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Nigerian Journal of Natural Products and Medicine最新文献

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Immunomodulatory Activity Of Saponin Mixture Isolated From Lagenaria Siceraria Fruits 木槿花果实皂苷复合物的免疫调节活性研究
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45667
A. Gangwal, S. Parmar, Rb Mardia, N. Sheth
{"title":"Immunomodulatory Activity Of Saponin Mixture Isolated From Lagenaria Siceraria Fruits","authors":"A. Gangwal, S. Parmar, Rb Mardia, N. Sheth","doi":"10.4314/NJNPM.V12I1.45667","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45667","url":null,"abstract":"An attempt has been made to assess the immunomodulatory activity of purified saponin mixture (PSM) isolated from the fruits of Lagenaria siceraria at three dose levels ranging from 50-150 mg/kg body weight in mice using haemagglutination antibody (HA) titre, delayed type hypersensitivity (DTH) and carbon clearance parameters. PSM increased haemagglutination antibody titre and carbon clearance significantly but inhibited delayed type hypersensitivity response in a dose dependent manner. Thus, present study, for the first time, demonstrated the immunomodulatory activity of Lagenaria siceraria fruits.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79239383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The effect of dietary supplementation with Peperomia pellucida on body weight, serum lipids and glucose in normal and nutritionally induced hypercholesterolemia in rats. 饲粮中添加透明胡椒对正常和营养性高胆固醇血症大鼠体重、血脂和葡萄糖的影响。
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45668
A. Odetola, Cm Nwanne, Ga Mafoluko, Aa Oyagbemi
{"title":"The effect of dietary supplementation with Peperomia pellucida on body weight, serum lipids and glucose in normal and nutritionally induced hypercholesterolemia in rats.","authors":"A. Odetola, Cm Nwanne, Ga Mafoluko, Aa Oyagbemi","doi":"10.4314/NJNPM.V12I1.45668","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45668","url":null,"abstract":"This study was designed to investigate the hypolipidemic and hypoglycemic properties of Peperomia pellucida as dietary supplement in normal and cholesterol fed albino rats. The plant was administered at 10% and 20%(w/w) in the standard rat feed of rat feed containing 5% cholesterol, 2.5% groundnut oil and 0.5% cholic acid for 28 days. In the high cholesterol diet fed rats, Peperomia dietary supplementation caused a dose dependent and significant reduction (p<0.05) in weight gain when compared with the control. Serum cholesterol, triglycerides, LDL cholesterol and glucose that were elevated in the high cholesterol fed rats were significantly reduced (p<0.05) in high cholesterol plant supplemented feed groups. The HDL cholesterol that was depressed in the control was also elevated in the plant fed groups resulting in a higher HDL/LDL cholesterol ratio compared with the ratio in the control group. This property may be responsible for its ethnomedicinal use in alleviating cardiovascular diseases and diabetes.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86047874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hypoglycaemic And Alpha-Amylase Inhibitory Activities Of Fermented Seeds Of Parkia Biglobosa (Jacq) Benth 枇杷发酵种子降糖和α -淀粉酶抑制活性研究
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45672
A. Fred-Jaiyesimi, O. Olúbòmęhìn, R. Wilkins, Ko Abo
{"title":"Hypoglycaemic And Alpha-Amylase Inhibitory Activities Of Fermented Seeds Of Parkia Biglobosa (Jacq) Benth","authors":"A. Fred-Jaiyesimi, O. Olúbòmęhìn, R. Wilkins, Ko Abo","doi":"10.4314/NJNPM.V12I1.45672","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45672","url":null,"abstract":"Following our continuing search for plant anti-diabetic agents, we report results of a bioactivity-guided fractionation of fermented seeds of Parkia biglobosa used in ethnomedicine in South West Nigeria to manage diabetes mellitus. An active aqueous MeOH macerate was separated by solvent partition and the bioactive CHCl3 extract fractionated on column chromatography packed with silica gel G60A, eluting with gradient mixtures of Pet ether, EtOAC and MeOH.Biologically monitored separation of extracts was achieved using alloxan-diabetic rats, glucose loading (1g/kg) and alpha-amylase inhibition assays as basis for identification of active constituent. Peak reduction (48.5%, P<0.5) of blood glucose was observed after eight hours and the crude extract significantly reduced elevated cholesterol and protein levels after ten days of treatment. An alpha-amylase inhibitor (40mg, 64% inhibition, P < 0.05) was purified on prep. TLC and characterized by spectroscopy and co-chromatography with authentic sample. The inhibition of ?  – amylase was significant and comparable to acarbose. The significance of isolation of polyunsaturated fatty acids in the management of diabetes mellitus is discussed.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89834778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
