Nigerian Journal of Natural Products and Medicine最新文献_第9页

An Overview of Herbal Medicine Research and Development in Nigeria 尼日利亚草药研究与开发概况

Nigerian Journal of Natural Products and Medicine Pub Date : 2011-04-01 DOI: 10.4314/NJNPM.V17I1.8

K. Osemene, A. Elujoba, M. Ilori

{"title":"An Overview of Herbal Medicine Research and Development in Nigeria","authors":"K. Osemene, A. Elujoba, M. Ilori","doi":"10.4314/NJNPM.V17I1.8","DOIUrl":"https://doi.org/10.4314/NJNPM.V17I1.8","url":null,"abstract":"The research pattern in medicinal plants and traditional medicine practices in Nigeria is largely unknown. Hence this paper examined such research patterns with a view to determining how the country fared in herbal medicine research and development. The study also identified the number of herbal medicine scientific research outputs. Factors that mar herbal medicine research were discussed. Descriptive analytical technique was adopted in analyzing the secondary data obtained from the book of abstracts of published research findings on Nigerian medicinal plants and traditional medicines practices for 42 years (1970-2012). Results showed that the most researched areas in herbal medicines were in the anti-infective drugs, gastro-intestinal tract drugs, analgesics, cardiovascular drugs, hypoglycemic, and mollucicidal in that order. The study also revealed that much work is yet to be done in other vital areas such as hormones, anti-viral agents, ear nose and throat (ENT), hemorrhoids and neurological disorder. Thus, it recommended among other things, that herbal medicine research and development should be intensified in the above –mentioned least-researched areas, if Nigeria intends to meet the health challenges of the 21 st century. Key words: Medicinal Plants, Patterns, Traditional Medicine Practices.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"17 1","pages":"82-85"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81055667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Quality control of Harpagophytum procumbens products using High Pressure Liquid Chromatography-Diode Array Detection (HPLC-DAD) 高压液相色谱-二极管阵列检测(HPLC-DAD)法控制原甘草产品的质量

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61584

S. Chigome, M. Nindi, Nm Munkombwe

引用次数: 2

Antioxidant activity and cytotoxicity study of Leucaena leucocephala (Lam.) de wit leaf extract constituents 银杏叶提取物成分的抗氧化活性及细胞毒性研究

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61612

M. Aderogba, L. McGaw, B. Bezabih, B. Abegaz

{"title":"Antioxidant activity and cytotoxicity study of Leucaena leucocephala (Lam.) de wit leaf extract constituents","authors":"M. Aderogba, L. McGaw, B. Bezabih, B. Abegaz","doi":"10.4314/NJNPM.V13I1.61612","DOIUrl":"https://doi.org/10.4314/NJNPM.V13I1.61612","url":null,"abstract":"Antioxidant activity of the solvent fractions obtained from a 20% aqueous methanol dried leaf extract of Leucaena leucocephala was evaluated using a 1, 1-diphenyl-2-picrylhydrazyl (DPPH) TLC assay. The more polar fractions ethyl acetate and butanol fractions demonstrated strong activity. A DPPH activity-guided fractionation procedure was used to isolate the antioxidant constituents of these active fractions. Separate fractionation of the fractions led to the isolation of epicatechin-3-O-gallate (1) along with two quercetin glycosides: quercetin-3-O-arabinofuranoside (2) and quercetin-3-O-rhamnoside (3) together with apigenin (4). The structures of the isolated compounds were elucidated using spectroscopic techniques NMR (1D and 2D) and mass spectrometry. Compounds 1 and 4 are reported for the first time from this species. In the qualitative antioxidant TLC assay, isolated compounds instantly bleached the DPPH (0.2% in MeOH) purple colour indicating strong antioxidant activity. The antioxidant quercetin glycosides were not cytotoxic at the highest concentration tested (200 ig/ml), and apigenin was not isolated in sufficient quantity to test for cytotoxicity. Epicatechin-3-O-gallate showed slight cytotoxicity against Vero cells (LC 50 = 92 μg/ml). Keywords : Leucaena leucocephala , Fabaceae, antioxidant, DPPH, cytotoxicity.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"112 1","pages":"65-68"},"PeriodicalIF":0.0,"publicationDate":"2010-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78382380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Toxicological studies of the stem bark extract of Khaya grandifoliola in rats. 桔梗茎皮提取物对大鼠的毒理学研究。

