Odontology最新文献

{"title":"Dimensions and morphology of sella turcica in different skeletal malocclusions: a systematic review and network meta-analysis.","authors":"Peng Mengxia, Ahmed Lotf Algahefi, Esam Halboub, Al-Sharabi A M Qassem, Zhihua Li, Maged S Alhammadi","doi":"10.1007/s10266-025-01189-z","DOIUrl":"https://doi.org/10.1007/s10266-025-01189-z","url":null,"abstract":"<p><p>This systematic review and meta-analysis aimed to determine whether the morphology and linear dimensions of sella turcica differ by the different skeletal malocclusions. PubMed, Scopus, EMBASE, and Google Scholar were comprehensively searched for the relevant articles published until 21 May 2024 using combinations of the following terms: sella turcica, lateral cephalometric, skeletal malocclusion, and morphology. Observational studies that assessed sella turcica in different skeletal malocclusions in systemically healthy subjects were included. Data analysis was accomplished using R. Twenty-six studies were included and subjected to quantitative analysis. The length and diameter of sella turcica in Class III were higher compared to Class I [Mean Difference (MD) = 0.42, 95% CI: 0.18-0.67, p value < 0.001; and MD = 0.29, 95% CI: 0.05-0.53, p value = 0.0197, respectively], and compared to Class II (MD = 0.48. 95%CI: 0.23-0.73, p value ≤ 0.001, and MD = 0.4, 95%CI: 0.14-0.65, p value = 0.002, respectively). The depth of sella turcica in Class III was also higher than that of Class II (MD = 0.29, 95%CI: 0.03-0.56, p = 0.03. Furthermore, Class III showed the highest rates of bridge and notch shape of sella turcica compared to Class I (Risk Ratio (RR) = 1.42, 95%CI: 1.13-1.79, p value = 0.0026; and RR = 1.55, 95%CI: 1.11-2.17, p value = 0.011, respectively), and compared to Class II regarding the bridge shape (RR = 1.35, 95%CI: 1.07-1.71, p value = 0.012. The Class III malocclusion showed larger dimensions of sella turcica, and higher prevalence of bridging, notching, and double shape in sella turcica. The present findings do not provide direct diagnostic evidence for orthodontic clinical practice.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction of orthodontic gingival enlargement using S100A4: a biomarker-based risk stratification model.","authors":"Víctor Simancas-Escorcia, Jaime Plazas-Román, Antonio Díaz-Caballero, Adel Martínez-Martínez, Carlos M Ardila","doi":"10.1007/s10266-025-01194-2","DOIUrl":"https://doi.org/10.1007/s10266-025-01194-2","url":null,"abstract":"<p><p>Orthodontic-induced gingival enlargement (OIGE) affects approximately 15-30% of patients undergoing orthodontic treatment and remains largely unpredictable, often relying on subjective clinical assessments made after irreversible tissue changes have occurred. S100A4 is a well-characterized marker of activated fibroblasts involved in pathological tissue remodeling. This was a cross-sectional precision biomarker study that analyzed gingival tissue samples from three groups: healthy controls (n = 60), orthodontic patients without gingival enlargement (n = 31), and patients with clinically diagnosed OIGE (n = 61). Immunohistochemical analysis quantified S100A4-positive fibroblasts, type I collagen synthesis, and microvascular density. Advanced statistical analyses included multivariate logistic regression, machine learning-based validation, causal mediation analysis, and survival modeling for risk stratification. The density of S100A4-positive fibroblasts was significantly higher in OIGE patients (245.8 ± 38.7 cells/mm²) compared to orthodontic controls (165.3 ± 29.4 cells/mm²) and healthy individuals (98.2 ± 18.5 cells/mm²) (p < 0.001; η² = 0.891). Multivariate analysis confirmed S100A4 as an independent predictor of OIGE (OR = 1.028 per cell/mm²; 95%CI 1.021-1.035; p < 0.001). Machine learning validation demonstrated high predictive accuracy (AUC = 0.946). Survival analysis identified distinct risk strata: individuals with S100A4 densities > 180 cells/mm² had a 78% probability of developing OIGE within 24 months, compared to 12% for those with < 130 cells/mm². S100A4 demonstrates 95% predictive accuracy for OIGE, supporting its role in personalized risk stratification and early preventive interventions during a defined therapeutic window. This study presents the first validated precision biomarker in orthodontics with the potential to prevent an estimated 180,000-360,000 OIGE cases globally each year.