Nutrition in Clinical Practice最新文献

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Analysis of factors driving variations in neonatal parenteral nutrition over a decade: A retrospective study. 十年来新生儿肠外营养变化的驱动因素分析:一项回顾性研究。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-05-10 DOI: 10.1002/ncp.70134
Thanaphong Phongpreecha, Lucas W Y Sin, Shabnam Gaskari, Nima Aghaeepour
{"title":"Analysis of factors driving variations in neonatal parenteral nutrition over a decade: A retrospective study.","authors":"Thanaphong Phongpreecha, Lucas W Y Sin, Shabnam Gaskari, Nima Aghaeepour","doi":"10.1002/ncp.70134","DOIUrl":"10.1002/ncp.70134","url":null,"abstract":"<p><strong>Background: </strong>Parenteral nutrition (PN) is essential for supporting preterm and critically ill neonates who are unable to tolerate adequate enteral feeds. However, PN composition remains highly variable due to differences in guidelines, institutional practices, prescriber discretion, and more. This lack of standardization contributes to inconsistent nutrient delivery and may affect clinical outcomes. A deeper understanding of the sources of variation is needed to inform efforts toward more consistent and evidence-aligned prescribing.</p><p><strong>Methods: </strong>This retrospective study analyzed 54,464 neonatal PN prescriptions issued between 2011 and 2021 to 5052 infants. Patient demographics, prescriber identifiers, and prescription year were linked through electronic health records. Temporal trends in nutrient composition were evaluated using linear mixed-effects models, with covariate adjustment. Dimensionality reduction with t-distributed Stochastic Neighbor Embedding (t-SNE) was applied to visualize temporal clustering of prescriptions and prescriber-level similarity in dosing patterns.</p><p><strong>Results: </strong>PN composition demonstrated clear temporal variability across the decade. Macronutrient shifts diminished after adjusting for patient demographics, indicating that changes were primarily driven by shifts in the NICU population. In contrast, most micronutrients retained significant year effects. Variance partitioning revealed that prescriber identity explained substantially more variability than prescription year for nearly all electrolytes. Guideline updates also shaped certain changes, such as Selenium, which shifted in line with a specific update rather than prescriber preference.</p><p><strong>Conclusion: </strong>Neonatal PN is influenced by multiple factors, with prescriber-level differences emerging as a dominant driver for micronutrients. These findings highlight the need for targeted standardization efforts that reduce unnecessary heterogeneity while preserving flexibility for clinical judgment.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1457-1465"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of combined supplementation of vitamins A/D/K1/K2 on the growth and development of preterm infants: A randomized controlled trial. 联合补充维生素A/D/K1/K2对早产儿生长发育的影响:一项随机对照试验
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-05-13 DOI: 10.1002/ncp.70132
Yuanyuan Ding, Huiyan Du
{"title":"Efficacy of combined supplementation of vitamins A/D/K1/K2 on the growth and development of preterm infants: A randomized controlled trial.","authors":"Yuanyuan Ding, Huiyan Du","doi":"10.1002/ncp.70132","DOIUrl":"10.1002/ncp.70132","url":null,"abstract":"<p><strong>Objective: </strong>This study elucidates the effects of additional supplementation of vitamins A and K2 on skeletal development and growth in preterm infants.</p><p><strong>Methods: </strong>This study was a single-center, single-blind, randomized controlled trial. Eighty-six preterm infants were randomized into the control group (who received vitamin D 400 IU/day and K1 20 μg/day) and intervention group (who additionally received vitamin A 1500 IU/day and K2 (MK-7) 50 μg/day for 12 months). Bone mineral density (BMD), height standard deviation score (HtSDS), serum vitamin levels, and adverse events were assessed.