Novelty in Biomedicine最新文献

{"title":"Prevalence of Epstein–Barr virus, Human Papillomavirus and Porphyromonas Gingivalis in Oral Cancer","authors":"M. Ghazi, H. Goudarzi, M. Goudarzi, E. Faghihloo, Maryam Zakeri, Ayda Amini, F. Dayyani, D. Yadegarynia, Farahnaz Bidari Zerehpoosh, M. Dadashi","doi":"10.22037/NBM.V9I2.32773","DOIUrl":"https://doi.org/10.22037/NBM.V9I2.32773","url":null,"abstract":"Background: Multiple risk factors are supposed to progress oral cavity carcinoma and among them, the role ofneither bacterial nor viral infections should be underestimated. Despite relentless efforts, the accelerating effectsof human papillomavirus (HPV), Epstein–Barr virus (EBV), and Porphyromonas gingivalis (P. gingivalis) onoral cancer has not yet been recognized successfully. Taking advantage of these facts, in this study we evaluatedthe prevalence of HPV, EBV, and P. gingivalis in oral cavity carcinoma.Materials and Methods: A total of 43 oral cavity cancerous tissues and 29 healthy oral ones were collected fromLoghman Hospital, Tehran, Iran, between 2016 and 2018. After DNA extraction, the prevalence of HPV, EBV,and P. gingivalis was evaluated by PCR.Results: There were 53.5 well-differentiated (15 male, 9 female), 41.8% moderate (10 male, 5 female), and4.7% poor (1 male, 3 female) adenocarcinoma paraffin-embedded tissue samples. PCR analysis has shownthat there were 1 HPV (age: 46; moderate adenocarcinoma) and 1 EBV (age: 62; moderate adenocarcinoma)positive in different samples. No P. gingivalis was found and there was not any infected tissue with both EBVand HPV. In 31% of control tissues, blisters were observed and in 51.7% there was no mucus. We did not findany association between age, sex, and HPV, EBV positive samples.Conclusion: As sample size can affect the results of epidemiological and clinical study, and due to the lownumber of positive samples in this study, we concluded that HPV, EBV, and P. gingivalis may not have adetrimental effect on the progression of oral cancer, but further studies are needed.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"19 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85490210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidiasis in COVID-19 Patients","authors":"M. Rabiei, A. Zali, Sara Rahmati Roodsari, Zahra Arab-Mazar, E. Lotfali","doi":"10.22037/NBM.V9I2.34133","DOIUrl":"https://doi.org/10.22037/NBM.V9I2.34133","url":null,"abstract":"Based on previous studies, some comorbidities influence the morbidity and mortality of COVID-19 disease. Among these factors, opportunistic fungal infections could have a major impact on the mortality of COVID-19 patients.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"67 1","pages":"101-103"},"PeriodicalIF":0.0,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80186128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy of Sofosbuvir and Kaletra on Outcome of Covid-19. Is Sofosbuvir A Potential Treatment For COVID-19?","authors":"S. Tehrani","doi":"10.22037/NBM.VI.31956","DOIUrl":"https://doi.org/10.22037/NBM.VI.31956","url":null,"abstract":"Introduction The COVID-19 is a family of large enveloped non-segmented positive-sense RNA viruses which was first reported in December 2019 in Wuhan, China with a cluster of unexplained pneumonia. Although various medications have been tried to manage the COVID-19 pandemic, there is no exclusive medication or vaccine so far. In this study, we aimed to focus on the effectiveness of Hydroxychloroquine + Kaletra (lopinavir/ritonavir ) versus Hydroxychloroquine + Sofosbuvir in patients hospitalized with COVID-19 to given the urgent need for an effective drug against SARS-CoV-2 in the current pandemic context. Methods: Fifty-four eligible patients with moderate to severe COVID-19 symptoms, according to the WHO criteria entered the study. Patients were randomized into two treatment groups. Thirty-two patients received Hydroxicholoroquine (400 mg stat) and Kaletra (400/100 mg q 12 h) as a control group (group A) and the trial group of 22 patients, received Hydroxicholoroquine (200 mg q 12 h) plus Sofosbuvir (400 mg daily) (group B) for a period of 7 to 14 days. Eventually, Collected data included demographic characteristics, underlying diseases, clinical symptoms, laboratory data, and mortality were analyzed. Results: There was no significant difference in age, sex, and underlying diseases between the two groups. There was no significant statistical difference between the two groups on the seventh day of treatment in terms of cough relief, leukocyte count, and improvement of lymphopenia however in terms of the time of defervescence of fever, there was a significant difference between the two groups. Conclusion:  Therefore, it can be said that our study is one of the first studies in the world to evaluate the effectiveness of sofosbuvir in the treatment of patients with COVID-19. According to our results, although Kaletra was assumed as an effective therapy, its superiority over Sofosbuvir was confined to the earlier effervescence of the 7-day fever And sofosbuvir can be used as an effective treatment, especially in patients with underlying heart disease who are at risk for arrhythmias with Kaletra","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86276466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of brain natriuretic peptide in predicting prognosis of coronary artery disease in Myocardial infarction","authors":"Roja Qobadighadikolaei, Maryam Ekhlaspour, Mohammad Sistanizad, Roxana Sadeghi","doi":"10.22037/NBM.VI.32128","DOIUrl":"https://doi.org/10.22037/NBM.VI.32128","url":null,"abstract":"Background:  