{"title":"Influence of norepinephrine and fasting on the oxygen consumption of genetically-obese mice.","authors":"I A Macdonald, M J Stock","doi":"10.1159/000176263","DOIUrl":"https://doi.org/10.1159/000176263","url":null,"abstract":"<p><p>Oxygen consumption was monitored in fed and fasted, lean and obese mice of the ob/ob strain before and after subcutaneous injections of norepinephrine (NE). The increase in oxygen consumption after NE was of a similar magnitude in both lean and obese fed mice, but of a longer duration in the obese. Prior fasting caused a diminution of the response in the lean but was associated with an enhanced response in the obese mice. Fasting also resulted in a significant depression of the resting oxygen consumption of the obese mice but not of the lean. The relevance of these findings to the inability of the obese mouse to withstand cold exposure and to the maintenance of the obese state is discussed.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 4","pages":"250-5"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000176263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11646319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Changes in zinc retention in pregnancy].","authors":"U A Schneider, M Kirchgessner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Enhanced retention of nutrients in the gravid organism, which exceeds the normal deposition in the reproductive organs and in fetuses, is called 'pregnancy anabolism'. For zinc this superretention could be established only in the liver which was enlarged in gravid rats, too. In all other tissues of gravid animals, zinc contents were lower compared with nongravid rats. After lactation, these changes in zinc status were equalized, and gravid and nongravid animals showed the same values.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 4","pages":"241-9"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11646542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Drouin, D Lambert, L Mejean, J P Pointel, G Debry
{"title":"[Study of lipid metabolic coefficient K2 in patients with hyperlipoproteinemia type IV before and after reduction of triglyceride level by adapted diet therapy].","authors":"P Drouin, D Lambert, L Mejean, J P Pointel, G Debry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An intravenous fat tolerance test (IV FTT) was performed in a group of patients with type IV hyperlipoproteinemia before and after reduction of triglyceride level, the latter is obtained through a diet adapted to the nutritional sensitivity, body weight remaining constant. Before the diet the increase in cholesterol (CT) and triglycerides (TG) was related in both obese and non-obese patients to an increase in very-low-density lipoproteins (VLDL), while other lipoprotein fractions were not affected. In these patients, K2 is significantly lower than in controls whatever the nutritional sensitivity. However, K2 is lower in obese patients than in patients with normal weight, VLDL-CT and VLDL-TG are tremendously reduced by the relevant diet and K2 is constantly and significantly increased, although it does not reach a normal value in obese subjects. There is a highly significant correlation between VLDL-TG levels and K2 in obese and non-obese subjects. Several physiopathological explanations are discussed to account for the variation of K2 according to TG levels. The results obtained support the view that the K2 defect is secondary to the hyperlipoproteinemia.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 5","pages":"416-28"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11441076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forebrain fatty acid composition during development in protein-calorie and essential fatty acid deficiencies in the rat.","authors":"I Karlsson","doi":"10.1159/000176289","DOIUrl":"https://doi.org/10.1159/000176289","url":null,"abstract":"<p><p>Rats were fed three different dietary levels of essential fatty acids (EFA), 3.0, 0.75 and 0.1 cal%, representing normal, subnormal and severely deficient dietary intakes. From the animals kept on these diets, with a protein content of 16 cal%, 3-month-old females were randomly selected to be fed diets with only 6 cal% protein but with unchanged amounts of EFA. The rats were then mated, and the effects of the diets were studied in the forebrains of their offspring. The growth and the fatty acid patterns of the ethanolamine phosphoglyceride and total phosphoglyceride fractions were studied during the first 60 days of life. Addition of protein-calorie deficiency to rats severely undernourished in EFA mitigated the biochemical signs of EFA deficiency. In EPG the developmental pattern with a decrease of 20:4 (n-6) and an increase of 22:6 (n-3) was retarded between 11 and 21 days of age in the protein-calorie deficient groups suggesting a delay in the maturation of the forebrain.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 6","pages":"429-37"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000176289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11341127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M N Cenarruzabeitia, S Santidrian, J Bello, J Larralde
{"title":"Effect of raw field bean (Vicia faba) on amino-acid-degrading enzymes in rats and chicks.","authors":"M N Cenarruzabeitia, S Santidrian, J Bello, J Larralde","doi":"10.1159/000176257","DOIUrl":"https://doi.org/10.1159/000176257","url":null,"abstract":"<p><p>The effects of Vicia faba diet on urinary nitrogenous compounds and on enzyme activities of pathways directly associated with amino acid metabolism were studied in rats and chicks. The urea and creatinine excretion of rats fed on V. faba was approximately 90% more than that of control rats. The V.-faba-fed rats had increased activities of liver arginase (EC 3.5.3.1), argininosuccinate synthetase (EC 6.3.4.5) and alanine aminotransferase (EC 2.6.1.2). The chicks fed on V. faba also showed increased activity of xanthine dehydrogenase (EC 1.2.3.2). The possible nature of these altered amino-acid-degrading enzyme activities is discussed.