</p><p><strong>Results: </strong>After 12 months, the intervention group had higher lumbar spine and femur BMD, greater HtSDS, and higher serum vitamin A, D, K1, K2, and 25-OH-D levels, with statistically significant differences (all P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between groups (P > 0.05).</p><p><strong>Conclusion: </strong>Supplementing vitamins A and K2 alongside routine vitamin D/K1 was associated with significant improvements in skeletal maturity, bone mineral density, and micronutrient status in preterm infants, without affecting safety.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1491-1502"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing It Right theory-based staged video education for patients on home enteral nutrition: A randomized controlled trial. 基于时机正确理论的患者家庭肠内营养分期视频教育:一项随机对照试验。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-06-29 DOI: 10.1002/ncp.70142
Yuanyuan Li, Meng Liu, Yang Yang, Dongmei Zhu, Juan Ni, Chulin Chen
{"title":"Timing It Right theory-based staged video education for patients on home enteral nutrition: A randomized controlled trial.","authors":"Yuanyuan Li, Meng Liu, Yang Yang, Dongmei Zhu, Juan Ni, Chulin Chen","doi":"10.1002/ncp.70142","DOIUrl":"10.1002/ncp.70142","url":null,"abstract":"<p><strong>Background: </strong>Home enteral nutrition (HEN) is life-sustaining but poses long-term management challenges. One-time discharge education often fails to meet patients' evolving post-discharge needs. Video support offers a promising solution, yet its application in HEN rarely rests on a theoretical foundation to guide when and how support is delivered.</p><p><strong>Methods: </strong>This prospective, two-arm randomized controlled trial randomly assigned 100 eligible patients in a 1:1 ratio to Timing It Right (TIR)-based staged video education (intervention) or video access at discharge (control). Outcomes (quality of life as the primary outcome; anxiety, depression, functional status, patient satisfaction, complications, readmissions as secondary outcomes) were assessed at baseline, 1 and 3 months. Data were analyzed with generalized estimating equations.</p><p><strong>Results: </strong>The intervention group demonstrated significantly greater improvements in functional status (KPS) and reductions in anxiety (SAS) and depression (SDS) scores over time compared with the control group (all P ≤ 0.001), as well as an improvement in patient satisfaction (PSQ-18, P < 0.05). No significant differences were found in quality of life (NutriQoL), readmission rates, or complication incidence. Video engagement data indicated high interest in self-management and complication content.</p><p><strong>Conclusion: </strong>A TIR-based staged video intervention is feasible and effective for improving key patient-centered outcomes in HEN. Tailored information at critical post-discharge timepoints addresses evolving needs. Future research should include multicenter trials with longer follow-up and integrate multidimensional support to enhance quality of life.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1360-1374"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary beliefs, barriers, and acceptability of diet in adult patients with inflammatory bowel disease-A multicenter survey of the Asia-Pacific region. 炎症性肠病成年患者的饮食观念、障碍和可接受性——亚太地区的一项多中心调查
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-07-25 DOI: 10.1002/ncp.70158
Shu Wen Tay, Shu-Chen Wei, Hilmi Ida, Nur Nasyitah Binte Mohamed Salim, Rupert Leong, Webber Pak Wo Chan, Justin Wen Hao Leong, Xiaohui Xin, Khoon Lin Ling, Wee Chian Lim, Osamah Al-Obaidi, Chin Kimg Tan, Tze Tong Tey, Yi Yuan Tan, Zhi Hao Yan, Thomson Chong Teik Lim, Choon Jin Ooi, Kelvin Thia, Shim Hang Hock, Juanda Leo Hartono, David Ong, Malcolm Teck Kiang Tan, Ennaliza Salazar
