Nutrition and health最新文献

{"title":"Benefit of <i>Lycium barbarum</i> polysaccharide supplementation in patients with nonalcoholic fatty liver disease: A pre-post study.","authors":"Yanna Fan, Yan Pu, Xiaojuan Xu, Jianjun Yang","doi":"10.1177/02601060251357979","DOIUrl":"https://doi.org/10.1177/02601060251357979","url":null,"abstract":"<p><p><b>Background:</b> Nonalcoholic fatty liver disease (NAFLD) is characterized by an abnormal accumulation of lipids in the liver tissue. <b>Aim:</b> This study aims to evaluate the potential therapeutic effect of oral <i>Lycium barbarum</i> polysaccharide (LBP) capsules in patients with NAFLD. <b>Methods:</b> A pre-post-intervention clinical trial involving 13 participants, aged 28-50 years, was conducted at a community health center. Participants underwent abdominal ultrasound and laboratory tests, including alanine aminotransferase level measurements. During the 12-week intervention period, participants received a daily oral LBP supplement capsule (300 mg). We collected blood and stool samples at baseline and postintervention, which were for 16S rRNA gene sequencing and metabolomics analysis. <b>Results:</b> Postintervention, significant reductions (<i>p</i> < 0.05) were observed in gamma-glutamyltransferase (GGT), ALB, TP, and D-BIL levels. There were 125 upregulated and 65 downregulated metabolites. LBP supplementation increased Gemmiger abundance. Microbiota diversity, analyzed through 16S rRNA sequencing, showed altered phylum distribution in fecal samples, with PICRUSt2 indicating effects on linoleic acid metabolism. Changes in negative correlations between specific lipid metabolites, such as Her2Cer(d14:0_22:6), and enzyme activities like GGT, were also noted. <b>Conclusion:</b> <i>Lycium barbarum</i> polysaccharide intervention may enhance GGT, ALB, TP, and D-BIL levels, demonstrating beneficial effects on critical biochemical parameters in NAFLD patients. Correlation analysis showed LBP alters the relationship between specific lipid metabolites and enzyme activity, notably between GGT and Her2Cer(d14:0_22:6), laying groundwork for further research on LBP's impact on NAFLD. <b>Trial registration:</b> Chinese Clinical Trial Registry, ChiCTR2000034740, and Institutional Ethics Committee of Ningxia Medical University, 2019-329.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251357979"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis.","authors":"Ahmad Abdualrazag Albalawi","doi":"10.1177/02601060251363647","DOIUrl":"https://doi.org/10.1177/02601060251363647","url":null,"abstract":"<p><p>BackgroundThe global medicine market is projected to reach US$417 billion by 2033, reflecting rising demand for natural healthcare alternatives. Ashwagandha (<i>Withania somnifera</i>) is widely used in Ayurvedic medicine for stress management, but evidence supporting its efficacy remains inconsistent.AimThis systematic review and meta-analysis evaluated Ashwagandha's impact on cortisol levels (a biological stress marker) and perceived stress via Perceived Stress Scale (PSS) scores across randomized controlled trials (RCTs).MethodPRISMA guidelines were followed. Four databases (PubMed, CINAHL, Google Scholar, and Scopus) were searched for studies from January 2012 to February 2024, yielding seven studies on cortisol and six on perceived stress (<i>n</i> = 488 participants). Inclusion criteria were RCTs longer than or equal to two weeks, oral doses ≥250 mg/day, and reporting cortisol and PSS outcomes. The Cochrane Risk of Bias 2 tool was used to assess the risk of bias.ResultsThere was a statistically significant reduction in cortisol levels (-1.16 µg/dL, 95% CI: -1.64 to -0.69, <i>P</i> < 0.001). No significant impact was observed on perceived stress (SMD = -0.355, 95% CI: -1.188 to 0.47; <i>P</i> = 0.40). Heterogeneity was moderate (<i>I</i>² = 50.9%). However, no statistically significant impact was observed on perceived stress (SMD = -0.355, 95% CI: -1.188 to 0.47; <i>P</i>-value = 0.40). The heterogeneity among studies was moderate (<i>I</i>² = 50.9%). Risk of bias was generally moderate; most studies reported adequate randomization, but some lacked allocation concealment. No publication bias was detected.ConclusionFindings support Ashwagandha's role in lowering cortisol, but gaps remain regarding long-term safety, dosing, and effectiveness across diverse populations. The disconnect between cortisol and PSS outcomes highlights the need for longer treatment duration and broader demographic inclusion. Longitudinal research is recommended to validate Ashwagandha as a holistic stress management tool.