Nutrition and health最新文献

Long-term effects of zinc replacement therapy continuation in hemodialysis patients on mortality and nutritional indices: A posthoc analysis. 血液透析患者继续锌替代治疗对死亡率和营养指标的长期影响：一项事后分析。

IF 1.4

Nutrition and health Pub Date : 2026-05-08 DOI: 10.1177/02601060261445340

Kazuhiro Furumachi, Yuuta Hara, Ken Hosokawa, Akihiro Kurihara, Etsuko Kumagai, Keiko Hosohata, Shinji Takai

{"title":"Long-term effects of zinc replacement therapy continuation in hemodialysis patients on mortality and nutritional indices: A posthoc analysis.","authors":"Kazuhiro Furumachi, Yuuta Hara, Ken Hosokawa, Akihiro Kurihara, Etsuko Kumagai, Keiko Hosohata, Shinji Takai","doi":"10.1177/02601060261445340","DOIUrl":"https://doi.org/10.1177/02601060261445340","url":null,"abstract":"BackgroundZinc deficiency has been identified as an important factor contributing to chronic nutritional disorders in maintenance hemodialysis (HD) patients.AimWe assessed the long-term effect of zinc replacement therapy on all-cause mortality among patients undergoing HD.MethodsThis posthoc analysis utilized data from an open-label, multicenter, randomized, active-controlled study including HD patients aged 40-94 years, registered between December 2019 and May 2020. Patients who initiated zinc supplementation were categorized into two groups based on treatment status 12 months after initiation: continuation (n = 46) and discontinuation (n = 22). The primary outcome was 4-year all-cause mortality. Survival was compared by Kaplan-Meier analysis, and hazard ratios (HRs) were estimated using Cox proportional hazards models.SummaryThe 4-year survival rate was higher in the continuation group (54.8%) than in the discontinuation group (33.9%, log-rank P = 0.122). Continuation of zinc therapy significantly reduced mortality risk (HR: 0.33, 95% CI: 0.11-0.95, P = 0.041). Independent predictors of mortality included age (HR: 1.09 per year), female sex (HR: 2.46), primary kidney disease (HR: 2.81), serum albumin <3.5 g/dL (HR: 4.35), transthyretin <20 mg/dL (HR: 3.59), and phosphorus <3.7 mg/dL (HR: 3.28). Subgroup analysis revealed that albumin ≥3.5 g/dL was protective in the continuation group, while malnutrition and inflammation markers were strongly associated with mortality in the discontinuation group. Continuation of zinc replacement therapy was associated with significantly improved survival in HD patients. These findings suggest that sustained supplementation may provide prognostic benefit, particularly in those with preserved nutritional status.RegistrationThe study was registered with the University Hospital Medical Information Network (UMIN) under registration number 000038759.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261445340"},"PeriodicalIF":1.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of intermittent fasting combined with a ketogenic diet versus a hypocaloric diet on metabolic outcomes in adults with type 2 diabetes mellitus: A controlled clinical study. 间歇性禁食结合生酮饮食与低热量饮食对成人2型糖尿病代谢结局的影响：一项对照临床研究

IF 1.4

Nutrition and health Pub Date : 2026-05-08 DOI: 10.1177/02601060261446178

Edgar Barrionuevo-Burgos, Ruth Marina García-García, Lucía Muñoz, Andrea Arreguín-Coronado