{"title":"Dietary beliefs, barriers, and acceptability of diet in adult patients with inflammatory bowel disease-A multicenter survey of the Asia-Pacific region.","authors":"Shu Wen Tay, Shu-Chen Wei, Hilmi Ida, Nur Nasyitah Binte Mohamed Salim, Rupert Leong, Webber Pak Wo Chan, Justin Wen Hao Leong, Xiaohui Xin, Khoon Lin Ling, Wee Chian Lim, Osamah Al-Obaidi, Chin Kimg Tan, Tze Tong Tey, Yi Yuan Tan, Zhi Hao Yan, Thomson Chong Teik Lim, Choon Jin Ooi, Kelvin Thia, Shim Hang Hock, Juanda Leo Hartono, David Ong, Malcolm Teck Kiang Tan, Ennaliza Salazar","doi":"10.1002/ncp.70158","DOIUrl":"10.1002/ncp.70158","url":null,"abstract":"<p><strong>Background: </strong>Dietary interventions can serve as an alternative or adjunct to pharmacological intervention in inflammatory bowel disease (IBD). This study aimed to investigate various dietary beliefs, barriers and acceptability of diet among IBD patients.</p><p><strong>Methods: </strong>A multicenter, cross-sectional survey was conducted across four Asia-Pacific countries. An anonymized online questionnaire was distributed through 10 participating IBD centers. Respondents rated the acceptability of IBD-related diets using a five-point Likert scale, with a score of 4 or more indicating acceptability.</p><p><strong>Results: </strong>A total of 567 responses were received from 56.2% patients with Crohn's disease, and 42.5% with disease duration exceeding 10 years. While only 40.6% believed diet contributes to IBD causation, 80.2% avoided certain food during disease relapse. Respondents receiving advice from friends, family or acquaintances were more likely to avoid certain food during relapse (P < 0.01) and attempt therapeutic diets (P < 0.01) than those who were advised by healthcare professionals. Although many respondents modified diet during flares (46.4%), long term adherence remained low across most dietary patterns (24.4%). Key barriers included difficulties in meal preparation (46.0%) and social interference (42.9%). Respondents prioritized dietary effectiveness in symptom control (77.2%) and ease of meal preparation (69.6%). Low-fiber and Mediterranean diets were most acceptable, whereas exclusive enteral nutrition was least acceptable.</p><p><strong>Conclusion: </strong>Dietary choices are influenced by ease of preparation and social factors. A reliance on non-professional advice highlights an opportunity to strengthen clinician-patient communication around dietary modifications. Tailored, culturally sensitive dietary strategies may enhance adherence and acceptability in a diverse population, factors that are important when evaluating the role of dietary interventions in IBD management.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1375-1384"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Breathing and balance: Clinical insights and management strategies of respiratory acid-base disorders". 对“呼吸与平衡:呼吸酸碱失调的临床洞察与管理策略”的修正。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-07-13 DOI: 10.1002/ncp.70154
{"title":"Correction to \"Breathing and balance: Clinical insights and management strategies of respiratory acid-base disorders\".","authors":"","doi":"10.1002/ncp.70154","DOIUrl":"10.1002/ncp.70154","url":null,"abstract":"","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1521"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the reliability of current neonatal malnutrition indicators in diagnosis: An analysis of a retrospective cohort. 评价当前新生儿营养不良诊断指标的可靠性:回顾性队列分析。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-07-26 DOI: 10.1002/ncp.70157
Stephanie Merlino Barr, Rosa K Hand, Marc Collin, Thomas E Love, Sharon Groh-Wargo
{"title":"Evaluation of the reliability of current neonatal malnutrition indicators in diagnosis: An analysis of a retrospective cohort.","authors":"Stephanie Merlino Barr, Rosa K Hand, Marc Collin, Thomas E Love, Sharon Groh-Wargo","doi":"10.1002/ncp.70157","DOIUrl":"10.1002/ncp.70157","url":null,"abstract":"<p><strong>Background: </strong>Proposed diagnostic criteria for neonatal malnutrition have not been validated. The objective of this study was to evaluate the reliability of the 2018 neonatal malnutrition criteria for identifying malnutrition in preterm infants.