Journal of Pharmacy & Bioresources最新文献_第4页

Isolation of pentacyclic triterpene, phenolic content and antioxidant activity of root bark of Irvingia gabonesis Baill. (Irvingiaceae) 加蓬根皮五环三萜、酚类含量及抗氧化活性的分离。(Irvingiaceae)

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.8

A. Nuhu, E. M. Abdurahman, U. Danmalam, M. U. Kawu, S. Adebayo, M. Bashir

{"title":"Isolation of pentacyclic triterpene, phenolic content and antioxidant activity of root bark of Irvingia gabonesis Baill. (Irvingiaceae)","authors":"A. Nuhu, E. M. Abdurahman, U. Danmalam, M. U. Kawu, S. Adebayo, M. Bashir","doi":"10.4314/jpb.v19i2.8","DOIUrl":"https://doi.org/10.4314/jpb.v19i2.8","url":null,"abstract":"The aim of this study was to investigate the phytochemical constituents and antioxidant potentials of the ethanol extract and fractions of Irvingia gabonensis root bark in order to establish the scientific basis and rationale for its folkloric use. The powdered root bark of I. gabonensis was macerated with 70% ethanol and then partitioned with different solvents based on their polarity to afford 4 fractions. The extract and fractions were subjected to phytochemical analysis. The in vitro antioxidant activity was evaluated using DPPH assay. The quantitative phytochemical determination showed that ethyl acetate fraction of I. gabonensis root bark (EFIGR) had the highest content of tannins (154.44 mg/GAE g), phenol (106.26 mg/GAE g and flavonoid (76.07 mg/QE g). The in vitro antioxidant activity of the extract and the fractions had IC50 values of 76.0±0.03, 27.0± 0.05, 39.0±0.07 and 28.0±0.10 μg/mL for Ethanol extract, EFIGR, Butanol fraction and Aqueous fraction respectively while the standard had 29.0±0.03 μg/mL.Further fractionation of EFIGR led to the isolation of hederagenin which was characterized using 1D-NMR and mass spectrometric data. The present study revealed that root bark of I. gabonensis is a potential sourceof natural antioxidant which justified its uses in the traditional medicine.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131784016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a colorimetric method for determination of tadalafil using ion-pair complexation with bromophenol blue 溴酚蓝离子对络合法测定他达拉非的比色方法的建立与验证

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.6

U. Ajima, Olaitan James Idowu, O. C. Poyi, J. Onah

引用次数: 0

Effect of educational intervention on knowledge about hypertension and factors predicting adherence to drug therapy 教育干预对高血压知识及药物依从性预测因素的影响

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.4

U. Ibrahim, S. Mohammed, A. Zezi

{"title":"Effect of educational intervention on knowledge about hypertension and factors predicting adherence to drug therapy","authors":"U. Ibrahim, S. Mohammed, A. Zezi","doi":"10.4314/jpb.v19i2.4","DOIUrl":"https://doi.org/10.4314/jpb.v19i2.4","url":null,"abstract":"The present study was aimed at identifying the degree of knowledge of people with hypertension about the disease, identifying the factors predicting adherence to therapy and administering intervention. It was a quasi-experimental study involving 600 patients selected by multistage sampling technique. Adherence status was assessed using Morisky medication adherence scale8. Knowledge was measured using an eight-item instrument. Educational intervention in form of group discussions was administered. Values of p ≤ 0.05 were considered statistically significant. BP control was significantly higher in those that adhered to antihypertensive medication compared with non-adhering patients (χ2 = 14.526; df = 1; p-value = < 0.001). Comorbidity and number of antihypertensive drugs the patients were taking were found to be the predictors of adherence. After intervention, the percentage of respondents with good adherence increased from 41.3% to 48.3% (p = 0.369) in the intervention group. Furthermore educational intervention had a positive effect on knowledge of the respondents [from 64% to 66.3% (p= 0.623)] in the intervention group. The results revealed that the educational intervention had positive impact of knowledge of hypertension and its treatment. Additionally, Comorbidity and number of antihypertensive prescribed were found to be the predictors of adherence to medications. ","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125480725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmacognostic and physicochemical analysis of the leaves of Fadogia andersonii Robyns (Rubiaceae) 枇杷叶的生药学和理化分析

