Journal of Pharmacy & Bioresources最新文献

Phytochemicals, proximate and elemental analysis, antioxidant and cytotoxic potentials of purple (Capitata F. rubra) and green (Capitata Linn.) Brassica oleraceae (cabbage) 紫甘蓝（Capitata F. rubra）和绿甘蓝（Capitata Linn.

Journal of Pharmacy & Bioresources Pub Date : 2024-05-09 DOI: 10.4314/jpb.v21i2.4

Thomas Abu, B. O. Ezea, Saka Alabi Yusuf, Olorunsola Olasunkanmi Bamidele, Latifat O. Sidiq, A. Yusuf, O. Ogbole

{"title":"Phytochemicals, proximate and elemental analysis, antioxidant and cytotoxic potentials of purple (Capitata F. rubra) and green (Capitata Linn.) Brassica oleraceae (cabbage)","authors":"Thomas Abu, B. O. Ezea, Saka Alabi Yusuf, Olorunsola Olasunkanmi Bamidele, Latifat O. Sidiq, A. Yusuf, O. Ogbole","doi":"10.4314/jpb.v21i2.4","DOIUrl":"https://doi.org/10.4314/jpb.v21i2.4","url":null,"abstract":"Malnutrition remains a significant impediment to growth in many countries. Exploring the medicinal potentials of exotic vegetables represents a strategic approach to achieving sustainable development goals. This study focused on the evaluation of proximate, elemental, and phytochemical composition, including the antioxidant and cytotoxic potentials of green and purple cabbage varieties. The findings revealed different percentages of moisture, crude fat, fibre, protein, and carbohydrates in both varieties. Calcium, magnesium, potassium, sodium, iron, copper, zinc, saponins, terpenoids, flavonoids, phenolics, tannins, anthraquinones, and steroids were also detected and quantified. The green (IC50=186.3 μg/mL) and purple (IC50=187.6 μg/mL) cabbage extracts demonstrated broad-spectrum 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, as compared with the standard, ascorbic acid(IC50=267 μg/mL). Similarly, the green (IC50=148.7 μg/mL) and purple (IC50=103.9 μg/mL) cabbage extracts exhibited nitric oxide inhibitory activity, as compared with the standard, ascorbic acid (IC50=135.2 μg/mL). The green (CC50=10.6 μg/mL) and purple (CC50=16.66 μg/mL) cabbage extracts exhibited an inhibition on the growth of Rhabdomyosarcoma cell lines as compared with the standard, Vincristine (CC50=0.30 μg/mL). These results support the utilization of the two cabbage varieties as dietary supplements, potentially aiding in the discovery of anticancer drugs and the management of other disease conditions owing to their antioxidant properties.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of haematinic activity of Tapinanthus globiferus (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats 评估 Tapinanthus globiferus (A. Rich.) van Tiegh 叶提取物和馏分对苯肼诱导的贫血大鼠的造血活性

Journal of Pharmacy & Bioresources Pub Date : 2024-05-09 DOI: 10.4314/jpb.v21i2.2

F. K. Asogwa, K. Okolo, Augustine Oluchukwu Asogwa, Jude Ibeabuchi Ali, C. O. Ugwu, R. Offiah

{"title":"Evaluation of haematinic activity of Tapinanthus globiferus (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats","authors":"F. K. Asogwa, K. Okolo, Augustine Oluchukwu Asogwa, Jude Ibeabuchi Ali, C. O. Ugwu, R. Offiah","doi":"10.4314/jpb.v21i2.2","DOIUrl":"https://doi.org/10.4314/jpb.v21i2.2","url":null,"abstract":"Anaemia is a leading cause of morbidity and mortality in both males and females of all ages. Anaemia was induced by intraperitoneal (i.p.) administration of phenylhydrazine (60 mg/kg) for a period of 3 days. Anaemic rats were allotted to five (5) groups; group I served as the negative control, group II served as the positive control received Astyfer syrup (0.15 mg/kg p.o) , groups III-V served as the test groups that received Tapinanthus globiferus methanol extract, ethyl acetate and n-hexane fractions (100, 200 and 400 mg/kg, p.o.), respectively. Packed cell volume (PCV), haemoglobin concentration (HB) and red blood cell count (RBC) were analysed as indices of anaemia at 7-day intervals for 21 days. The mean cell volume (MCV) and mean cell haemoglobin concentration (MCHC) were calculated accordingly. Leaf extract and fractions of Tapinanthus globiferus significantly (P<0.001) increased the PCV, the HB concentration and the RBC, which had been originally decreased by phenylhydrazine (P<0.001) administration within one week of treatment. The extract and fractions were compared with rats administered with the positive and vehicle-treated group. The results suggested that Tapinanthus globiferus leaves have haematinicactivities.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"184 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piper guineense Schum. & Thonn. (Piperaceae) - a review of its pharmacognostic, phytochemical, ethnomedicinal and pharmacological properties Piper guineense Schum.

