Nouvelle revue francaise d'hematologie最新文献_第9页

D-dimer levels in the cerebrospinal fluid: a marker of central nervous system involvement in neoplastic disease. 脑脊液中d -二聚体的水平:肿瘤疾病中中枢神经系统受累的标志。

Nouvelle revue francaise d'hematologie Pub Date : 1994-08-01

V Eclache, T Vu, G Le Roux

引用次数: 0

Quality and functional capacity of the bone marrow microenvironment of autologous blood stem cell transplantation (ABSCT) recipients. 自体造血干细胞移植(abt)受者骨髓微环境的质量和功能。

Nouvelle revue francaise d'hematologie Pub Date : 1994-08-01

C Barbot, A Rice, I Vanès, F X Mahon, B Jazwiec, J Reiffers

{"title":"Quality and functional capacity of the bone marrow microenvironment of autologous blood stem cell transplantation (ABSCT) recipients.","authors":"C Barbot, A Rice, I Vanès, F X Mahon, B Jazwiec, J Reiffers","doi":"","DOIUrl":"","url":null,"abstract":"We have previously reported that the rate of haematopoietic recovery following Autologous Blood Stem Cell Transplantation (ABSCT) could be influenced by the type of conditioning regimen or by the underlying disease. Furthermore, Peripheral Blood Stem Cell (PBSC) growth was found to be sensitive to stimulation by irradiated allogeneic stromal layers. In the present study, we used the long term culture system (LTC) to investigate the quality of the bone marrow (BM) microenvironment from patients who had undergone ABSCT for either Malignant Lymphoma (ML, 13 patients) or Multiple Myeloma (MM, 8 patients) after conditioning regimens comporting myeloablative chemotherapy (CT) or Total Body Irradiation (TBI). Among the 13 ML patients, 10 received CT conditioning and 9 of the 10 BM samples developed a complete confluent stromal layer. The remaining 3 ML patients received TBI prior to ABSCT and 2 of the 3 samples developed confluent stroma. In contrast, when LTC were established with BM from the 8 MM patients, all of whom were treated with TBI prior to ABSCT, only 3 of the 8 marrow samples developed a complete confluent stromal layer. Thus BM from patients who had received CT conditioning therapy tended to form confluent stroma more often than BM from those who had received TBI (p = 0.08). CFU-GM production was also evaluated for the stromal layers derived from all transplanted patients.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"36 4","pages":"325-31"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary neoplasms in two patients treated with purine analogues. 用嘌呤类似物治疗2例继发性肿瘤。

Nouvelle revue francaise d'hematologie Pub Date : 1994-08-01

D Schlaifer, F Riga-Huguet, J Pris, P Brousset, A Delannoy, A Bosly

引用次数: 0

Balance between human peripheral blood CFU-GEMM and CFU-Meg in sustained and acute thrombocytopenia. 人外周血CFU-GEMM和CFU-Meg在持续和急性血小板减少症中的平衡。

Nouvelle revue francaise d'hematologie Pub Date : 1994-08-01

E Sumereau-Dassin, T Goulamhoussen, P Breton

{"title":"Balance between human peripheral blood CFU-GEMM and CFU-Meg in sustained and acute thrombocytopenia.","authors":"E Sumereau-Dassin, T Goulamhoussen, P Breton","doi":"","DOIUrl":"","url":null,"abstract":"Quantitative variations of blood cell progenitors were studied in thrombocytopenic post-chemotherapy patients and in healthy plateletpheresis donors with the aim of better understanding the reasons for their varying presence in peripheral blood. In 6 post-chemotherapy patients with severe thrombocytopenia on days 21-27 after initiation of chemotherapy when white blood cell counts were approximately 2.1-6.0 x 10(9)/l, a balance was observed between the most and least immature progenitors: levels of CFU-Meg were significantly lower than control values whereas levels of CFU-GEMM were 2-fold higher than in controls. Results suggest that an activator distinct from the known poietins may stimulate very immature progenitors. In 15 plateletpheresis donors, numbers of CFU-GEMM and CFU-Meg were greatly increased, respectively 5.5-fold and 10-fold, following plateletpheresis. Data once again indicate a major role of CFU-GEMM in the production of mature blood cells. As the most immature progenitors and thrombocytopoiesis stimulating factor(s) are both present in peripheral blood, such factors may be responsible for the initial engagement of these very early progenitors into a specific cell line.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"36 4","pages":"301-5"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18965290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-Chlorodeoxyadenosine therapy in advanced chronic lymphocytic leukaemia. 2-氯脱氧腺苷治疗晚期慢性淋巴细胞白血病。

