Nutrition in Clinical Practice最新文献

{"title":"Association of enteral nutrition reduction or discontinuation with diarrhea volume and caloric delivery in critically ill adults with diarrhea: A retrospective cohort study.","authors":"Ryohei Yamamoto, Takatoshi Koroki, Yuna Ueta, Fumitaka Yanase, Ryo Ueno","doi":"10.1002/ncp.70188","DOIUrl":"https://doi.org/10.1002/ncp.70188","url":null,"abstract":"<p><strong>Background: </strong>When critically ill patients receiving enteral nutrition (EN) develop diarrhea, clinicians often reduce or discontinue EN, although evidence supporting this practice is limited. We examined the association between EN management after diarrhea and diarrhea volume in critical care patients.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included adult intensive care unit patients who developed new-onset diarrhea (Bristol Stool Form Scale ≥6 on 2 consecutive days) during EN. Based on Day 1 EN management, patients were classified as continuation (infusion rate decrease <10 mL/h) or reduction/discontinuation (decrease ≥10 mL/h or complete discontinuation). The primary outcome was cumulative diarrhea volume (grams) on Days 1-2. Cumulative EN calories (kcal) on Days 1-2 was a key secondary outcome. Inverse probability of treatment weighting with regression adjustment accounted for 8 pre-specified confounders. Sensitivity analyses included alternative exposure thresholds and propensity score models.</p><p><strong>Results: </strong>Of 135 patients analyzed (median age, 74 years; 32% female), 96 (71.1%) continued EN and 39 (28.9%) underwent EN reduction/discontinuation. After adjustment, the reduction/discontinuation group had lower cumulative diarrhea volume on Days 1-2 (adjusted mean difference, -183.4 g; 95% confidence interval [CI], -350.1 to -16.7; p = 0.033) but received substantially fewer calories (-1260.1 kcal; 95% CI, -1464.4 to -1055.9; p < 0.001). The direction of the reduction in diarrhea volume was consistent across sensitivity analyses.</p><p><strong>Conclusion: </strong>Reducing or discontinuing EN after diarrhea was associated with a modest reduction in diarrhea volume but a substantial caloric deficit. This trade-off should be considered when reducing EN for diarrhea.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of gastric aspirate pH measurement for verifying nasogastric tube placement in children receiving home enteral nutrition: An observational diagnostic accuracy study.","authors":"Hatice Pars, Ömer Faruk Yaşaroğlu, Selen Serel Arslan, Numan Demir, Tutku Soyer","doi":"10.1002/ncp.70185","DOIUrl":"https://doi.org/10.1002/ncp.70185","url":null,"abstract":"<p><strong>Background: </strong>Accurate verification of nasogastric (NG) tube placement is essential to prevent complications. Although radiography remains the reference standard, repeated imaging is impractical for children receiving home enteral nutrition. Gastric aspirate pH measurement is recommended as the preferred bedside method, but evidence of its diagnostic accuracy in pediatric home care is limited.</p><p><strong>Methods: </strong>This observational diagnostic accuracy study included 40 children receiving home enteral nutrition via NG tubes. Gastric aspirate pH was measured once immediately before a fluoroscopic swallowing assessment scheduled as part of routine care. Standardized pH indicator strips were used, and fluoroscopic findings served as the reference standard. Receiver operating characteristic (ROC) analysis was performed to identify a sample-derived optimal pH cutoff.</p><p><strong>Results: </strong>Fluoroscopy confirmed gastric placement in 27 children (67.5%) and nongastric placement in 13 (32.5%), including high and duodenal tube positions. Gastric pH values were lower than those in nongastric placements (P < 0.001). ROC analysis identified a sample-derived cutoff of 5.65. At the prespecified internationally recommended clinical threshold of ≤5.5, pH measurement correctly classified all tube locations in this cohort. Caregiver verification practices varied considerably, and many used methods not recommended as stand-alone techniques.</p><p><strong>Conclusions: </strong>Gastric aspirate pH measurement showed high diagnostic accuracy for verifying NG tube placement in children receiving home enteral nutrition. Standardized pH testing may offer an inexpensive, practical component of multimethod tube-position assessment. Larger multicenter studies are needed before these findings can be generalized to routine practice. These findings may inform caregiver education and development of standardized pediatric home-care verification protocols.