{"title":"Effects of intermittent fasting combined with a ketogenic diet versus a hypocaloric diet on metabolic outcomes in adults with type 2 diabetes mellitus: A controlled clinical study.","authors":"Edgar Barrionuevo-Burgos, Ruth Marina García-García, Lucía Muñoz, Andrea Arreguín-Coronado","doi":"10.1177/02601060261446178","DOIUrl":"https://doi.org/10.1177/02601060261446178","url":null,"abstract":"BackgroundType 2 diabetes mellitus (T2DM) continues to rise globally, highlighting the need for effective and sustainable dietary strategies. Intermittent fasting (IF) and ketogenic diets have been associated with metabolic adaptations such as enhanced fat oxidation, ketone body production, and improved insulin sensitivity; however, evidence on their combined implementation in clinical settings remains limited.ObjectiveTo evaluate the associations of three dietary strategies-IF combined with a ketogenic diet (IF + KD), a hypocaloric diet (HD), and a control group (CG)-with anthropometric, metabolic, behavioral, and quality-of-life outcomes in adults with T2DM.MethodsA 12-week controlled, parallel-group clinical study was conducted in 30 adults with T2DM allocated to IF + KD (n = 10), HD (n = 10), or CG (n = 10). The IF + KD group followed a structured 16:8 IF protocol combined with a ketogenic diet, while the HD group received an individualized energy-restricted diet. Anthropometric, biochemical, physical activity, and quality-of-life measures were assessed at baseline and week 12.ResultsReductions were observed in body weight, body mass index, waist circumference, and body fat percentage (all p < 0.05). HbA1c decreased in both IF + KD and HD groups, and total cholesterol was reduced without adverse changes in renal function. Physical activity and quality-of-life scores improved in intervention groups, with minimal variation in the CG.ConclusionIF + KD and HD were associated with short-term improvements in metabolic and anthropometric outcomes in adults with T2DM. Findings provide real-world evidence on combined dietary strategies and should be interpreted within the context of a non-randomized design.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261446178"},"PeriodicalIF":1.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward sustainable food service systems: Dietitians' perspectives on digitalization. 迈向可持续食品服务系统：营养师对数字化的看法。

IF 1.4

Nutrition and health Pub Date : 2026-05-08 DOI: 10.1177/02601060261448451

Nida Nur Adiyan, Yasemin Beyhan

{"title":"Toward sustainable food service systems: Dietitians' perspectives on digitalization.","authors":"Nida Nur Adiyan, Yasemin Beyhan","doi":"10.1177/02601060261448451","DOIUrl":"https://doi.org/10.1177/02601060261448451","url":null,"abstract":"BackgroundIntegrating digital applications-which provide convenience across many domains-into Food Service Systems (FSS) plays a key role in improving operational efficiency and ease. This study aimed to evaluate the professional experiences of dietitians working in FSS and their perspectives on innovative developments within the context of sustainability.MethodsThis descriptive, cross-sectional study included 70 dietitians employed in FSS. Data were collected through an online survey developed after expert consultation. The survey addressed demographic characteristics, professional practice experiences, stages of the service process where digitalization could facilitate work, and perspectives on digital menu planning.ResultsA weak but statistically significant positive correlation was identified between the ranking of professional issues encountered by dietitians and the ranking of consumer dissatisfaction (ρ = 0.280, p < 0.05). Most respondents (89.2%) reported no general difficulties in professional processes, while 70% indicated that digitalization could facilitate FSS-related tasks. A significant difference by graduation degree was observed in tendencies toward digitalization in sustainable menu planning, specifically in seasonal food selection (p < 0.05).ConclusionDigital applications may contribute to the perceived facilitation of work processes, according to dietitians' evaluations. The integration of professional experiences and digital tools across food service operations may enhance workflow efficiency and support the implementation of innovative practices as technological advancements continue.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261448451"},"PeriodicalIF":1.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

trans-Chalcone protects against high-fat diet-induced kidney injury in rats by regulating the miR-874/TLR4 pathway. 反式查尔酮通过调节miR-874/TLR4通路，保护大鼠免受高脂肪饮食诱导的肾损伤。