Nouvelle revue francaise d'hematologie Pub Date : 1994-08-01

A Delannoy, A Ferrant, P Martiat, L Montfort, C Doyen, G Sokal, J L Michaux

{"title":"2-Chlorodeoxyadenosine therapy in advanced chronic lymphocytic leukaemia.","authors":"A Delannoy, A Ferrant, P Martiat, L Montfort, C Doyen, G Sokal, J L Michaux","doi":"","DOIUrl":"","url":null,"abstract":"The therapeutic potential of 2-chlorodeoxyadenosine (CdA) in patients with advanced chronic lymphocytic leukaemia (CLL) remains controversial with response rates in clinical trials ranging from 44 to 67%. This report describes our experience with CdA in 22 CLL patients having already undergone previous treatment. CdA was given by continuous intravenous infusion at a dose of 4 mg/m2/day for 7 days (4 patients) or as 2-h intravenous infusions at a dose of 5.6 mg/m2/day for 5 days (18 patients). Partial (n = 5) or complete (n = 2) response was obtained in 7 cases. As compared to unresponsive patients, responding subjects received CdA earlier in the course of their disease (mean interval between diagnosis and CdA therapy 58 vs 102 months), were less thrombocytopenic at initiation of CdA (mean platelet count 165 x 10(9)/L vs 81 x 10(9)/L) and experienced less severe neutropenia during the first course of therapy (mean minimal neutrophil count 1.55 x 10(9)/L vs 0.43 x 10(9)/L). None of 6 patients with CLL refractory to fludarabine responded to CdA. An evaluation of haematological toxicity during the first course of treatment showed grade 4 neutropenia (< 0.5 x 10(9)/L) in 7 cases and grade 4 thrombocytopenia (< 25 x 10(9)/L) in one of 19 cases where the platelet count was greater than 25 x 10(9)/L at initiation of CdA. In comparison with earlier reports, the present series of patients had received relatively heavy prior therapy, experienced more severe haematological toxicity and demonstrated a lower total response rate.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"36 4","pages":"311-5"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-Chlorodeoxyadenosine therapy in Waldenstrom's macroglobulinaemia. 2-氯脱氧腺苷治疗Waldenstrom巨球蛋白血症。

Nouvelle revue francaise d'hematologie Pub Date : 1994-08-01

A Delannoy, A Ferrant, P Martiat, A Bosly, A Zenebergh, J L Michaux

引用次数: 0

[Mitoxantrone-aracytine with or without quinine in the treatment of refractory or relapsed acute leukemia]. [米托蒽醌-aracytine联合或不联合奎宁治疗难治性或复发性急性白血病]。

Nouvelle revue francaise d'hematologie Pub Date : 1994-07-01

E Solary, F Witz, P Moreau, I Quiquandon, P Genne, M Flesch, A Saddoun, F Maloisel, B Pignon, J F Abgrall

引用次数: 0

[Sequential chemotherapy with or without GM-CSF in acute myeloid leukemia (AML) in the advanced phase: current status of protocols EMA 86 and EMA 91]. [有或无GM-CSF序贯化疗治疗晚期急性髓性白血病(AML): EMA 86和EMA 91方案的现状]。

Nouvelle revue francaise d'hematologie Pub Date : 1994-07-01

E Archimbaud, V Leblond, P Fenaux, H Dombret, C Cordonnier, P Cony-Makoul, F Dreyfus, X Troussard, G Auzanneau, A M Stoppa

引用次数: 0

[Role of double induction in the treatment of acute myeloblastic leukemia in the adult: intermediate results of protocol LAM90]. [双诱导在成人急性髓母细胞白血病治疗中的作用:LAM90方案的中间结果]。

Nouvelle revue francaise d'hematologie Pub Date : 1994-07-01

S Castaigne, E Archimbaud, P Fenaux, D Bordessoule, H Tilly, M Simon, B Dupriez, G Auzanneau, M Legros, G Tertian

引用次数: 0

[Cell Dyn 3000: technical performance and applications in hematologic pathology]. Cell Dyn 3000:技术性能及在血液病理学中的应用

Nouvelle revue francaise d'hematologie Pub Date : 1994-07-01

H Merle-Béral

{"title":"[Cell Dyn 3000: technical performance and applications in hematologic pathology].","authors":"H Merle-Béral","doi":"","DOIUrl":"","url":null,"abstract":"The Abbott Cell-Dyn (CD) 3000 is an automatic analyser, designed to give cell blood counts (CBC) and white blood differential (WBCD) by 4 angels diffraction analysis. Evaluation was performed by comparison between results obtained by CD and those obtained by Technicon H1 and by microscopic examination. Technical performances as reproducibility, linearity, carryover were quite well acceptable. On normal samples, neutrophils (NE), lymphocytes (LY) and eosinophils (EO) were found to correlate with optical method with coefficient (R) values higher than 0.9. Weaker R coefficients were found for monocytes (MO) and basophils (BA), however it didn't involve clinical consequences. Significant threshold for immature granulocytes (IG) and variant lymphocytes (VL) flags were built. By using those, a false positive rate of 7% was shown. In hematological diseases, no false negative was detected because all samples were flagged. However, no acute lymphoblastic leukemia (ALL) was studied, so the detection of lymphoblast, as known as a real difficulty for analyser, was not yet evaluated. Blasts in acute myeloblastic leukemia (AML) and hairy cells were both noticed by CD. Moreover, for chronic lymphocytic leukemia (CLL), three groups were described, according to the flags released. Knowing its performances and its limits, CD is a good analyser usable in an all round or a hematological laboratory with high number of WBCD per day.","PeriodicalId":19366,"journal":{"name":"Nouvelle revue francaise d'hematologie","volume":"36 Suppl 2 ","pages":"S111-3"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0