Journal of Pharmacy & Bioresources最新文献_第2页

Validation of a method for measuring rifampicin plasma drug concentration in tuberculosis patients 结核病患者利福平血浆药物浓度测量方法的验证

Journal of Pharmacy & Bioresources Pub Date : 2023-10-19 DOI: 10.4314/jpb.v20i3.5

C. N. Sariem, Jacob Kolawole, Moshood Akinleye, Patricia Odumosu, Sophia Osawe, J. Aguiyi

引用次数: 0

In vitro radical scavenging and in vivo antiarthritic effects of Spondias mombin (L.) stem bark Spondias mombin（L. ）茎皮的体外自由基清除和体内抗关节炎作用

Journal of Pharmacy & Bioresources Pub Date : 2023-10-19 DOI: 10.4314/jpb.v20i3.1

Adedokun Oluwasegun Adekanmi, Ume Oguchukwu, Adewunmi Tolani, Daniel Akpe-efiak Ambe

{"title":"In vitro radical scavenging and in vivo antiarthritic effects of Spondias mombin (L.) stem bark","authors":"Adedokun Oluwasegun Adekanmi, Ume Oguchukwu, Adewunmi Tolani, Daniel Akpe-efiak Ambe","doi":"10.4314/jpb.v20i3.1","DOIUrl":"https://doi.org/10.4314/jpb.v20i3.1","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disorder that affects about 1% of the population globally. Numerous conventional medications are available for the management of RA. However, their usage is limited due to the associated side effects. Spondias mombin is a member of the Anacardiaceae family known for its anti-arthritic effects. This study aimed to evaluate the anti-arthritic activity of S. mombin (L.) stem bark in RA. Radical scavenging activity was determined using DPPH assay. The anti-inflammatory effect was determined using protease inhibition and formaldehyde-induced arthritis models. S. mombin aqueous fraction (SMAF) exhibited a significant (p<0.0001) radical scavenging effect (IC50 of 57.87 µg/mL) over the S. mombin methanol extract (SMME) and S. mombin chloroform fraction (SMCF) when compared to the sham control. SMAF at 500 µg/mL significantly (p<0.05) inhibited (56.89 ± 2.02%) the effect of protease when compared to the sham control. SMME significantly (p<0.001) reduced inflammation in rat paws when compared to the control with peak effects seen at the dose of 50 mg/kg body weight. The result of the study has revealed that the stem bark has radical scavenging and anti-inflammatory effects.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"246 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and 28-day toxicity evaluation of hydroethanolic extract of Eragrostis tremula (Poaceae) in Wistar rats Eragrostis tremula（Poaceae）水乙醇提取物对 Wistar 大鼠的急性毒性和 28 天毒性评估

Journal of Pharmacy & Bioresources Pub Date : 2023-10-19 DOI: 10.4314/jpb.v20i3.6

A. Nazifi, Abdulhakim Abubakar, M. Magaji, Musa Aliyu, A. Yaro, N. Danjuma

{"title":"Acute and 28-day toxicity evaluation of hydroethanolic extract of Eragrostis tremula (Poaceae) in Wistar rats","authors":"A. Nazifi, Abdulhakim Abubakar, M. Magaji, Musa Aliyu, A. Yaro, N. Danjuma","doi":"10.4314/jpb.v20i3.6","DOIUrl":"https://doi.org/10.4314/jpb.v20i3.6","url":null,"abstract":"Eragrostis tremula is utilized in Nigeria and other African countries as a memory enhancer, lactation stimulant, antiemetic, aphrodisiac and remedy for snake bites. Scientific reports revealed that this plant has anti-oxidant, anticholinesterase, cytotoxic and memory enhancing properties; despite these potentials, there is paucity of safety data to support its continued usage. This study investigated the toxicity profile of hydroethanolic extract of E. tremula (HEET) in Wistar rats. Acute and sub-acute (28 days at doses of 250, 500 and 1000 mg/kg per oral) toxicity tests were conducted using OECD 425 and 407 guidelines respectively. Limit test at 5,000 mg/kg was conducted to ascertain the midpoint lethal dose (LD50). The LD50 of HEET was above 5000 mg/kg per oral and no significant alterations in haematological parameters and tissue morphology were observed. In the sub-acute study, no death was recorded. There were no changes in food intake, organ/body weight, lipid profile, liver and renal function indices. However, histology of the kidneys showed slight tubular adhesion and glomerular necrosis. HEET was practically safe after acute administration with no practical deleterious effect at 250 mg/kg after prolonged administration in rats. However, 28 days administration of high doses caused slight kidney injury.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity and in vitro antioxidant potential of Curcuma longa Linn and Zingiber officinale Rosc rhizomes in Drosophila melanogaster 莪术和细辛根茎对黑腹果蝇的毒性和体外抗氧化潜力

