NPJ Digital Medicine最新文献

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Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor 医疗决策和公平的无偏见预测信息指南(GUIDE):种族可能成为预后因素时的考虑因素
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-19 DOI: 10.1038/s41746-024-01245-y
Keren Ladin, John Cuddeback, O. Kenrik Duru, Sharad Goel, William Harvey, Jinny G. Park, Jessica K. Paulus, Joyce Sackey, Richard Sharp, Ewout Steyerberg, Berk Ustun, David van Klaveren, Saul N. Weingart, David M. Kent
{"title":"Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor","authors":"Keren Ladin, John Cuddeback, O. Kenrik Duru, Sharad Goel, William Harvey, Jinny G. Park, Jessica K. Paulus, Joyce Sackey, Richard Sharp, Ewout Steyerberg, Berk Ustun, David van Klaveren, Saul N. Weingart, David M. Kent","doi":"10.1038/s41746-024-01245-y","DOIUrl":"10.1038/s41746-024-01245-y","url":null,"abstract":"Clinical prediction models (CPMs) are tools that compute the risk of an outcome given a set of patient characteristics and are routinely used to inform patients, guide treatment decision-making, and resource allocation. Although much hope has been placed on CPMs to mitigate human biases, CPMs may potentially contribute to racial disparities in decision-making and resource allocation. While some policymakers, professional organizations, and scholars have called for eliminating race as a variable from CPMs, others raise concerns that excluding race may exacerbate healthcare disparities and this controversy remains unresolved. The Guidance for Unbiased predictive Information for healthcare Decision-making and Equity (GUIDE) provides expert guidelines for model developers and health system administrators on the transparent use of race in CPMs and mitigation of algorithmic bias across contexts developed through a 5-round, modified Delphi process from a diverse 14-person technical expert panel (TEP). Deliberations affirmed that race is a social construct and that the goals of prediction are distinct from those of causal inference, and emphasized: the importance of decisional context (e.g., shared decision-making versus healthcare rationing); the conflicting nature of different anti-discrimination principles (e.g., anticlassification versus antisubordination principles); and the importance of identifying and balancing trade-offs in achieving equity-related goals with race-aware versus race-unaware CPMs for conditions where racial identity is prognostically informative. The GUIDE, comprising 31 key items in the development and use of CPMs in healthcare, outlines foundational principles, distinguishes between bias and fairness, and offers guidance for examining subgroup invalidity and using race as a variable in CPMs. This GUIDE presents a living document that supports appraisal and reporting of bias in CPMs to support best practice in CPM development and use.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-12"},"PeriodicalIF":12.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01245-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized clinical trial testing digital mindset intervention for knee osteoarthritis pain and activity improvement 一项随机临床试验,测试针对膝关节骨性关节炎疼痛和活动改善的数字心态干预措施
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-17 DOI: 10.1038/s41746-024-01281-8
Melissa A. Boswell, Kris M. Evans, Disha Ghandwani, Trevor Hastie, Sean R. Zion, Paula L. Moya, Nicholas J. Giori, Jennifer L. Hicks, Alia J. Crum, Scott L. Delp
{"title":"A randomized clinical trial testing digital mindset intervention for knee osteoarthritis pain and activity improvement","authors":"Melissa A. Boswell, Kris M. Evans, Disha Ghandwani, Trevor Hastie, Sean R. Zion, Paula L. Moya, Nicholas J. Giori, Jennifer L. Hicks, Alia J. Crum, Scott L. Delp","doi":"10.1038/s41746-024-01281-8","DOIUrl":"10.1038/s41746-024-01281-8","url":null,"abstract":"This randomized clinical trial evaluated the effectiveness of short, digital interventions in improving physical activity and pain for individuals with knee osteoarthritis. We compared a digital mindset intervention, focusing on adaptive mindsets (e.g., osteoarthritis is manageable), to a digital education intervention and a no-intervention group. 408 participants with knee osteoarthritis completed the study online in the US. The mindset intervention significantly improved mindsets compared to both other groups (P < 0.001) and increased physical activity levels more than the no-intervention group (mean = 28.6 points, P = 0.001), but pain reduction was not significant. The mindset group also showed significantly greater improvements in the perceived need for surgery, self-imposed physical limitations, fear of movement, and self-efficacy than the no-intervention and education groups. This trial demonstrates the effectiveness of brief digital interventions in educating about osteoarthritis and further highlights the additional benefits of improving mindsets to transform patients’ approach to disease management. The study was prospectively registered (ClinicalTrials.gov: NCT05698368, 2023-01-26).","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-11"},"PeriodicalIF":12.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01281-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing fairness issues in deep learning-based medical image analysis: a systematic review 解决基于深度学习的医学图像分析中的公平性问题:系统综述
