Adaptation to restricted intake of protein and energy.

M A Khan, A E Bender
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引用次数: 14

Abstract

Adult rats that maintained nitrogen balance on a diet containing 5% casein fed ad libitum were restricted to 70% of their normal food intake for 31 days. This resulted in a negative N balance, loss of body weight and increased activities of hepatic glutamic pyruvic transaminase and arginase--all of which persisted for 10 days. After this time there was no further weight loss, the negative N balance returned to equilibrium and the activities of the two enzymes returned to normal indicating adaptation to the dietary restriction. Radio-isotope studies with labelled methionine showed that dietary restriction led to an increase in the radioactivity of the liver and a decrease of that of the muscles indicating maintenance of liver protein at the expense of muscle protein. Resting oxygen consumption decreased by 34% after 20 days of dietary restriction and this would account for the adaptation observed.

适应有限的蛋白质和能量摄入。
成年大鼠以含5%酪蛋白的饮食维持氮平衡,自由喂养31天,限制其正常食物摄入量的70%。这导致负氮平衡,体重下降,肝谷丙转氨酶和精氨酸酶活性增加,所有这些持续10天。在此之后,体重不再下降,负氮平衡恢复平衡,两种酶的活性恢复正常,表明对饮食限制的适应。用标记蛋氨酸进行的放射性同位素研究表明,饮食限制导致肝脏放射性增加,肌肉放射性降低,表明肝脏蛋白质的维持是以肌肉蛋白质为代价的。在饮食限制20天后,静息耗氧量下降了34%,这可以解释观察到的适应性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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