Nigerian Journal of Natural Products and Medicine最新文献

{"title":"Review of the use ethnobotanicals in the treatment of skin infections","authors":"Idayat Titilayo Gbadamosi, M. Faniyan","doi":"10.4314/njnpm.v20i1.21","DOIUrl":"https://doi.org/10.4314/njnpm.v20i1.21","url":null,"abstract":"Skin problems are common in most of the tribal inhabitants and are caused by infections, over-exposure to sunlight, toxicity, parasites, unclean water and even stress. Infectious skin diseases are primarily categorized as bacterial, fungal, viral or parasitic diseases. Skin diseases occur all over the world, but are more prevalent in tropical regions and it is commonly observed in children, young adults and aged people. Globally, the prevalence studies in children documented the occurrence of skin diseases to be ranging from 21% to 87%. Socio-economic impacts of skin infections include poverty, joblessness, severe disability for work and limited life quality. High cost of orthodox antibiotics, resistance of microorganisms to the drugs and undesirable side effects of some antibiotics have led to the search for medicinal plants with plausible therapeutic effect in the management of skin infections. Plants have also been found to be less toxic, potent, readily available and affordable. Several medicinal plants have been used to manage skin infections in the traditional medicinal systems of many cultures worldwide. The present review gives information on the prevalence of skin infections, ethnobotanical survey reports of plants used in the management of skin infections and the pharmacological activities of the plants. The pharmacological activities of these plants include antibacterial, antifungal, anti-viral and anti-inflammatory properties. The present review constitutes a resource material which can engender further scientific investigation in the potential discovery of new natural bioactive compounds with antimicrobial effects on skin diseases. Keywords: Skin infections, Prevalence, Anti-infective plants, Pharmacological activity, Indigenous Knowledge","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"66 1","pages":"128-139"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82231113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploitation of petiole, nodal segment, bulbil and tuber anatomy for species identification in Dioscorea Linn. species from Oyo and Ekiti states- southwestern Nigeria","authors":"A. Adeniran, M. Sonibare","doi":"10.4314/NJNPM.V20I0.8","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I0.8","url":null,"abstract":"Herb sellers and Traditional Medical Practitioners often substitute D. hirtiflora, cultivars of D. bulbifera and D. dumetorum with closely related cultivars within species during herbal preparations. This practice, which may be as a result of mis-identification, may be very injurious to users of herbal products. The present study investigated anatomical characters of three wild and edible species of Dioscorea used in ethnomedicine in Southwestern Nigeria with a view to aiding species identification. Thin sections of the median petiole and nodal segments were prepared using free hand sectioning. Bulbils and tubers stored in 50% ethanol were sectioned at 5 μm with the aid of a sledge microtome. Sections were stained in Safranin O solution for 2-10 min while sections from bulbils of D. hirtiflora were counter stained with toluidine for 1 min and mounted with glycerol. All slides were examined under the light microscope at x100 and x400 magnifications and photos were taken using digital camera mounted on Zenith Ultra-500 A light microscope. Petiole and nodal segments anatomy showed six and nine vascular bundles, respectively in D. hirtiflora, whereas eight and eleven bundles were observed in D. dumetorum and D. bulbifera. Petioles of D. hirtiflora and D. dumetorum were profusely surrounded with stellate and simple unicellular trichomes. Parenchyma cells in wild D. dumetorum were beaded, while they were not in the edible cultivar. Generally, scattered vascular bundles, layers of collenchymas cells, and dilated parenchyma cells filled with tannins were observed in the bulbils/tubers of all species. Anatomical characters in the selected Dioscorea species are taxonomically significant for species identification and could serve as diagnostic taxonomic tools for their standardization.Keywords: Anatomy, Dioscorea spp., Identification, Medicinal application","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"24 1","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78446226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary black pepper (Piper nigrum) on gut ecosystem and blood profile of broiler chickens under production conditions","authors":"E. Ndelekwute, E. Assam, P. C. Ekere","doi":"10.4314/NJNPM.V20I1.4","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I1.4","url":null,"abstract":"Effect of dietary black pepper (BP) on the digseta pH, viscosity, bacteria population, and blood profile of broilers was investigated. 