Journal of Pharmacy & Bioresources Pub Date : 2023-10-19 DOI: 10.4314/jpb.v20i3.4

K. Amagon, David Agyo, Leritshimwa Amagon, Ernest Magani Wanche

{"title":"Toxicity and in vitro antioxidant potential of Curcuma longa Linn and Zingiber officinale Rosc rhizomes in Drosophila melanogaster","authors":"K. Amagon, David Agyo, Leritshimwa Amagon, Ernest Magani Wanche","doi":"10.4314/jpb.v20i3.4","DOIUrl":"https://doi.org/10.4314/jpb.v20i3.4","url":null,"abstract":"Medicinal plants like Curcuma longa and Zingiber officinale contain phytochemicals which have antioxidant properties. The study evaluated the antioxidant effect of Curcuma longa and Zingiber officinale on the survival of Drosophila melanogaster administered isoniazid. Drosophila melanogaster aged 3-5 days old were exposed to different concentrations (5-1000 mg/ 5 g diet) of isoniazid, and extract for 7 days to determine the lethal concentration (LC50). A 14-day survival assay was performed to evaluate the effect of isoniazid and the herbal extract on the survival rate of Drosophila melanogaster. The antioxidant activity of the herbal extract on the stable 2,2- diphenyl-1- picrylhydrazyl (DPPH) was also evaluated. The result showed an antioxidant activity greater than that of a standard, silymarin. An increase in survival rate of the fruit flies was observed at the lowest dose of the extract, when compared to those fed diet only. In conclusion, this study provided valuable insights into the antioxidant properties of the herbal extract, highlighting its potential benefits, while further research to elucidate the effects of phytochemicals especially at high doses is necessary. The results also underscore the importance of considering various factors in toxicity assessments as they affect fly survival.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of knowledge and practice of zinc sulphate supplementation in the treatment of diarrhoea among under-five children in Primary Health Care centres in Keffi, Nigeria 评估尼日利亚凯菲初级保健中心五岁以下儿童在治疗腹泻时补充硫酸锌的知识和做法

Journal of Pharmacy & Bioresources Pub Date : 2023-10-19 DOI: 10.4314/jpb.v20i3.2

Kamal A. Ibrahim, Simeon Omale, D. Dayom, O. Onyebuchi

{"title":"Assessment of knowledge and practice of zinc sulphate supplementation in the treatment of diarrhoea among under-five children in Primary Health Care centres in Keffi, Nigeria","authors":"Kamal A. Ibrahim, Simeon Omale, D. Dayom, O. Onyebuchi","doi":"10.4314/jpb.v20i3.2","DOIUrl":"https://doi.org/10.4314/jpb.v20i3.2","url":null,"abstract":"Zinc supplementation reduces the severity, duration and recurrence of diarrhoea in children. This study assessed the level of knowledge and practice of zinc supplementation in the management of diarrhoea in children in primary health care facilities in Keffi, Nigeria. Retrospective and qualitative studies were conducted in nine facilities. Validated data collection form and questionnaire were used to collect medications prescribed for diarrhoea in children less than five years old. Descriptive statistics was done, and associate variables were tested using Chi-square Tests. The study assessed 380 case files and 19 health care workers in nine facilities. The finding revealed that 21.1% and 10.5% of the prescribers were aware of and had formal training on the use of zinc in the management of diarrhoea respectively. Oral rehydration salt with zinc and antibiotics were prescribed in 10.5% and 57.9% cases respectively. Only 13.2%, 8.2% and 8.5% of children managed for diarrhoea had correct doses, frequencies and durations of zinc respectively. Only 44.4% facilities had zinc tablet in stock. The study revealed low knowledge and practice among primary health care workers about treatment guidelines on zinc supplementation in the management of diarrhoea in children less than five years.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic and anti-inflammatory studies of the methanol extract of Globimetula braunii (Loranthaceae) growing on Terminalia catappa Linn (Combretaceae) 长在樟子树上的樟子树甲醇提取物的镇痛和抗炎作用

Journal of Pharmacy & Bioresources Pub Date : 2023-06-13 DOI: 10.4314/jpb.v20i2.2