α-Amyrin And β-Amyrin From The Seeds Of Zea Mays 玉米种子中的α-Amyrin和β-Amyrin
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45658
Ma Hossain, A. Das, P. Mohanta
{"title":"α-Amyrin And β-Amyrin From The Seeds Of Zea Mays","authors":"Ma Hossain, A. Das, P. Mohanta","doi":"10.4314/NJNPM.V12I1.45658","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45658","url":null,"abstract":"Two pentacyclic terpenoids, α-amyrin and β-amyrin were isolated from the petroleum spirit extract of methanolic extract of the seeds of Zea mays. The isolated pentacyclic terpenoids compounds was identified on the basis of UV, IR, 1H-NMR, 13C-NMR, COSY, DEPT 45, DEPT 90, DEPT 135 and mass spectral data.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79492144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacognostical Studies On Leaves And Stem Of Cocculus Hirsutus 毛毛球叶和茎的生药学研究
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45652
V. Satish, U. Gavani, P. Paarakh
{"title":"Pharmacognostical Studies On Leaves And Stem Of Cocculus Hirsutus","authors":"V. Satish, U. Gavani, P. Paarakh","doi":"10.4314/NJNPM.V12I1.45652","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45652","url":null,"abstract":"Pharmacognostical studies were carried out on the leaves and stem of Cocculus hirsutu s Linn, which showed covering trichomes, epidermal cells in leaf and fragments of fibres, sclerenchymatous tissues with xylem vessels in stem. Physicochemical parameters such as water, alcohol soluble extractive values were found to be 6.30 %, 13.10 % and 19 %, 8.60 % w/w for leaves and stem respectively. The total ash values, acid insoluble ash and water soluble ash were found to be 2.20 %, 0.40 %, 0.60 % and 5.2 %,0.60 %, 1.50 % w/w for leaves and stem respectively. The loss on drying was found to be 1.21 % and 1.30 % w/w for the leaves and stem respectively. The leaf constants such as stomatal index (6.50), vein islet number (3), vein termination number (5) and palisade ratio (4.9) were also determined.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74260504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viminalol From Orthosiphon Stamineus
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45659
Ma Hossain, Z. Ismail
{"title":"Viminalol From Orthosiphon Stamineus","authors":"Ma Hossain, Z. Ismail","doi":"10.4314/NJNPM.V12I1.45659","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45659","url":null,"abstract":"Viminalol and some known compound were isolated have been isolated from the leaves of Malaysian tropical medicinal plant of Orthosiphon stamineus. Viminalol was obtained for the first time from this plant. All the isolated compounds were identified on the basis of UV, IR, 1H-NMR, 13C-NMR, Dept 90 and 135o, cosy and mass spectral data.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72699016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect Of Ocimum Gratissimum (Ram Tulsi) On Sexual Behaviour In Male Mice 枸杞对雄性小鼠性行为的影响
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45653
Pande, K. Pathak
{"title":"The Effect Of Ocimum Gratissimum (Ram Tulsi) On Sexual Behaviour In Male Mice","authors":"Pande, K. Pathak","doi":"10.4314/NJNPM.V12I1.45653","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45653","url":null,"abstract":"The suspension of the extract of Ocimum gratissimum Linn. was administered orally at the dose of 100, 250, and 500 mg / kg body weight, to different groups of male rats (n = 6) once a day for seven days. The female Swiss Albino mice involved in mating were made receptive by hormonal treatment. The general mating behaviour, libido and potency were determined and compared with the standard reference drug sildenafil citrate. The probable gastric ulceration and adverse effects of the extract were also evaluated. Oral administration of the extract significantly increased the Mounting Frequency, Intromission Frequency; Intromission Latency, Erections as well as aggregate of penile reflexes and caused significant reduction in the Mounting Latency and Post Ejaculatory Interval. The most appreciable effect of the extract was observed at the dose of 500 mg/kg. The test drug was also found to be devoid of any conspicuous gastric ulceration and adverse effects. The results indicated that the ethanolic extract of Ocimum gratissimum produced a significant and sustained increase in the sexual activity of normal male mice. Thus, the resultant aphrodisiac effectivity of the extract lends support to the claims for its traditional usage in sexual disorders.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78260084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antimicrobial Activity Of Methanolic Extract And Oil Of Saussurea Costus Roots 木莲根甲醇提取物和精油的抑菌活性研究