Journal of Pharmacy & Bioresources Pub Date : 2024-05-09 DOI: 10.4314/jpb.v21i2.1

T. L. Ohemu, Hidayat Oyiza Bello, Tongret Datok, D. G. Dafam

{"title":"Piper guineense Schum. & Thonn. (Piperaceae) - a review of its pharmacognostic, phytochemical, ethnomedicinal and pharmacological properties","authors":"T. L. Ohemu, Hidayat Oyiza Bello, Tongret Datok, D. G. Dafam","doi":"10.4314/jpb.v21i2.1","DOIUrl":"https://doi.org/10.4314/jpb.v21i2.1","url":null,"abstract":"Piper guineense Schum. & Thonn. (Piperaceae) is a spice plant cultivated in West Africa for its aromatic, pungent, or otherwise desirable qualities. The leaves of P. guineense are used as a leafy vegetable, while its fruits are favoured for imparting flavour to a wide range of African soups. This study aimed to review available scientific literature on the pharmacognostic, ethnomedicinal, phytochemical, and pharmacological studies of P. guineense Schum. & Thonn. in Africa, from the year 2000 till date. Pharmacognostic studies have identified various macroscopic, organoleptic, microscopic, and physicochemical characteristics have been identified, providing valuable tools for the accurate identification and authentication of P. guineense. The phytochemical studies of the plant revealed the presence of alkaloids, steroids, glycosides, saponins, flavonoids, tannins, and terpenoids. Several studies have explored various plant parts of P. guineense, to elucidate its pharmacological effects, including its potential as an antimalarial, anticancer, antioxidant, aphrodisiac, antiplatelet, hepatoprotective, and antimicrobial agent. This review has shown that beyond its traditional role as a spice, P. guineense offers significant nutritional and biological benefits.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":" 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proximate, elemental and anti-nutritional composition of Pachycarpus bisacculatus (bitter butter) roots used locally as anti-snake venom 当地用作抗蛇毒的苦黄油（Pachycarpus bisacculatus）根的近似值、元素和抗营养成分

Journal of Pharmacy & Bioresources Pub Date : 2024-05-09 DOI: 10.4314/jpb.v21i2.3

Juliet D. Dodo, Monday Kpaji, Ekirigwe Ogah, A. E. Eseyin

{"title":"Proximate, elemental and anti-nutritional composition of Pachycarpus bisacculatus (bitter butter) roots used locally as anti-snake venom","authors":"Juliet D. Dodo, Monday Kpaji, Ekirigwe Ogah, A. E. Eseyin","doi":"10.4314/jpb.v21i2.3","DOIUrl":"https://doi.org/10.4314/jpb.v21i2.3","url":null,"abstract":"Snake bite remains a public health problem in many countries including Nigeria; hence search for snake antivenom has intensified. One plant that is potentially useful in this regard is Pachycarpus bisacculatus roots (bitter butter). This study determined; proximate, phytochemical, of the aqueous, n-hexane, methanol and ethyl acetate extracts of Pachycarpus bisacculatus roots. These extracts obtained by maceration were subjected to qualitative and quantitative phytochemical screening. Proximate, elemental, anti-nutritional compositions of this plant were carried out using standard methods. Results obtained were: moisture content (71.56±0.06, 7.53±0.37)%, crude protein (3.19±0.19, 1.92±0.05)%, crude fibre (11.33±0.31, 3.98±0.28)%, crude fat (1.05±0.07, 0.30±0.03)%, Ash (4.68±0.17, 2.32±0.32)%, carbohydrate (72.21±0.24, 19.92±0.48)% for the dried and fresh roots respectively. Elemental content showed that level of Ca was highest while that of Zn was the lowest. Al, Si, V, Pb were not detected. Anti-nutritional composition showed: oxalate (1.68±0.02 mg/100g), tannins (7.10±0.78 mg/100g), phytate (8.47±0.25 mg/100g) and cyanogenic glycosides (0.03±0.01 mg/100g). Extraction yields were 21.068% in aqueous solution, 1.6391% in ethyl acetate. The results indicate that root extracts of Pachycarpus bisacculatus contain bioactive chemicals and micronutrients which may be responsible for the medicinal properties reported for the plant.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide-rich extracts from leaves of Newbouldia laevis (P. Beauv.) Seem. ex. Bureau (Bignoniaceae) with antimicrobial and brine shrimp lethality activities Newbouldia laevis (P. Beauv.) Seem.