</p><p><strong>Methods: </strong>A retrospective study of premature infants admitted to a level III neonatal intensive care unit from 2013 to 2022 was performed. Malnutrition diagnoses were assigned using each indicator. Weight and linear growth velocities were defined using the preferred approach (maintaining z-score on Fenton growth chart) and generalized growth goals (weight: 15-20 g/kg/day for infants <2000 g, 20-30 g/day for infants ≥2000 g, length: 1 cm/week). Kappa (k) values assessed the inter-indicator reliability of the full criteria and the inter-indicator and intra-indicator reliability of individual malnutrition criteria. Acceptable reliability was defined as k > 0.8.</p><p><strong>Results: </strong>This study included 2305 infants. The 2018 neonatal malnutrition criteria had poor inter-indicator reliability for diagnosis in the first 2 weeks of life (k = 0.054) and after the first 2 weeks (k = 0.087). Inter-indicator reliability varied but was better among growth-based indicators. Intra-indicator reliability was strong for weight gain velocity definitions (k values ranging from 0.86 to 0.94), but poor for linear growth definitions (k = 0.12).</p><p><strong>Conclusion: </strong>Proposed neonatal malnutrition criteria have poor reliability when all indicators are used and limited reliability at the individual indicator level. Utilization of generalized weight gain goals may be appropriate for malnutrition diagnosis, but the generalized linear growth goal of 1 cm/week is not. Differing patterns in malnutrition diagnoses should be investigated for clinical significance. Redevelopment of current indicators is likely warranted.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1445-1456"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of sarcopenia in patients with Takayasu arteritis: A cross-sectional observational study. 高须动脉炎患者肌肉减少的评估:一项前瞻性横断面观察性研究。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-07-01 DOI: 10.1002/ncp.70144
Zeynep Dilara Selcuk, Busra Can, Nurdan Senturk-Durmus, Asli Tufan, Haner Direskeneli, Fatma Alibaz-Oner
{"title":"Assessment of sarcopenia in patients with Takayasu arteritis: A cross-sectional observational study.","authors":"Zeynep Dilara Selcuk, Busra Can, Nurdan Senturk-Durmus, Asli Tufan, Haner Direskeneli, Fatma Alibaz-Oner","doi":"10.1002/ncp.70144","DOIUrl":"10.1002/ncp.70144","url":null,"abstract":"<p><strong>Background: </strong>We aimed to evaluate muscle mass, muscle function, and sarcopenia prevalence in patients with Takayasu arteritis (TAK), and to explore associations with disease activity and vascular involvement.</p><p><strong>Methods: </strong>A total of 103 TAK patients and 75 age- and sex-matched healthy controls (HC) were included. The muscle strength of the participants was assessed using handgrip and chair-stand tests, while muscle mass was evaluated through two separate measurement methods: bioelectrical impedance analysis (BIA) and ultrasonography (US). For US measurement, the quadriceps and the biceps muscle were measured. Prevalence of sarcopenia was defined using the updated European Working Group on Sarcopenia in Older People (EWGSOP2) and International Society of Physical and Rehabilitation Medicine (ISarcoPRM) algorithm. Probable, confirmed and severe sarcopenia were collectively categorized as sarcopenia.</p><p><strong>Results: </strong>Sarcopenia prevalence was 29.1% in TAK and 12% in HC by ISarcoPRM (P < 0.001), and 59.2% versus 26.7% by EWGSOP2 (P < 0.001). Agreement between the EWGSOP2 and ISarcoPRM definitions for sarcopenia were poor (P = 0.062, ĸ = 0.153). No difference in BIA-based muscle mass was observed between the TAK and HC groups; however, quadriceps muscle thickness (MT) and Sarcopenia Thigh Adjusted Ratio (STAR) index were significantly lower in TAK (P < 0.001).</p><p><strong>Conclusion: </strong>This first study of sarcopenia in TAK shows that the prevalence of sarcopenia is higher in TAK compared with HC. US-based measurements were more sensitive than BIA, suggesting US may be a practical screening tool in TAK, detecting regional changes due to combined systemic inflammation and vasculitic arterial involvement.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1433-1444"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of GLP-1 receptor agonist on nutrient intake: A narrative review. GLP-1受体激动剂对营养摄入的影响:综述。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-10-01 Epub Date: 2026-09-17 DOI: 10.1002/ncp.70172