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.3

K. I. Imam, Abubakar Ahmed, A. A. Ambi

{"title":"Pharmacognostic and physicochemical analysis of the leaves of Fadogia andersonii Robyns (Rubiaceae)","authors":"K. I. Imam, Abubakar Ahmed, A. A. Ambi","doi":"10.4314/jpb.v19i2.3","DOIUrl":"https://doi.org/10.4314/jpb.v19i2.3","url":null,"abstract":"Fadogia andersonii has long been used in Africa in treatment of diseases including inflammation, arthritis, malaria and as aphrodisiac. The use and demand of this medicinal plants has been growing over long period of time. This study was carried out to determine some important pharmacognostic parameters of F. andersonii leaf. Evaluation of the fresh, powdered leaves was carried out to determine the macro-morphological, qualitative and quantitative microscopic, chemomicroscopic features, physicochemical properties and elemental analysis of the leaves. The leaves are pinnate opposite arranged, oblique lamina, glabrous appearance, elliptical in shape, entire margin with reticulate venation. The microscopy revealed straight polygonal wall of epidermal cells, paracytic stomata, unicellular trichomes, xylem, phloem, prismatic & druse crystals, and starch grains. Chemomicroscopy revealed presence of cellulose, cutin, lignin, tannins, starch, calcium oxalate crystals and gum & mucilage. The physicochemical parameters for the leaves estimated include moisture contents (13.11%), total ash value (5.67%), water soluble ash (1.33%), acid insoluble ash (2.00%), water extractive values (13.33%) and alcohol extractive values (10.67%). Elemental analysis revealed the presence of iron, copper, manganese, zinc, nickel, and lead. The pharmacognostic standard observed in this study will be of help in correct identification and quality control of F. andersonii.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127359153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cynodon dactylon L. extract as an eco-friendly corrosion inhibitor of mild steel in saline solution 水蟹提取物在盐水溶液中对低碳钢的环保型缓蚀剂

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.1

Einas Ben Sultan, K. Areef, Manar Abazeid, E. Khalil, Mohammed H. Mahklouf, M. Shushni

引用次数: 0

Anti-cataleptic, skeletal muscle relaxant and cognitive properties of the ethanol extract of Lophira alata Banks ex C.F. Gaertn. (Ochnaceae) stem bark in mice 龙葵乙醇提取物的抗炎、骨骼肌松弛和认知特性。(桔梗科)小鼠茎皮

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.7

L. Iniaghe, E. Okpakpor, Ifunanya Lydia Okonna, Osatohamhen Favour Ikhile, Joy Ozioma Ogbuehi, Joshua Iluobe Idemudia, Smart Chukwudi Kaluaso

{"title":"Anti-cataleptic, skeletal muscle relaxant and cognitive properties of the ethanol extract of Lophira alata Banks ex C.F. Gaertn. (Ochnaceae) stem bark in mice","authors":"L. Iniaghe, E. Okpakpor, Ifunanya Lydia Okonna, Osatohamhen Favour Ikhile, Joy Ozioma Ogbuehi, Joshua Iluobe Idemudia, Smart Chukwudi Kaluaso","doi":"10.4314/jpb.v19i2.7","DOIUrl":"https://doi.org/10.4314/jpb.v19i2.7","url":null,"abstract":"Lophira alata is a perennial tree which grows in many parts of sub-Saharan and East Africa and is used in Ethnomedicine for a wide range of disorders including insomnia, algesia, psychosis and memory enhancement. Phytochemical screening was carried out and acute toxicity of ethanol stem bark extract of L. alata was determined. The central nervous system modulating activities of Lophira alata stem bark extract (200, 400 and 800 mg/kg, per oral) were evaluated via haloperidol and morphine induced catalepsy, rotarod performance test, diazepam induced sleep, the novel object recognition and Y-maze tests. Phytochemical screening revealed the presence of phytochemicals such as alkaloids, flavonoids, saponins and tannins; the LD50 of L. alata was estimated to be greater than 5000 mg/kg. L. alata significantly (p<0.05) attenuated catalepsy in a non-dose dependent manner, decreased latency time on the rotarod (all dose levels), did not reduce onset of sleeping time nor increase duration of sleep. L. alata also significantly (p<0.05) increased time spent with the novel object (200, 400 and 800 mg/kg) and increased percentage spontaneous alternation in the Y-maze test (800 mg/kg). L. alata possess CNS activity which may account for its use in ethnomedicine for management of psychosis and cognitive enhancement.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124811351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative prescription patterns of antipsychotics among schizophrenic patients attending two public health facilities in North-Eastern and North-Central Nigeria: a crosssectional study 在尼日利亚东北部和中北部两家公共卫生机构就诊的精神分裂症患者的抗精神病药物处方模式比较:一项横断面研究