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61601

V. Bumah, J. Agbedahunsi

{"title":"Toxicological studies of the stem bark extract of Khaya grandifoliola in rats.","authors":"V. Bumah, J. Agbedahunsi","doi":"10.4314/NJNPM.V13I1.61601","DOIUrl":"https://doi.org/10.4314/NJNPM.V13I1.61601","url":null,"abstract":"Khaya grandifoliola (Welw) CDC (Meliaceae) is a tropical medicinal plant widely used in Africa for the management of malaria. In this study, toxicological evaluation of the aqueous extract of the stem bark of the plant has been evaluated with a view to ascertaining some of its possible toxic effects in the rats. Healthy rats of both sexes weighing between 62 g - 69 g body weight were used for this study. A group of rats were administered with graded doses (100, 200 and 500 mg/kg body weight, o.p) of the extract daily for 21 days. At the end of the 7 days, 21 days treatment periods and 21 days post-treatment (Recovery) period, the different groups of animals were sacrificed and assessed for tissue damage by measuring the plasma, liver, heart and spleen activities of alanine amino transferase (ALT), aspartate amino transferase (AST), and alkaline phosphatase (ALP). The liver, kidney, heart and spleen were also subjected to histopathological assessment. The result showed that following 1 week of administration of the extract that there was significant (p of activity in the plasma. This indicates that K. grandifoliola extract could be toxic when administered chronically at high doses. Keywords: ALP, AST, ALT, Heart, Histology, Kidney, Liver, Spleen.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"81 1","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2010-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83969710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Curative potential of aqueous extract of Ziphus mauritiana leaf against chronic alcohol-induced hepatotoxicity in male rats 毛提叶水提物对雄性大鼠慢性酒精性肝毒性的治疗作用

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61585

D. Dahiru, O. Obidoa

引用次数: 2

Curative effect of hydroalcoholic extract of leaves of Moringa oleifera Lam. against adjuvant induced established arthritis in rats 辣木叶水醇提取物的疗效研究。抗佐剂诱导的大鼠关节炎

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61580

S. Mahajan, A. Mehta

{"title":"Curative effect of hydroalcoholic extract of leaves of Moringa oleifera Lam. against adjuvant induced established arthritis in rats","authors":"S. Mahajan, A. Mehta","doi":"10.4314/NJNPM.V13I1.61580","DOIUrl":"https://doi.org/10.4314/NJNPM.V13I1.61580","url":null,"abstract":"Moringa oleifera Lam. (Moringacea) is cultivated through out India and is extensively used in Indian traditional medicine to treat different diseases. This study was carried out to explore relationship between oxidative stress and the inflammatory process, and extends more to investigate the effect of hydroalcoholic extract of leaves of Moringa oleifera Lam. (MOLE- a herbal remedy) in experimentally induced adjuvant-arthritis in Wistar rats. During the experimental period, body weight, paw edema volume (primary lesion), inflammation at noninjected sites of left hind paw and arthritic index (secondary lesion) were observed. On the 21st day, serum from each animal was used for estimation of Rheumatoid Factor (RF) value and levels cytokines like TNFa, IL-1, and IL-6. Whole blood was used for measurement of erythrocyte sedimentation rate (ESR). For assessment of oxidative stress liver homogenate was utilized. Histopathology of synovial joint of each rat present in each group was performed to measure degree of inflammation. Our results suggest that, percentage reduction in body weight was found to be less, paw edema volume; arthritic index score and ESR was found to be decreased significantly in drug treated groups as compared with diseased control animals. Serum levels of RF, TNFa, IL-1, and IL-6 also showed decreased levels as compared with those in the disease control group. In addition, treatment with MOLE altered oxidative stress in relation to its anti-inflammatory activity. Histopathological sections from animals present in drug treatment group’s showed improvement which was confirmed by mild or moderate inflammation, less infiltration of lymphocytes and less angiogenesis as compared with sections from arthritic animals. From the results of this study, it can be concluded that Moringa oleifera leaves possess some antiarthritic properties. Keywords: Moringa oleifera Lam; Leaves; Adjuvant arthritis; Cytokines","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"29 1","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2010-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88076015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Acute toxicities of diethyl ether and ethanol extracted Nerium indicum leaf to the fish, Heteropneustes fossilis 二乙醚和乙醇提取的凤尾草叶片对鱼类化石的急性毒性研究

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61604

M. Prasad, Abhishek Kumar, D. Mishra, Sl Srivastav, N. Suzuki, A. Srivastav

引用次数: 8

Studies on the chemical constituents, antioxidants and membrane stability activities of Hibiscus rosa sinensis 木槿化学成分、抗氧化剂及膜稳定性研究

Nigerian Journal of Natural Products and Medicine Pub Date : 2010-11-04 DOI: 10.4314/NJNPM.V13I1.61609

O. Falade, M. Aderogba, O.Kehinde, B. Akinpelu, B. O. Oyedapo, S. Adewusi

引用次数: 7

The Effect Of Cucumis Metuliferus E Meye (Cucurbitaceae) On Rat Gastric Functions And Mucosa Intergrity 黄瓜对大鼠胃功能和胃黏膜完整性的影响

Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45663

N. Wannang, S. Gyang, S. Omale, M. Dapar, N. Jimam, Chukwuma Samuel Anakwe

引用次数: 9

MORPHOANATOMICAL AND PHYSICO-CHEMICAL STUDIES OF ANNONA RETICULATA, A COMMON SUBSTITUTE FOR ANNONA SQUAMOSA 番荔枝常见替代品网纹番荔枝的形态解剖学和理化研究

Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45657

C. Kumar, D. Yadav, R. Patidar, P. Kumar, R. Lobo, MM Setty, S. Prabu, A. Shirwaikar

引用次数: 1