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251363647"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of three ketogenic diet plans: Congruency with the Healthy Eating Index (HEI) and consistency of the day-to-day HEI scores for a period of 1 week.","authors":"Alan M Preston","doi":"10.1177/02601060251314573","DOIUrl":"https://doi.org/10.1177/02601060251314573","url":null,"abstract":"<p><p><b>Background:</b> The consistency of the day-to-day scores of the Healthy Eating Index (HEI) for commercial ketogenic meal plans and if these scores are compliant with the Dietary Guidelines for Healthy Americans (DGA) have not yet been evaluated. <b>Aim:</b> To make this determination. <b>Methods:</b> We have selected three commercial ketogenic meal plans: MP1, MP2 and MP3. Using scores calculated for the HEI during the period of 1 week each, we are able to determine day-to-day compliance of HEI scores to the DGA as well as consistency of HEI values throughout the week. <b>Results:</b> The 7-day mean score of HEI for MP1 was 54.1 ± 2.6 and classified as \"Some changes needed\"; however, MP1 had a relatively consistent pattern of HEI scores. MP2 had a score of 44.3 ± 7.8 and classified as \"Big changes needed\" as well as an inconsistent pattern of HEI values. MP3 had a score of 53.3 ± 10.3, also classified as \"Some changes needed\" and an inconsistent pattern of HEI values. <b>Conclusions:</b> Commercial meal plans based on ketogenic metabolism will have HEI scores from a minimum in the 30s to a maximum, not exceeding 70. Depending upon the adherence of the manufacturer's recipes to the DGA, the day-to-day HEI scores will vary accordingly. These results suggest that if some or major changes are not taken, continuation would not be advisable for long-term use.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251314573"},"PeriodicalIF":1.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D status and its association with diabetic complications in type 2 diabetes mellitus: A case-control study.","authors":"Ashna Chackochan, Swetha R Reghunath, Vasudeva Guddattu, Girish Thunga, Shivashankara Kaniyoor Nagri, Revathi P Shenoy, Vishnu Prasad Shenoy, Leelavathi D Acharya","doi":"10.1177/02601060251359708","DOIUrl":"https://doi.org/10.1177/02601060251359708","url":null,"abstract":"<p><p><b>Background:</b> Vitamin D deficiency remains as a significant public health challenge, even in sun-rich countries like India. Emerging evidence indicates that vitamin D plays a critical role in the pathophysiology of various chronic conditions, including type 2 diabetes mellitus (T2DM). <b>Aim:</b> Our study aims to examine the association between vitamin D deficiency and diabetic complications. <b>Methods:</b> This case-control study was conducted at a south Indian tertiary care facility between August 2023 and August 2024. The medical records of patients with T2DM admitted to the Department of Medicine between 2017 and 2022, with recorded vitamin D levels, were included. Patients with diabetic complications were enrolled as cases (n = 873), and those without any complications (n = 566) served as controls. The association between vitamin D deficiency and diabetic complications was determined using multivariate logistic regression, expressed as odds ratios (OR) with 95% confidence intervals (CI) using R version 4.4.1. <b>Results:</b> Multivariate logistic regression indicated that vitamin D deficiency was significantly associated with the development of diabetic complications, specifically neuropathy (adjusted OR (AOR) = 4.09, 95% CI 2.34-7.63, p < 0.001), nephropathy (AOR = 5.23, 95% CI 2.72-10.85, p < 0.001), retinopathy (AOR = 2.52 95% CI 1.44-4.69, p < 0.001), ischaemic heart disease (IHD) (AOR = 2.19, 95% CI 1.33-3.76, p = 0.003) and diabetic foot disease (DFD) (AOR = 2.66, 95% CI 1.34-5.91, p = 0.008). Vitamin D levels were significantly associated with factors affecting sun exposure, such as gender (p = 0.005), place of residence (p < 0.001) and type of occupation (p = 0.006). <b>Conclusion:</b> Vitamin D deficiency was found to be independently associated with neuropathy, nephropathy, retinopathy, IHD and DFD, indicating its possible involvement in the pathophysiology of these diabetic complications.