150 Abor-acre day old chicks were used. Five diets (BP1-BP5) containing respectively 0.00, 0.25, 0.50, 0.75 and 1.0% BP were formulated. BP1 was the control containing no BP. Each treatment was replicated thrice each having 10 birds arranged in completely randomized design. Feed and water were given ad libitum for 7 weeks. Results indicated that BP increased (P 0.05) differences in urea and creatinine. BP reduced pH in crop and gizzard, while all the levels reduced viscosity. Bacteria population was not reduced in the crop (P>0.05). In gizzard, staphylococcus was reduced by 0.75 and 1.0%. In duodenum, ileum, and caecum , above 0.25%, number of bacteria was reduced. No significant difference was observed in large intestine. In conclusion, BP could be used to improve the well being of broilers but should not be used above 0.50%. Keywords: bacteria population, black pepper, blood profile, broilers, digesta viscosity","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"1 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83118529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical survey of tree species used for wound healing in Ibadan, southwest Nigeria","authors":"B. Rafiu, M. Sonibare","doi":"10.4314/NJNPM.V20I1.16","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I1.16","url":null,"abstract":"The disruption of cells and tissues at the sites of injury leads to varying degrees of wounds, which can be as a result of the physical, chemical, microbiological or immunological process. The present study reports the findings from an ethnobotanical survey of three Local Government areas (LGAs) in Ibadan, Oyo State in Southwest Nigeria, carried out to document tree species and plant parts used in the treatment of wound and related skin disorders. Semi-structured questionnaires were used to interview the herb sellers, traditional medical practitioners, and some elders in the study area comprising of Ibadan North, Ibadan Southeast and Ibadan Northwest LGAs. Eighty-five respondents were questioned on their knowledge of skin diseases and wound care management. Seventy-one plants out of which sixty-five were tree species belonging to thirty angiosperm families were identified as plant species used for the treatment of wound and related skin disorders. Some of the most frequently used tree species mentioned by the respondents are: Khaya grandifoliola  C. D. C., Vitellaria paradoxa C.F. Gaertn., Xylopia aethiopica (Dunal) A. Rich, Kigelia africana (Lam.) Benth., Bombax buonopozense P. Beauv.,  Terminalia glauscescens Planch. ex Benth. and Lophira alata Banks ex Gaertn. The most frequently mentioned family is Fabaceae, followed by Meliaceae and Annonaceae. Stem barks were predominant in the prescription. Preparations including two or more plant species were common. However, in some cases, prescriptions were in powder form. The mode of preparation and dosages are presented in this paper. The results of this study revealed many tree species used to treat wounds and skin disorders in the three Local Government Areas surveyed in Ibadan, Southwest Nigeria. Keywords: Wound healing, ethnobotanical survey, tree species, medicinal uses, conservation","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"26 1","pages":"96-104"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81328241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salubrious effect of Parinari curatellifolia seed extract in doxorubicin intoxicated rats","authors":"O. Crown, M. Olaleye, A. Akinmoladun, A. Akindahunsi","doi":"10.4314/NJNPM.V20I1.13","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I1.13","url":null,"abstract":"The seed of Parinari curatellifolia Ex Benth (Chrysobalanaceae) is widely used in Southwestern Nigeria for the treatment of diabetes and hypertension, important cardiovascular disease (CVD) risk factors. This study was designed to investigate the effect of Parinari curatellifolia seed extract (PCE) on the antioxidant status, lipid profile and cardiac health in doxorubicin (DOX) induced cardiotoxicity. Phenolic profile of the extract was determined by high performance liquid chromatography-diode array detector (HPLC-DAD). Male Wistar rats were divided into seven groups that were pretreated with ramipril (10 mg/kg) or PCE (50-, 100-, 150- and 200 mg/kg) orally for two weeks. On the 13 th day, single dose of (15 mg/kg i.p ) DOX was administered to all the groups except control. Antioxidant parameters (superoxide dismutase {SOD}, glutathione peroxidase {GPx}, glutathione transferase {GT}, reduced glutathione {GSH}, thiobarbituric reacting substance {TBARS}), cholesterol, triglycerides, low density lipoprotein (LDL) and high density lipoprotein (HDL); lactate dehydrogenase (LDH) and creatine kinase (CK-MB) were evaluated in cardiac tissue homogenate or plasma. Catechin, epicatechin, quercetin, isoquercitrin, rutin, kaempferol and quercitrin were confirmed present in PCE. DOX intoxication in experimental rats resulted in significant increase (P<0.05) in plasma activities of LDH and CK-MB, concentrations of all lipid types, except HDL which was significantly (P<0.05) reduced, as well as the tissue level of TBARS as compared with control. In addition, activities of the antioxidant enzymes (SOD, GT and GPx) were reduced (P<0.05) in the DOX intoxicated group. However, pretreatment with PCE significantly ameliorated the alterations caused by doxorubicin. PCE protected against doxorubicin-induced cardiotoxicity in rats possibly through positive modulation of the cardiac antioxidant defense system and amelioration of dyslipidemia by the constituent flavonols. Keywords: Parinari curatellifolia , cardiotoxicity, Doxorubicin, antioxidant, phenolic compounds, dyslipidemia","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"21 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78876194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity study on the methanol fruit extract of Solanum anomalum in albino wistar rats","authors":"B. Abubakar, A. Zezi, M. Bisalla","doi":"10.4314/NJNPM.V20I1.18","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I1.18","url":null,"abstract":"The study investigated the acute and sub-acute effects of methanolic fruit extract of Solanum anomalum in Wistar rats. Extraction of the powdered fruit was accomplished using 80% v/v methanol. The oral and intraperitoneal acute toxicity studies (LD 50 ) were evaluated using Lorke’s method. Sub-acute toxicity test was conducted by administering graded doses of the extract and distilled water for 15 days. Thereafter the animals were sacrificed and their blood samples were examined for changes in haematological parameters and serum biochemical parameters. The livers, kidneys, hearts and spleens were weighed to determine the relative organ body ratios. The organs were then fixed in 10% formalin and prepared for histopathological examination. The oral LD 50 was found to be above 5,000 mg/kg while the intraperitoneal LD 50 was calculated to be approximately 1,150 mg/kg showing that the extract is relatively safe orally in rats. The relative organ body weight of the animals that were administered graded doses of the extract showed no statistical significant difference when compared to the group that received distilled water as control. Also, the haematological and serum biochemical parameters showed no statistical significant difference among all the groups but the histopathological analysis of the liver and spleen revealed slight haemosiderosis on the spleen at the dose of 2,000 mg/kg. Also, the liver revealed slight congestion of the central vein at the dose of 2,000 mg/kg. The histology of the heart and kidney was normal at all doses. In conclusion, methanol extract of S. anomalum fruit is not toxic up to 1,000 mg/kg in rats. Keywords: LD 50 , Solanum anomalum , haemosiderosis, haematology, serum biochemistry, histopathology","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"34 1","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73983991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-sickling activities of the stem bark of three Khaya species found in Nigeria: K. senegalensis A. Juss., K. grandifoliola , (Welw) CDC., and K. ivorensis A. Chev.","authors":"O. A. Oyedapo, J. Agbedahunsi, C. Cyril-Olutayo","doi":"10.4314/njnpm.v20i1.24","DOIUrl":"https://doi.org/10.4314/njnpm.v20i1.24","url":null,"abstract":"According to the World Health Organization (WHO), at least 100,000 babies die from sickle cell disorder (SCD) in Nigeria every year, making it the highest sickle-cell endemic country in Africa. WHO also stated that over 500,000 babies with severe forms of sickle cell disorder are born worldwide, with majority in low and middle income countries. There has been no cure for this disease, even after over a century of research into this disorder. Sickle cell disease is managed by the traditional medical practitioner using medicinal plants or herbs especially in the developing countries among the lower economic strata of the population and one of such herbs used is Khaya species which are generally called Mahogany in English and Oganwo by the Yoruba speaking people of Nigeria. Three species are found along the Western African region and they are Khaya senegalensis (KS), Khaya grandifoliola (KG) and Khaya ivorensis (KI). Therefore, in this study the in vitro activities of the cold and hot extracts of the stem barks of the three Khaya species used in the management of SCD were evaluated using standard anti-sickling methods of inhibitory and reversal of sickled red blood cells. Sodium metabisulphite (2%) was used to induce sickling while vanillic acid and p-hydroxyl benzoic acid were used as positive controls. The three species of Khaya ( KS, KG and KI) stem barks showed antisickling activities for inhibition against sickling of red blood cell (RBC) 51.77% ± 1.47, 65.55% ± 1.65, 80.71% ± 2.93 and reversal of sickled red blood cell 44.95% ± 2.00, 43.28% ± 2.80, 41.61% ± 1.22 respectively and could be recommended for further development into herbal remedy in the management of sickle cell disease.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"48 1","pages":"161-166"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73912675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical detection of cysteine-rich circular petides in selected tropical Violaceae and Moringaceae families using modified G-250 and mass spectrometry","authors":"A. Attah, M. Sonibare, J. Moody","doi":"10.4314/NJNPM.V20I1.15","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I1.15","url":null,"abstract":"Cysteine-rich circular peptides (CRCs) comprise a large family of gene encoded and low molecular weight polypeptides that has recently engaged the attention of scientists. This class of peptides exhibit a continuous circular configuration and a cystine knot backbone, which defines their resilient nature-directed structural design. Many CRCs have been reported