Journal of Pharmacy & Bioresources Pub Date : 2024-05-09 DOI: 10.4314/jpb.v21i2.5

Abraham O. Nkumah, Christianah T. Kehinde, B. Oluremi, A. Attah, O. Ogbole

{"title":"Peptide-rich extracts from leaves of Newbouldia laevis (P. Beauv.) Seem. ex. Bureau (Bignoniaceae) with antimicrobial and brine shrimp lethality activities","authors":"Abraham O. Nkumah, Christianah T. Kehinde, B. Oluremi, A. Attah, O. Ogbole","doi":"10.4314/jpb.v21i2.5","DOIUrl":"https://doi.org/10.4314/jpb.v21i2.5","url":null,"abstract":"Global concerns over antibiotic-resistant microbial pathogens have spurred a quest for innovative, stable, and target-specific molecules like bioactive peptides. This study evaluates the antimicrobial properties and toxicity of peptide-enriched extracts from Newbouldia laevis leaves. Aqueous extraction, thin layer chromatography (TLC), and Phenomenex's Stratum Giant Tube C18-E were used to obtain partly purified fraction (PPF) and crude peptide extracts (CPE). Antimicrobial inhibitory capacity was determined using p-INT dye, with gentamicin and fluconazole as standards. Cytotoxicity was assessed with Artemia salina nauplii. Microsoft Excel and GraphPad Prism 5 was used in analysing the data. Peptides were detected in CPE and PPF via TLC and modified G-250. PPF demonstrated more efficacy (IC50: 5.89μg/mL to 33.94μg/mL) against bacteria and fungi, with low toxicity (LC50: 5964.87μg/mL for PPFand 1094.20μg/mL for CPE) in the Brine shrimp lethality assay. The study presents the discovery of bioactive peptides from the leaves of Newbouldia laevis. Consequently, bioactive peptides extracted from this plant hold potential as foundational compounds for the development of novel broad-spectrum antibiotics aimed at combating microbial infections.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140997209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of heavy metal content of Manihot esculenta tubers and soil in Rivers State, Nigeria: Effect on histology of kidney and liver of Wistar rats 尼日利亚河流州 Manihot esculenta 块茎和土壤中重金属含量的比较研究：对 Wistar 大鼠肾脏和肝脏组织学的影响

Journal of Pharmacy & Bioresources Pub Date : 2024-02-15 DOI: 10.4314/jpb.v21i1.4