Journal of Pharmacy & Bioresources Pub Date : 2022-06-07 DOI: 10.4314/jpb.v19i2.5

S. Bello, W. Ojieabu, F. O. Aliyu, Ibrahim Lafegana

{"title":"Comparative prescription patterns of antipsychotics among schizophrenic patients attending two public health facilities in North-Eastern and North-Central Nigeria: a crosssectional study","authors":"S. Bello, W. Ojieabu, F. O. Aliyu, Ibrahim Lafegana","doi":"10.4314/jpb.v19i2.5","DOIUrl":"https://doi.org/10.4314/jpb.v19i2.5","url":null,"abstract":"In the care of patients, assessment of the use of drugs is very imperative as it shows the quality of care delivered to patients by the caregivers. The study aimed to compare the prescription patterns of antipsychotics in two public healthcare facilities in Nigeria using a standardized World Health Organization instrument. The studies were conducted at the General Hospital, Offa (GHO), Kwara State, and the Federal Neuropsychiatric Hospital, Maiduguri (FNPHMM), Borno State. Ethical approvals were obtained from the studied facilities. A total of 625 prescriptions in each of the facilities were selected by random sampling. Frequency distributions and student t-test were used. The average number of drugs prescribed per encounter was 3.9 in the GHO, while 1.2 was recorded in the FNPHMM. Injections were prescribed in 14.4% and 18.7% of encounters in the GHO and the FNPHMM, respectively. One hundred percent (100.0%) of the drugs were prescribed by generic name in the GHO and 98.2% in the FNPHMM. The percentage of drugs from the National Essential Drug List was 72% in the FNPHMM and 100% in the GHO. The prescribing indicators assessed were found to be below standard in the FNPHMM while the GHO showed polytherapy.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133566033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a reverse phase High Performance Liquid Chromatographic method, using standard addition calibration, for determination of risperidone in human plasma 建立和验证反相高效液相色谱法，使用标准添加校准，用于测定人血浆中的利培酮

Journal of Pharmacy & Bioresources Pub Date : 2022-05-11 DOI: 10.4314/jpb.v19i1.2

R. Oloyede, Awwalu Salisu, I. Nasir, A. Musa

{"title":"Development and validation of a reverse phase High Performance Liquid Chromatographic method, using standard addition calibration, for determination of risperidone in human plasma","authors":"R. Oloyede, Awwalu Salisu, I. Nasir, A. Musa","doi":"10.4314/jpb.v19i1.2","DOIUrl":"https://doi.org/10.4314/jpb.v19i1.2","url":null,"abstract":"Risperidone is a drug of choice in the management of psychosis and high performance liquid chromatography (HPLC) is regarded as the most sensitive and accurate method for quantitative analysis of risperidone, as well as other drugs having low plasma concentrations in biological fluids. A simple and accurate HPLC method was developed for the determination of risperidone in human plasma using the standard addition calibration technique to augment the weak signals due to low plasma concentrations of risperidone. Risperidone was eluted using isocratic mode with a mobile phase of methanol: acetonitrile (60:40) on a Chemisil ODS C18 column (250 mm×4.6 mm i.d., 5 μ particle size). The sample injection volume, flow rate, column temperature and wavelength of detection were set at 10 µl, 1.0 ml/min, 35 ˚C and 280 nm respectively. The run time for the method was 7 minutes, with risperidone having a retention time of 3.566 minutes. The method was linear within the concentration 10-50 ng/ml (R2= 0.998), with LOD and LOQ of 0.13 and 0.40 ng/ml respectively. The precision and relative error was 3.44 % and 3.38 % respectively. The developed method can be employed in the quantitative determination of risperidone in pharmacokinetic and bioequivalence studies.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114205436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary knowledge, attitudes and practices: a cross-sectional survey of type 2 diabetic patients in two tertiary hospitals in Jos, Nigeria 饮食知识、态度和做法:尼日利亚乔斯两所三级医院2型糖尿病患者的横断面调查