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional evaluation of age-related changes in root canal curvature and dentin thickness in mandibular first molars using micro-computed tomography.","authors":"Cangül Keskin, Jong-Ki Lee, Alper Ceylan, Özlem Sivas Yılmaz, Ali Keleş, Hiran Perinpanayagam","doi":"10.1007/s10266-025-01196-0","DOIUrl":"https://doi.org/10.1007/s10266-025-01196-0","url":null,"abstract":"<p><p>This study aimed to investigate the age-related alterations in mesial roots of mandibular first molar in terms of root canal curvature values, dentin thickness, interorifice distance, deviation from apical foramen, and location of apical foramen using a three-dimensional curvature measurement method and micro-computed tomography (micro-CT). Forty-five mesial roots of mandibular first molars from three age groups (Group 1: ≤ 30 years, Group 2: 31-59 years, Group 3: ≥ 60 years) were scanned using micro-CT. The central axis of each mesiobuccal and mesiolingual canal was analyzed using cubic B-spline curves to calculate canal curvature. Dentin thickness, deviation of apical foramen from the anatomical apex, and the location of apical foramen in mesiobuccal and mesiolingual canals were measured and recorded. Statistical analyses, including one-way ANOVA, Mann-Whitney U, Kruskal-Wallis and Pearson's correlation tests, were performed to assess age-related differences in curvature, interorifice distance, and dentin thickness with a 5% significance threshold. No statistically significant differences in root canal curvature were observed across the three age groups (p > .05), although a slight increase in curvature was noted in Group 3. Interorifice distance was significantly lower in Group 2 (p < .05), but no significant relationship was found between mesiobuccal curvature and interorifice distance. Dentin thickness, however, showed significant variations: Groups 1 and 2 exhibited thinner mesial dentin (2-6 mm levels), while Group 3 demonstrated greater distal dentin thickness (5-8 mm levels) (p < .05). Apical foramen location and deviation remained consistent across age groups (p > .05), predominantly situated centrally on the root surface. While root canal curvature did not vary significantly with age (p > .05), dentin thickness showed notable age-related differences (p < .05). A significant correlation was observed between the mesiolingual canal curvature and interorifice distance, but no such correlation was found for the mesiobuccal canal. A significant age-related increase in dentin thickness in both the mesiobuccal and mesiolingual canals underscores the impact of secondary dentin deposition, which is probably uniform as the root canal curvature seems to remain relatively stable across the lifespan in mandibular first molars.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of magnetic fields on the antimicrobial and antioxidant properties of toothpaste produced by phycoerythrin and Oliveria decumbens Vent. oil.","authors":"Bahareh Nowruzi, AmirHossein Sadeghi, Mohammad Meftahi","doi":"10.1007/s10266-025-01188-0","DOIUrl":"https://doi.org/10.1007/s10266-025-01188-0","url":null,"abstract":"<p><p>Streptococcus mutans, a key cause of dental caries, is not treated by conventional toothpaste, brushing, flossing, or antiseptic mouthwashes. This necessitates the development of enriched toothpaste. Cyanobacteria-derived phycoerythrin (PE) has antioxidant and antibacterial properties. Magnetic field (MF) treatments are also effective in cyanobacterial metabolism and antioxidant defense. This study aimed to develop toothpaste with Aliinostoc sp. pigment under MFs of 30 and 60 millitesla (mT), along with Oliveria decumbens Vent. oil, to evaluate its antioxidant and antibacterial properties. The findings of several assessments over 45 days on 5 varieties of toothpaste indicated that the 30 mT MF had the highest wavelength and PE absorption. In addition, the purity of PE in cultures treated with MFs rose considerably compared to the control. The findings of the average diameter of the growth inhibition zone of toothpaste treatments against S. mutans bacteria indicated that the combination of Oliveria decumbens Vent. oil and PE led to a substantial increase in antibacterial activity compared to the control treatment (1.5 times) (p < 0.05). The addition of PE and Oliveria decumbens Vent. oil under MFs reduced water loss (1.5 times), enhanced texture uniformity (2 times), increased phenolic content (2 times), boosted antioxidant activity, and lowered pH in toothpaste treatments compared to the control (p < 0.05). In addition, the findings of the sensory evaluation of the overall acceptability of various toothpaste treatments revealed that the combination of Oliveria decumbens Vent. oil and PE boosted the overall acceptability of toothpaste treatments compared to the control treatment (p<0.05). In general, the employment of PE under MFs and Oliveria decumbens Vent. oil in toothpaste formulations was particularly beneficial for reducing tooth decay and periodontal illnesses.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of gingiva-colored composite resins: cytotoxicity, apoptosis, and p53/NF-κB expression.","authors":"Mualla Pınar Elçi, Aliye Ezgi Güleç Taşkıran, Ülkü Tuğba Kalyoncuoğlu, Tuğba Fatsa, Sema Ören, Bengi Yilmaz Erdemli","doi":"10.1007/s10266-025-01186-2","DOIUrl":"https://doi.org/10.1007/s10266-025-01186-2","url":null,"abstract":"<p><p>This study evaluates the cytotoxicity, apoptosis, and expression of stress-related genes (TP53 and NF-κB) in response to gingiva-colored indirect composite resins used for veneering tooth or implant-supported prostheses or characterization of denture bases. A total of 120 disc-shaped specimens (2 mm thick, 10 mm diameter) gingiva-colored indirect composite resin specimens (Group A: Anaxgum-Anaxdent, Group B: Crealing Paste Gum-Bredent, Group G: Gradia Gum-GC, Group N: SR Nexco GUM-Ivoclar Vivadent) were prepared and divided into four groups (n = 10 per group). Surface wettability was assessed using water contact angle (WCA) measurements. Cytocompatibility was evaluated using the MTT assay with human gingival fibroblast (HGF-1) cells. Apoptosis and necrosis rates were assessed by flow cytometry, and TP53 and NF-κB gene expressions were analyzed via qRT-PCR. Data were analyzed using the Kruskal-Wallis test with Bonferroni-adjusted pairwise comparisons. The MTT assay revealed no cytotoxic effects, with all groups maintaining > 70% cell viability relative to the control. Exposure to the gingiva-colored composites did not result in significant changes in the rates of apoptosis and necrosis rates, indicating good cytocompatibility. TP53 mRNA expression levels did not differ significantly across groups. However, NF-κB expression was significantly downregulated in Group A (p < 0.001). These results indicate that the tested gingiva-colored indirect composite resins are cytocompatible with human gingival fibroblasts. While this suggests biocompatibility at the cellular level, further studies are necessary to confirm their overall clinical performance.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of inflammatory periodontal tissue by detecting the hemoglobin released in gingival crevicular fluid during supportive periodontal therapy.","authors":"Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Satoshi Sekino, Etsuko Murakashi, Hitomi Ishiguro, Daisuke Sasaki, Takashi Yaegashi, Hideki Takai, Masaru Mezawa, Yorimasa Ogata, Hisashi Watanabe, Yuichi Izumi, Jun-Ichi Kido, Yuka Hiroshima, Toshihiko Nagata","doi":"10.1007/s10266-025-01182-6","DOIUrl":"https://doi.org/10.1007/s10266-025-01182-6","url":null,"abstract":"<p><p>The purpose of this study was to longitudinally investigate the hemoglobin (Hb) test in gingival crevicular fluid of periodontitis patients, together with clinical parameters (plaque index: PlI, probing depth: PD, clinical attachment level: CAL, bleeding on probing: BOP, and gingival index: GI) during two-year supportive periodontal therapy (SPT). A total of 191 periodontal sites in 91 patients during the SPT period were clinically and biochemically evaluated three times (first, second, and third examinations) over two years. After the first examination of the clinical and biochemical parameters, periodontal support treatments were administered and then repeated every three months until the third examination. The values of PD, CAL, GI, and Hb decreased from the first examination to the second or third examination. Notably, the percentage reduction of Hb test values was significant. However, only the BOP value tended to increase. The decreases in these clinical and biochemical parameters suggested that the periodontitis was not exacerbated, but rather tended to recover with periodontal treatment. These reductions in PD, CAL, and Hb values from the first examination were clearly more common in the PD ≥ 5 mm group than in the PD ≤ 4 mm group for all test sites. In this study, the highly sensitive Hb test showed that periodontal treatment for two years suppressed the progression of periodontitis. This trend was significant in the deep gingival sulcus (PD ≥ 5 mm) group, suggesting that the Hb test may be a useful quantitative marker to predict recurrence of periodontitis.