Nuclear Medicine and Molecular Imaging最新文献

{"title":"¹⁵³Sm-EDTMP Therapy as a Therapeutic Option in Mixed Skeletal Metastases from Renal Cell Carcinoma with Disease Progression Post 2nd Line Tyrosine Kinase Therapy.","authors":"Srinivas Ananth Kumar, Madhur Kumar Srivastava","doi":"10.1007/s13139-025-00938-w","DOIUrl":"https://doi.org/10.1007/s13139-025-00938-w","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 1","pages":"48-50"},"PeriodicalIF":2.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auger Emitting [¹⁶¹Tb]Tb-PSMA-617 Radioligand Therapy in mCRPC with Peritoneal Carcinomatosis.","authors":"Florian Rosar, Arne Blickle, Moritz B Bastian, Tilman Speicher, Andrea Schaefer-Schuler, Caroline Burgard, Stephan Maus, Samer Ezziddin","doi":"10.1007/s13139-025-00973-7","DOIUrl":"10.1007/s13139-025-00973-7","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 1","pages":"54-56"},"PeriodicalIF":2.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Music on Patient' Overall Experience, Perception and the Quality of Myocardial Perfusion Imaging Procedure.","authors":"Maryam Alvandi, Amirhossein Yazdi, Mohammadreza Dehbanpour, Zahra Shaghaghi, Salman Khazaei","doi":"10.1007/s13139-025-00978-2","DOIUrl":"https://doi.org/10.1007/s13139-025-00978-2","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impact of music on anxiety, procedure quality, and overall experience during MPI.</p><p><strong>Patients and methods: </strong>At Farshchian heart center in Hamadan, Iran, 120 patients undergoing SPECT MPI were randomly assigned to either a music intervention group, (calming classical music) or a control group (standard care). Metrics like anxiety levels, exercise performance parameters, non-cardiac dipyridamole side effects, imaging quality, and patient satisfaction were evaluated.</p><p><strong>Results: </strong>The study found that the music intervention group exhibited significantly improved exercise duration (12.15 ± 2.70 vs. 10.73 ± 2.48 min, <i>P</i> = 0.015) and greater distance covered (1010.22 ± 314.06 vs. 802.22 ± 270.49 m, <i>P</i> < 0.05). Autonomic nervous system markers, including the Chronotropic index (0.727 ± 0.2 vs. 0.602 ± 0.17, <i>P</i> = 0.003) and heart rate recovery index (31.92 ± 10.56 vs. 19.65 ± 5.39, <i>P</i> = 0.001), were better in the music group. Myocardial oxygen consumption, reflected by the double product, was higher (21558 ± 17557 vs. 15892 ± 4297, <i>P</i> = 0.048). The music group experienced fewer dipyridamole side effects, including headache, dizziness, chest pain, and flushing. Fewer repeated acquisitions and inadequate gating windows were shown with music. Post-procedure, the music group had reduced anxiety and depression scores (anxiety: 5.45 ± 3.36 to 5.7 ± 3.68; depression: 5.8 ± 3.41 to 4.02 ± 3.5), unlike the control group. Satisfaction was significantly higher with music.</p><p><strong>Conclusion: </strong>Integrating music into MPI alleviates anxiety, improves exercise performance, mitigates non-cardiac dipyridamole side effects. Music greatly improves nuclear medicine practices and patient care quality.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 1","pages":"38-45"},"PeriodicalIF":2.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Early Stage of post-traumatic Stress Disorder (PTSD) Event Induces Down-Regulation of the Gamma-Aminobutyric Acidergic- Serotonergic System: Multiple PET Imaging in a PTSD Animal Model","authors":"Bo Hyun Kim, Se Jong Oh, Namhun Lee, Jong Hee Choi, Kyung Rok Nam, Kyung Jun Kang, Sang Jin Han, Jae Yong Choi","doi":"10.1007/s13139-025-00976-4","DOIUrl":"https://doi.org/10.1007/s13139-025-00976-4","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147382175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of Masking in Planar and Single-Photon Emission Computed Tomography/Computed Tomography Lung Perfusion Imaging in the Presence of ^99mTc-Macroaggregated Albumin Embolus.","authors":"Ji-Young Kim, Seo Young Kang, Byung Seok Moon, Bom Sahn Kim, Hai-Jeon Yoon","doi":"10.1007/s13139-025-00929-x","DOIUrl":"https://doi.org/10.1007/s13139-025-00929-x","url":null,"abstract":"<p><p>A 74-year-old male with lung cancer in right lower lobe underwent lung perfusion planar imaging and SPECT/CT scan for preoperative evaluation. A focal intense uptake artifact was shown on the initial scan, prompting a repeat scan 5 days later. A MAA embolus artifact can disrupt the analysis of radioactivity in each lung segment, potentially causing errors in postoperative residual lung function. Consequently, repeat imaging or correction may be necessary. When repeat images without MAA embolus were used for comparison, applying a mask to exclude the MAA embolus lesion provided reliable results, eliminating the need for further repeat imaging.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 6","pages":"479-481"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2024 National Diagnostic Reference Levels for Nuclear Medicine Imaging in Korea.","authors":"Jahae Kim, Soo Jin Kwon, Myoung Hyoun Kim, Byungwook Choi, Young Jin Jeong, Yong Hyu Jeong, Ho-Chun Song","doi":"10.1007/s13139-025-00930-4","DOIUrl":"https://doi.org/10.1007/s13139-025-00930-4","url":null,"abstract":"<p><strong>Purpose: </strong>The Korean Society of Nuclear Medicine (KSNM) established the first diagnostic reference levels (DRLs) in Korea in 2019. Over the past five years, the need to update the DRLs has emerged for adult nuclear medicine imaging in Korea. The KSNM therefore conducted a nationwide survey and updated the DRLs for adult nuclear medicine examinations.</p><p><strong>Methods: </strong>A national DRL survey was conducted from March 2024 to April 2024 to investigate the administered activities of radiopharmaceuticals and the radiation doses from hybrid CT associated with PET/CT and SPECT/CT. Compared with the 2019 DRLs, the updated DRLs reflect newly approved radiopharmaceuticals in Korea, the introduction of SiPM-based PET/CT scanners, and expanded data on hybrid CT radiation exposure. The DRL survey team performed data collection and cleaning, while the DRL Task Force under the Radiation Safety Committee reviewed the draft. The 2024 DRLs were subsequently approved by the Radiation Safety Committee.</p><p><strong>Results: </strong>The current updated DRLs include 41 nuclear medicine imaging studies and nine hybrid CT studies. For PET radiopharmaceuticals, new DRLs were established for ¹⁸F-FDG in the purpose of myocardial viability assessment, infection/inflammation, and screening. Additionally, DRLs for ¹⁸F-Florbetaben, ¹⁸F-Flutemetamol and ¹⁸F-Florapronol for brain amyloid imaging were newly introduced. For SPECT radiopharmaceuticals, new DRLs were established for cardiac scintigraphy using ^99mTc-DPD, HDP, or PYP, and for cardiac sympathetic nerve imaging with ¹²³I-MIBG. The DRLs for hybrid CT doses (three PET/CT and six SPECT/CT studies) represent a novel addition in the 2024 nationwide survey. Furthermore, administered doses of radiopharmaceuticals and hybrid CT radiation doses were compared between conventional and SiPM-based PET/CT scanners.</p><p><strong>Conclusions: </strong>The DRLs for nuclear medicine imaging in Korean were updated. The 2024 DRLs will support the optimization of medical exposure to ionizing radiation in nuclear medicine imaging practice in Korea.