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of food-drug interaction-oriented nutritional education on quality of life in Parkinson's disease: A pilot quasi-experimental study.","authors":"Mustafa Özgür, Zehra Baloğlu, Merve Horan, Nur Taşçi","doi":"10.1002/ncp.70184","DOIUrl":"https://doi.org/10.1002/ncp.70184","url":null,"abstract":"<p><strong>Background: </strong>This pilot study aimed to evaluate the effect of nutritional counseling/education interventions focusing on levodopa food-drug interactions on the physical and mental quality of life of patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>A quasi-experimental pre-post design was used. Thirty participants with PD for at least 1 year were selected from pharmacies in Konya, Türkiye. Participants completed an ad hoc, unvalidated questionnaire that included the Short Form-12 (SF-12) quality-of-life evaluation as well as other questions regarding socio-demographic data, general eating habits, and 3-day food consumption records prior to nutritional counseling/education intervention. After baseline data collection, each participant received one-on-one nutritional counseling/education. Four weeks post-intervention, participants were surveyed for 3-day dietary records and repeated the SF-12 evaluation. The dietary data were processed using the Nutrition Information System Software (BEBiS 8.1). A registered dietitian performed all nutritional analyses.</p><p><strong>Results: </strong>The mean age of participants was 66.8 ± 7.2 years, and the mean body mass index was 27.5 ± 3.3 kg/m². The intervention resulted in statistically significant enhancements in physical and mental SF-12 scores (P < 0.05). Participants showed decreased protein intake (from 0.87 ± 0.4 to 0.78 ± 0.3 g/kg), lower consumption of large neutral amino acids (phenylalanine, tryptophan, and tyrosine), and decreased total daily energy intake.</p><p><strong>Conclusion: </strong>Short-term nutritional counseling/education targeting food-drug interactions can improve quality of life and dietary habits in people with PD. To further validate and expand upon these promising findings, the long-term efficacy of such targeted nutritional interventions should be demonstrated in future large-scale, randomized controlled trials.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding practices and nutritional management of infants with transient and congenital hyperinsulinism: A tertiary single-center retrospective study.","authors":"Lauren Cheng, Graeme O'Connor, Emma Harris, Annaruby Cunjamalay, Antonia Dastamani","doi":"10.1002/ncp.70146","DOIUrl":"10.1002/ncp.70146","url":null,"abstract":"<p><strong>Background and aims: </strong>Hyperinsulinism (HI) is the most common cause of persistent neonatal hypoglycemia and requires careful nutritional management to maintain glycemic stability. Infants with transient hyperinsulinism (THI) often recover within months, whereas congenital hyperinsulinism (CHI) frequently requires prolonged medical and nutritional support. This study aimed to compare feeding practices and nutritional management of infants with THI and CHI.</p><p><strong>Methods: </strong>This single-center retrospective study included infants diagnosed with HI under 12 months of age between January 2020 and January 2023. Infants were classified as THI if diazoxide was discontinued within six months and as CHI if treatment continued beyond six months. Data was collected at baseline and at one, three, and six months post-diagnosis, with an additional one-year follow-up for the CHI group.</p><p><strong>Results: </strong>Ninety-six infants were included (THI n = 74, CHI n = 22). 78% of the THI group and all infants with CHI required support from intravenous dextrose and/or parenteral nutrition at diagnosis. The CHI group demonstrated greater use of glucose polymers, high-energy and hydrolyzed formulas by six months. By six months, 95% of the THI group were exclusively orally fed compared with 59% in the CHI group. Breastfeeding rates were low in both groups, declined over time and did not recover after medication was stopped.</p><p><strong>Conclusions: </strong>Infants with CHI require more prolonged and complex nutritional management, characterized by sustained reliance on tube feeding and higher carbohydrate feeds. Early optimization of nutritional intake and clearer strategies to support breastfeeding are areas for improving clinical management and feeding outcomes of infants with THI and CHI.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1466-1475"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and discriminative value of serum inflammatory biomarkers for sarcopenic obesity: A retrospective cross-sectional study.","authors":"Yasemin Polat Özer, Merve Güner, Didem Karaduman, Mert Eşme, Cafer Balci, Burcu Balam Doğu, Mustafa Cankurtaran, Meltem Gülhan Halil","doi":"10.1002/ncp.70166","DOIUrl":"10.1002/ncp.70166","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenic obesity (SO) is a complex geriatric syndrome characterized by excess adiposity and impaired muscle function, in which chronic low-grade inflammation plays a key role. Serum-based inflammatory indices may provide accessible tools for identifying individuals at risk. This study investigated the association between SO and serum-based inflammatory indices and evaluated their discriminative performance.</p><p><strong>Methods: </strong>This cross-sectional study included 156 older adults (≥65 years) with obesity, based on retrospectively collected medical records. SO was defined according to European Society for Clinical Nutrition and Metabolism/European Association for the Study of Obesity criteria. Body composition was assessed using bioelectrical impedance analysis. Serum-based inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein-to-albumin ratio, and C-reactive protein-albumin-lymphocyte index, were calculated. Multivariable logistic regression analyses were performed, adjusting for age, sex, marital status, polypharmacy, and Clinical Frailty Scale. Receiver operating characteristic (ROC) analyses were conducted.