Brain natriuretic peptide (BNP) is an important predictor of outcomes in patients with heart failure but the prognostic value of BNP elevation in patients with myocardial infarction is not (MI) incompletely defined. This study aims to identify the prognostic value of BNP changes in patients with MI. Methods: We studied patients with MI who were hospitalized in the Coronary Care Unit of Imam Hossein Hospital. Patients' demographic data, past medical and drug history besides echocardiography report and BNP levels were documented during the hospital stay and  echocardiography was repeated after 3 months. Results: This prospective observational cross-section study was done between January 2018 through January 2019. During the study period, 124 patients were recruited.. There were significant negative correlation between BNP levels and ejection fraction (P =0.001), systolic blood pressure (P =0.012), diastolic blood pressure (P =0.003) and ratio between early mitral inflow velocity and early diastolic mitral annular velocity (E/e') (P=0.03) and EF follow up (P=0.001). The correlation between BNP levels with infarction location (P =0.40), arterial involvement in the left main coronary artery ( P= 0.15), left anterior descending artery (P=0.53), left circumflex artery  (P= 0.97) ,right coronary artery (P=0.50) and hospital (P= 0.66) were not significant. Conclusion: BNP is a valuable marker for predicting prognosis and severity of coronary artery disease in patients with the acute coronary syndrome. Also, it could be considered as a prognostic long term marker for evaluating the EF of patients with AMI.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85785748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the role of the anti-parasitic drugs in the treatment of coronavirus disease 2019 (COVID-19)?","authors":"Sara Rahmati Roodsari","doi":"10.22037/NBM.VI.31803","DOIUrl":"https://doi.org/10.22037/NBM.VI.31803","url":null,"abstract":"","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76399890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Anti Dermatophytosis Potential of Medicinal Plants: In-Vitro, In-Vivo and Important Components:","authors":"Hossein Toreyhi, E. Lotfali, A. Fattahi, Yasaman Rezaee, R. Ghasemi, Ebrahim Salimi Sabour","doi":"10.22037/NBM.VI.31939","DOIUrl":"https://doi.org/10.22037/NBM.VI.31939","url":null,"abstract":"Background and Aim: Dermatophytosis refers to superficial fungal infection of keratinised tissues that increase remarkable costs for community of human. A great number of plants are being used as traditional medicinal practitioners to treat fungal diseases. The current review aimed to provide an update on some plants used as antidermatophytosis agents and investigate the action mechanism of each plant. Material and Methods: This systematic review was conducted on the literature available in the databases PubMed, Scopus, Web of Science, and Science Direct using the search engine Google Scholar, and the following search terms: Dermatophytosis and Herbal/Herbal Medicine and Dermatophytosis treatment. Result: Forty plants were identified and information on their scientific and common name, family, parts, preparation, extraction method, fractions, solvents, phytochemical categories, compounds, dermatophyte species and inhibitory concentrations was provided from multiple in vitro, in vivo and clinical studies. Conclusion: Herbals are the most effective herbs on dermatophytosis which have antidermatophytosis effects due to their essential compounds.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78106366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Helicobacter pylori and its cagA gene in patients with gastric cancer or peptic ulcer at an Iranian medical center","authors":"Maryam Kianmehr, Mohsen Zargar, A. Hormati, R. Fateh, R. Nazari","doi":"10.22037/NBM.VI.32595","DOIUrl":"https://doi.org/10.22037/NBM.VI.32595","url":null,"abstract":"Introduction: Iran has a high incidence rate for gastric cancer among the Middle East countries. In addition to gastric cancer, peptic ulcer is also life-threatening; thus, investigating the prevalence of Helicobacter pylori infection and other risk factors are essential. The present study was aimed to assess the frequency of H. pylori and the cagA-positive strains in patients with gastric cancer or peptic ulcer at a teaching hospital in Qom, one of the most populated cities of Iran.  Materials and methods: The presence of H. pylori was investigated in gastric cancer and peptic ulcer biopsy specimens using the standard culture method. PCR analysis was performed to detect the presence of the cagA gene. Results: The frequency of H. pylori isolates among the 86 investigated biopsies were 20 (23.2%). Likewise, the rate of H. pylori was the highest when samples were examined from patients with gastric cancer (25.8%), while it was 21.8% when obtained from peptic ulcer patients. The frequency of the cagA gene in H. pylori isolates was 9 (56.2%), as confirmed by PCR. Conclusions: Our results indicated that H. Pylori infection and its virulent strains are frequent and widely spread in the Qom city. The cagA gene was present in almost half of H. pylori isolates from peptic ulcer or gastric cancer patients. Therefore, it is necessary to screen it in all cases with H. pylori infection for early detection of gastric cancer.