IF 1.4

Nutrition and health Pub Date : 2026-05-08 DOI: 10.1177/02601060261446821

Elham Karimi-Sales, Khalil Hajiasgharzadeh, Mohammad Reza Alipour

{"title":"trans-Chalcone protects against high-fat diet-induced kidney injury in rats by regulating the miR-874/TLR4 pathway.","authors":"Elham Karimi-Sales, Khalil Hajiasgharzadeh, Mohammad Reza Alipour","doi":"10.1177/02601060261446821","DOIUrl":"https://doi.org/10.1177/02601060261446821","url":null,"abstract":"BackgroundChronic high-fat diet (HFD) consumption is linked to chronic kidney disease. Toll-like receptor 4 (TLR4) promotes pro-fibrotic and pro-inflammatory pathways in the kidney. It is directly inhibited by renal miR-874. trans-Chalcone has protective effects against HFD-related diseases. However, its effects on renal miR-874 and TLR4 expression in HFD-fed animals remain unexamined.AimThe current study examined the possible influences of trans-chalcone and HFD on the renal miR-874/TLR4 axis.MethodsMale rats were divided into control, HFD, and HFD + trans-chalcone groups. They received Tween 80 in control, high-fat emulsion in HFD and HFD + trans-chalcone groups, and trans-chalcone in the HFD + trans-chalcone group. Fasting insulin resistance index (FIRI) was calculated, and real-time PCR was used to determine the expression levels of miR-874 and TLR4 in the kidneys.ResultsChronic HFD feeding elevated FIRI levels. In contrast, co-treatment with trans-chalcone and HFD significantly reduced FIRI levels in the HFD + trans-chalcone group compared with the HFD group. Consumption of an HFD also significantly reduced miR-874 and increased TLR4 expression. These HFD-induced changes were inhibited by trans-chalcone. There were no significant differences in renal expression of miR-874 and TLR4 between the control and HFD + trans-chalcone groups.ConclusionDown-regulation of renal miR-874 may be responsible for elevated TLR4 mRNA levels during HFD feeding. Furthermore, miR-874 dysregulation may be linked to the development of HFD-related kidney disease. This study suggests that trans-chalcone is a potential therapeutic chalcone for protecting the kidney against the dysregulation of the miR-874/TLR4 pathway during HFD feeding.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261446821"},"PeriodicalIF":1.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The game of chess: Future directions for sports nutrition and supplementation. 棋局：运动营养和补充的未来方向。

IF 1.4

Nutrition and health Pub Date : 2026-05-07 DOI: 10.1177/02601060261447179

Nikola Todorovic, Bogdan Andjelic, David Nedeljkovic, Sergej Ostojic

{"title":"The game of chess: Future directions for sports nutrition and supplementation.","authors":"Nikola Todorovic, Bogdan Andjelic, David Nedeljkovic, Sergej Ostojic","doi":"10.1177/02601060261447179","DOIUrl":"https://doi.org/10.1177/02601060261447179","url":null,"abstract":"Competitive chess is a cognitively intensive sport that demands sustained executive control, complex visuospatial processing, prolonged attention, and effective regulation of psychological stress under time pressure. Despite growing professionalization, research on nutritional strategies to support chess performance remains limited. Existing work has largely emphasized pharmacological cognitive enhancers, which offer limited ecological validity and raise ethical and regulatory concerns, while comparatively little attention has been paid to safe, non-prohibited interventions applicable to real-world competition. This paper synthesizes evidence on the neurocognitive and psychophysiological demands of competitive chess and identifies priorities for future nutrition and supplementation research. Drawing on mechanistic and translational insights from cognitive neuroscience and esports, we evaluate dietary supplements with potential to support cerebral bioenergetics, attentional stability, and stress modulation. Finally, we propose a structured, ecologically grounded research framework to guide evidence-based, ethically compliant performance optimization in chess.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261447179"},"PeriodicalIF":1.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition security, diet quality, and food assistance program use among food insecure households with children: A cross-sectional analysis. 有儿童的粮食不安全家庭的营养安全、饮食质量和粮食援助计划的使用：一项横断面分析。