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251359708"},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The differential impact of gaze direction on food evaluation.","authors":"Kenichi Shibuya, Mana Miyamoto","doi":"10.1177/02601060251362331","DOIUrl":"https://doi.org/10.1177/02601060251362331","url":null,"abstract":"<p><p><b>Background:</b> The influence of others' gaze on human behavior remains incompletely understood. However, it remains unclear whether direct gaze actively enhances evaluation. <b>Aim:</b> The primary aim of this study was to investigate whether direct gaze increases the evaluation of food items. <b>Methods:</b> To address this gap, we conducted an experiment in which 29 Japanese participants (aged 19-22; 6 males) evaluated food images paired with facial images displaying either direct or averted gaze. Using a 9-point Likert scale, participants rated the attractiveness of 12 food items under each gaze condition. <b>Results:</b> Statistical analysis via linear mixed models revealed that food was rated significantly higher when accompanied by direct gaze compared to averted gaze (Estimate = 0.303, <i>p</i> = 0.008; 95% CI: 0.078-0.528). These findings support the hypothesis that direct gaze enhances positive evaluation, possibly through mechanisms such as reputation management, increased arousal, and social facilitation. <b>Conclusion:</b> Our results contribute to a growing body of literature on social influences in perception and suggest that subtle social cues can modulate sensory evaluations. Future research should incorporate dynamic or immersive stimuli, assess physiological responses, and explore cross-cultural differences to clarify the underlying mechanisms. These efforts will deepen our understanding of how gaze direction shapes food perception and may inform applications in marketing, health communication, and user experience design.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251362331"},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"First Bite\": An intervention to increase children's vegetable consumption in Early Childhood Education and Care (ECEC) services in areas of high socioeconomic disadvantage - a cluster randomized controlled trial protocol.","authors":"Sharon Duncan, Megan Hammersley, Jennifer Norman, Sarah T Ryan, Emma Davies, Rebecca Junor Cook, Monica Nour, Laura Attallah, Bridget Kelly","doi":"10.1177/02601060251360303","DOIUrl":"https://doi.org/10.1177/02601060251360303","url":null,"abstract":"<p><p>BackgroundOnly 2% of 4-8-year-old Australian children consume the daily recommended vegetable serves, with implications on the development of lifelong dietary behaviors. Evidence suggests that enhancing children's access, exposure and familiarity with vegetables can help increase their vegetable intake. Most children attend Early Childhood Education and Care (ECEC) services, which are well placed to increase vegetable consumption through curriculum change, play-based learning and parental education.AimWe aim to determine the efficacy of the 'First Bite-Get it Right' (First Bite) intervention to improve the vegetable intake of 3-5-year-old children in ECEC services compared to a control group.MethodThis 8-week cluster-randomized controlled trial involves ECEC services (n = 30) and children (n∼300) from socioeconomically disadvantaged areas in two local health districts in New South Wales, Australia and includes an intervention and wait-list control group. The First Bite program comprises: 1) Educator professional development; 2) Child daily \"Veggie Break\"; 3) Child experiential learning activities; and 4) Parent resources. Baseline and post-intervention measures include skin carotenoid scanning, vegetable serves plate waste, lunch box audits, child-reported vegetable preferences, and child parent-reported vegetable intake. Group-by-time interactions will be analyzed by linear mixed model regression, accounting for ECEC clustering.SummaryThis study will evaluate whether a comprehensive ECEC-based intervention can improve children's vegetable consumption in socioeconomically disadvantaged areas. The findings will inform recommendations for ECEC policies, educator training programs, and parent engagement strategies to promote healthy eating in early childhood.Trial registrationAustralian New Zealand Clinical Trials Registry: ACTRN: 12624000249550 (Date: 14/03/2024). https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=387095.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251360303"},"PeriodicalIF":1.