Journal of Pharmacy & Bioresources Pub Date : 2022-05-11 DOI: 10.4314/jpb.v19i1.1

R. C. Okunlola, Samuel J. Abu, B. Joseph, P. A. Damun, Temitope Selowo, M. Dapar

{"title":"Dietary knowledge, attitudes and practices: a cross-sectional survey of type 2 diabetic patients in two tertiary hospitals in Jos, Nigeria","authors":"R. C. Okunlola, Samuel J. Abu, B. Joseph, P. A. Damun, Temitope Selowo, M. Dapar","doi":"10.4314/jpb.v19i1.1","DOIUrl":"https://doi.org/10.4314/jpb.v19i1.1","url":null,"abstract":"Diet is a crucial aspect of diabetes management and healthy eating is one of the main focus in preventing type 2 diabetes mellitus. Despite mounting evidence of the role of the dietary approach in the management of diabetes mellitus, studies still show low adherence to dietary recommendations. This study aimed at assessing the dietary knowledge, attitudes, and practices of type 2 diabetes mellitus patients in two tertiary hospitals in Jos, Nigeria. This was a descriptive cross-sectional study among 448 type 2 diabetic patients using systematic random sampling. Quantitative data was collected using a self- administered questionnaire and analyzed using Statistical Package for Social Sciences (SPSS) version 20. A 95% confidence interval was used and a probability value of P≤0.05 was considered statistically significant. The study revealed that dietary knowledge of type 2 diabetic patients attending tertiary health care facilities in Jos, Nigeria was poor, their attitudes were positive, but they had poor dietary practices. A significant association was observed between marital status (P=0.022), religion (P=0.003), education level (P=0.000), employment status (P=0.000), family history (P=0.012), and dietary knowledge. This study highlights the importance of proper health education as this could possibly improve dietary knowledge, dietary practices that potentially change patient outcomes.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128398599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical screening and analgesic effect, in mice, of the methanolic leaf extract of Manniophyton fulvum Mull.-Arg. (Euphorbiaceae) 甘露赘醇叶提取物的植物化学筛选及小鼠镇痛作用。(大戟科)

Journal of Pharmacy & Bioresources Pub Date : 2022-05-11 DOI: 10.4314/jpb.v19i1.4

J. Ofeimun, Happy A. Aghulor, Z. Nworgu

{"title":"Phytochemical screening and analgesic effect, in mice, of the methanolic leaf extract of Manniophyton fulvum Mull.-Arg. (Euphorbiaceae)","authors":"J. Ofeimun, Happy A. Aghulor, Z. Nworgu","doi":"10.4314/jpb.v19i1.4","DOIUrl":"https://doi.org/10.4314/jpb.v19i1.4","url":null,"abstract":"Medicinal plants continue to attract attention as an alternative form of therapy. Phytochemical screening, analgesic properties and probable mechanism/s of action of the methanol leaf extract of Manniophyton fulvum were carried out following claimed folkloric usefulness in this regard. Standard methods were used to screen for classes of phytochemicals. Acetic acid-induced writhing and hot plate tests in albino mice were used to evaluate the peripheral and central analgesic effects using acetylsalicylic acid and morphine respectively as positive controls, while 50% DMSO served as negative control. Elucidation of the possible mechanism/s of action of the extract was carried using phenoxybenzamine, naloxen, ondansetron, atropine and haloperidol. Alkaloids, saponins, carbohydrates, terpenoids, steroids tannins, and flavonoids were detected in the extract. At 100 mg/kg dose, significant (P<0.01) reduction in pain stimuli, compared to the negative control group in both models was observed. Higher doses of extract (200 and 400 mg/kg) did not produce any significant effect. Observed results suggest that the leaf extract of M. fulvum may have an analgesic effect that is centrally and peripherally mediated at a lower dose compared to the high dose. The findings provide possible scientific basis for the ethnomedicinal use of the plant in several pain conditions.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132886207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Journal of Pharmacy &amp; Bioresources最新文献

Journal of Pharmacy & Bioresources最新文献