IF 1.4

Nutrition and health Pub Date : 2026-05-02 DOI: 10.1177/02601060261445338

Kieley L Chapman, Keally Haushalter, Allison J Wu, Mandy Luo, Meghan Perkins, Anisha Gundewar, Eric E Calloway, Daniel Taitelbaum, Rachel Burgun, Jaimie Davis, Lauren Fiechtner

{"title":"Nutrition security, diet quality, and food assistance program use among food insecure households with children: A cross-sectional analysis.","authors":"Kieley L Chapman, Keally Haushalter, Allison J Wu, Mandy Luo, Meghan Perkins, Anisha Gundewar, Eric E Calloway, Daniel Taitelbaum, Rachel Burgun, Jaimie Davis, Lauren Fiechtner","doi":"10.1177/02601060261445338","DOIUrl":"https://doi.org/10.1177/02601060261445338","url":null,"abstract":"BackgroundWhile food insecurity (FI) assesses household access to sufficient food, increasing attention is being paid to nutrition security (NS), the ability to obtain health-promoting foods.AimThis cross-sectional analysis examined differences in sociodemographics, diet quality, and health status between food insecure families with low versus high NS and assessed if FI and NS severity was associated with food assistance program use.MethodsData were obtained from the 2023 Massachusetts Statewide Food Access Survey of >3000 adults. FI was assessed using the United States Department of Agriculture 18-item Household Food Security Module, NS via a validated four-item scale, and diet quality via the Prime Diet Quality Score (PDQS). FI and NS were analyzed as binary and continuous variables. Inferential statistics assessed group differences. Logistic regression assessed associations between the severity of FI and NS and food assistance program use.SummaryHouseholds with FI, ≥1 child (≤18 years), and annual income ≤$50,000 (n = 335) were included. Forty-three percent reported low NS. Low (vs. high) household NS was associated with a higher prevalence of child-level FI (79% vs. 43%, P < 0.001), SNAP use (83% vs. 70%, P = 0.009), food pantry use (69% vs. 44%, P < 0.001), adult overweight/obesity (39% vs. 17%, P < 0.001), and lower adult PDQS (43 ± 5.1 vs. 44 ± 4.3, P = 0.023), indicating lower diet quality. More severe household FI and lower NS were associated with higher odds of SNAP and food pantry use (P < 0.001). These findings support expanding food assistance programs to increase nutritious food access for families with children before food and nutrition insecurity become severe.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261445338"},"PeriodicalIF":1.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing dietary patterns and weight outcomes between smokers and ex-smokers. 比较吸烟者和戒烟者之间的饮食模式和体重结果。

IF 1.4

Nutrition and health Pub Date : 2026-05-02 DOI: 10.1177/02601060261446179

Driton Shabani, Dion Haliti, Ardiana Murtezani, Zana Ibraimi

{"title":"Comparing dietary patterns and weight outcomes between smokers and ex-smokers.","authors":"Driton Shabani, Dion Haliti, Ardiana Murtezani, Zana Ibraimi","doi":"10.1177/02601060261446179","DOIUrl":"https://doi.org/10.1177/02601060261446179","url":null,"abstract":"BackgroundSmoking and obesity are two major health problems that are strongly associated with chronic diseases. While weight gain after smoking cessation is well recognized, less is known about the specific dietary patterns that may drive it.AimThis study aimed to compare dietary patterns between smokers and ex-smokers and to examine how changes in eating behaviors relate to body weight outcomes.MethodsWe conducted a descriptive cross-sectional pilot study between May and June 2025 in two large private companies in Prishtina, Kosova. A total of 500 sedentary employees (aged 18+) participated over a six-week period. Participants completed a self-administered questionnaire that collected sociodemographic data, smoking history, and dietary patterns during smoking and after cessation.SummaryOverall, 55% of participants were smokers (34% smoked 10-20 cigarettes/day; 10% smoked >20/day), while 45% were ex-smokers. Increased appetite after quitting smoking was reported by 81% of ex-smokers, who experienced greater overall weight gain compared to smokers, rather than weight gain limited to the thigh or chest area. Ex-smokers reported higher intake of protein-rich foods, pastries, sweets, fast food, and healthy foods, reflecting broader dietary changes after cessation. These findings indicate that increased appetite and higher consumption of pastries, sweets, and fast food among ex-smokers may be associated with weight gain. They also suggest that nutritional counseling could help manage postcessation weight gain.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261446179"},"PeriodicalIF":1.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ashwagandha supplementation on athletic performance and recovery: A narrative review. 补充ashwagandha对运动表现和恢复的影响：一个叙述性的回顾。