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 3","pages":"203-10"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000176257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of different dietary carbohydrates on liver and plasma constituents in rats adapted to meal feeding.","authors":"S S Kang, K R Bruckdorfer, J Yudkin","doi":"10.1159/000176269","DOIUrl":"https://doi.org/10.1159/000176269","url":null,"abstract":"<p><p>Male Sprague-Dawley rats were given in one experiment diets with starch or sucrose and in a second experiment diets with glucose or fructose. In each experiment, one group of 5 rats was fed ad libitum and five other groups fed a 3-hour meal each day. After 36 days, one group of the meal-fed rats was killed when the meal was due, and the other groups at intervals after the beginning of the meal. The group fed ad libitum was killed the next day after 21 h fasting. Meal feeding led to a smaller food intake and a smaller gain in weight, and a lower blood concentration of triacylglycerol. The diets with sucrose or fructose produced heavier livers and kidneys than did those with starch or glucose. The consumption of the meal led also to a temporary increase in the weight of the liver. The weight of the kidney, however, did not change in rats given starch or gluocse, but fell in rats given sucrose or fructose. Meal consumption was also followed by an increase in the concentration of liver glycogen, irrespective of the nature of the dietary carbohydrate. The concentration of plasma fatty acids was affected differently by meals containing the different carbohydrates, the extremes being a continuing fall with starch and no change with fructose. The concentration of triacyglycerol was increased by sucrose or fructose after the presentation of the meal. The concentration of blood glucose rose and then fell when the meal contained starch or glucose, but fell and then rose when it contained sucrose, and especially when it contained fructose. The concentration of insulin in meal-fed rats receiving sucrose was higher than that of rats receiving starch, both before and after the meal. This difference was not seen in rats fed ad libitum. The results indicate that the effects of meal feeding, or of sucrose or fructose, are not additive.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 4","pages":"301-15"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000176269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11646325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Enhanced retention of zinc in the gravid organism].","authors":"U A Schneider, M Kirchgessner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Enhanced retention of nutrients in the gravid organism, which exceeds the normal deposition in the reproductive organs and in fetuses, is called 'pregnancy anabolism'. For zinc this superretention could be established only in the liver which was enlarged in gravid rats, too. In all other tissues of gravid animals, zinc contents were lower compared with nongravid rats. After lactation, these changes in zinc status were equalized, and gravid and nongravid animals showed the same values.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 4","pages":"241-9"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11646543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effects of conjugates of linolenic acid and erucic acid on rat cardiac and liver lipids].","authors":"G Rocquelin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac and liver lipids (triglycerides and phospholipids) were analyzed in weanling rats fed for 8 days diets containing 15% by weight of four different lipid mixtures: trierucin and peanut oil (1/1), trierucin and linseed oil (1/1), triolein and peanut oil (1/1), triolein and linseed oil (1/1). Linolenic acid (8 cal% of the diet) does not influence the steatogenic effect of erucic acid (15 cal% of the diet) on the myocardium but seems to increase the hepatic conversion of erucic acid into shorter monoenes (C 18:1 mainly). The (n-6), (n-3) fatty acid spectra in heart and liver phospholipids are strongly affected when linolenic acid is added to the diet whereas erucic acid has little effect.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 2","pages":"98-108"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11785022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adaptation to restricted intake of protein and energy.","authors":"M A Khan, A E Bender","doi":"10.1159/000176291","DOIUrl":"https://doi.org/10.1159/000176291","url":null,"abstract":"<p><p>Adult rats that maintained nitrogen balance on a diet containing 5% casein fed ad libitum were restricted to 70% of their normal food intake for 31 days. This resulted in a negative N balance, loss of body weight and increased activities of hepatic glutamic pyruvic transaminase and arginase--all of which persisted for 10 days. After this time there was no further weight loss, the negative N balance returned to equilibrium and the activities of the two enzymes returned to normal indicating adaptation to the dietary restriction. Radio-isotope studies with labelled methionine showed that dietary restriction led to an increase in the radioactivity of the liver and a decrease of that of the muscles indicating maintenance of liver protein at the expense of muscle protein. Resting oxygen consumption decreased by 34% after 20 days of dietary restriction and this would account for the adaptation observed.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 6","pages":"449-57"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000176291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11751640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Loriette, H Pasantes-Morales, C Portemer, F Chatagner
{"title":"Dietary casein levels and taurine supplementation. Effects on cysteine dioxygenase and cysteine sulfinate decarboxylase activities and tuarine concentration in brain, liver and kidney of the rat.","authors":"C Loriette, H Pasantes-Morales, C Portemer, F Chatagner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Activities of cysteine dioxygenase (CO) and cysteine sulfinate decarboxylase (CSD) and the concentrations of taurine (T) in brain, liver and kidney of rats fed on diets containing 18% casein (A), 60% casein (B) and 17% casein supplemented with 1% of taurine (+T), were measured. Regardless of the diet, the three measurements were the same in the brains of the animals in the three groups. In the liver and the kidney, CO activity was also the same in all three diets, but a decrease of CSD activity associated to an increase of T was observed in rats fed on diet B. The taurine-supplemented diet led to an increase in T concentration.</p>","PeriodicalId":19333,"journal":{"name":"Nutrition and metabolism","volume":"23 6","pages":"467-75"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11751641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}