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 6","pages":"439-452"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of [⁶⁸Ga]GaNOTA-Ubiquicidin PET-CT for Differentiating Infections from Cancer in Oncology Practice: Preliminary Results from a Pilot Study.","authors":"Abhinav Singhal, Nishikant Avinash Damle, Akash Kumar, Sulochana Sarswat, Sanjana Ballal, Varsha Tiwari, Apoorva Tyagi, Vikas Kumar Jaiswal","doi":"10.1007/s13139-025-00924-2","DOIUrl":"https://doi.org/10.1007/s13139-025-00924-2","url":null,"abstract":"<p><strong>Purpose: </strong>Ubiquicidin (UBI) is a natural antimicrobial peptide that has shown potential for targeting microbial pathogens in both in-vitro and human studies. Infections are common in patients with cancer and can mimic the appearance of primary neoplasms or metastatic lesions on Fluorine-18 fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography-computed tomography (PET-CT) imaging. This pilot study aimed to determine the diagnostic accuracy of Gallium-68-1,4,7-triazacyclononane-1,4,7 triacetic acid ([⁶⁸Ga]GaNOTA)-UBI PET-CT for differentiating infective from neoplastic lesions.</p><p><strong>Methods: </strong>This was a prospective diagnostic accuracy study. Consecutive patients presenting with lesions identified on [¹⁸F]FDG PET-CT scans, which were equivocal for diagnosing malignancy and focal infection, were eligible for inclusion in the study. 30 selected patients who gave written informed consent underwent [⁶⁸Ga]GaNOTA-UBI PET-CT for lesion characterization. The lesions were considered positive for infection if the uptake of [⁶⁸Ga]GaNOTA-UBI in the lesion was higher than in the mediastinal blood pool. Biopsy and microbiological assay from the lesions and/or clinicoradiologic follow-up were the reference standard. Measures of diagnostic accuracy of [⁶⁸Ga]GaNOTA-UBI PET-CT were computed based on patient-based analysis. The statistical analysis was performed with the statistical package SPSS Version 27.0 (Armonk, NY, USA: IBM Corp). A 2-tailed P value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>According to the reference standard 21/30 (70%) patients were eventually diagnosed with infective lesions, 8/30 (26.7%) with neoplastic lesions and one patient with sterile inflammation. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [⁶⁸Ga]GaNOTA-UBI PET-CT were calculated as 52%, 78%, 85%, 41% and 60%, respectively. The maximum standardized uptake value (SUVmax) of infective lesions was not significantly different from malignant lesions; however, the mean of the ratios of lesional SUVmax to mediastinal blood pool SUVmax (SUVratio) of the former was significantly higher than that of latter (<i>p</i> = 0.042). The area under the curve (AUC) for SUVratio as a diagnostic parameter was 0.688 at an optimal cutoff value of 0.74. Good interrater agreement for the interpretation of [⁶⁸Ga]GaNOTA-UBI PET-CT scans was achieved (Cohen's κ = 0.73).</p><p><strong>Conclusion: </strong>[⁶⁸Ga]GaNOTA-UBI PET-CT shows only a moderate diagnostic accuracy for distinguishing infective from neoplastic lesions in oncology patients. A higher PPV however indicates its potential applicability as a confirmatory test for infection in patients with a higher clinical probability for the latter.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 6","pages":"418-428"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphoscintigraphy in Lymphedema: Procedure and Interpretation Guideline by the Korean Society of Nuclear Medicine and Korean Society of Lymphedema.","authors":"Minseok Suh, Sangwon Han, Min Young Yoo, Sun Young Chae, Joon Young Choi","doi":"10.1007/s13139-025-00934-0","DOIUrl":"https://doi.org/10.1007/s13139-025-00934-0","url":null,"abstract":"<p><p>The Korean Society of Nuclear Medicine (KSNM) was established in 1961 to promote clinical and technical advancements in nuclear medicine in Republic of Korea, and is composed mainly of nuclear medicine physicians and related scientists. The Korean Society of Lymphedema (KSL) was founded in 2010, gathering physicians, scientists, physical therapists and nurses from various fields to perform basic and clinical research and to study clinical and basic aspects including its pathophysiology, prevention, diagnosis, and treatment related to lymphedema. The KSNM and the KSL have agreed to collaborate on