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-17 DOI: 10.1038/s41746-024-01276-5
Zikang Xu, Jun Li, Qingsong Yao, Han Li, Mingyue Zhao, S. Kevin Zhou
{"title":"Addressing fairness issues in deep learning-based medical image analysis: a systematic review","authors":"Zikang Xu, Jun Li, Qingsong Yao, Han Li, Mingyue Zhao, S. Kevin Zhou","doi":"10.1038/s41746-024-01276-5","DOIUrl":"10.1038/s41746-024-01276-5","url":null,"abstract":"Deep learning algorithms have demonstrated remarkable efficacy in various medical image analysis (MedIA) applications. However, recent research highlights a performance disparity in these algorithms when applied to specific subgroups, such as exhibiting poorer predictive performance in elderly females. Addressing this fairness issue has become a collaborative effort involving AI scientists and clinicians seeking to understand its origins and develop solutions for mitigation within MedIA. In this survey, we thoroughly examine the current advancements in addressing fairness issues in MedIA, focusing on methodological approaches. We introduce the basics of group fairness and subsequently categorize studies on fair MedIA into fairness evaluation and unfairness mitigation. Detailed methods employed in these studies are presented too. Our survey concludes with a discussion of existing challenges and opportunities in establishing a fair MedIA and healthcare system. By offering this comprehensive review, we aim to foster a shared understanding of fairness among AI researchers and clinicians, enhance the development of unfairness mitigation methods, and contribute to the creation of an equitable MedIA society.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-16"},"PeriodicalIF":12.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01276-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
India’s evolving digital health strategy 印度不断发展的数字医疗战略
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-16 DOI: 10.1038/s41746-024-01279-2
Aditya Narayan, Indu Bhushan, Kevin Schulman
{"title":"India’s evolving digital health strategy","authors":"Aditya Narayan, Indu Bhushan, Kevin Schulman","doi":"10.1038/s41746-024-01279-2","DOIUrl":"10.1038/s41746-024-01279-2","url":null,"abstract":"India’s evolving digital health strategy leverages innovative technologies to enhance access to healthcare services. This paper explores the key components of India’s digital health transformation, including the Ayushman Bharat Digital Mission (ABDM) and India’s integration of biometric identification and digital infrastructure to improve healthcare delivery. The lessons learned from India’s large-scale implementation of digital health provide valuable insights for global health markets and digital transformations in healthcare systems.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-3"},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01279-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge abstraction and filtering based federated learning over heterogeneous data views in healthcare 基于知识抽象和过滤的医疗保健领域异构数据视图联合学习
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-16 DOI: 10.1038/s41746-024-01272-9
Anshul Thakur, Soheila Molaei, Pafue Christy Nganjimi, Andrew Soltan, Patrick Schwab, Kim Branson, David A. Clifton
{"title":"Knowledge abstraction and filtering based federated learning over heterogeneous data views in healthcare","authors":"Anshul Thakur, Soheila Molaei, Pafue Christy Nganjimi, Andrew Soltan, Patrick Schwab, Kim Branson, David A. Clifton","doi":"10.1038/s41746-024-01272-9","DOIUrl":"10.1038/s41746-024-01272-9","url":null,"abstract":"Robust data privacy regulations hinder the exchange of healthcare data among institutions, crucial for global insights and developing generalised clinical models. Federated learning (FL) is ideal for training global models using datasets from different institutions without compromising privacy. However, disparities in electronic healthcare records (EHRs) lead to inconsistencies in ML-ready data views, making FL challenging without extensive preprocessing and information loss. These differences arise from variations in services, care standards, and record-keeping practices. This paper addresses data view heterogeneity by introducing a knowledge abstraction and filtering-based FL framework that allows FL over heterogeneous data views without manual alignment or information loss. The knowledge abstraction and filtering mechanism maps raw input representations to a unified, semantically rich shared space for effective global model training. Experiments on three healthcare datasets demonstrate the framework’s effectiveness in overcoming data view heterogeneity and facilitating information sharing in a federated setup.