O. Shorinwa, Jephtha Chukwuemeka

{"title":"Comparative study of heavy metal content of Manihot esculenta tubers and soil in Rivers State, Nigeria: Effect on histology of kidney and liver of Wistar rats","authors":"O. Shorinwa, Jephtha Chukwuemeka","doi":"10.4314/jpb.v21i1.4","DOIUrl":"https://doi.org/10.4314/jpb.v21i1.4","url":null,"abstract":"There is a concern that Manihot esculenta Crantz (Euphorbiaceae) grown in Rivers State, Nigeria may be contaminated with heavy metals due to industrial activities with likely risk to human health. This study determined the heavy metal contents in the soil and tubers of M. esculenta and potential health risks in Wistar rats. Tubers harvested from different farms in Rumuji, Omoku and Gokhana areas of the state with their corresponding soil samples were combined and analyzed for heavy metals such as Pb, Cd, Hg, Cr, As and Ni. The control group rats received normal feed while test groups were fed with 30g of blended tubers from the locations respectively for 28 days. The liver and the kidneys were harvested for histopathological examination. Nickel, Pb, and Cr were present in the three locations while Cd and As were not found in Rumuji and Omoku but were present in Gokhana with a concentration of (0.01 ± 0.00 and 0.01±0.00 mg/kg) respectively. Bioconcentration factor was >1 for Pb and Cr in Rumuji. Liver histopathology showed fatty degeneration while the kidney tissues exhibited occluded Bowman’s capsule space. Heavy metals concentrations were within permissible limits although histological findings indicated some degree of hepatotoxicity and nephrotoxicity.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"162 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-efficacy of essential oils of Eryngium foetidum L. and Plectranthus amboinicus (Lour.) Spreng against Anopheles gambiae Giles Eryngium foetidum L.和 Plectranthus amboinicus (Lour.) Spreng 的精油对冈比亚按蚊 Giles 的生物功效

Journal of Pharmacy & Bioresources Pub Date : 2024-02-15 DOI: 10.4314/jpb.v21i1.5

P. Ubulom, Paul S. Thomas, A. U. Akpan, E. J. Udofa

{"title":"Bio-efficacy of essential oils of Eryngium foetidum L. and Plectranthus amboinicus (Lour.) Spreng against Anopheles gambiae Giles","authors":"P. Ubulom, Paul S. Thomas, A. U. Akpan, E. J. Udofa","doi":"10.4314/jpb.v21i1.5","DOIUrl":"https://doi.org/10.4314/jpb.v21i1.5","url":null,"abstract":" \u0000Malaria and lymphatic filariasis transmitted by female Anopheles mosquitoes remain health challenges in tropical Africa. Resistance by vectors to synthetic insecticides limits control efforts. This study evaluated efficacy of essential oils of Eryngium foetidum and Plectranthus amboinicus against Anopheles gambiae. Test oils were obtained by hydro-distillation using Clevenger apparatus. From 1 mL stock solution, 31.25, 62.50, 125 and 250 and 500 μL/mL concentrations of E. foetidum and P. amboinicus oils were prepared using serial-dilution with tween 80 as diluent. Each concentration had eighty adult mosquitoes exposed. Results of knockdown and insecticidal tests after 30 and 60 minutes respectively revealed higher susceptibility of An. gambiae to E. foetidum. Eryngium foetidum (250μL/mL) elicited 100% knockdown after 20 minutes. In the insecticidal test, the same concentration resulted in 100% mortality at 40 minutes. Same effect was observed for 500 μL/mL of P. amboinicus oil at 25 and 60 minutes. From Probit analysis, KD50 values were 66.793 and 251.350 μL/mL for E. foetidum and P. amboinicus respectively. Values for LC50 were 85.818 and 428.663 μL/mL for E. foetidum and P. amboinicus respectively. Results demonstrate that E. foetidum oil holds promise as control agent against An. gambiae. Plectranthus amboinicus oil did not demonstrate appreciable efficacy.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"461 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation of quercetin-3-O-rutinoside from the leaves of Globimetula braunii (Loranthaceae) growing on Terminalia catappa (Combretaceae) 从生长在Terminalia catappa (Combretaceae) 上的Globimetula braunii (Loranthaceae)叶片中分离出槲皮素-3-O-芸香糖苷

Journal of Pharmacy & Bioresources Pub Date : 2024-02-15 DOI: 10.4314/jpb.v21i1.1

S. Danladi, A. M. Alhassan

引用次数: 0

In vitro studies on the antidiabetic and antibacterial activity of biosynthesized silver nanoparticles with aqueous extract of Moringa oleifera leaf 利用油辣木叶水提取物生物合成银纳米粒子的抗糖尿病和抗菌活性的体外研究

Journal of Pharmacy & Bioresources Pub Date : 2024-02-15 DOI: 10.4314/jpb.v21i1.2