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of apical root resection level and filling technique on the fracture resistance of endodontically treated teeth: a biomechanical study.","authors":"Guilherme Pauletto, Sidnei Flores de Pellegrin, Yasmin Padoin, Andressa Weber Vargas, Duvan Cala Castillo, Gabriel Kalil Rocha Pereira, Carlos Alexandre Souza Bier, Renata Dornelles Morgental","doi":"10.1007/s10266-025-01185-3","DOIUrl":"https://doi.org/10.1007/s10266-025-01185-3","url":null,"abstract":"<p><p>This study aimed to investigate the influence of apical root resection level and root canal filling technique on the fracture resistance of endodontically treated teeth. Eighty mandibular premolars were selected and evenly distributed based on similar anatomical characteristics into two groups (n = 40) according to the root canal filling technique: single-cone technique and lateral compaction technique. One week after root canal treatment, each group was further divided into four subgroups (n = 10) based on the level of apical root resection: without root resection, 3 mm, 4 mm, and 5 mm. Following resection, a retrograde cavity was prepared and filled with mineral trioxide aggregate. All specimens were embedded in cylindrical acrylic molds and subjected to a fracture resistance test and fracture pattern analysis. Two-way ANOVA, Tukey's post hoc and Fisher's exact tests were performed (α = 5%). Teeth that underwent apical root resection 5 mm from the apex demonstrated significantly lower fracture resistance compared to those without root resection (p < 0.05). No differences were observed among the 3 mm and 4 mm resection groups, nor between these groups and the groups without resection or with 5 mm resection (p > 0.05). The root canal filling technique did not affect fracture resistance (p > 0.05) and the fracture pattern was similar between groups (p > 0.05). In conclusion, the fracture resistance of endodontically treated teeth decreased following a 5 mm apical root resection. The single-cone and lateral compaction techniques demonstrated comparable biomechanical performance.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-511-5p is a potential biomarker of periodontitis and inhibits the inflammatory response via targeting SOST.","authors":"Jie Yu, Jianhong Zhou, Yanqing Jiao","doi":"10.1007/s10266-025-01181-7","DOIUrl":"https://doi.org/10.1007/s10266-025-01181-7","url":null,"abstract":"<p><p>Periodontitis seriously affects oral health and quality of life. MiRNAs have demonstrated a key role in regulating gene expression. To analyze and explore the expression characteristics of miR-511-5p in periodontitis and its potential mechanism of action. This study screened for miRNAs using the GSE89081 dataset. Clinical samples were collected to measure the expression levels of miR-511-5p. The diagnostic potential of miR-511-5p in periodontitis was evaluated through receiver operating characteristic (ROC) curve analysis. TargetScan was employed to predict the downstream target genes of miR-511-5p. The direct interaction between miR-511-5p and SOST was validated using a dual-luciferase reporter assay. Their correlation was assessed using Pearson correlation analysis. Cell viability was assessed by CCK-8 assay. IL-6, IL-1β, and TNF-α expression levels were quantified using RT-qPCR and ELISA assays. miR-511-5p was downregulated in the gingival crevicular fluid obtained from patients with periodontitis. The ROC curve analysis revealed that miR-511-5p could effectively discriminate between patients with periodontitis and healthy controls. SOST has been identified as a downstream target gene of miR-511-5p. The binding interaction between them was validated through a dual-luciferase reporter assay, and the Pearson correlation analysis revealed a negative correlation. The mimic of miR-511-5p enhanced the proliferation of PDLCs and suppressed the LPS-induced expression of IL-6, IL-1β, and TNF-α, whereas overexpression of SOST exerts opposing effects. miR-511-5p, as a potential biomarker for periodontitis, inhibited the proliferation and inflammatory response of PDLCs by negatively regulating SOST through targeting.