</p><p><strong>Results: </strong>The prevalence of SO was 28.8%. NLR, SII, and PIV were significantly higher in the SO group (all P < 0.05). In multivariable analyses, NLR (OR 2.56, 95% CI 1.14-5.76, P = 0.023), SII (OR 2.38; 95% CI 1.16-4.89, P = 0.018), and PIV (OR 1.96; 95% CI 1.10-3.48, P = 0.022) remained independently associated with SO. ROC analysis demonstrated modest discriminative ability, with AUC values of 0.643 for NLR, 0.628 for SII, and 0.633 for PIV.</p><p><strong>Conclusions: </strong>NLR, SII, and PIV are independently associated with SO; however, their discriminative performance is limited, suggesting they should be used as supportive rather than diagnostic markers.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1422-1432"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic small bowel therapies for type 2 diabetes.","authors":"Roma Patel, Zehra Naseem, Prisha Gattu, Stephen Firkins, Roberto Simons-Linares","doi":"10.1002/ncp.70111","DOIUrl":"10.1002/ncp.70111","url":null,"abstract":"<p><p>Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux-en-Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the pathophysiology of type 2 diabetes. This has led to the emergence of small bowel endoscopic therapies for type 2 diabetes. These therapies include procedures such as duodenal ablation, luminal liners, endoscopic bypasses, and endoscopic injections.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1296-1306"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.","authors":"Vikash Singhani, Muhammad Ehsan, Sara Valencia, Ahmed Nadeem, Eisha Moazzam, Winfield Scott Butsch, Samita Garg","doi":"10.1002/ncp.70180","DOIUrl":"10.1002/ncp.70180","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists have transformed the management of type 2 diabetes and obesity. Gastrointestinal (GI) adverse events are the most common limitation of these therapies and a leading cause of discontinuation.</p><p><strong>Methods: </strong>This narrative expert review synthesizes evidence from randomized controlled trials, observational studies, meta-analyses, and pharmacovigilance data to characterize the incidence, mechanisms, and clinical implications of GI adverse effects across approved agents and late-stage pipeline therapies.</p><p><strong>Results: </strong>Nausea, vomiting, diarrhea, and constipation are established class effects, occurring in approximately 30%-50% of patients, typically during initiation and dose escalation. These events are generally mild to moderate and manageable with dose titration and dietary modification. Mechanisms include delayed gastric emptying, central activation of emetic pathways, altered intestinal motility, and physiologic effects of rapid weight loss itself. Randomized trial data are reassuring for acute pancreatitis, with no class-level excess risk demonstrated; pharmacovigilance signals are most plausibly explained by diagnostic misclassification rather than true causal risk. Cholelithiasis shows a probable class-level association, substantially mediated by weight loss rather than direct receptor signaling. Peri-procedural data show increased residual gastric volume without confirmed aspiration events. Preliminary data on late-stage pipeline agents (retatrutide, survodutide, and cagrilintide-semaglutide) suggest a similar GI adverse event profile to approved agents, though evidence remains largely limited.</p><p><strong>Conclusion: </strong>GI adverse events with GLP-1-based therapies are predictable and manageable. A proactive, patient-centered approach is essential to optimize adherence, safety, and clinical outcomes as newer agents expand the therapeutic landscape.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":"41 5","pages":"1318-1333"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between acute nutritional goal achievement and outcomes in critically ill pediatric patients: A single-center retrospective cohort study.","authors":"Satoshi Nakano, Takehiro Niitsu, Ikuya Ueta, Aya Kuchiba, Kazuhiro Ohwaki","doi":"10.1002/ncp.70116","DOIUrl":"10.1002/ncp.70116","url":null,"abstract":"<p><strong>Background: </strong>Although malnutrition in critically ill children is linked to poor outcomes, the impact of achieving guideline-recommended nutritional goals remains unclear. We examined the association between achievement of American Society for Parenteral and Enteral Nutrition (ASPEN) goals via enteral nutrition (EN) and clinical outcomes in a Japanese pediatric intensive care unit (PICU).</p><p><strong>Methods: </strong>This single-center, retrospective cohort study included patients aged <16 years admitted between July 2022 and December 2024 who required mechanical ventilation and had a PICU/high care unit (HCU) stay of ≥7 days. We compared patients who achieved the ASPEN goal (≥2/3 of resting energy expenditure and ≥1.5 g/kg/day protein via EN) within 7 days with those who did not. Multivariable Cox proportional hazards models were used to evaluate the association between nutritional goal achievement and the primary outcome of total length of stay (LOS).