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamine: A misunderstood amino acid with therapeutic potential.","authors":"Michael K McMullen","doi":"10.1177/02601060251356147","DOIUrl":"https://doi.org/10.1177/02601060251356147","url":null,"abstract":"<p><p><b>Background:</b> Glutamine is an amino acid with trophic activity in the small intestine. The small intestine derives exogenous glutamine from foods and endogenous glutamine from arterial blood. Glutamine is vital for the rapidly proliferating enterocytes lining the intestinal mucosa and promotes the expression of proteins in the tight junctions, strengthening the barrier function and reducing gut permeability. With excessive physical activity, malnutrition, acute and chronic illnesses, sarcopenia or prolonged fasting, plasma levels drop. When glutamine is depleted, the small intestine atrophies causing increased gut permeability and bacterial dislocation. The use of intravenous glutamine is well established in critical medicine, by increasing depressed glutamine plasma levels intestinal atrophy is averted. Therefore, glutamine is classified as a conditionally essential amino acid. <b>Aim:</b> To calculate the amounts of glutamine derived from both food and endogenous processes and to establish a suitable dosage for oral supplementation. <b>Methods:</b> The contribution of dietary amino acids and endogenous glutamine was assessed and compared. The pharmacokinetics of glutamine supplementation was reviewed. <b>Results:</b> Approximately 88% of the glutamine metabolised daily is endogenously produced. Almost half of this comes from muscle protein breakdown. Studies with supplemental free-form glutamine for treating intestinal permeability, at doses based on dietary intake, have not yielded positive results, whereas doses of 30 g glutamine, similar to daily amount metabolised by the enterocytes yielded positive results. <b>Discussion:</b> Clinical doses of free-form glutamine for intestinal disorders should be akin to the daily amount of glutamine metabolised by the small intestine rather than the daily dietary intake.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251356147"},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postprandial glycemic response in different ethnic groups in East London and its association with vitamin D status: Study protocol for an acute randomized crossover trial.","authors":"Honglin Dong, Christian Reynolds, Saiful Islam, Swrajit Sarkar, Sophie Turner","doi":"10.1177/02601060251356528","DOIUrl":"https://doi.org/10.1177/02601060251356528","url":null,"abstract":"<p><p>BackgroundIn the UK, Black African-Caribbeans (ACs) and South Asians (SAs) have 3-6 times greater risks of developing type-2 diabetes mellitus (T2DM) and significantly higher prevalence of vitamin D (vitD) deficiency than White Caucasians. East London is among the areas with the highest prevalence of T2DM and the highest proportion of ethnic minority groups. This ethnic health inequality is ascribed to socioeconomic standing, dietary habits, culture, and attitudes, while biological diversity has rarely been investigated.AimThe study aims to investigate the difference in the postprandial glycemic response (PGR), an independent risk factor of T2DM, between ethnic groups (White Caucasians, SAs, and ACs) in East London and its association with vitD status.MethodsThis acute randomized crossover trial will recruit healthy adults (n = 106) in East London between November 2023 and March 2025. Two test drinks are consumed by participants (a glucose drink containing 75 g glucose and pure orange juice) on different occasions. PGRs are monitored before and after drinking every 30 min for up to 2 h via finger prick. A fasting blood sample obtained via phlebotomy will be used for plasma 25(OH)D and relevant tests. A knowledge/perception questionnaire about vitD and a 4-day food diary (analyzing vitD dietary intake) will also be collected. Data will be analyzed using a multiple linear regression model adjusted by confounding factors (age, gender, body mass index, and body fat percentage).SummaryThe study results will be disseminated through journals and conferences, and target stakeholders.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251356528"},"PeriodicalIF":1.