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-14"},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01272-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective clinical evaluation of deep learning for ultrasonographic screening of abdominal aortic aneurysms 用于腹主动脉瘤超声筛查的深度学习前瞻性临床评估
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-15 DOI: 10.1038/s41746-024-01269-4
I-Min Chiu, Tien-Yu Chen, You-Cheng Zheng, Xin-Hong Lin, Fu-Jen Cheng, David Ouyang, Chi-Yung Cheng
{"title":"Prospective clinical evaluation of deep learning for ultrasonographic screening of abdominal aortic aneurysms","authors":"I-Min Chiu, Tien-Yu Chen, You-Cheng Zheng, Xin-Hong Lin, Fu-Jen Cheng, David Ouyang, Chi-Yung Cheng","doi":"10.1038/s41746-024-01269-4","DOIUrl":"10.1038/s41746-024-01269-4","url":null,"abstract":"Abdominal aortic aneurysm (AAA) often remains undetected until rupture due to limited access to diagnostic ultrasound. This trial evaluated a deep learning (DL) algorithm to guide AAA screening by novice nurses with no prior ultrasonography experience. Ten nurses performed 15 scans each on patients over 65, assisted by a DL object detection algorithm, and compared against physician-performed scans. Ultrasound scan quality, assessed by three blinded expert physicians, was the primary outcome. Among 184 patients, DL-guided novices achieved adequate scan quality in 87.5% of cases, comparable to the 91.3% by physicians (p = 0.310). The DL model predicted AAA with an AUC of 0.975, 100% sensitivity, and 97.8% specificity, with a mean absolute error of 2.8 mm in predicting aortic width compared to physicians. This study demonstrates that DL-guided POCUS has the potential to democratize AAA screening, offering performance comparable to experienced physicians and improving early detection.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":12.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01269-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Towards harmonizing assessment and reimbursement of digital medical devices in the EU through mutual learning 作者更正:通过相互学习实现欧盟数字医疗器械评估和报销的协调统一
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-14 DOI: 10.1038/s41746-024-01285-4
Rosanna Tarricone, Francesco Petracca, Hannah-Marie Weller
{"title":"Author Correction: Towards harmonizing assessment and reimbursement of digital medical devices in the EU through mutual learning","authors":"Rosanna Tarricone, Francesco Petracca, Hannah-Marie Weller","doi":"10.1038/s41746-024-01285-4","DOIUrl":"10.1038/s41746-024-01285-4","url":null,"abstract":"","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-1"},"PeriodicalIF":12.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01285-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Privacy-friendly evaluation of patient data with secure multiparty computation in a European pilot study 在一项欧洲试点研究中,通过安全的多方计算对患者数据进行隐私友好型评估
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-14 DOI: 10.1038/s41746-024-01293-4
Hendrik Ballhausen, Stefanie Corradini, Claus Belka, Dan Bogdanov, Luca Boldrini, Francesco Bono, Christian Goelz, Guillaume Landry, Giulia Panza, Katia Parodi, Riivo Talviste, Huong Elena Tran, Maria Antonietta Gambacorta, Sebastian Marschner
{"title":"Privacy-friendly evaluation of patient data with secure multiparty computation in a European pilot study","authors":"Hendrik Ballhausen, Stefanie Corradini, Claus Belka, Dan Bogdanov, Luca Boldrini, Francesco Bono, Christian Goelz, Guillaume Landry, Giulia Panza, Katia Parodi, Riivo Talviste, Huong Elena Tran, Maria Antonietta Gambacorta, Sebastian Marschner","doi":"10.1038/s41746-024-01293-4","DOIUrl":"10.1038/s41746-024-01293-4","url":null,"abstract":"In multicentric studies, data sharing between institutions might negatively impact patient privacy or data security. An alternative is federated analysis by secure multiparty computation. This pilot study demonstrates an architecture and implementation addressing both technical challenges and legal difficulties in the particularly demanding setting of clinical research on cancer patients within the strict European regulation on patient privacy and data protection: 24 patients from LMU University Hospital in Munich, Germany, and 24 patients from Policlinico Universitario Fondazione Agostino Gemelli, Rome, Italy, were treated for adrenal gland metastasis with typically 40 Gy in 3 or 5 fractions of online-adaptive radiotherapy guided by real-time MR. High local control (21% complete remission, 27% partial remission, 40% stable disease) and low toxicity (73% reporting no toxicity) were observed. Median overall survival was 19 months. Federated analysis was found to improve clinical science through privacy-friendly evaluation of patient data in the European health data space.