</p><p><strong>Results: </strong>Of the 110 patients, 80 (72.7%) achieved their nutritional goals. The achievement group had a significantly shorter total LOS (median 12 vs 20 days; P < 0.001). After multivariable adjustment, meeting the nutritional target was independently associated with a higher likelihood of discharge (adjusted hazard ratio: 2.41; 95% confidence interval: 1.45-4.02; P < 0.001). The achievement group also had fewer new-onset infections (8.8% vs 40%) and more ventilator-free days.</p><p><strong>Conclusion: </strong>Achievement of ASPEN-recommended nutritional targets through EN within the first week is strongly associated with short LOS and reduced complications in critically ill children. Although early EN is a potential marker of better prognosis, our findings support its optimization in this vulnerable population.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1476-1484"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between predictive equations and indirect calorimetry in estimating resting metabolic rate among free-living older adults with sarcopenia: A prospective observational study.","authors":"Qi Dong, Lu Wu, Jiao Liu, Li Wang, Danye Niu, Ning Li, Yanmin Zheng, Lei Ding, Yating Ma, Jiaxian Liu, Bo Wang, Haitao Wang, Ming Zhou","doi":"10.1002/ncp.70131","DOIUrl":"10.1002/ncp.70131","url":null,"abstract":"<p><p>Resting metabolic rate (RMR) accounts for the largest proportion of daily total energy expenditure. The purpose of this study is to systematically evaluate the agreement of predictive equations for RMR and indirect calorimetry (IC) in a population with sarcopenia. The study included 43 individuals with sarcopenia aged 60 and above (diagnosed according to the AWGS 2019 criteria for sarcopenia). One-on-one measurements and questionnaires were used to obtain information including height, weight, body composition, gait speed, and grip strength. A total of 11 different predictive equations were used to estimate RMR and were compared with the IC in multiple dimensions. The RMR of the study participants ranged from 652 to 1244 kcal/day, with an average of 920.5 ± 150.3 kcal/day. All predictive equations exhibited an accuracy rate of less than 40%, with the Mifflin equation based on body weight (Mifflin_W) showing the lowest bias (16.54%), the lowest root mean square error (RMSE) value (216.51 kcal/day), the highest Lin's Concordance Correlation Coefficient (CCC) value (0.40) and the lowest median absolute percentage error (MAPE) (16.52%). The predictions of the Porter equations were not influenced by age or body mass index (BMI), making its predictions more stable, whereas the biases of other equations were significantly affected by age or BMI. Despite overall poor performance by all equations, the Mifflin_W equation showed the best agreement with IC measurements and may be used with caution when IC is unavailable, noting its tendency to overestimate RMR.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1503-1513"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition, sarcopenia, and quality of life among older adults receiving home healthcare services: A cross-sectional study.","authors":"Silan Arikan, Merve Yilmaz","doi":"10.1002/ncp.70138","DOIUrl":"10.1002/ncp.70138","url":null,"abstract":"<p><strong>Background: </strong>Older adults receiving home healthcare services represent a highly vulnerable group for functional decline. This study aimed to determine the prevalence of malnutrition and sarcopenia in this population, investigating their relationship with quality of life (QoL).</p><p><strong>Methods: </strong>This cross-sectional study was conducted between February 2024 and February 2025 among 254 older adults (≥65 years) receiving home healthcare in Balıkesir, Türkiye. The region was selected for its high elderly population ratio (16.9%), significantly exceeding the national average (10.6%). Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF), sarcopenia risk with the SARC-F (Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls) scale, and QoL with the CASP-19 (Control, Autonomy, Self-realization, and Pleasure) scale. Anthropometric measurements (Body Mass Index [BMI], mid-upper arm circumference [MUAC], and calf circumference [CC]) were recorded.</p><p><strong>Results: </strong>Malnutrition was identified in 32.7% of participants, while 58.3% were at risk. The risk of sarcopenia was high at 90.2%. Participants with malnutrition and sarcopenia risk had significantly lower QoL scores (p < 0.001). Better nutritional status, higher BMI, and greater MUAC and CC measurements were positively associated with higher QoL (all p < 0.001). Correlation analysis revealed significant negative relationships between nutritional status and sarcopenia risk (r = -0.33, p < 0.001) and between sarcopenia risk and QoL (r = -0.46, p < 0.001).</p><p><strong>Conclusions: </strong>Malnutrition and sarcopenia risk frequently coexist in home healthcare settings and are strongly associated with lower QoL. Routine nutritional and functional screening are essential in home care to facilitate early intervention and improve well-being in this vulnerable population.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":"1410-1421"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}