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional evaluation of extra virgin olive oil extracted from olive cultivars grown in Pothwar region of Pakistan.","authors":"Abida Mariam, Anwaar Ahmed, Asif Ahmad, Muhammad Sheeraz Ahmad, Nabeel Ahmad, Muhammad Akram Khan","doi":"10.1177/02601060251355869","DOIUrl":"https://doi.org/10.1177/02601060251355869","url":null,"abstract":"<p><p><b>Background:</b> There is negligible data available regarding nutritional evaluation of extra virgin olive oil (EVOO) obtained from olive cultivars from Pothwar region of Pakistan. <b>Aim:</b> The aim of this study was to profile nutritional parameters of EVOOs extracted from 10 olive cultivars of Pothwar. <b>Study Type:</b> This was an experimental quantitative research design. <b>Methods:</b> EVOO was extracted from Ten cultivars of olive namely Frantoio, Earlik, Manzanilla, Leccino, Ottobratica, Sevillano, Arbequina, Gamlik, Koroneiki, and Coratina, and their nutritional significance was determined using Near Infra-Red spectrophotometry (NIR). <b>Results:</b> The olive cultivars like Coratina, Frontoio, Koroneki, Sevillano, and Ottobratica were found with higher percentage of oil i.e., 23.9%, 23.7%, 22.8%, 22%, and 22% respectively. The lowest amount of oil was recorded in Gamlik cultivar of olive. The organoleptic traits of EVOO extracted were found in accordance with permissible range described for EVOO by International Olive Council (IOC) and Pakistan Standards and Quality Control Authority (PSQCA) i.e., light yellow tint, absence of any foreign matter, characteristic taste and fruity aroma. The chemical properties like peroxide value, acidity, free fatty acids, saponified value, unsaponified value, and iodine value were also observed in acceptable range according to international standards of IOC and PSQCA i.e., 1.5 to 5.2 meqO₂/kg, 0.5 to 1.6 mg/g acid, 0.1 to 0.8, 186 to 192 mg/g, 4 to 8 g/kg; and 82 to 90, respectively. Fatty acid profile and percentage of oleic acid were found to be the highest followed by linoleic, palmitic, stearic, palmitoleic, and alpha-linolenic acid, i.e., 55 to 66.1%, 10.4 to 20.4%, 13.8 to 19.5%, 3.9 to 4.4%, 0.3 to 1.7%, and 0.9 to 1.7%, respectively. Other nutritional and functional parameters like alpha-tocopherols, chlorophyll, carotenoids, total phenolic content, total flavonoids, and total tannins were also studied and ranged from 104.7 to 535.3 mg/kg, 1.15 to 13.12 mg/kg, 1.25 to 5.91 mg/kg, 320 to 1500 mgGAE/kg, 70 to 280 mgQE/kg, and 560 to 6560 mgCE/kg, respectively. <b>Conclusion:</b> The results were found statistically significant confirming substantial nutritional and functional properties in EVOO extracted from olive cultivars grown in Pothwar, Pakistan suggesting it a good source of plant oil rich in nutraceutical compounds.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251355869"},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of oral l-arginine alone or in combination with sodium butyrate on glucagon-like peptide-1 secretion in non-diabetic adults with obesity.","authors":"Afif Nakhleh, Wasim Said, Salim Hadad, Sagit Zolotov, Naim Shehadeh","doi":"10.1177/02601060251356584","DOIUrl":"https://doi.org/10.1177/02601060251356584","url":null,"abstract":"<p><p>BackgroundL-arginine and sodium butyrate may improve glycemic control and reduce appetite by increasing glucagon-like peptide-1 (GLP-1) secretion. This warrants further investigation in individuals with obesity.AimsThis study aimed to examine the effects of oral L-arginine, alone and with sodium butyrate, on circulating levels of GLP-1 and glucose, and subsequent appetite, in adults with obesity.MethodsSeven adults (5 females and 2 males) with obesity participated in the study. Each participant underwent three different interventions at 2-week intervals following consumption of a standard meal (Ensure^® 250 mL): 1) no intervention, 2) oral L-arginine administered 60 min before the meal, and 3) a combination of oral L-arginine and sodium butyrate administered 60 min before the meal. Blood samples for GLP-1 and glucose were collected, and hunger and fullness were assessed using visual analog scales over a 165-min period. Statistical analysis was performed using Friedman test for repeated measures. Wilcoxon signed-rank tests with Bonferroni correction were used for pairwise comparisons.ResultsOral L-arginine combined with sodium butyrate significantly increased the area under the curve of plasma GLP-1 (AUC_GLP-1) compared to no intervention (p = 0.0156). L-arginine alone showed a trend towards increased AUC_GLP-1 compared to no intervention (p = 0.031). No significant differences in glucose levels were observed between interventions. Neither intervention affected subjective satiety measures.ConclusionOral L-arginine and sodium butyrate increased circulating GLP-1 levels in adults with obesity. L-arginine alone showed a similar trend.</p>","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060251356584"},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}