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-12"},"PeriodicalIF":12.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01293-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A scoping review on advancements in noninvasive wearable technology for heart failure management 无创可穿戴技术在心力衰竭管理方面的进展范围综述
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-12 DOI: 10.1038/s41746-024-01268-5
Niels T. B. Scholte, Annemiek. E. van Ravensberg, Abdul Shakoor, Eric Boersma, Eelko Ronner, Rudolf A. de Boer, Jasper J. Brugts, Nico Bruining, Robert M. A. van der Boon
{"title":"A scoping review on advancements in noninvasive wearable technology for heart failure management","authors":"Niels T. B. Scholte, Annemiek. E. van Ravensberg, Abdul Shakoor, Eric Boersma, Eelko Ronner, Rudolf A. de Boer, Jasper J. Brugts, Nico Bruining, Robert M. A. van der Boon","doi":"10.1038/s41746-024-01268-5","DOIUrl":"10.1038/s41746-024-01268-5","url":null,"abstract":"Wearables offer a promising solution for enhancing remote monitoring (RM) of heart failure (HF) patients by tracking key physiological parameters. Despite their potential, their clinical integration faces challenges due to the lack of rigorous evaluations. This review aims to summarize the current evidence and assess the readiness of wearables for clinical practice using the Medical Device Readiness Level (MDRL). A systematic search identified 99 studies from 3112 found articles, with only eight being randomized controlled trials. Accelerometery was the most used measurement technique. Consumer-grade wearables, repurposed for HF monitoring, dominated the studies with most of them in the feasibility testing stage (MDRL 6). Only two of the described wearables were specifically designed for HF RM, and received FDA approval. Consequently, the actual impact of wearables on HF management remains uncertain due to limited robust evidence, posing a significant barrier to their integration into HF care.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-15"},"PeriodicalIF":12.4,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01268-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review and meta-analysis of standalone digital interventions for cognitive symptoms in people without dementia 针对无痴呆症患者认知症状的独立数字干预措施的系统回顾和荟萃分析
IF 12.4 1区 医学
NPJ Digital Medicine Pub Date : 2024-10-10 DOI: 10.1038/s41746-024-01280-9
Veronica Cabreira, Tim Wilkinson, Lisbeth Frostholm, Jon Stone, Alan Carson
{"title":"Systematic review and meta-analysis of standalone digital interventions for cognitive symptoms in people without dementia","authors":"Veronica Cabreira, Tim Wilkinson, Lisbeth Frostholm, Jon Stone, Alan Carson","doi":"10.1038/s41746-024-01280-9","DOIUrl":"10.1038/s41746-024-01280-9","url":null,"abstract":"Cognitive symptoms are prevalent across neuropsychiatric disorders, increase distress and impair quality of life. Self-guided digital interventions offer accessibility, scalability, and may overcome the research-to-practice treatment gap. Seventy-six trials with 5214 participants were identified. A random-effects meta-analysis investigated the effects of all digital self-guided interventions, compared to controls, at post-treatment. We found a small-to-moderate positive pooled effect on cognition (k = 71; g = −0.51, 95%CI −0.64 to −0.37; p < 0.00001) and mental health (k = 30; g = −0.41, 95%CI −0.60 to −0.22; p < 0.0001). Positive treatment effects on fatigue (k = 8; g = −0.27, 95%CI −0.53 to −0.02; p = 0.03) and quality of life (k = 22; g = −0.17, 95%CI −0.34 to −0.00; p = 0.04) were only marginally significant. No significant benefit was found for performance on activities of daily living. Results were independent of control groups, treatment duration, risk of bias and delivery format. Self-guided digital transdiagnostic interventions may benefit at least a subset of patients in the short run, yet their impact on non-cognitive outcomes remains uncertain.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-21"},"PeriodicalIF":12.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01280-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142397857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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