Ukorebi U. Asuquo, Bob I. Mgbeje, Kayode Dasofunjo, Kelvin U. Elot

{"title":"In vitro studies on the antidiabetic and antibacterial activity of biosynthesized silver nanoparticles with aqueous extract of Moringa oleifera leaf","authors":"Ukorebi U. Asuquo, Bob I. Mgbeje, Kayode Dasofunjo, Kelvin U. Elot","doi":"10.4314/jpb.v21i1.2","DOIUrl":"https://doi.org/10.4314/jpb.v21i1.2","url":null,"abstract":"Silver nanoparticles having applications in the field of medicine and biology are shown to have tremendous health benefits. Diabetes is still on rampage and antibacterial resistance is currently a global health challenge. This study focuses on the in-vitro antidiabetic and antibacterial activity of biosynthesized silver nanoparticles with aqueous extract of Moringa oleifera leaf. An aliquot (5 mL) of extract sample was added to 50 mL of 1 mM aqueous AgNO3. Reaction mixtures were heated and maintained at 700C for 10 minutes. Colour change to dark brown solution and a UV-vis spectrum peak at 400 nm confirmed silver nanoparticle synthesis. The antidiabetic activity of the nanoparticle was studied using an in vitro alpha-amylase inhibition assay. Acarbose was used as antidiabetic control drug. Disc diffusion method was used for antibacterial susceptibility testing on Mueller-Hinton agar medium with ampiclox as control antibiotic. Results of the analysis showed significant inhibition of alpha amylase that resembled the activity of acarbose. The highest percentage inhibition of alpha amylase by AgNPs was observed at 65.625% while that of acarbose was 90.357%. Antibacterial inhibition assay revealed that 100% biosynthesized silver nanoparticles had significant (p<0.05) inhibitory effects on Eschericia coli and Streptococcus pyogenes.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"300 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between diabetes mellitus and periodontal disease: A retrospective assessment of diabetics attending Murtala Muhammad Specialist Hospital, Kano 糖尿病与牙周病之间的相关性：对在卡诺穆尔塔拉-穆罕默德专科医院就诊的糖尿病患者的回顾性评估

Journal of Pharmacy & Bioresources Pub Date : 2024-02-15 DOI: 10.4314/jpb.v21i1.3

Umar Sabiu Hamza, Umar Idris Ibrahim, Abdurrahman Adamu, Aishatu Yarima Babayo, Muhammad Abubakar Adam, Nasiru Aminu Sani, Mustapha Tahir Idris

{"title":"Correlation between diabetes mellitus and periodontal disease: A retrospective assessment of diabetics attending Murtala Muhammad Specialist Hospital, Kano","authors":"Umar Sabiu Hamza, Umar Idris Ibrahim, Abdurrahman Adamu, Aishatu Yarima Babayo, Muhammad Abubakar Adam, Nasiru Aminu Sani, Mustapha Tahir Idris","doi":"10.4314/jpb.v21i1.3","DOIUrl":"https://doi.org/10.4314/jpb.v21i1.3","url":null,"abstract":"Periodontal disease is a common oral infection that affects the tissues that surrounds and support the teeth. The aim of the research was to study the relationship between diabetes and periodontal disease. The data was collected at Murtala Muhammad Specialist Hospital, Kano where a thorough review of patients’ record (files) who visited or were admitted at the facility within the period of January 2022-May 2023. Correlation coefficients showed the existence of a strong relationship between diabetes and periodontitis. Out of 80 patients with diabetes mellitus; 52(65%) had periodontal disease, 36(45%) were males and the disease was severe within the age range of 55-74; 16 (20%) were females with the disease being severe within the age range of 75 and above while 28 (35%) had no periodontal disease. Twenty percent of the patients had gingivitis, 15% have mild periodontitis, 20% have moderate periodontitis, 10% have severe periodontitis and 35% had no periodontitis. There exists strong relationship between diabetes mellitus and periodontal disease, the poorer the glycaemic control, and the longer the duration of diabetes mellitus; the greater will be the increased risk and severity of periodontitis.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"39 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journal of Pharmacy &amp; Bioresources最新文献

Journal of Pharmacy & Bioresources最新文献