in medicinal plants the first of which is kalata B1 cyclotide from the traditional African plant Oldenlandia affinis . Their detection and isolation can be very challenging and evasive. Only about 1% of plant species have so far been reportedly screened. A modified preliminary chemo-microscopic/macroscopic method involving the use of G-250 stain was applied followed by thin layer chromatographic protosite reaction for plant selection. This was followed by the Matrix Assisted Laser Desorption Time of Flight (MALDI-TOF) Mass spectrometry guided experiment for cyclotide discovery. The blue colouration produced upon sample reaction with modified G-250 led to the selection of potential circular peptide containing plant samples. A further MALDI-TOF MS-guided screening resulted in the detection of circular peptides and cyclotides in Moringa oleifera, Rinorea dentata, R. oblongifolia and R. brachypatela . Viola odorata and Viola tricolor (positive controls) indicated the presence of cyclotides. Results from this study can serve as proof-of-concept for plant selection based on preliminary cysteine-rich circular peptide detection in plants especially with the use of G-250 stain. Keywords: Cysteine-rich Cyclotides, Violaceae, Moringaceae, TLC, Microscopy, MALDI-TOF MS","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"7 1","pages":"88-95"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87542737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognostic evaluation of the leaves and stem-bark of Commiphora africana (A. Rich) Engl. (Burseraceae)","authors":"A. Nuhu, U. Danmalam, N. Ilyas, A. M. Zakariya, Z. Abdulhamid, A. Abubakar","doi":"10.4314/njnpm.v20i1.10","DOIUrl":"https://doi.org/10.4314/njnpm.v20i1.10","url":null,"abstract":"The study establishes some important pharmacognostic profile of Commiphora africana leaf and stem-bark with the hope of assisting in its proper identification as well as standardization for quality and sample purity. Evaluation of the fresh, powdered and anatomical sections of the leaves and stem bark were carried out to determine the macromorphological, micromorphological, chemomicroscopic and some physicochemical parameters. Macroscopical studies indicated presence of leaf with trifoliate arrangement, crenate margin with ovate shape, acute apex, cuneate base, petiolate with pinnate venation. The microscopy revealed the dorsiventral nature of the leaf and was observed to be hypostomatic with anomocytic type of stomata, with numerous unicellular covering and glandular trichomes on the abaxial surface. Chemomicroscopic characters present include; lignin, starch, cellulose, tannin, suberin and calcium oxalate crystals. The physicochemical parameters evaluated include moisture contents (8.1%), total ash value (9.3%), water soluble ash (5.5%), acid insoluble ash (3.2%), ethanol extractive values (22.3%) and water extractive values (19.0%). For quantitative leaf microscopy, on the average, stomatal number (38.0) and index (25.0), palisade ratio (11.7), vein termination numbers (5.7) and vein islets (1.3). The microscopy of stem bark revealed some prominent features like the cork, prism types and microcrystal of calcium oxalate crystals, fibres, phloem parenchyma cells, secretion canal and medullary ray. The physicochemical parameters evaluated include moisture contents (8.6%), total ash value (11.3%), water soluble ash (7.0%), acid insoluble ash (2.7%), ethanol extractive values (12.3%) and water extractive values (9.3%). Keywords: Commiphora africana, Macroscopic, Microscopic, Physicochemical parameters","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"32 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89579532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The larvicidal activities of three Jatropha species against Aedes aegypti mosquito","authors":"F. Famuyiwa, A. A. Ajiboye, O. Ayoola","doi":"10.4314/NJNPM.V20I1.17","DOIUrl":"https://doi.org/10.4314/NJNPM.V20I1.17","url":null,"abstract":"Jatropha curcas L., Jatropha gossipifolia L. and Jatropha multifida L. belong to the family Euphorbiaceae. There had been contradictory reports of the larvicidal potential of the Jatrophas and there was no report of the isolation of the larvicidal compound(s). The present study therefore reports the larvicidal activities of the petroleum ether, ethylacetate and methanol extracts of the leaves and stem barks of the three plants and the column chromatographic fractions of the petroleum ether extract of J. gossipifolia stem bark against the larvae of Aedes aegypti mosquito, the vector of dengue and yellow fevers. The methanol extract of J. curcas (LC 50 , LC 90 1.70 ± 0.03, 3.23 ± 0.07 mg/mL), the petroleum ether extracts of J. multifida (LC 50 , LC 90 1.96 ± 0.01, 3.50 ± 0.02 mg/mL) and J. gossipifolia (LC 50 , LC 90 1.58 ± 0.02, 3.02 ± 0.03 mg/mL) stem barks demonstrated high activities against the fourth instar larvae o f A. aegypti at 48 hours. Efforts are on-going to isolate the active compounds from the two active column fractions of J. gossipifolia stem bark. Keywords: Jatropha species, Aedes aegypti , purification, Yellow fever, Dengue fever","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"349 1","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75382593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}