A. Alhassan, Nafisah Bisallah Lawal, S. Danladi

{"title":"Analgesic and anti-inflammatory studies of the methanol extract of Globimetula braunii (Loranthaceae) growing on Terminalia catappa Linn (Combretaceae)","authors":"A. Alhassan, Nafisah Bisallah Lawal, S. Danladi","doi":"10.4314/jpb.v20i2.2","DOIUrl":"https://doi.org/10.4314/jpb.v20i2.2","url":null,"abstract":"This study was carried out to investigate the phytochemical constituents, analgesic and anti-inflammatory activity of methanol stem extract of Globimetula braunii. Preliminary phytochemical screening was done using standard protocols, median lethal dose (LD50) was determined by Lorke’s method. Analgesic and anti-inflammatory activities of extract were determined using acetic acid induced writhing and hot-plate model and the carrageenan-induced rat's paw edema model respectively at graded doses of 1000 mg/kg, 500 mg/kg and 250mg/kg. The phytochemical screening revealed the presence of flavonoids, steroid, triterpenes and saponins. Intraperitoneal median lethal dose of the extract was estimated to be greater than 5000 mg/kg bodyweight in mice. The extract exhibited highest percentage inhibition of writhing (99.24%) at a dose of 1000 mg/kg. However, the extract showed no central analgesic activity. Furthermore, the extract at lowest and highest dose (250 mg/kg and 1000 mg/kg) significantly (p<0.05) reduced paw size when compared to control group. The findings of this study suggest that the methanol stem extract of Globimetula braunii contains bioactive compounds with peripherally mediated analgesic and anti-inflammatory activity.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116704322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of vitamin C against ethanol induced oxidative stress in Wistar rats 维生素C对乙醇诱导大鼠氧化应激的保护作用

Journal of Pharmacy & Bioresources Pub Date : 2023-06-13 DOI: 10.4314/jpb.v20i2.3

O. Oyesola, A. A. Adebiyi, T. E. George

{"title":"Protective effect of vitamin C against ethanol induced oxidative stress in Wistar rats","authors":"O. Oyesola, A. A. Adebiyi, T. E. George","doi":"10.4314/jpb.v20i2.3","DOIUrl":"https://doi.org/10.4314/jpb.v20i2.3","url":null,"abstract":"Inflammation is a natural immune response to harmful agents. This study aimed to explore the protective effect of vitamin C against alcohol-induced toxicity on hematological inflammatory markers. Forty healthy adult male Wistar rats were acclimatized and divided into eight groups. Group A served as the control, while Group B received alcohol. Groups C, D, and E were given varying doses of vitamin C, and Groups F, G, and H received alcohol followed by vitamin C treatments. After twenty-one days, blood samples were collected and analyzed for various markers. Rats receiving alcohol only showed increased white blood cell count (WBC), platelet count (PLT), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR), along with decreased antioxidant enzyme activity. However, rats receiving vitamin C alone or in combination with alcohol exhibited reduced inflammatory markers and increased antioxidant activity compared to the alcohol-only group. The study demonstrated that commercial-grade vitamin C at doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg effectively reduced chronic low-grade inflammation. Overall, the findings suggest that vitamin C supplementation may mitigate the inflammatory effects of alcohol consumption.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132913460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on medicinal plants used in the management of liver diseases in West Africa 西非用于肝病治疗的药用植物综述

Journal of Pharmacy & Bioresources Pub Date : 2023-06-13 DOI: 10.4314/jpb.v20i2.1

S. Doumbia, A. Dénou, M. Haidara, Daouda Lassine Dembele, N. B. Y. Fofie, R. Sanogo

{"title":"A review on medicinal plants used in the management of liver diseases in West Africa","authors":"S. Doumbia, A. Dénou, M. Haidara, Daouda Lassine Dembele, N. B. Y. Fofie, R. Sanogo","doi":"10.4314/jpb.v20i2.1","DOIUrl":"https://doi.org/10.4314/jpb.v20i2.1","url":null,"abstract":"In West Africa, there is an extensive demand of plants traditionally used against liver diseases. This review gathered information on the plants used for the traditional management of liver diseases in West Africa. A literature review was used to gather information on medicinal plants such as the scientific names, the parts used, the forms prepared and the main liver diseases treated. Citation frequency and convergence score were calculated for each species. The findings presented 24 articles published in West Africa with a total of 401 species distributed in 283 genera belonging to 103 families. The Fabaceae family was the most represented with 73 species. The most cited species were Carica papaya L. (Caricaceae), Citrus aurantifolia (Christm.) Swing. (Rutaceae), Cochlospermum tinctorium Perr. ex A. Rich (Cochlosmarmaceae), Entada africana Guill. And Perr. (Fabaceae), Parkia biglobosa (Jacq.) R.Br. ex G.Don (Fabaceae) and Phyllanthus amarus Schumach. & Thonn. (Euphorbiaceae). These plant species presented the highest citation frequencies and convergence scores. The leaves were mostly used in the form of decoction. The main diseases recorded were related to jaundice. Safety, quality and efficacy data on some of these plants justify their traditional uses and will contribute to the development of new phytomedicines against liver diseases.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115423369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the knowledge and practice of pediatric pharmacy among hospital pharmacists in Delta State, Nigeria 对尼日利亚三角洲州医院药剂师儿科药学知识和实践的评估

