化和抗疟原虫活性

Journal of Pharmacy & Bioresources Pub Date : 2022-12-22 DOI: 10.4314/jpb.v19i3.6

O. S. Ojerinde, Yongle Du, David J. I. Kingston, A. Valenciano, M. Cassera, A. Sagay, T. Alemika

{"title":"Antiproliferative, antioxidant and antiplasmodial activities of the root bark of Adenodolichos paniculatus (Hua) Hutch (Fabaceae)","authors":"O. S. Ojerinde, Yongle Du, David J. I. Kingston, A. Valenciano, M. Cassera, A. Sagay, T. Alemika","doi":"10.4314/jpb.v19i3.6","DOIUrl":"https://doi.org/10.4314/jpb.v19i3.6","url":null,"abstract":"Adenodolichos paniculatus Hua & Hutch (Fabaceae) is a plant whose roots are traditionally employed for the treatment of non-communicable diseases such as diabetes and cancer. The powdered root bark of Adenodolichos paniculatus were extracted with dichloromethane followed by 70% methanol to afford dichloromethane (DCM) and hydromethanolic (HME) extracts respectively. Thereafter, fresh powdered root was extracted with water via decoction method and lyophilized to afford aqueous extract (AQE). The extracts were then subjected to standard phytochemical studies, antiproliferative (A2780 ovarian cancer cell assay), antiplasmodial (Dd2 strain of Plasmodium falciparum), antioxidant (DPPH, FRAP and ABTS methods) and brine shrimp lethality assay studies. The DCM extract was found to possess high levels of total phenolics and flavonoids with notable potential antiproliferative (IC50 = 0.14 μg/ml), antiplasmodial (IC50 = 7.50 μg/ml) and cytotoxic (brine shrimp, IC50 = 0.547 μg/ml) activities. However, HME had significant antioxidant (DPPH, IC50 = 17.54 ± 0.03 μg/ml; ABTS, IC50 = 8.08 ± 0.05 μg/ml). Both HME and AQE were found to be inactive against the drug-resistant Dd2 strain of Plasmodium falciparum with an IC50 value ˃100μg/mL. The study revealed the potential of Adenodolichos paniculatus as a promising antiproliferative agent and also corroborated the ethnomedical uses of the plant.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129575787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC-MS analysis and invitro cytotoxic activity of Ocimum basilicum (Lamiaceae) volatile oil and active fraction composed majorly of estragole 气相色谱-质谱分析及罗勒挥发油和主要由雌二醇组成的活性部位体外细胞毒活性

Journal of Pharmacy & Bioresources Pub Date : 2022-12-22 DOI: 10.4314/jpb.v19i3.3

R. Imade, B. Ayinde

{"title":"GC-MS analysis and invitro cytotoxic activity of Ocimum basilicum (Lamiaceae) volatile oil and active fraction composed majorly of estragole","authors":"R. Imade, B. Ayinde","doi":"10.4314/jpb.v19i3.3","DOIUrl":"https://doi.org/10.4314/jpb.v19i3.3","url":null,"abstract":"Ocimum basilicum leaves contain some bioactive compounds and this study was designed to evaluate the cytotoxic efficacy of its volatile oil and fractions. Preliminary screening of the oil obtained by hydrodistillation was carried out using bench-top assay methods employing tadpoles of Raniceps ranninus (10-40 μg/mL), nauplii of Artemia salina (10-1000 μg/mL) and radicles of Sorghum bicolor seeds (1-30 mg/mL). Application of column chromatography and preparative TLC on the oil resulted in fractions that were tested alongside the oil on breast (AU 565) and cervical (HeLa) cancer cell lines at 50 μg/mL. GCMS analysis was carried out on the oil and the most active fraction. A concentration dependent activity was observed in the preliminary screening with the bench-top assays. The active fraction produced greater growth inhibition of the radicle of S. bicolor seeds than the oil. Inhibitions of -1.02 and +23.02 % were realized against AU 565 and HeLa cell lines respectively with the oil, and these were increased to +33.19 and +89.3 % inhibitions respectively with the active fraction. GCMS results revealed the presence of estragole (88.61 %) as being most abundant in the fraction. This result shows the cytotoxic potential of O. basilicum volatile oil, which was increased in its estragole-containing fraction.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114545764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioacaricidal effects of three volatile oils on cattle ticks 三种挥发油对牛蜱的生物杀螨效果

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.2

B. Ayinde, I. Okeke, J. Ofeimun, R. Imade, Oluwaseun Onakomaya, M. Bamikole

{"title":"Bioacaricidal effects of three volatile oils on cattle ticks","authors":"B. Ayinde, I. Okeke, J. Ofeimun, R. Imade, Oluwaseun Onakomaya, M. Bamikole","doi":"10.4314/jpb.v19i2.2","DOIUrl":"https://doi.org/10.4314/jpb.v19i2.2","url":null,"abstract":"Use of synthetic chemicals in addressing livestock attacks by ticks has negative effects on animals, handlers and the environment. These problems necessitate search for potent alternatives in bioacaricides particularly volatile oils. Acaricidal effects of hydro-distilled volatile oils from the fresh leaves of Eucalyptus citriodora, Ocimum gratissimum (OG) and Callistemon citrinus were evaluated on ticks obtained from infested cattle using topical method at varying concentrations in acetone. For each concentration, ten ticks of similar species were placed in Petri dishes and administered 20μL of the mixture of volatile oil and acetone. Acetone (20μL) was used as control and the effects were observed for 24 h. Out of three tick species identified, Rhipicephalus microplus was most abundant and most sensitive to the oils. Others are Amblyomma hebraeum and Hyalomma rufipes (most resistant). The volatile oil of OG was the most potent with LC50 of < 2 % (< 0.4 μL), < 2 % and 7.97% (1.59 μL) on the organisms respectively. The 5% of OG produced 100% mortality on R. microplus in 10-25 min while 20% concentration produced 100% mortality on H. rufipes in 24 h. Volatile oils of these plants particularly OG can serve as potent alternative bio-acaricidal agents to chemicals.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121587527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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Journal of Pharmacy & Bioresources最新文献