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89968448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased level of Histamine in keloid Tissue","authors":"Feizollah Niazi, Keshvad Hedayatyanfard, M. Soroush, Behnam Habibi, Nazgol-Sadat Haddadi, K. Rostami, Sadegh Rajabi, A. Khalili, Sana Niazi","doi":"10.22037/NBM.V9I1.31246","DOIUrl":"https://doi.org/10.22037/NBM.V9I1.31246","url":null,"abstract":"Background: Keloid and hypertrophic scars (HTS) caused by an imbalance between the production and destruction of collagen during wound healing with an unknown underlying pathophysiological mechanism. This study was designed to evaluate the histamine level in the Keloid and HTS and comparison of results with normal skin. Materials and Methods: This pilot study included 36 participants, aged from 18 to 70 years with keloid (n=11), HTS (n=13) and normal (n=12) skin. The level of histamine in the skin samples was measured using enzyme-linked immunosorbent assay (ELISA). Results: Histamine level in keloid samples was significantly higher than in the normal (p=0.0012) or HTS (p=0.0028) groups. However, there was no significant difference between the normal and HTS samples (p=0.92). Conclusion: The increased histamine level in the keloid tissue may contribute to its pathogenesis and the application of anti-histamines could be of benefit for the prevention and treatment of keloids.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"37 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78366505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Molecular Detection of Saffold Virus in Children with Acute Gastroenteritis in Iran","authors":"Tabasom Sadat Yaghobi, H. Bahrami, N. Harzandi, A. Asadi, Mitra Shareghi, Mohammad Hassan Firouzjani, Abas Akbari, M. Fazeli, S. D. Mousavi-Nasab, Nasrin Majidi Gharenaz, R. Arjmand, M. Ghaderi","doi":"10.22037/NBM.VI.31662","DOIUrl":"https://doi.org/10.22037/NBM.VI.31662","url":null,"abstract":"Background: Saffold virus as a new member of cardiovirus genus in picornaviridae family has been suggested to be related to diarrheic cases and human airway diseases. However, relationship between Saffold virus and human diseases is unclear. In order to establish an investigation for the occurrence of Saffold virus among pediatric patients involved to acute gastroenteritis, we implemented a RT-PCR assay for detection and quantification of Saffold virus in stool specimens. Materials and Methods: In this study, a total of 160 stool samples from September 2018 to May 2019 were collected from presenting pediatric patients with acute gastroenteritis in a Karaj hospital, Iran. After viral RNA extraction, the RT-PCR was performed to amplify the 5’UTR region of Saffold virus genome. Results: Out of the 160 samples tested, the Saffold virus genomic RNA was detected in 26/160 (16.2%) of stool samples. The high Saffold virus detection rate was related to February (6/26 or 23%). The co-infection of Saffold virus with Aichivirus and Salivirus as other new emerging viruses was also assessed, among which high double or triple mixed-infections were determined. Conclusion: This is the first documentation of Saffold virus detection in stool samples that demonstrates Saffold virus has been circulating among Iranian pediatric patients. Our results indicated that Saffold virus in association with Aichivirus and Salivirus may be possibly considered as causative agent of acute gastroenteritis.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"26 1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81883216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post Helicobacter pylori Treatment Histopathological Findings in Laparoscopic Sleeve Gastrectomy Specimens.","authors":"K. Moghadam, H. Mirhashemi, Nasser Malekpour Alamdari, M. Souri","doi":"10.22037/NBM.VI.31645","DOIUrl":"https://doi.org/10.22037/NBM.VI.31645","url":null,"abstract":"Abstract Background:: The aim of this study is to investigate the persistent histopathologic changes after H pylori treatment in laparoscopic sleeve gastrectomy (LSG) specimens and wethere there is correlation between high BMI and histopathological findings. Methods: Patients who were candidate for laparoscopic sleeve gastrectomy in 2017-2019 and they were asymptomatic with negative history of Helicobacter pylori and had visually normal endoscopy and just have posotive H pylori ureas test treated with triple regimen(clarithromycin and amoxycillin for 2weeks and PPI for 2 mounth and then confirming eradication by Urea Breath Test (UBT) and after operation specimens were evaluated histopathologically. Results: Females comprised 58.3 % of the patients. Mean BMI were 44.2 (females) and 46.3 (males). Normal LSG specimens comprised 58.3 %. Most common abnormal histopathologies were; chronic mild active and inactive gastritis (21.3%), chronic moderate active and inactive gastritis (16.0%), chronic severe active and inactive gastritis(3.3% ),no follicular gastritis, lymphoid aggregates (0.6 %), intestinal metaplasia ( 0.2%) and  PPI effect(0.2% ). Significant correlation was observed between the higher BMI of patients(BMI>45) with abnormal histopathologies specially moderate and severe degree of chronic  active and inactive gastritis. Conclusion:Petients with higher BMI is at more risk for post H pylori treatment abnormal pathology like chronic active gastritis which is the risk factor for atrophic gastritis may lead to preventable gastric cancer.so in this course patients with higher BMI(≥45) and Hpylori positive ureas test with visually normal endoscopy who are scheduled for LRYGB which permanent endoscopic follow up is impossible, provide benefits from endoscopic random tissue mapping even after H pylori treatment.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83194572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}