Journal of Pharmacy & Bioresources Pub Date : 2023-06-13 DOI: 10.4314/jpb.v20i2.4

U. S. Ahwinahwi, Omotejohwo Emily Okolosi-Patani, Chimamaka Immaculata Chima

{"title":"Assessment of the knowledge and practice of pediatric pharmacy among hospital pharmacists in Delta State, Nigeria","authors":"U. S. Ahwinahwi, Omotejohwo Emily Okolosi-Patani, Chimamaka Immaculata Chima","doi":"10.4314/jpb.v20i2.4","DOIUrl":"https://doi.org/10.4314/jpb.v20i2.4","url":null,"abstract":"The importance of pediatric pharmacy practice cannot be overemphasized in a country with high morbidity in children. This study assessed the knowledge and practice of pediatric pharmacy among hospital pharmacists, Delta State, Nigeria. A cross-sectional study of hospital pharmacists from 10 randomly selected hospitals was done with the aid of a self-administered questionnaire. Fifty- two of the 90 (57.8%) questionnaires were analyzed, 41 (78.8%) respondents had pediatric units in their facilities and 6 (11.5%) had undertaken specialized courses in pediatric pharmacy. The overall knowledge score of pediatric pharmacy among the respondents was 48%. Forty-seven (90.4%) knew children handle medicines differently from adults, 45 (86.5%) knew young and older children respond to medicines differently. Forty-three (82.7%) respondents provided incorrect responses on oral absorption of rifampicin and phenobarbitone and 39(75.0%) for penicillins; 49(94.2%) lacked knowledge as to whether weight is the most accurate method of dosage calculation. Nineteen (36.5%) had dispensed unlicensed medicines, 47 (90.4%) had engaged in extemporaneous preparation, 41 (78.9%) had access to pediatric-tailored drug information sources and at least 38 (73.1%) could advice on measurement of small volumes of oral dosage formulation. Overall knowledge of the respondents was below average score but practice was nonetheless encouraging.","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115658038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmid DNA mediated vancomycin-resistant Staphylococcus aureus (VRSA) from cases of urinary tract infection 质粒DNA介导的尿路感染病例的耐万古霉素金黄色葡萄球菌(VRSA)

Journal of Pharmacy & Bioresources Pub Date : 2023-02-19 DOI: 10.4314/jpb.v20i1.2

O. Okunye, P. A. Idowu, B. Okanlawon, M. T. Durowaiye, O. Adejumo, C. Babalola, J. S. Ayedun, O. Oyinloye, M. Osungunna

{"title":"Plasmid DNA mediated vancomycin-resistant Staphylococcus aureus (VRSA) from cases of urinary tract infection","authors":"O. Okunye, P. A. Idowu, B. Okanlawon, M. T. Durowaiye, O. Adejumo, C. Babalola, J. S. Ayedun, O. Oyinloye, M. Osungunna","doi":"10.4314/jpb.v20i1.2","DOIUrl":"https://doi.org/10.4314/jpb.v20i1.2","url":null,"abstract":"Vancomycin resistance commonly occurs with Staphylococcus aureus, a pathogen that exhibits intrinsic virulence. Sixty isolates of Staphylococcus aureus tested positive as vancomycin possessive isolates on Brain Heart Infusion Agar medium fortified with 6 μg/mL vancomycin from 100 clinical samples of urine from patients with cases of UTIs via agar diffusion method. Standard 30 μg vancomycin disc served as control. Increase in zones of growth inhibition in relation to vancomycin concentrations was noticed in some of the isolates while it was reversed in others, despite the increase in concentration. Typed strain was susceptible to six concentrations of vancomycin exposed and to the control. Thirty one of the sixty isolates were resistant to vancomycin control. Resistant isolates from standard vancomycin discs were then subjected to molecular investigation. Of the 31 isolates exposed to gel electrophoresis, 14 (47%)elicited plasmids of varied molecular weights ranging from 0.79-23.13 kb. The magnitudes of vancomycinresistant isolates from the clinical samples studied, coupled with some incoherent zones of inhibition and the plasmid DNA obtained from the resistant isolates, suggest the need for infection control practitioners and epidemiologist to devise strategies to curtail the spread of this pathogen both in hospital and community settings. ","PeriodicalId":194477,"journal":{"name":"Journal of Pharmacy & Bioresources","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115586399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journal of Pharmacy &amp; Bioresources最新文献

Journal of Pharmacy & Bioresources最新文献