Ken Fujioka
{"title":"Effect of GLP-1 receptor agonist on nutrient intake: A narrative review.","authors":"Ken Fujioka","doi":"10.1002/ncp.70172","DOIUrl":"10.1002/ncp.70172","url":null,"abstract":"<p><p>Humans have a primitive defense mechanism called metabolic adaptation that slows voluntary weight loss. It works by downregulating hormones that reduce food intake and by lowering the metabolic rate. Second-generation GLP-1 receptor agonists, such as semaglutide or tirzepatide, promote weight loss by targeting this hormonal system to control appetite. Appetite can be divided into hunger, satiety, satiation, and reward eating. This review will examine how GLP-1 receptor agonists and newer satiety hormone agonists influence appetite and its components. Research indicates that these new satiety hormone agonists significantly reduce meal size and may decrease overall water intake. Additionally, the choice of highly palatable foods is affected and may extend to alcohol consumption. Clinicians need to understand how these new drugs affect food intake to counsel patients effectively. Most patients will experience gastrointestinal side effects, which can often be managed with dietary adjustments. Other clinical issues stemming from the substantial decrease in food intake will also need to be monitored. Loss of lean tissue, including bone and muscle, has been reported. Clinicians can adjust dosing of these medications but will need to make nutritional adjustments to help mitigate these effects. Now that these powerful weight-loss agents have been available for several years, vitamin deficiencies have been reported. Given the side effects of GLP-1 receptor agonists and their intended appetite suppression, clinicians' nutritional counseling and treatment become invaluable.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1308-1317"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of malnutrition on clinical outcomes in patients with perianal fistulizing Crohn's disease undergoing seton placement: A retrospective study. 营养不良对肛周瘘管性克罗恩病行塞顿置入术患者临床结果的影响:一项回顾性研究。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-09-22 DOI: 10.1002/ncp.70182
Bruno Augusto Alves Martins, Oswaldo de Moraes Filho, Tuane Colles, Clíslian Silva, Gabriela de Oliveira Lemos, Dannilo Brito Silveira, Heitor Siqueira Ribeiro, João Batista de Sousa
{"title":"The impact of malnutrition on clinical outcomes in patients with perianal fistulizing Crohn's disease undergoing seton placement: A retrospective study.","authors":"Bruno Augusto Alves Martins, Oswaldo de Moraes Filho, Tuane Colles, Clíslian Silva, Gabriela de Oliveira Lemos, Dannilo Brito Silveira, Heitor Siqueira Ribeiro, João Batista de Sousa","doi":"10.1002/ncp.70182","DOIUrl":"https://doi.org/10.1002/ncp.70182","url":null,"abstract":"<p><strong>Background: </strong>Perianal involvement occurs in up to 50% of patients with Crohn's disease (CD). Despite combined management, 10%-20% require fecal diversion or proctectomy. Nutritional status may influence prognosis, but its role in fistulizing perianal disease is unclear. This study examines the impact of malnutrition on clinical outcomes in patients with perianal fistulizing CD.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted. Clinical data were collected from the health records of patients with perianal CD at two centers from January 2010 to December 2022. Nutritional screening followed Nutrition Risk Screening-2002. Patients with a score ≥3 were evaluated for malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria. The prevalence of malnutrition and its association with the risk of adverse clinical outcomes were analyzed.