IF 1.4

Nutrition and health Pub Date : 2026-05-02 DOI: 10.1177/02601060261447118

Büşra AKbulut, Eren Canbolat

{"title":"Effects of ashwagandha supplementation on athletic performance and recovery: A narrative review.","authors":"Büşra AKbulut, Eren Canbolat","doi":"10.1177/02601060261447118","DOIUrl":"https://doi.org/10.1177/02601060261447118","url":null,"abstract":"Background: Ashwagandha, a plant belonging to the Solanaceae family, has gained increasing attention in recent years due to its antioxidant, anti-inflammatory, and adaptogenic properties, and its potential to improve physical performance and support post-exercise recovery. Objectives: This narrative review aims to summarize and critically evaluate the current scientific evidence regarding the effects of Ashwagandha supplementation on exercise-induced oxidative stress, athletic performance, and safety. Methodology: This study is a narrative review based on previously published literature. The synthesis involved evaluating current studies focusing primarily on Ashwagandha supplementation and its relationship to exercise and sports performance. The included sources comprise clinical trials, meta-analyses, and review articles reporting outcomes related to strength, endurance, recovery, and safety. Results: Studies suggest that Ashwagandha dosages of 330-1000 mg daily will increase endurance and facilitate quicker recoveries, with a twice daily dose of 300 mg in combination with weight training increasing muscular strength and hypertrophy. Ashwagandha is also believed to regulate cortisol levels and relieve anxiety and insomnia. Typical dosage levels in the sporting field appear to be higher, at approximately 600 mg/day, but a lower dose will be required by less active people. Side effects are mild in the majority of the literature and no dangerous side effects occur at recommended dosages. Conclusion: Ashwagandha has been found to be safe and effective in a natural supplementary capacity in sports and athletics. The correct dosage and application period of Ashwagandha should be taken into consideration to reap its properties in the human body.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"2601060261447118"},"PeriodicalIF":1.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaempferitrin modulates AMPK phosphorylation and PEPCK expression in the liver after a short-term high-fat, high-sucrose diet intervention in mice. 山奈霉素在短期高脂高糖饮食干预后调节小鼠肝脏AMPK磷酸化和PEPCK表达。

IF 1.4

Nutrition and health Pub Date : 2026-05-01 Epub Date: 2025-05-20 DOI: 10.1177/02601060251340447

Ingrid Candido Garofolo, Paloma Freire Santos, Milena Ferreira Silva, Viviane de Mello Veneza, Thiago André Moura Veiga, Vera Lucia Flor Silveira, Maria Isabel Cardoso Alonso-Vale, Luciana Chagas Caperuto