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall fit of anterior and posterior single crown substructures fabricated with different additive manufacturing and conventional techniques.","authors":"Gürel Pekkan, Hilal Gülgezen Aydın, Süleyman Hakan Tuna, Canan Hekimoğlu","doi":"10.1007/s10266-025-01178-2","DOIUrl":"https://doi.org/10.1007/s10266-025-01178-2","url":null,"abstract":"<p><p>Marginal and internal fit of single crowns is critical for clinical success. Further research is necessary to investigate the effects of various conventional and additive/subtractive manufacturing techniques on restoration fit, particularly for different tooth types. This in vitro study compared the fit of anterior and posterior crown substructures fabricated using five techniques: milled wax patterns for casting (CAW), 3D-printed polymer patterns for casting (3DP), direct metal laser sintering (DMLS), selective laser melting (SLM), and manual wax carving (Cast). The maxillary lateral and first molar teeth were prepared on a polyamide model, and substructures were designed after scanning. Cobalt-chromium (Co-Cr) specimens were fabricated for each technique (n = 10). Discrepancies were measured using the silicone replica technique and analyzed with two-way ANOVA and Bonferroni tests (α = .05). The 3DP group exhibited the highest overall discrepancies, while DMLS had the highest for molars, and DMLS, Cast, and SLM had the highest for laterals, respectively (p < 0.05). Tooth type significantly affected chamfer (p = 0.023, partial η² = 0.283), axial (p = 0.009, partial η² = 0.017), and incisal/occlusal discrepancies (p < 0.001, partial η² = 0.083). Significant differences were noted among fabrication techniques regarding overall, marginal, chamfer, axial, and incisal/occlusal discrepancies (p < 0.001). The DMLS technique showed results comparable to manual wax carving, demonstrating superior marginal and internal adaptation in posterior substructures (p < 0.05).</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic fatigue in NiTi files: a bibliometric and science mapping analysis.","authors":"Huda Melike Bayram, Emre Bayram","doi":"10.1007/s10266-025-01180-8","DOIUrl":"https://doi.org/10.1007/s10266-025-01180-8","url":null,"abstract":"<p><p>This study aimed to systematically map and analyze the scientific literature on the cyclic fatigue resistance of nickel-titanium (NiTi) rotary instruments, using bibliometric and science mapping techniques. Eight hundred eighty-one publications indexed in the Web of Science Core Collection between 1980 and 2024 were analyzed. Bibliometric performance indicators, keyword co-occurrence networks, thematic maps, and co-citation analyses were utilized. Data were processed using Bibliometrix, a comprehensive R-based science mapping software. Trends in publication volume, author and journal productivity, influential articles, thematic evolution, and international collaboration patterns were evaluated. There has been a steady increase in publication output over the last four decades, with a significant acceleration after 2010. Thematic mapping revealed that keywords such as \"cyclic fatigue,\" \"reciprocation,\" \"heat treatment,\" and \"fracture resistance\" have been central to the field. Citation analysis identified key foundational studies frequently referenced in fatigue testing methodology. International research collaborations were most prominent among North American, East Asia, and European institutions. This bibliometric study underscores the clinical importance of innovations in NiTi rotary instrumentation, particularly for enhancing cyclic fatigue resistance. By identifying key research trends and thematic clusters, the study provides valuable guidance for clinicians and researchers aiming to optimize instrument durability, reduce procedural complications, and advance endodontic practice.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}