</p><p><strong>Results: </strong>Of 64 patients, 17 (26.6%) had malnutrition. Malnourished patients had higher proctitis rates (100% vs. 78.7%, P = 0.038), lower serum albumin (3.47 vs. 3.97 g/dL, P = 0.002), and lower hemoglobin (10.9 vs. 12.5 g/dL, P = 0.003). They were younger at diagnosis (24.2 vs. 30 years, P = 0.046), had lower body mass indices (19.7 vs. 24.9 kg/m<sup>2</sup>, P < 0.001), higher Harvey-Bradshaw index (10 vs. 5, P < 0.001), and more corticosteroid use (29.4% vs. 4.3%, P = 0.012). Malnourished patients had lower fistula healing (17.6% vs. 44.7%, P = 0.048), more proctectomies (47.1% vs. 14.9%, P = 0.007), and were more likely to undergo abdominal surgery (70.6% vs. 38.3%, P = 0.022). In the prespecified parsimonious multivariable model, malnutrition was significantly associated with proctectomy (aOR 4.478; 95% CI: 1.227-16.343; P = 0.023).</p><p><strong>Conclusion: </strong>Malnutrition is a significant clinical risk marker associated with the requirement for proctectomy in patients with perianal fistulizing CD who undergo seton placement.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning curve of nurse-performed electromagnetic-guided nasogastric tube placement in adult ICU patients: A multicenter prospective study. 成人ICU患者电磁引导鼻胃管置入的学习曲线:一项多中心前瞻性研究。
IF 2.7 4区 医学
Nutrition in Clinical Practice Pub Date : 2026-09-15 DOI: 10.1002/ncp.70181
Kazunao Mori, Hideaki Sakuramoto, Tomoaki Ikezawa, Megumi Kamogawa, Hideaki Note, Toshifumi Miki, Saiko Okamoto, Maiko Motoki, Hideki Hashimoto, Junko Tatsuno, Tomomi Yoshida, Saori Kajiwara, Masako Shirasaka, Megumi Mukouyama, Hitoshi Tsugu, Kensuke Nakamura
{"title":"Learning curve of nurse-performed electromagnetic-guided nasogastric tube placement in adult ICU patients: A multicenter prospective study.","authors":"Kazunao Mori, Hideaki Sakuramoto, Tomoaki Ikezawa, Megumi Kamogawa, Hideaki Note, Toshifumi Miki, Saiko Okamoto, Maiko Motoki, Hideki Hashimoto, Junko Tatsuno, Tomomi Yoshida, Saori Kajiwara, Masako Shirasaka, Megumi Mukouyama, Hitoshi Tsugu, Kensuke Nakamura","doi":"10.1002/ncp.70181","DOIUrl":"https://doi.org/10.1002/ncp.70181","url":null,"abstract":"<p><strong>Background: </strong>Safe and timely nasogastric tube (NGT) placement is essential for effective enteral nutrition delivery in critically ill patients. Electromagnetic-guided systems has been shown to improve placement accuracy and may reduce delays from confirmatory imaging, but evidence on how nurses acquire competence with this technology remains limited.</p><p><strong>Methods: </strong>This pre-specified subgroup analysis used data from the nurse-performed electromagnetic-guided arm of a previously published multicenter prospective non-inferiority study conducted across seven ICUs. A total of 23 ICU nurses without prior experience performed 197 tube-placement episodes following simulator training and four supervised cases. Target-range placement was defined as tube tip positioning 3-10 cm below the esophagogastric junction, confirmed by electromagnetic guidance and radiography. Segmented regression was used to explore the learning curve.</p><p><strong>Results: </strong>A potential change point was suggested at Case 2.3 (95% CI: 2.0-2.3), indicating a trend toward early improvement following supervised practice, although this did not reach statistical significance (P = 0.068). Target-range placement rates improved progressively, rising from 57.1% during the supervised phase (Cases 1-4) to 64.6% and 69.2% in the independent-practice phase (Cases 5-7 and 8-15, respectively). Gastric placement was achieved in 99.5% of cases, with no serious complications.</p><p><strong>Conclusion: </strong>To our knowledge, this exploratory multicenter study provides the first quantitative characterization of a potential learning curve for nurse-performed electromagnetic-guided NGT placement. Structured training incorporating supervised practice may support early performance improvement and facilitate timely initiation of enteral nutrition in critical care settings.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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