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45675
M. Pandey, Manjul Singh, S. Rastogi, A. Rawat
{"title":"Antimicrobial Activity Of Methanolic Extract And Oil Of Saussurea Costus Roots","authors":"M. Pandey, Manjul Singh, S. Rastogi, A. Rawat","doi":"10.4314/NJNPM.V12I1.45675","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45675","url":null,"abstract":"The methanolic extract (SCE) as well as the essential oil (SCO) prepared from the roots of Saussurea costus (Falc.) Lipschitz, were tested for their antimicrobial activity against 14 G+ve and G-ve bacteria implicated in gastro-intestinal (GI), respiratory tract (RT) and urinary tract infections (UTI). Their effects were also compared to standard concentration of antibiotic erythromycin. The in vitro antibacterial activity was assessed qualitatively (by disc diffusion method) and quantitatively (by microdilution method). SCO exhibited better antimicrobial activities as compared with SCE. The GI pathogens viz. Shigella flexneri and Salmonella typhimurium were the strains most susceptible to the oil (strong inhibition zones 25-28 mm). SCO showed also had minimal inhibitory concentrations (MIC) ranging from 1.09-8.75 il/ml on 10 of the 14 pathogens tested. The overall results provide promising baseline information for the potential use of the oil from the roots of S. costus in the treatment of bacterial infections.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80568949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cytotoxicity Study Of Antioxidant Flavonoids From Bauhinia Tomentosa Leaf Extract 毛毛紫荆叶提取物抗氧化总黄酮的细胞毒性研究
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45670
M. Aderogba, L. McGaw, A. Ogundaini, J. Eloff
{"title":"Cytotoxicity Study Of Antioxidant Flavonoids From Bauhinia Tomentosa Leaf Extract","authors":"M. Aderogba, L. McGaw, A. Ogundaini, J. Eloff","doi":"10.4314/NJNPM.V12I1.45670","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45670","url":null,"abstract":"A 1, 1-diphenyl-2-picrylhydrazyl (DPPH) activity-guided fractionation procedure was used to isolate the antioxidant constituents of a 50% ethanol dried leaf extract of Bauhinia tomentosa. Four flavonol glycosides: kaempferol-7-O-rhamnoside (1), kaempferol-3-O-glucoside (2), quercetin-3-O-glucoside (3) and quercetin-3-Orutinoside (4) were isolated by accelerated gradient chromatography (AGC) and Sephadex LH-20 column chromatography. Compounds 1-3 are reported for the first time from this species. The structures of the compounds were established by spectroscopic methods (1H NMR, 13C NMR and MS). A DPPH spectrophotometric assay was employed to evaluate the antioxidant activity of the isolated compounds. Compound 3 had higher antioxidant activity than L-ascorbic acid while 1 and 4 similar and 2 lower activities. Compounds 2-4 were non-cytotoxic, but kaempferol-7-O-rhamnoside (compound 1) displayed slight cytotoxicity to bovine dermal cells (LC50 = 116.58 μg/ml) in the tetrazolium (MTT) based assay","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88625033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Effects of two in-organic fertilizers on volatile oil and biomass yields of Cymbopogon citratus (dc) stapf., in ile-ife, Nigeria 两种无机肥料对香茅挥发油和生物量产量的影响。在尼日利亚的ile-ife
Nigerian Journal of Natural Products and Medicine Pub Date : 2009-09-03 DOI: 10.4314/NJNPM.V12I1.45654
A. Oladele, S. Adesanya, O. Omobuwajo
{"title":"Effects of two in-organic fertilizers on volatile oil and biomass yields of Cymbopogon citratus (dc) stapf., in ile-ife, Nigeria","authors":"A. Oladele, S. Adesanya, O. Omobuwajo","doi":"10.4314/NJNPM.V12I1.45654","DOIUrl":"https://doi.org/10.4314/NJNPM.V12I1.45654","url":null,"abstract":"Cymbopogon citratus (DC) Stapf (Poaceae) was cultivated in a randomized completely block design experiment, (RCBD) in Ile-Ife, Nigeria. Effects of two inorganic fertilizers on the oil yield and biomass production were evaluated. NPK (4.63ml/kg and 3.91ml/kg at 12 and 24 weeks respectively) application leads to higher oil yield than Urea (4.40ml/kg and 4.09ml/kg at 12 and 24 weeks respectively, while. NPK (2.49kg/6.48m2, 8.36kg/6.48m2 at 12 and 24 weeks respectively) application gave a higher biomass than Urea (1.91kg/6.48m2, 5.68kg/6.48m2 at 12 and 24 weeks respectively).","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87074333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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