the establishment of a guideline for the implementation and interpretation of lymphoscintigraphy used for the diagnosis and evaluation of lymphedema, and they decided to periodically revise these guidelines to improve the quality of care for lymphedema patients. The purpose of this guideline was to help healthcare providers in taking reasonable actions based on current medical knowledge, available resources, and patient needs while ensuring effective and safe exams, and accurate interpretations in the administration of lymphoscintigraphy for the diagnosis and evaluation of lymphedema.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13139-025-00934-0.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 6","pages":"389-408"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG-PET and Multimodal Biomarker Integration: A Powerful Tool for Alzheimer's Disease Diagnosis.","authors":"Yvonne Bouter, Robert M Glasnek, Jannis M Wenzel, Caroline Bouter","doi":"10.1007/s13139-025-00932-2","DOIUrl":"10.1007/s13139-025-00932-2","url":null,"abstract":"<p><p>An early, biomarker-based diagnosis of Alzheimer's Disease (AD) is crucial, especially with the emerging availability of novel therapeutic options. However, the role of ¹⁸F-FDG-PET and its relationship to other PET and CSF biomarkers remains unclear. Therefore, the aim of this study was the evaluation of the role of ¹⁸F-FDG-PET in AD diagnosis and its relationship to other commonly used fluid and PET biomarkers and their individual and multimodal accuracy in AD diagnosis. We included <i>n</i> = 157 AD patients, <i>n</i> = 603 MCI patients, and <i>n</i> = 380 cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) that underwent PET imaging with ¹⁸F-FDG or ¹⁸F-Florbetapir. Clinical and imaging data including patient characteristics, CSF biomarkers, cognition tests, ¹⁸F-FDG-PET, ¹⁸F-Florbetapir-PET, and ¹⁸F-Flortaucipir-PET were retrospectively analyzed. PET images were quantified in several brain regions. The uptake of ¹⁸F-FDG was inversely correlated with ¹⁸F-Florbetapir and positively correlated with CSF Aβ42 in several brain regions commonly affected by AD. Additionally, ¹⁸F-FDG uptake showed an inverse correlation with both forms of CSF tau, t-tau and p-tau, in various brain regions, but did not correlate with ¹⁸F-Flortaucipir uptake. Moreover, regional ¹⁸F-FDG uptake was positively correlated with cognitive function. Diagnostic accuracies were similarly high for ¹⁸F-FDG uptake in the PCC/Precuneus region, ¹⁸F-Florbetapir uptake, CSF Aβ42, CSF p-tau, and ¹⁸F-Flortaucipir uptake in differentiating AD from cognitively normal individuals. ¹⁸F-FDG-PET and its combination with CSF p-tau/ Aβ42 ratio showed the highest predictive power for disease severity. The study underscores the potential of integrating ¹⁸F-FDG-PET with CSF biomarkers to enhance the diagnosis, prognosis, and monitoring of AD, highlighting the complexity and regional specificity of biomarker interactions in neurodegeneration.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13139-025-00932-2.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 6","pages":"453-471"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Current Status of Theranostics in West Asia: A Country-based Surveillance Study.","authors":"Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Batool Albalooshi, Maryam Alkuwari, Dyab Al Mahariq, Khalsa Al-Nabhani, Abdullah Alqarni, Mohammed Al-Rowaily, Riyadh AlSalloum, Murat Fani Bozkurt, Habibollah Dadgar, Abdulredha Esmail, Shazia Fatima, Mohamad Haidar, Aysar Khalaf, Fairoz Mohammed, Fuad Novruzov, Majdi Zein","doi":"10.1007/s13139-025-00923-3","DOIUrl":"https://doi.org/10.1007/s13139-025-00923-3","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s13139-025-00914-4.].</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 6","pages":"484-485"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}