{"title":"Kaempferitrin modulates AMPK phosphorylation and PEPCK expression in the liver after a short-term high-fat, high-sucrose diet intervention in mice.","authors":"Ingrid Candido Garofolo, Paloma Freire Santos, Milena Ferreira Silva, Viviane de Mello Veneza, Thiago André Moura Veiga, Vera Lucia Flor Silveira, Maria Isabel Cardoso Alonso-Vale, Luciana Chagas Caperuto","doi":"10.1177/02601060251340447","DOIUrl":"10.1177/02601060251340447","url":null,"abstract":"Background: Type 2 Diabetes Mellitus is a metabolic disease characterized by hyperglycemia and hyperinsulinemia, closely linked to obesity. According to the International Diabetes Federation, in 2021, almost 6.7 million adults aged 20-79 died due to complications from diabetes. In light of this concerning statistic, novel alternatives, including bioactive compounds such as flavonoids, are undergoing clinical and scientific evaluation to hinder the advancement of metabolic disorders or maybe avert their onset. Aim: We postulate that kaempferitrin may act on glycemic homeostasis in mice challenged with high-fat, high-sucrose diet (HFHS) for 24 h. Methods: Kaempferitrin at a 100 mg/kg dose was administered to two-month-old male C57BL/6 mice challenged with a HFHS diet for 3, 6, or 24 h. Glucose intolerance was assessed by an oral glucose tolerance test (oGTT). In the liver, AMP-activated protein kinase (AMPK) was measured via western blotting, and gene expression of the phosphoenolpyruvate carboxykinase (PEPCK) enzyme was assessed by quantitative PCR (qPCR). Results: At 6 h, kaempferitrin reduced the PEPCK gene expression compared to the group receiving only the HFHS diet. For the 24 h challenge with the HFHS diet, kaempferitrin did not prevent glucose intolerance (oGTT). However, kaempferitrin reduced the pAMPK/AMPK ratio and the PEPCK gene expression compared to the HFHS group. Conclusions: Kaempferitrin, when administered alongside a hypercaloric and hyperlipidic diet, even for short periods, did not prevent glucose intolerance. Nevertheless, it did lead to significant modulations in AMPK phosphorylation and PEPCK gene expression.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"925-935"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-operative fasting in a cohort of patients undergoing surgery for fractured neck of femur - a retrospective cross-sectional study. 股骨颈骨折手术患者的术前禁食-一项回顾性横断面研究。

IF 1.4

Nutrition and health Pub Date : 2026-05-01 Epub Date: 2025-06-06 DOI: 10.1177/02601060251347447

Alice Melton, Nicholas Thorne, Sim Yee Tan, Nicola Riley, Sharon Carey

{"title":"Pre-operative fasting in a cohort of patients undergoing surgery for fractured neck of femur - a retrospective cross-sectional study.","authors":"Alice Melton, Nicholas Thorne, Sim Yee Tan, Nicola Riley, Sharon Carey","doi":"10.1177/02601060251347447","DOIUrl":"10.1177/02601060251347447","url":null,"abstract":"Background: Despite strong evidence indicating detrimental impacts, surgical patients often experience prolonged peri-operative fasting. Aim: The aim of this retrospective cross-sectional study was to assess duration of pre-operative fasting in a cohort of acute inpatients undergoing surgery for fractured neck of femur within a large tertiary referral hospital in Sydney, Australia; and to compare fasting times with recommended pre-operative fasting guidelines. Methods: Patients that underwent surgery for fractured neck of femur between February and September 2023 were retrospectively assessed for the length of pre-operative fasting. The pre-operative fasting period was defined as the time documented in the medical record that patients were advised to fast from the time of general anaesthetic administration as per operative records. Fasting times were compared to current evidence-based pre-operative fasting guidelines. Results: Ninety-two participants were included in this study, with a pre-operative fasting period from solids of 11.1 h (interquartile range [IQR] 5.5) and pre-operative fluids of 10.8 h (IQR 5.3). No participants were given the opportunity to have solids up to 6 h prior to surgery and/or pre-operative fluids up to 2 h prior to surgery as per current fasting guideline. Majority of participants were female with a median age of 82 (IQR 13.3) and over 40% were assessed as malnourished on admission to hospital. Conclusion: Pre-operative fasting greatly exceeded recommended fasting times. Given patients undergoing fractured neck or femur surgery are often older and at high nutrition risk, more research focusing on strategies to reduce excessive fasting is needed in this vulnerable population.","PeriodicalId":19352,"journal":{"name":"Nutrition and health","volume":" ","pages":"1005-1010"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0